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The Distribution of Different Clades of Seneca Valley Viruses in Guangdong Province,China

Virologica Sinica 2018年第5期33卷 394-401页

作者： Pan Chen Fan Yang Weijun Cao huanan liu Keshan Zhang Xiangtao liu Zhiwen Xu Zixiang Zhu Haixue Zheng State Key Laboratory of Veterinary Etiological Biology National Foot and Mouth Diseases Reference LaboratoryKey Laboratory of Animal Virology of Ministry of Agriculture Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences Animal Biotechnology Center Key Laboratory of Animal Disease and Human Health of Sichuan Province Sichuan Agricultural University

Seneca Valley virus (SVV), a newly determined etiological agent of vesicular disease in swine, causes porcine idiopathic disease and occasional acute death in piglets. Recently, an increased number of SVV infection cases have been reported in the United States (US) and China, resulting in significant economic losses to the swine industry. The first identification of SVV in China was reported in Guangdong Province, a major swine producing province. The cases of SVV were continuously reported in Guangdong in 2015 and 2016. However, the spread of SVV in Guangdong in 2017 remains *** this study, we determined two new SVV strains, CH-GD-2017-1 and CH-GD-2017-2, from Guangdong. The genetic analysis suggested that the two Guangdong strains showed different characteristics to previous Guangdong strains. They showed lower nucleotide similarity with strains isolated in 2015 and 2016, and were more similar to the US *** analyses indicated that the new strains were clustered in a different clade with previous Guangdong *** found 28 mutated amino acids in the new strains, compared with the first Guangdong strain, SVV CH-01-2015. In the geographic analysis, we found that the US and China reported more SVV cases than other countries, and most of the SVV cases were reported in east and central China—of which, Guangdong Province is one of the major epidemic regions. In conclusion, our findings indicate that SVV continued to spread in Guangdong Province in 2017, and two different clades of SVVs have emerged in this region.

关键词： Seneca Valley virus (SVV) Genomic sequence Phylogenetic tree Epidemiological analysis

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STING agonist 22免疫增强剂配伍ASFV P30蛋白对猪免疫效果的评价

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中国兽医科学 2024年第9期54卷 1137-1148页

作者：彭勤曹伟军杨帆刘华南茹毅朱紫祥郑海学张桂红华南农业大学兽医学院广东广州510642 广东省人畜共患病防控重点实验室广东广州510642 中国农业科学院兰州兽医研究所兰州大学动物医学与生物安全学院动物疫病防控全国重点实验室甘肃兰州730046 甘肃省病原生物学基础学科研究中心甘肃兰州730046

本试验旨在探究STING agonist 22为候选免疫增强剂,配伍ASFV P30靶标蛋白开展对猪的免疫效果评价,为非洲猪瘟亚单位疫苗免疫增强剂的筛选提供前期实验依据。选取本实验室原核表达ASFV免疫原性较高的P30结构蛋白作为靶标抗原,并结合STING... 详细信息

本试验旨在探究STING agonist 22为候选免疫增强剂,配伍ASFV P30靶标蛋白开展对猪的免疫效果评价,为非洲猪瘟亚单位疫苗免疫增强剂的筛选提供前期实验依据。选取本实验室原核表达ASFV免疫原性较高的P30结构蛋白作为靶标抗原,并结合STINGagonist 22免疫增强剂与ISA201VG佐剂配伍ASFV P30蛋白2次免疫试验猪,比较STING agonist 22免疫增强剂诱导细胞免疫、体液免疫和抗原递呈反应的增强作用。结果显示,与单独201VG佐剂配伍相比,增加STING agonist 22免疫增强剂组免疫试验猪可以显著提早P30介导的抗体应答时间,提高B细胞成熟分化相关转录因子的表达水平,促进DCs成熟并增强其抗原递呈。本研究结果表明,STING agonist 22免疫增强剂配伍ASFV P30蛋白可以明显提高猪的细胞免疫、体液免疫反应及诱导更强的抗原递呈,可作为一种ASF亚单位疫苗的免疫增强剂。

关键词：非洲猪瘟病毒 STING agonist 22 免疫增强剂树突状细胞

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基于粘结单元法的干热岩储层水力压裂数值模拟与参数优化

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钻探工程 2024年第2期51卷 23-31页

作者：翟梁皓荀杨苏博刘华南戚波吴景华长春工程学院勘查与测绘工程学院吉林长春130021 长春工程学院管理学院吉林长春130021 西安科技大学地质与环境学院陕西西安710054

水力压裂技术是实现低渗油气及地热储层的高效开发利用的关键技术手段,为了研究干热岩型地热储层水力压裂过程中水力裂缝的扩展规律,本文使用粘结单元法(Cohesive Zone Method,CZM)研究了压裂液排量、压裂液粘度以及水平地应力差对水力... 详细信息

水力压裂技术是实现低渗油气及地热储层的高效开发利用的关键技术手段,为了研究干热岩型地热储层水力压裂过程中水力裂缝的扩展规律,本文使用粘结单元法(Cohesive Zone Method,CZM)研究了压裂液排量、压裂液粘度以及水平地应力差对水力裂缝形态的影响,并利用正交试验对上述压裂工艺参数的组合进行优化。结果表明:压裂液排量对水力裂缝的长度具有重要影响,而压裂液的粘度对水力裂缝的宽度具有显著影响;压裂液的排量和粘度的增加,促进了分支裂缝的萌生和扩展;水平地应力差为1 MPa时,本文所建立的模型在压裂液排量和粘度分别取0.004 m3/s和0.07 Pa·s条件下,可获得最佳的压裂改造效果;随着压裂液的排量和粘度的持续增加,当压裂液的排量和粘度分别超过0.004 m3/s和0.07 Pa·s后,继续增加压裂液的排量和粘度将导致水力裂缝的长度和宽度的减小,可见在实际压裂过程中不能盲目通过提高压裂液的排量和粘度的方式实现对压裂效果的持续改进。本文丰富了干热岩储层改造的数值模拟手段,相关研究成果有望为干热岩型地热资源开采过程中裂缝扩展行为预测和压裂工艺参数的优化提供技术支撑。

关键词：干热岩储层改造水力压裂裂缝扩展粘结单元法正交试验数值模拟

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水文地质勘探分层抽水取样装置的优化研究

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长春工程学院学报（自然科学版） 2024年第2期25卷 52-57页

作者：孙梓航贾玉昆张建良尉玺赵静欧刘华南北京市工程地质研究所北京100048 长春工程学院勘查与测绘工程学院长春130021

针对分层抽水装置施工烦琐的问题,研制了一种新型定向分层抽水装置,主要对抽水装置、电缆密封装置和隔水装置等进行了改进,从而实现了对分层抽水取样试验装置的优化,确保抽水试验全过程安全可靠、便捷高效。并通过现场试验确定了第1~2... 详细信息

针对分层抽水装置施工烦琐的问题,研制了一种新型定向分层抽水装置,主要对抽水装置、电缆密封装置和隔水装置等进行了改进,从而实现了对分层抽水取样试验装置的优化,确保抽水试验全过程安全可靠、便捷高效。并通过现场试验确定了第1~2含水层硝酸盐氮指标超限,表明该装置能满足水文地质勘探单井精准分层取样的工作要求。

关键词：抽水装置分层抽水抽水试验止水

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Adverse Effects of Inactivated Foot-and-Mouth Disease Vaccine—Possible Causes Analysis and Countermeasures

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World Journal of Vaccines 2018年第4期8卷 81-88页

作者： Keshan Zhang Bingzhou Lu huanan liu Junhao Zhao Haixue Zheng Xiangtao liu State Key Laboratory of Veterinary Etiological Biology National Foot and Mouth Disease Reference Laboratory Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences Lanzhou China

Foot-and-mouth disease (FMD) is an infectious and sometimes fatal viral disease that affects cloven-hoofed animals, and Chinese government adopts compulsory immunization measures for FMD. The adverse effects of FMD vaccine to pigs, cattle and goats have been reported increasingly frequent during the spring and autumn seasons when large numbers of farm livestock are vaccinated. The financial losses caused by vaccine adverse effects have been a serious concern for both farmers and primary prevention personnel. There are various causative factors reported to involve into adverse effect of FMD vaccine, including the inappropriate vaccine production, transportation and storage, livestock poor tolerance, and unqualified vaccinating manipulations. Symptomatic treatment and early drug prevention have a certain effect on the adverse effects. To analyze causes and propose countermeasures, in the current study possible reasons during the production and processing procedures of inactivated FMD vaccine were reviewed and corresponding countermeasures were recommended. The review may provide references for better use of vaccine to prevent FMD.

关键词： Foot-and-Mouth Disease Inactivated Vaccine Adverse Effects Causes Analysis and Countermeasures

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Brain-inspired artificial intelligence research: A review

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Science China(Technological Sciences) 2024年第8期67卷 2282-2296页

作者： WANG GuoYin BAO huanan liu Qun ZHOU TianGang WU Si HUANG TieJun YU ZhaoFei LU CeWu GONG YiHong ZHANG ZhaoXiang HE Sheng Chongqing Key Laboratory of Computational Intelligence Chongqing University of Posts and TelecommunicationsChongqing 400065China Key Laboratory of Cyberspace Big Data Intelligent Security Chongqing University of Posts and TelecommunicationsChongqing 400065China College of Computer and Information Science Chongqing Normal UniversityChongqing 401331China State Key Laboratory of Brain and Cognitive Science Institute of BiophysicsChinese Academy of SciencesBeijing 100101China School of Psychological and Cognitive Sciences Peking UniversityBeijing 100871China State Key Laboratory of Multimedia Information Processing School of Computer SciencePeking UniversityBeijing 100871China Department of Computer Science School of ElectronicsInformation and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Faculty of Electronic and Information Engineering Xi’an Jiaotong UniversityXi’an 710049China The Center for Research on Intelligent Perception and Computing Institute of AutomationChinese Academy of SciencesBeijing 100190China Institute of Biophysics Chinese Academy of SciencesBeijing 100101China

Artificial intelligence(AI) systems surpass certain human intelligence abilities in a statistical sense as a whole, but are not yet the true realization of these human intelligence abilities and behaviors. There are differences, and even contradictions, between the cognition and behavior of AI systems and humans. With the goal of achieving general AI, this study contains a review of the role of cognitive science in inspiring the development of the three mainstream academic branches of AI based on the three-layer framework proposed by David Marr, and the limitations of the current development of AI are explored and analyzed. The differences and inconsistencies between the cognition mechanisms of the human brain and the computation mechanisms of AI systems are analyzed. They are found to be the cause of the differences and contradictions between the cognition and behavior of AI systems and humans. Additionally, eight important research directions and their scientific issues that need to focus on braininspired AI research are proposed: highly imitated bionic information processing, a large-scale deep learning model that balances structure and function, multi-granularity joint problem solving bidirectionally driven by data and knowledge, AI models that simulate specific brain structures, a collaborative processing mechanism with the physical separation of perceptual processing and interpretive analysis, embodied intelligence that integrates the brain cognitive mechanism and AI computation mechanisms,intelligence simulation from individual intelligence to group intelligence(social intelligence), and AI-assisted brain cognitive intelligence.

关键词： artificial intelligence cognitive science brain science intelligence science large language model

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Optimal Configuration of Fault Location Measurement Points in DC Distribution Networks Based on Improved Particle Swarm Optimization Algorithm

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Energy Engineering 2024年第6期121卷 1535-1555页

作者： huanan Yu Hangyu Li He Wang Shiqiang Li Key Laboratory of Modern Power System Simulation and Control&Renewable Energy Technology Ministry of EducationNortheast Electric Power UniversityJilin132012China

The escalating deployment of distributed power sources and random loads in DC distribution networks hasamplified the potential consequences of faults if left uncontrolled. To expedite the process of achieving an optimalconfiguration of measurement points, this paper presents an optimal configuration scheme for fault locationmeasurement points in DC distribution networks based on an improved particle swarm optimization ***, a measurement point distribution optimization model is formulated, leveraging compressive *** model aims to achieve the minimum number of measurement points while attaining the best compressivesensing reconstruction effect. It incorporates constraints from the compressive sensing algorithm and networkwide viewability. Subsequently, the traditional particle swarm algorithm is enhanced by utilizing the Haltonsequence for population initialization, generating uniformly distributed individuals. This enhancement reducesindividual search blindness and overlap probability, thereby promoting population diversity. Furthermore, anadaptive t-distribution perturbation strategy is introduced during the particle update process to enhance the globalsearch capability and search speed. The established model for the optimal configuration of measurement points issolved, and the results demonstrate the efficacy and practicality of the proposed method. The optimal configurationreduces the number of measurement points, enhances localization accuracy, and improves the convergence speedof the algorithm. These findings validate the effectiveness and utility of the proposed approach.

关键词： Optimal allocation improved particle swarm algorithm fault location compressed sensing DC distribution network

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中国足球话语实践背景下社会公共精神的生长

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体育与科学 2017年第4期38卷 103-108页

作者：刘桦楠华东师范大学体育与健康学院

话语实践是深探公共精神的关键之眼。在特定历史条件下发生的中国足球话语实践典型案例,为窥视中国社会的公共精神生长发育态势提供了一个具有分析意义的现实背景和切入角度,揭示出中国社会公共精神"勃勃萌发→良性发育成长→最终渐趋成... 详细信息

话语实践是深探公共精神的关键之眼。在特定历史条件下发生的中国足球话语实践典型案例,为窥视中国社会的公共精神生长发育态势提供了一个具有分析意义的现实背景和切入角度,揭示出中国社会公共精神"勃勃萌发→良性发育成长→最终渐趋成熟"这样一个积极的生长发育态势。在整个话语实践过程中,社会各界人士基本上都可以无障碍地参与到"基于足球并超越足球"的话语实践中,多元话语主体之间在话语议题的遴选和升华上,之后在话语交锋和商讨中对所涉及的问题症结的深究和问责,并在话语商讨和交锋中注意寻找并获得制度依据,这些都充分体现出社会公共精神良性发育并渐趋成熟的积极态势。

关键词：公共精神话语实践普罗大众话语争论话语共鸣话语交锋

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Risk-Balanced Routing Strategy for Service Function Chains of Cyber-Physical Power System Considering Cross-Space Cascading Failure

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Energy Engineering 2024年第9期121卷 2525-2542页

作者： He Wang Xingyu Tong huanan Yu XiaoHu Jing Bian The Key Laboratory of Modern Power System Simulation and Control Renewable Energy Technology Ministry of EducationNortheast Electric Power UniversityJilin132000China

Cyber-physical power system(CPPS)has significantly improved the operational efficiency of power ***,cross-space cascading failures may occur due to the coupling characteristics,which poses a great threat to the safety and reliability of CPPS,and there is an acute need to reduce the probability of these *** this end,this paper first proposes a cascading failure index to identify and quantify the importance of different information in the same class of communication *** this basis,a joint improved risk-balanced service function chain routing strategy(SFC-RS)is proposed,which is modeled as a robust optimization problem and solved by column-and-constraint generation(C-CG)*** with the traditional shortest-path routing algorithm,the superiority of SFC-RS is verified in the IEEE 30-bus *** results demonstrate that SFC-RS effectively mitigates the risk associated with information transmission in the network,enhances information transmission accessibility,and effectively limits communication disruption from becoming the cause of cross-space cascading failures.

关键词： Cyber-physical power system service function chain risk balance routing optimization cascading failure

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上海市校园足球“一条龙”培养体系的集聚、辐射效应

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武汉体育学院学报 2012年第7期46卷 84-90页

作者：刘桦楠季浏华东师范大学体育与健康学院青少年健康评价与运动干预教育部重点实验室上海200241

运用文献资料法、专家访谈法、数理统计法等研究方法,对上海市校园足球从小学一直到大学的"一条龙"培养体系,在体系的布局结构上、地域分布上、资源上、技术支撑上、各项工作的衔接上发挥出的集聚效应与辐射效应进行研究。发现集聚、辐... 详细信息

运用文献资料法、专家访谈法、数理统计法等研究方法,对上海市校园足球从小学一直到大学的"一条龙"培养体系,在体系的布局结构上、地域分布上、资源上、技术支撑上、各项工作的衔接上发挥出的集聚效应与辐射效应进行研究。发现集聚、辐射效应体现在:"大金字塔"式整体布局结构以及"1-2-4-8"单元布局结构的构建;校园足球地域"拓荒"初步完成;布点大中小学之间在师资、场地设施、人才资源上的互动共享;布点大中小学之间利用专业技术力量支撑开发教材、指导活动;将大中小学校园足球系列活动进行衔接,建立"一条龙"活动体系以及人才输送体系。

关键词：校园足球上海一条龙培养体系集聚效应辐射效应

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