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Fluorine Substitution Effect on the Material Properties in Transparent Aromatic Polyimides

Chinese Journal of Polymer Science 2022年第7期40卷 781-788页

作者： Wei-Feng Peng huan-yu lei Xin-Xin Zhang Lu-Hao Qiu Ming-Jun huang South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhou510640China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou510640China

The recent development of flexible display technology raised additional requirements for optical and electric properties of polyimides,accelerating the structure and property tunning of transparent *** unique electronic effect and steric hindrance effect of fluorine substitutions make fluorine-containing polyimides occupy an important position in the transparent polyimide *** this work,a series of transparent aromatic polyimides were prepared from a fixed 4,4’-(hexafluoroisopropylidene)diphthalic anhydride(6FDA)and biphenyl diamines with different substitute groups at the 2,2’,6,6’-*** systematically studied the effects of pendant groups on the thermal,mechanical,optical and dielectric properties of these 6FDA-based polyimides with the aid of density function theory(DFT)*** particular,we paid special attention to the simple but compact fluoro group *** simple fluoro substitution brought the advantages of maintaining the linearity of the backbone and dense polymer chain packing,which would minimize the weakening of polyimides’inherent thermal,dimensional and mechanical *** with trifluoromethyl substituted polyimides with the best optical transparency,polyimides containing fluoro substitutes exhibited slightly decreased optical transparency,but increased thermal and dimensional stability and higher mechanical *** results could shed light on the ultimate transparent polyimide film development toward the application in extreme working condition,e.g.,the colorless polyimide substrate film for the flexible display technology.

关键词： Polyimides Fluorine substitution Transparent Dielectric Colorless

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Fluorinated Colorless Polyimides with High Heat-resistance and Low Birefringence

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Chinese Journal of Polymer Science 2023年第10期41卷 1599-1608页

作者： Bing-yu Zou Lu-Hao Qiu huan-yu lei Jin-Ming Liu Wei-Feng Peng Hong-Qin Zhao Feng Bao Ming-Jun huang South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhou510640China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou510640China

The development of optical films with high transparency,high thermal resistance and low birefringence remains a challenge in the flexible display *** this work,we designed and synthesized a series of fluorinated colorless polyimides(CPIs)materials using 2,5-substituted m-phenylenediamine diamine monomers and 1,2,4,5-cyclohexanetetracarboxylic dianhydride(CHDA).We systematically studied the effects of fluorinated group substitutions on the thermal,mechanical,optical and dielectric properties of CPI *** introduction of alicyclic CHDA dianhydride affords high transparency and low yellowness,while the 2,5-substituted m-phenylenediamine diamines offer the CPIs with quite low birefringence as well as high glass transition temperatures.A particular CHDA/o3FBDA film with simple chemical structure stands out,exhibiting well-balanced overall properties.

关键词： Colorless polyimide Low birefringence Fluorinated Optical flm

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Clinicopathological analysis of 14 patients with combined hepatocellular carcinoma and cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2011年第6期10卷 620-625页

作者： Xian-huan yu,lei-Bo Xu,Hong Zeng,Rui Zhang,Jie Wang and Chao LiuAuthor Affiliations:Department of Hepato-Pancreato-Biliary Surgery and Department of Pathology,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou 510120,China Department of Hepato-Pancreato-Biliary Surgery Sun Yat-Sen Memorial Hospital Sun Yat-Sen University Guangzhou 510120 China Department of Pathology Sun Yat-Sen Memorial Hospital Sun Yat-Sen University Guangzhou 510120 China

BACKGROUND:Combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) is an uncommon subtype of primary hepatic carcinoma,and its prognosis is *** study was undertaken to investigate the prognosis and the clinicopathological characteristics of cHCC-CC,including their possible cellular ***:Among 852 patients with a primary hepatic carcinoma who underwent hepatectomy from January 1998 to April 2008 at our hospital,cHCC-CC was identified in 14 patients The clinicopathological characteristics of the 14 patients were analyzed *** expression of the liver stem cell markers (c-kit,CD90,CD133 and CK19) in the tumor tissue was detected by immunohistochemistry,and the Kaplan-Meier method was used to evaluate ***:Among the 14 patients,9 presented with abdominal pain,3 with anorexia and debilitation,and the remaining two patients were *** mean age was 53.6±3.0 (range 38-74) *** the included patients,11 had an elevated serum alpha-fetoprotein level,13 were infected with hepatitis B virus,9 had vascular invasion and 1 had lymph node metastasis The average diameter of the tumors was 9.9±1.1 (range 5.0-16.0) *** median overall survival time was 7.9±1.0 months In addition,the presence of the liver stem cell markers,c-kit CD90,CD133 and CK19 was 71.4%,85.7%,92.9% and 78.6% *** four markers were simultaneously expressed in eight ***:cHCC-CC has aggressive characteristics and the prognosis is extremely *** high expression of liver stem cell markers in the tumor tissue suggests that these tumors may derive from liver stem cells.

关键词： liver neoplasms hepatocellular carcinoma cholangiocarcinoma prognosis stem cells

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Fluorinated poly(p-triphenylene isatin) anion exchange membranes based on hydrophilic hydroxyl side chain modulation for fuel cells

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Journal of Energy Chemistry 2025年第1期100卷 702-709页

作者： Yiman Gu Yanchao Zhang Zhanyu Li Yijia lei Baozeng Sun Xiaoyu yu Zhe Wang College of Chemistry and Life Science Changchun University of Technology College of Chemical Engineering Changchun University of Technology School of Materials Science and Engineering Changchun University of Technology Key Laboratory of Advanced Functional Polymer Membrane Materials of Jilin Province

The development of alkaline fuel cells is moving forward at an accelerated pace,and the application of ether-free bonded polymers to anion exchange membranes （AEMs） has been widely ***,the question of the“trade-off”between AEM ionic conductivity and dimensional stability remains *** strategy of inducing microphase separation to improve the performance of AEM has attracted much attention recently,but the design of optimal molecular structures is still being ***,this work introduced different ratios of 3-bromo-1,1,1-trifluoroacetone （x=40,50,and 60） into the main chain of poly（p-terphenylene isatin）.Because fluorinated groups have excellent hydrophobicity,hydrophilic hydroxyl-containing side chains are introduced to jointly adjust the formation of phase separation *** results show that PTI-PTF50-NOH AEM with the appropriate fluorinated group ratio has the best ionic conductivity and alkali stability under the combined effect of *** has an ionic conductivity of 133.83 mS cm-1at 80°*** addition,the OH-conductivity remains at 89%of the initial value at 80°C and 3 M KOH for 1056 h of *** cell polarization curve based on PTI-PTF50-NOH shows a power density of 734.76 mW cm-2at a current density of 1807.7 mA cm-2.

关键词： Anion exchange membranes Poly(p-terphenylene isatin) Hydrophilic-hydrophobic phase separation Fluorinated group

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分子模拟在聚酰亚胺研究中的应用

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高分子学报 2019年第12期50卷 1253-1262页

作者：雷环宇田国峰肖美凤李小兰齐胜利武德珍北京化工大学化工资源有效利用国家重点实验室材料科学与工程学院

聚酰亚胺(PI)是一类通过酰亚胺键连接的环链状高分子聚合物,其化学组成可调,同时具有复杂的多尺度多层次结构特征,更进一步地影响了材料的热学、力学和光电性能.本文综述了近年来分子模拟方法在PI中的应用,辅助研究和解释了PI材料的结... 详细信息

聚酰亚胺(PI)是一类通过酰亚胺键连接的环链状高分子聚合物,其化学组成可调,同时具有复杂的多尺度多层次结构特征,更进一步地影响了材料的热学、力学和光电性能.本文综述了近年来分子模拟方法在PI中的应用,辅助研究和解释了PI材料的结构和性能的关系.结构上,包括分子链结构、凝聚态的结晶、取向结构、自由体积以及相结构;性能上,介绍了分子模拟在PI材料热性能、机械性能、气体分离以及PI基复合材料的界面结合性能方面的应用.最后,对计算机模拟在聚酰亚胺研究中的发展趋势进行了展望,本文对于PI性能优化和功能性PI的设计制备具有一定的理论指导意义.

关键词：聚酰亚胺结构与性能分子模拟

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie Mu yu Leng lei Ma yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian Yang Jiang Wu Xueshun Xie Pengfei Xia Jinxin Lu Jiale Liu lei Bai Xiang Li Zhengquan yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

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Invariant measures for the strong-facilitated exclusion process

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Applied Mathematics(A Journal of Chinese Universities) 2023年第3期38卷 317-337页

作者： lei yu-huan SU Zhong-gen School of Mathematical Sciences Zhejiang UniversityHangzhou 310027China.

Consider a generalized model of the facilitated exclusion process, which is a onedimensional exclusion process with a dynamical constraint that prevents the particle at site x from jumping to x+1 (or x-1) if the sites x-1, x-2 (or x+1, x+2) are empty. It is nongradient and lacks invariant measures of product form. The purpose of this paper is to identify the invariant measures and to show that they satisfy both exponential decay of correlations and equivalence of ensembles. These properties will play a pivotal role in deriving the hydrodynamic limit.

关键词： equivalence of ensembles exclusion process facilitated dynamic invariant measure

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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan yu-Ming Wang Han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo Wen Jing Miao huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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Tracy-Widom distribution, Airy2 process and its sample path properties

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Applied Mathematics(A Journal of Chinese Universities) 2021年第1期36卷 128-158页

作者： SU Zhong-gen lei yu-huan SHEN Tian School of Mathematical Sciences Zhejiang UniversityHangzhou 310027China

Tracy-Widom distribution was rst discovered in the study of largest eigenvalues of high dimensional Gaussian unitary ensembles(GUE),and since then it has appeared in a number of apparently distinct research *** is believed that Tracy-Widom distribution have a universal feature like classic normal ***2 process is de ned through nite dimensional distributions with Tracy-Widom distribution as its marginal *** this introductory survey,we will briey review some basic notions,intuitive background and fundamental properties concerning Tracy-Widom distribution and Airy2 *** sake of reading,the paper starts with some simple and well-known facts about normal distributions,Gaussian processes and their sample path properties.

关键词： Airy2 process Dyson Brownian motion Tracy-Widom distribution sample path property.

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