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Roles of Serum Amyloid A 1 Protein Isoforms in Rheumatoid Arthritis

Engineering 2022年第3期8卷 174-182页

作者： Elaine laihan Leung huan-ling lai Run-Ze Li Hu-Dan Pan Ze-Bo Jiang Ying Li Fu-Gang Duan Jia-Hui Xu Yi-Zhong Zhang A-Xi Shi Chun-Li Wei Fang-Yuan Zhang Xiao-Jun Yao Liang Liu State Key Laboratory of Quality Research in Chinese Medicine&Macao Institute for Applied Research in Medicine and Health&Faculty of Chinese Medicine Macao University of Science and TechnologyMacao 999078China Department of Pediatrics Pennsylvania State University College of MedicineHersheyPA 17033USA

Secondary amyloid A amyloidosis,a lethal complication,is induced when acute or chronic infection coexists with over-secretion of the serum amyloid A 1(SAA1)protein and deposition in key internal ***,using the whole-exome sequencing method,we identified a novel deleterious mutation SAA1.2 in rheumatoid arthritis(RA)***,the role of SAA1 in RA pathogenesis and its complications remains *** purpose of this study was to determine the pathogenetic roles of SAA1 protein isoforms in RA *** modified an experimental adenovirus infection protocol to introduce SAA1.2 gene alleles into the knee joints of mice and used SAA1.3 and SAA1.5 as *** tomography analysis was applied to determine changes in bone morphology and ***(IHC)analysis,flow cytometry,enzyme-linked immunosorbent assay(ELISA),and real-time polymerase chain reaction(RT-PCR)were used to investigate disease progression and cytokine alterations in the course of adenoviral SAA-induced knee joint inflammation and bone *** found that the arthritis-inducing effect of SAA1.2 transcription in the knee joints and mutant SAA1 protein secretion in blood resulted in the stimulation of immune responses,leading to CD8^(+)T cell and pro-inflammatory cytokine elevation,such as interleukin(IL)-6,IL-22,matrix metalloproteinase(MMP)-3,MMP-9,with subsequent synovial inflammation and bone *** findings indicate that SAA1 protein isoforms,particularly SAA1.2,play a significant role in the induction and progression of RA and may have potential value in the early diagnosis and severity prediction of RA.

关键词： Serum amyloid A 1 Rheumatoid arthritis Pathogenetic Intra-articular

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Semitransparent Organic Solar Cells with Superior Thermal/Light Stability and Balanced Efficiency and Transmittance

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Energy & Environmental Materials 2024年第4期7卷 215-222页

作者： Zhipeng Yin huan Zhao Yang Liu Xunwen Xiao Yong Zhang Huahang lai Ning Li Hai-Qiao Wang School of Materials Science and Engineering Ningbo Tech University State Key Laboratory of Luminescent Materials and Devices Institute of Polymer Optoelectronic Materials and Devices School of Materials Science and Engineering South China University of Technology Ningbo University of Technology Ningbo Institute of Technology Beihang University Hangna Nanofabrication Equipment Co. Ltd.

Semitransparent organic solar cells show attractive potential in the application of building-integrated photovoltaics,agrivoltaics,floating photovoltaics,and wearable electronics,as their multiple functionalities of e... 详细信息

关键词： organic solar cell semitransparent thermal/light stability

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Regulation role of miR-204 on SIRT1/VEGF in metabolic memory induced by high glucose in human retinal pigment epithelial cells

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1232-1237页

作者： Qiao-ling lai Ting Xie Wei-Dong Zheng Yan huang Department of Ophthalmology Renmin Hospital of Wuhan UniversityWuhan 460060Hubei ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350004Fujian ProvinceChina Department of Ophthalmology&Optometry Fujian Medical UniversityFuzhou 350004Fujian ProvinceChina

AIM:To examine the regulatory role of microRNA-204(miR-204)on silent information regulator 1(SIRT1)and vascular endothelial growth factor(VEGF)under highglucose-induced metabolic memory in human retinal pigment epithelial(hRPE)***:Cells were cultured with either normal(5 mmol/L)or high D-glucose(25 mmol/L)concentrations for 8d to establish control and high-glucose groups,*** induce metabolic memory,cells were cultured with 25 mmol/L D-glucose for 4d followed by culture with 5 mmol/L D-glucose for *** addition,exposed in 25 mmol/L D-glucose for 4d and then transfected with 100 nmol/L miR-204 control,miR-204 inhibitor or miR-204 mimic in 5 mmol/L D-glucose for *** reverse transcription-polymerase chain reaction(RT-qPCR)was used to detect miR-204 mRNA ***1 and VEGF protein levels were assessed by immunohistochemical and Western *** cytometry was used to investigate apoptosis ***:It was found that high glucose promoted miR-204 and VEGF expression,and inhibited SIRT1 activity,even after the return to normal glucose culture *** of miR-204 promoted apoptosis inhibiting SIRT1 and increasing VEGF ***,downregulation of miR-204 produced the opposite ***:The study identifies that miR-204 is the upstream target of SIRT1and VEGF,and that miR-204 can protect hRPE cells from the damage caused by metabolic memory through increasing SIRT1 and inhibiting VEGF expression.

关键词： human retinal pigment epithelial metabolic memory microRNA-204 silent information regulator 1 vascular endothelial growth factor high-glucose

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New Frontiers on Intracellular cGAS Activation:Molecular Mechanisms,Cellular Signaling,and Therapeutic Strategies

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Chemical Research in Chinese Universities 2024年第4期40卷 632-645页

作者： SONG Xingrui ling Xiaoting LIU Hailong ZHAO Qiang LI Xiangjun lai Weiyi WANG Hailin State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing10085P.R.China School of Chemical Sciences University of Chinese Academy of SciencesBeijing101408P.R.China

Cyclic GMP-AMP(cGAMP)synthase(cGAS)plays a pivotal role in the innate immune *** the primary DNA sensor in cells,cGAS binds to dsDNA in the cytoplasm and forms cGAS-DNA liquid-liquid phase separation(LLPS)and activates its catalytic *** activation triggers the cGAS-stimulator of interferon genes(STING)signaling pathway,establishing an efficient system for pathogen *** pathogen surveillance,cGAS performs a diverse range of roles,involved in inflammatory response,metabolic homeostasis,DNA damage repair,and cell *** biological functions regulate cellular physiological homeostasis and influence the occurrence and development of *** review provides an overview of the structure,localization,and intracellular biological functions of the cGAS-STING signaling pathway and cGAS-DNA ***,we discuss their contribution to the development of tumors,autoimmune diseases,and inflammatory diseases and highlight the innovative strategies in modulating cGAS activity,either through activation or inhibition,as a promising therapeutic approach.

关键词： Cyclic GMP-AMP(cGAMP)synthase(cGAS)-stimulator of interferon genes(cGAS-STING) Liquid-liquid phase separation(LLPS) Biological function Disease

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Dissolved organic matter accelerates microbial degradation of 17 alpha-ethinylestradiol in the presence of iron mineral

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Journal of Environmental Sciences 2024年第5期139卷 364-376页

作者： huan He Min Shi Xiaoxia Yang Juhong Zhan Yanting Lin Ziwei Guo Zhicheng Liao Chaochao lai Xiaomin Ren Bin huang Xuejun Pan Faculty of Environmental Science and Engineering Kunming University of Science and TechnologyKunming 650500China Yunnan Provincial Key Lab of Soil Carbon Sequestration and Pollution Control Kunming 650500China Research Institute for Environmental Innovation(Suzhou)Tsinghua Suzhou 215163China

Dissolved organic matter(DOM)and iron minerals widely existing in the natural aquatic environment can mediate the migration and transformation of organic ***,the mechanism of interaction between DOM and iron minerals in the microbial degradation of pollutants deserves further *** this study,the mechanism of 17 alphaethinylestradiol(EE2)biodegradation mediated by humic acid(HA)and three kinds of iron minerals(goethite,magnetite,and pyrite)was *** results found that HA and iron minerals significantly accelerated the biodegradation process of EE2,and the highest degradation efficiency of EE2(48%)was observed in the HA-mediated microbial system with pyrite under aerobic ***,it had been demonstrated that hydroxyl radicals(HO·)was the main active substance responsible for the microbial degradation of ***·is primarily generated through the reaction between hydrogen peroxide secreted by microorganisms and Fe(II),with aerobic conditions being more *** presence of iron minerals and HA could change the microbial communities in the EE2 biodegradation *** findings provide new information for exploring the migration and transformation of pollutants by microorganisms in iron-rich environments.

关键词： Dissolved organic matter Iron mineral 17 alpha-ethinylestradiol Biodegradation

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Random Terpolymer Based on Simple Siloxane-functionalized Thiophene Unit Enabling High-performance Non-fullerene Organic Solar Cells

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Chinese Journal of Polymer Science 2024年第3期42卷 311-321,I0006页

作者： Fuliang Cheng Shiting lai Yihan Zhang ling Xue Xinxin Xia Peipei Zhu Xinhui Lu Xunfan Liao Yiwang Chen National Engineering Research Center for Carbohydrate Synthesis/Key Laboratory of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education College of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang 330022China Department of Physics Chinese University of Hong Kong New TerritoriesHong Kong 999077China Institute of Polymers and Energy Chemistry(IPEC)/Jiangxi Provincial Key Laboratory of New Energy Chemistry Nanchang UniversityNanchang 330031China

Incorporation of siloxane-functionalized units into polymers backbone has proven to be an efficient strategy to improve photovoltaic performance. In this work, a low-cost siloxane-containing unit was developed to construct a series of terpolymers, and the effects of siloxane on the polymer performance were systematically studied. Different contents of thiophene containing siloxane-functionalized side chain were introduced into PM6 to obtain a series of polymers(PM6, PM6-SiO-10, PM6-SiO-20 and PM6-SiO-30). The siloxane-functionalized side chains in polymers have only a slight effect on the absorption behavior and frontier molecular orbitals. However, when the siloxane content increased, the terpolymers' aggregation property decreased and the temperature-dependency increased, leading to improved donor-acceptor compatibility. The power conversion efficiency(PCE) based on PM6:Y6, PM6-SiO-20:Y6 and PM6-SiO-30:Y6 devices was 15.64%, 16.03% and 15.82%, respectively. In comparison, the active layer based on PM6-SiO-10:Y6 exhibits the most appropriate phase separation morphology, resulting in effective exciton dissociation, more balanced hole-electron transport and less recombination. Consequently, the highest PCE of 16.69% with an outstanding shortcircuit current density of 26.96 mA·cm^(-2) was obtained, which are one of the highest values for siloxane-functionalized polymer-based *** work demonstrates that finely controlling the content of siloxane-functionalized thiophene is beneficial for obtaining high-performance terpolymer donors and provides a novel and low-cost method to improve photovoltaic performance.

关键词： Organic solar cells Terpolymers Siloxane-functionalized unit Low-cost Morphology

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A comparative lattice analysis of SU(2)dark glueballs

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Chinese Physics C 2024年第8期48卷 113-126页

作者： Min-huan Chu Jun-Hui lai Wei Wang Jialu Zhang Qianteng Zhu INPAC Key Laboratory for Particle Astrophysics and Cosmology(MOE)Shanghai Key Laboratory for Particle Physics and CosmologySchool of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Yang Yuanqing Scientific Computering Center Tsung-Dao Lee InstituteShanghai Jiao Tong UniversityShanghai 200240China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China

We study the mass and scattering cross section of SU(2)glueballs as dark matter candidates using lattice *** employ both naive and improved SU(2)gauge actions in 3+1 dimensions with severalβvalues,and we adopt both the traditional Monte Carlo method and flow-based model based on machine learning techniques to generate lattice *** mass of a dark scalar glueball with J^(PC)=0^(++)and the Nambu-Bethe-Salpeter wave function are *** a coupling constant ofβ=2.2 as an illustration,we compare the dark glueball mass calculated from the configurations generated from the two *** consistent results can be achieved,the two methods demonstrate distinct *** the Runge-Kutta method,we extract the glueball interaction potential and two-body scattering cross *** the observational constraints,we obtain the lower bound of the mass of scalar glueballs as candidates of dark matter.

关键词： lattice QCD dark matter machine learning

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Meibomian glands segmentation in infrared images with limited annotation

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 401-407页

作者： Jia-Wen Lin ling-Jie Lin Feng Lu Tai-Chen lai Jing Zou Lin-ling Guo Zhi-Ming Lin Li Li College of Computer and Data Science Fuzhou UniversityFuzhou 350108Fujian ProvinceChina Fujian Provincial Key Laboratory of Networking Computing and Intelligent Information Processing Fuzhou UniversityFuzhou 350108Fujian ProvinceChina Shengli Clinical Medical College of Fujian Medical University Fuzhou 350001Fujian ProvinceChina Department of Ophthalmology Fujian Provincial Hospital South BranchFujian Provincial HospitalFuzhou 350001Fujian ProvinceChina

●AIM:To investigate a pioneering framework for the segmentation of meibomian glands(MGs),using limited annotations to reduce the workload on ophthalmologists and enhance the efficiency of clinical diagnosis.●METHODS:Totally 203 infrared meibomian images from 138 patients with dry eye disease,accompanied by corresponding annotations,were gathered for the study.A rectified scribble-supervised gland segmentation(RSSGS)model,incorporating temporal ensemble prediction,uncertainty estimation,and a transformation equivariance constraint,was introduced to address constraints imposed by limited supervision information inherent in scribble *** viability and efficacy of the proposed model were assessed based on accuracy,intersection over union(IoU),and dice coefficient.●RESULTS:Using manual labels as the gold standard,RSSGS demonstrated outcomes with an accuracy of 93.54%,a dice coefficient of 78.02%,and an IoU of 64.18%.Notably,these performance metrics exceed the current weakly supervised state-of-the-art methods by 0.76%,2.06%,and 2.69%,***,despite achieving a substantial 80%reduction in annotation costs,it only lags behind fully annotated methods by 0.72%,1.51%,and 2.04%.●CONCLUSION:An innovative automatic segmentation model is developed for MGs in infrared eyelid images,using scribble annotation for *** model maintains an exceptionally high level of segmentation accuracy while substantially reducing training *** holds substantial utility for calculating clinical parameters,thereby greatly enhancing the diagnostic efficiency of ophthalmologists in evaluating meibomian gland dysfunction.

关键词： infrared meibomian glands images meibomian gland dysfunction meibomian glands segmentation weak supervision scribbled annotation

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Animal models of tendon calcification:Past,present,and future

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Animal Models and Experimental Medicine 2024年第4期7卷 471-483页

作者： Ruichen Li Canhao lai Hong Luo Yujian Lan Xinfang Duan Dingsu Bao Zhipeng Hou huan Liu Shijie Fu Department of Bone and Joint The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhouChina Chengdu University of Traditional Chinese Medicine ChengduChina

Tendon calcification is a common clinical condition that frequently occurs as a complication after tendon injury and surgery,or as an expression of fibrodysplasia ossificans *** condition can be referred to by various names in clinical practice and literature,including tendon ossification,tendon mineralization,heterotopic ossification,and calcific *** exact pathogenesis of tendon calcification remains uncertain,but current mainstream research suggests that calcification is mostly cell *** further elucidate the pathogenesis of tendon calcification and to better simulate the overall process,selecting appropriate experimental animal models is *** animal models have been utilized in various clinical studies,each with its own set of advantages and *** this review,we have discussed the advancements made in research on animal models of tendon calcification,with a focus on the selection of experimental animals,the sites of injury in these models,and the methods employed for modeling.

关键词： animal models review tendon calcification

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Teneligliptin mitigates diabetic cardiomyopathy by inhibiting activation of the NLRP3 inflammasome

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World Journal of Diabetes 2024年第4期15卷 724-734页

作者： Gu-Lao Zhang Yuan Liu Yan-Feng Liu Xian-Tao huang Yu Tao Zhen-huan Chen Heng-Li lai Department of Cardiology Jiangxi Provincial People's HospitalThe First Affiliated Hospital of Nanchang Medical CollegeNanchang 330000Jiangxi ProvinceChina

BACKGROUND Diabetic cardiomyopathy(DCM),which is a complication of diabetes,poses a great threat to public *** studies have confirmed the role of NLRP3(NOD-like receptor protein 3)activation in DCM development through the inflammatory *** is an oral hypoglycemic dipeptidyl peptidase-IV inhibitor used to treat *** has recently been reported to have anti-inflammatory and protective effects on myocardial *** To examine the therapeutic effects of teneligliptin on DCM in diabetic *** Streptozotocin was administered to induce diabetes in mice,followed by treatment with 30 mg/kg *** Marked increases in cardiomyocyte area and cardiac hypertrophy indicator heart weight/tibia length reductions in fractional shortening,ejection fraction,and heart rate;increases in creatine kinase-MB(CK-MB),aspartate transaminase(AST),and lactate dehydrogenase(LDH)levels;and upregulated NADPH oxidase 4 were observed in diabetic mice,all of which were significantly reversed by ***,NLRP3 inflammasome activation and increased release of interleukin-1βin diabetic mice were inhibited by *** mouse cardiomyocytes were treated with high glucose(30 mmol/L)with or without teneligliptin(2.5 or 5μM)for 24 ***3 inflammasome *** in CKMB,AST,and LDH levels in glucose-stimulated cardiomyocytes were markedly inhibited by teneligliptin,and AMP(p-adenosine 5‘-monophosphate)-p-AMPK(activated protein kinase)levels were ***,the beneficial effects of teneligliptin on hyperglycaemia-induced cardiomyocytes were abolished by the AMPK signaling inhibitor compound *** Overall,teneligliptin mitigated DCM by mitigating activation of the NLRP3 inflammasome.

关键词： Diabetic cardiomyopathy Teneligliptin NLRP3 AMPK Interleukin-1β

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