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Association between Genetic Variants of Transforming Growth Factor-β1 and Susceptibility of Pneumoconiosis： A Meta-analysis

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Chinese Medical Journal 2017年第3期130卷 357-364页

作者： Chang-Wen Deng Xing-Xing Zhang Jin-huan Lin Li-Fei huang Yu-Lan Qu chong Bai Department of Respiratory and Critical Care Medicine Changhai Hospital The Second Military Medical University Shanghai 200433 China Department of Cell Biology and Stem Cell Research Center School of Basic Medical Sciences Peking University Health Science Center Beijing 100191 China Department of Gastroenterology Changhai Hospital The Second Military Medical University Shanghai 200433 China Department of Respiratory Haining People's Hospital Jiaxing Zhejiang 314400 China

Background： Transforming growth factor-beta 1 （TGF-β 1） and gene variants have been extensively studied in various human diseases. For example, TGF-β1 polymorphisms were associated with fibrosis and pneumoconiosis, but the data remained controversial. The aim of this meta-analysis was to assess the association between TGF-β1-509 C〉T [rs 1800469], ＋869 T〉C [rs 1800470], and ＋915 G〉C [rs 1800471 ] polymorphisms and pneumoconiosis, Methods： A comprehensive literature search was conducted through searching in PubMed, Embase, the Chinese Biomedical Database, and the Wei Pu （Chinese） Database by the end of April 2016. Eleven publications with 21 studies were included in this recta-analysis, covering a total of 4333 patients with pneumoconiosis and 3478 controls. Study quality was assessed, and heterogeneity and publication bias were measured. All statistical analyses were performed using STATA version 12.0 （StataCorp, College Station, TX, USA） software. Results： The data showed significant associations between TGF-β1-509 C〉T polymorphism and the risk ofpneumoconiosis development （T vs. C, odds ratio [OR] = 1.35, 95% confidence interval [CI]： 1.00-1.81, P = 0.046）; between TGF-fll ＋915 G〉C polymorphism and the pneumoconiosis risk （C vs. G, OR = 1.69, 95% CI： 1.19-2.40, P = 0.004; CG vs. GG, OR = 1.79, 95% CI： 1.23-2.60, P = 0.002; CC＋CG vs. GG, OR = 1.80, 95% CI： 1.24-2.61, P = 0.002）. In addition, the subgroup analysis of ethnicity versus pneumoconiosis types indicated a significant association of silicosis among Asian populations but not that of coal workers＇ pneumoconiosis in Caucasian populations. In contrast, no significant association was exhibited between TGF-β1 ＋869 T〉C polymorphism and risk ofpneumoconiosis. Conclusion： The polymorphisms of both TGF-β1 -509 C〉T and ＋915 G〉C are associated with increased risk of pneumoconiosis. Key words： Meta analysis; Pneumoconiosis; Polymorphism; Transforming Growth Factor-betal

关键词： Meta analysis Pneumoconiosis Polymorphism Transforming Growth Factor-betal

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运动健身能量消耗简易测量方法的效度研究

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体育科学 2013年第6期33卷 69-76页

作者：邱淑敏王欢江崇民中央财经大学体育经济与管理学院北京100081 国家体育总局体育科学研究所北京100061

目的:使用SWA传感器测量跑台走跑和实地自行车运动时的能量消耗,并与间接测热法测量结果相比较,对SWA测量运动健身时能量消耗的有效性进行研究,为传感器的准确应用提供参考。方法:15名成年男性在平板运动跑台完成4.8km/h、6.4km/h、8.0k... 详细信息

目的:使用SWA传感器测量跑台走跑和实地自行车运动时的能量消耗,并与间接测热法测量结果相比较,对SWA测量运动健身时能量消耗的有效性进行研究,为传感器的准确应用提供参考。方法:15名成年男性在平板运动跑台完成4.8km/h、6.4km/h、8.0km/h 3个速度的走、跑运动,并在室内完成10km/h、13km/h、15km/h的场地自行车运动,使用SWA(两个软件版本V6.1、V7.0)和间接测热法预测运动时的能量消耗,对预测数据进行配对t检验、回归分析、相关性分析、ICC系数以及Bland-Altman一致性检验。结果:1)SWA 6.1高估了跑台走跑(高估1%)和实地自行车运动(高估9%)的能量消耗,但相关性和一致性较好(r=0.91,ICC=0.91)。2)SWA 7.0高估了跑台走跑(高估325%)和实地自行车运动(高估357%)的能量消耗,其与IC预测能量消耗的差值随着强度的增加而增大,但两者之间的相关性较好(r=0.91),一致性在可接受的范围之内(ICC=0.44),且SWA 7.0预测走跑能量消耗时与IC的一致性大于预测自行车运动能量消耗与IC的一致性。结论:SWA传感器预测的运动健身能量消耗值远远大于间接测热法预测的能量消耗,且预测的能量消耗差值随着运动速度的增加而不断增加,与该传感器旧版本高估低强度运动能量消耗和低估高强度能量消耗有所不同,但预估的能量消耗与间接测热法之间有较高的相关性和一致性。

关键词：臂带式多功能传感器间接测热法效度运动健身能量消耗

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Two Zinc based metal-organic frameworks: syntheses, crystal structure, and photocatalytic performance

Two Zinc based metal-organic frameworks: syntheses, crystal ...

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第九届全国环境催化与环境材料学术会议——助力两型社会快速发展的环境催化与环境材料

作者： chong-Chen wang Dao-Xin Xu huan-Ping Jing Yan-Qiu Zhang Peng wang Shi-Jie Gao Key Laboratory of Urban Stormwater System and Water Environment (Ministry of Education) Beijing University of Civil Engineering and Architecture Beijing Engineering Research Center of Sustainable Urban Sewage System Construction and Risk Control Beijing University of Civil Engineering and Architecture

Metal–organic frameworks(MOFs),a class of newly-developed inorganic-organic hybrid porous materials have attracted much *** researches indeed demonstrated that some porous MOFs materials to be a new class of photocatalysts usable in photocatalytic degradation of organic pollutants under UV/visible/UV-visible irradiation[1,2].In this paper,employing chelating 1,10-phenanthroline(phen)and two similar azophenyl ligands,

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Deep Sequencing of Brachypodium Small RNAs at the Global Genome Level Identifies MicroRNAs involved in Cold Stress Response

Deep Sequencing of Brachypodium Small RNAs at the Global Gen...

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第十二届全国植物基因组学大会

作者： Jingyu Zhang,Yunyuan Xu,Qing huan,Kang chong~* 中科院植物所

High-throughput sequencing and whole-genome-wide data mining led to the identification of 27 conserved miRNAs,as well as 129 predicted miRNAs in *** expression of 3 conserved miRNAs and 25 predicted miRNAs showed significant changes in response to cold *** these miRNAs, some were cold-induced and some were cold-suppressed,but all the conserved miRNAs were up-regulated under cold stress *** results suggest that Brachypodium miRNAs are composed of a set of

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Imaging in detecting sites of pulmonary fibrosis induced by paraquat

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World Journal of Emergency Medicine 2011年第1期2卷 45-49页

作者： Xiao-li Xu Wei wang Zu-jun Song Hong Ding Xiao-hong Duan huan-cheng Meng Jian chong The Medical Team in Command Academy of the Frontier Control Urumqi 830049China Emergency Medicine Department Xijing Hospital Fourth Military Medical University Xi'an 710032 China Emergency Medicine Department 309 Hospital of the People's Liberation Army Beijing 100091 China School of Stomatology Fourth Military Medical University Xi'an 710032 China

BACKGROUND： The most common cause of death from paraquat （PQ） poisoning is respiratoryfailure from pulmonary fi brosis, which develops through pathological overproduction of extracellularmatrix proteins such as collagens. In this study, a MicroCT system was used to observe dynamicchanges of pulmonary fi brosis in rats with PQ poisoning, and fi nd the characteristics of interstitial lungdiseases via density-based and texture-based analysis of CT images of the lung ***： A total of 15 male SD rats were randomly divided into a control group （n=5） and aPQ poisoning group （n=10）. The rats in the poisoning group were intraperitoneally administered with4 mg/ mL PQ at 14 mg/kg, and the rats in the control group were administered with the same volumeof saline. The signs of pulmonary fi brosis observed by the MicroCT included ground-glass opacity,nodular pattern, subpleural interstitial thickening, consolidation honeycomb-like shadow of the ***： Compared with the control group, the rats with acute PQ poisoning had differentsigns of pulmonary fibrosis. Ground-glass opacity and consolidation of the lung appeared at theearly phase of pulmonary fi brosis, and subpleural interstitial thickening and honeycomb-like shadowdeveloped at the middle or later stage. MicroCT images showed that fibrotic lung tissues weredenser than normal lungs, and their density was up-regulated with pulmonary fi brosis. There was nodifference in the progress of pulmonary fi brosis between the right lung and the left lung （P〉0.05）, butthere were differences in fi brosis degree at different sites in the lung （P〈0.05 or P〈0.01）. Pulmonaryfi brosis was mainly seen in the exterior area of the middle-lower part of the ***： Imaging can show the development of pulmonary fi brosis in PQ poisoning rats,and this method may help to administer drugs more reasonably in treating pulmonary fi brosis.

关键词： MicroCT CT value Paraquat Pulmonary fibrosis Region of interest

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论心脏功能的“泵说”与“波说”

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爆炸与冲击 2020年第11期40卷 2-11页

作者：王晖王礼立缪馥星龚文波浣石徐冲宁波市中医医院王晖工作室浙江宁波315000 宁波大学冲击与安全工程教育部重点实验室浙江宁波315211 季华实验室广东佛山528200

分析了心脏功能的“泵说”和“波说”。研究表明,心脏扮演的角色实际上不是泵,而是脉搏波发生器,产生一系列携带能量的脉搏波。每个脉搏波由升支和降支组成。前者对应于加载过程:压力、粒子速度、能量和血氧饱和度均随时间升高。而后者... 详细信息

分析了心脏功能的“泵说”和“波说”。研究表明,心脏扮演的角色实际上不是泵,而是脉搏波发生器,产生一系列携带能量的脉搏波。每个脉搏波由升支和降支组成。前者对应于加载过程:压力、粒子速度、能量和血氧饱和度均随时间升高。而后者则对应于卸载过程:压力、粒子速度、能量以及血氧饱和度都下降,直至为零。因此,“泵说”中诸如Windkessel效应、一机二泵和舒张泵等概念都难以成立。所谓约1.5 W的心脏功率实质上表征了每个脉搏波的功率。针对脉搏波是流-固耦合和纵波-横波耦合的复杂波之特征,研究表明,能量的主要部分(99.99%)由横波携带,它沿固体血管传播,损耗低,效率高。研究还表明,血管分支处广义波阻抗的增大有助于抵消脉搏波传播中的衰减耗散,升高传入血管分支的脉搏波脉压,可视为人体的一种自我调节机制。

关键词：心脏功能泵说波说中医脉搏波

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Identification of bioactive anti-angiogenic constitutes targeting tumor endothelial cells in Shenmai Injection using multidimensional pharmacokinetics

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中国药理学与毒理学杂志 2019年第9期33卷 681-682页

作者： ZHONG chong-jin JIANG Chao NI Sui-ying wang Qi-zhi CHENG Ling-ge wang huan ZHANG Qi-xiang LIU Wen-yue ZHANG Jing-wei LIU Jia-li wang Mu-lan JIN Min SHEN Pei-qiang YAO Xue-quan wang Guang-ji ZHOU Fang Key Laboratory of Drug Metabolism and Pharmacokinetics State Key Laboratory of Natural MedicinesChina Pharmaceutical UniversityNanjing 210009China Department of Digestive Tumor Surgery Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029China Chiatai QingChunbao Pharmaceutical Co.Ltd. Hangzhou 310023China

OBJECTIVE To identify the bioactive anti-angiogenic constitutes targeting tumor endothelial cells(TECs)in Shenmai Injection(SMI).METHEODS For pharmacokinetic(PK)studies,Balb/c mice harboring human colorectal cancer(LoVo)xenografts were treated with SMI 10 mL·kg^-1 daily for 1 or 8 *** PK profiles of ginsenosides in plasma,subcutaneous tumors,and TECs were *** PD studies,the tumor-bearing mice Intravital multi-photon imaging and CD31 immunofluorescence staining were used to evaluate the number of microves⁃sels and *** staining of CD31 and α-SMA was performed to evaluate pericytes coverage ratios around *** was performed to determine the concentrations of VEGF and FGF in tumor *** synergistic anti-tumor study,the tumor-bearing mice were treated with SMI 10 mL·kg^-1 daily,Rd 5 mg·kg^-1 daily with or without 5-FU 15 mg·kg^-1 every 3 d for 20 ***-MS/MS was used to determine the concentrations of 5-FU in plasma and tumor *** SMI decreased the number of microvessels(P<0.05)and vessel branches(P<0.05)and improved vascular pericytes coverage(P<0.05).PK studies showed that the concentrations of protopanaxadiol-type(PPD)ginsenosides(Rb1,Rb2/Rb3,Rc,and Rd)in both,plasma and tumors,were higher than those of protopanaxatriol-type(Rg1 and Re)and oleanane-type(Ro)*** PPD ginsenosides,Rd exhibited the greatest concentrations in tumors and TECs after repeated *** fact,the proportion of Rd in the detectable components of SMI gradually increased in the following order:SMI formula(2.8%),plasma(16.0%),tumor tissues(34.3%),and TECs(40.3%).In vivo bioactivity results showed that Rd 5 mg·kg^-1 daily significantly decreased the number of microvessels(P<0.05)and vessel branches(P<0.05)and increased pericytes coverage(P<0.05)while Rd 0.5 mg·kg^-1 daily,Rb1 and Rg1 had no significant effect on *** 5 mg·kg^-1 suppressed the expression of VEGF and FGF *** 5 mg·kg^-1 enhanced the antit

关键词： Shenmai Injection multidimensional pharmacokinetics ginsenoside Rd anti-angiogenic tumor endo⁃thelial cell

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Decreased adiponectin effects contribute to the development of benign prostatic hyperplasia in obesity

Decreased adiponectin effects contribute to the development ...

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中国中西医结合学会泌尿外科专业委员会第十四次全国学术会议暨2016年广东省中西医结合学会泌尿外科专业委员会学术年会

作者： Shi Fu chong Liu huan Xu Yanbo Chen Qi Chen Zhikang Cai Juan Zhou Zhong wang Department of Urology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of Medicine

Objectives Increased incidence of benign prostatic hyperplasia(BPH) among obesity individuals,but few fully studies explain theunderlying mechanisms. We aimed to elucidate the further details between obesity and BPH. Methods Acase-control study and tissue micro-array analysis were performed to investigate the correlation between adiponectin and BPH patients. These studies were followed by in vivo assays utilizing a high-fat-diet mice model. Further mechanism research such as cell proliferation,cell apoptosis,cell cycle and ERK signal pathways were detected by utilizing various in vitro approaches. Results BPH patients associated with lower serum adiponectin levels,and Adiponectin receptor 1 was down-regulated in benign hyperplastic prostate tissues compared with normal prostate tissues. We found reduction of serum adiponectin levels and Adipo R1 expression in a high-fat-diet mediated BPH mice model,and adiponectin treatment can alleviate histological prostatic hyperplasia. In vitro,adiponectin treatment results in inhibiting proliferation and increasing apoptosis of prostatic epithelial and stromal cells via inhibiting MEKs-ERKs-p90 RSK pathways. Conclusions Reduction of serum adiponectin levels and down-regulation of Adio R1 are associated with BPH in human and mice. These decreased adiponectin effects leading to imbalance of prostatic cell proliferation and apoptosis via MEKs-ERKs-p90 RSK pathway. These findings could help explain the development of BPH in obesity. Whether ameliorating the failures of adiponectin can prevent or delay the onset of BPH remains to be clarified.

关键词： Benign prostatic hyperplasia(BPH) Adiponectin Adiponectin receptor 1(Adipo R1) P90RSK Obesity

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低镍泡沫铁镍合金镀层的制备工艺

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材料保护 2009年第12期42卷 38-40页

作者：陈焕骏王殿龙王崇温娜哈尔滨工业大学化工学院黑龙江哈尔滨150001

用泡沫铁镍合金镀层替代金属镍镀层,可以节约镍资源和生产成本。通过电沉积在导电化处理过的聚氨酯泡沫棉上制备了低镍泡沫铁镍合金镀层,并对电解液体系及制备工艺条件进行了研究。结果表明:升高镀液温度和增大电流密度可以细化晶粒;二... 详细信息

用泡沫铁镍合金镀层替代金属镍镀层,可以节约镍资源和生产成本。通过电沉积在导电化处理过的聚氨酯泡沫棉上制备了低镍泡沫铁镍合金镀层,并对电解液体系及制备工艺条件进行了研究。结果表明:升高镀液温度和增大电流密度可以细化晶粒;二元有机酸配位剂H-1使得赫尔槽试样光亮区明显增长;H-1和MnCl2均能使阴极极化增强;镍离子使阳极峰显著正移200mV,抗蚀性增强;制备的低镍泡沫铁镍合金镀层结晶致密,显微硬度高达770HV。

关键词：泡沫铁镍合金电沉积极化曲线抗蚀性

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中老年肥胖男性身体活动水平与能量消耗特征

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体育科学 2011年第11期31卷 21-26页

作者：王欢江崇民尚文元上海体育学院运动人体科学学院上海200438 国家体育总局体育科学研究所北京100061

以中老年男性肥胖人群为对象,同正常体重人群相比,研究肥胖人群自由生活下的身体活动水平、静息代谢、特定活动下的能耗代谢率、能源底物利用特征,为肥胖机制研究和干预措施制定提供参考。方法：14名50~60岁肥胖男性者（BMI〉30）和15... 详细信息

以中老年男性肥胖人群为对象,同正常体重人群相比,研究肥胖人群自由生活下的身体活动水平、静息代谢、特定活动下的能耗代谢率、能源底物利用特征,为肥胖机制研究和干预措施制定提供参考。方法：14名50~60岁肥胖男性者（BMI〉30）和15名体重正常者（BMI=23）使用加速度计RT3连续7天测量身体活动。之后使用Cortex MetaMax 3 B进行静息代谢和特定身体活动能耗的测量（坐、站、步行3.2 km/h,4.8 km/h,6.4 km/h）。结果：1）肥胖者的每日总能耗、身体活动能耗、中等强度以上活动能耗、中等以上活动的累计时间都显著大于对照组（P〈0.05）。调整了体重因素后,肥胖者单位体重每日能耗/kg略低于对照组,而单位体重身体活动能耗显著高于对照组。2）肥胖组静息能耗高于体重正常组,若是以单位体重计算,静息代谢率显著低于体重正常组（P〈0.05）。3）在坐、站、走活动中,肥胖组消耗的能量显著高于对照组（P〈0.05）。若以公斤体重计算能耗,肥胖组坐姿和站姿的相对能耗略低于对照组,步行的相对能耗两组无差别。4）相同运动下两组人群安静平卧、坐、站、3.2 km/h和4.8 km/h步行时的呼吸交换率没有差异。6.4 km/h步行时,肥胖组的呼吸交换率显著高于体重正常组（P〈0.05）。5）用回归统计法分析影响肥胖的危险因素,静息代谢率可以作为预测肥胖的因子。结论：肥胖人群的身体活动量和每日消耗能量不低于体重正常组,造成肥胖的原因很可能与能量消耗有关,较低的静息代谢率是肥胖发生的重要因素。此外,运动中脂肪氧化能力下降也可能是肥胖危险因素。

关键词：中老年男性肥胖身体活动能量消耗静息代谢率底物利用

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