检索结果-南通市图书馆

Cancer Communications 2024年第5期44卷 589-592页

作者： Jian-rong li Chao Cheng Institute for Clinical and Translational Research Baylor College of MedicineHoustonTexasUSA Section of Epidemiology and Population Sciences Department of MedicineBaylor College of MedicineHoustonTexasUSA Dan L Duncan Comprehensive Cancer Center Baylor College of MedicineHoustonTexasUSA

Infiltrating immune cells in the tumor microenvironment(TME)play critical roles in the initiation,progression,and metastasis of cancer[1].Previous studies have reported that the infiltration levels of various immune cell types are significantly associated with patient prognosis in different cancers[2,3].Specifically,in non-small cell lung cancer(NSCLC)the prognostic associations of major immune cell types have been investigated[4–6],however,some of the reported associations are inconsistent and remain debated[7].limited by technical issues,most studies focused on a few immune cell lineages or relied on inferred immune cell levels from computational *** investigate the prognostic effects of all major immune cell types unbiasedly,more systematic high-quality immune cell profiling data with matched patient survival information are needed.

关键词： prognosis cancer lung

Ultra-highly selective recognition of nucleosides over nucleotides by rational modification of tetralactam macrocycle and its application in enzyme assay

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第6期35卷 274-278页

作者： huan Yao Jian Qin Yan-Fang Wang Song-Meng Wang liu-huan Yi Shi-Yao li Fangfang Du liu-Pan Yang li-li Wang School of Pharmaceutical Science Postdoctoral Research Station of Basic MedicineHengyang Medical SchoolUniversity of South ChinaHengyang 421001China Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China

Artificial macrocycle with high binding selectivity in water is often challenging but urgently needed in various research and application ***,we report a new water-soluble biomimetic tetralactam macrocycle and realize the ultra-high selectivity to nucleosides over corresponding monophosphate nucleotides by rational *** introduction of charged groups at the periphery of endofunctionalized cavity makes the selectivity(guanosine to guanosine 5-monophosphate)increase remarkably from 100 to *** on the ultra-high selectivity of biomimetic tetralactam macrocycle,the sensitive CD73 enzyme activity assay was then achieved through product-selective fluorescence indicator displacement ***,the capability of the proposed method for inhibitor screening was successfully displayed.

关键词： Rational modification Biomimetic macrocycle Ultra-high selectivity Enzyme assay

Carbon fiber confined mixed Ni-based crystal phases with interfacial charge redistribution induced by high bond polarity for electrochemical urea-assisted hydrogen generation

在线全文

学校读者我要写书评

暂无评论

Carbon Energy 2024年第9期6卷 292-305页

作者： Chun Yin Jiaxin li Shuli Wang huan Wen Fulin Yang ligang Feng School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhouChina Guangxi Key Laboratory of Electrochemical Energy Materials School of Chemistry and Chemical EngineeringGuangxi UniversityNanningChina

Interfacial electronic structure modulation of nickel-based electrocata-lysts is significant in boosting energy-conversion-relevant urea oxidation reaction(UOR).Herein,porous carbon nanofibers confined mixed Ni-based crystal phases of Ni_(2)P and NiF_(2) are developed via fluorination and phosphorization of Ni coated carbon nanofiber(Ni_(2)P/NiF_(2)/PCNF),which possess sufficient mesoporous and optimized Gibbs adsorption free energy by mixed phase-induced charge *** novel system further reduces the reaction energy barrier and improves the reaction activity by addressing the challenges of low intrinsic activity,difficulty in active site formation,and insufficient synergism.A considerably high current density of 254.29 mA cm^(-2) is reached at 1.54 V versus reversible hydrogen electrode on a glass carbon electrode,and the cell voltage requires 1.39 V to get 10 mA cm^(-2) in hydrogen generation,with very good stability,about 190 mV less than that of the traditional water *** facile active phase formation and high charge transfer ability induced by asymmetric charge redistribution are found in the interface,where the urea molecules tend to bond with Ni atoms on the surface of heterojunction,and the rate-determining step is changed from CO_(2) desorption to the fourth H-atom *** work reveals a novel catalyst system by interfacial charge redistribution induced by high bond polarity for energy-relevant catalysis reactions.

关键词： carbon fiber nickel fluoride nickel phosphide urea oxidation water electrolysis

Deliberate self-harm among pediatric psychiatric inpatients in China:A single-center retrospective study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2024年第3期14卷 398-408页

作者： Xing-Zhi Jiang huan-huan li Zhen-Zhen Yu Chen Wang Department of Child and Adolescent Psychiatry Shenzhen Kangning HospitalShenzhen Mental Health CenterShenzhen Key Laboratory for Psychological Healthcare and Shenzhen Institute of Mental HealthShenzhen 518020Guangdong ProvinceChina Department of Psychiatry Xiamen Xianyue HospitalXiamen 361012Fujian ProvinceChina Department of Geriatric Medicine Dalian Medical UniversityDalian 116000Liaoning ProvinceChina Department of Neurology The Second Affiliated Hospital of Xiamen Medical CollegeXiamen 361000Fujian ProvinceChina Department of Neurology and Department of Neuroscience The First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361000Fujian ProvinceChina

BACKGROUND For children and adolescents,deliberate self-harm(DSH)is becoming a mental health problem of *** several studies on the prevalence and factors of DSH in the world,there is little information on DSH among children and adolescents in *** study explores the prevalence,types,associated risk factors and tendency of DSH in pediatric psychiatric inpatients in *** To understand the situation of DSH among hospitalized children and adolescents and its related *** In this study,we retrospectively studied 1414 hospitalized children and adolescents with mental illness at Xiamen Mental Health Center from 2014 to 2019,extracted the demographic and clinical data of all patients,and analyzed clinical risk factors of *** A total of 239(16.90%)patients engaged in at least one type of DSH in our ***(n=115,48.12%)was the most common type of ***(n=171,71.55%)were more likely to engage in DSH than males(n=68,28.45%).DSH was positively associated with depressive disorders[OR=3.845(2.196-6.732);P<0.01],female[OR=2.536(1.815-3.542);P<0.01],parental marital status[OR=5.387(2.254-12.875);P<0.01]and negative family history of psychiatric illness[OR=7.767(2.952-20.433);P<0.01],but not with occupation,substance use and history of physical *** Our findings suggest that for patients with depression,females,an abnormal marriage of parents,and no history of mental illness,attention should be paid to the occurrence of DSH.

关键词： Deliberate self-harm Children Adolescent Psychiatric inpatients Retrospective study

Amide naphthotubes:Biomimetic macrocycles for selective molecular recognition

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第4期35卷 124-131页

作者： Cheng-Da Zhao huan Yao Shi-Yao li Fangfang Du li-li Wang liu-Pan Yang School of Pharmaceutical Science Postdoctoral Research Station of Basic MedicineHengyang Medical SchoolUniversity of South ChinaHengyang 421001China

Selective molecular recognition in water is routine for bioreceptors,but remains challenging for synthetic *** is principally because noncovalent interactions are usually less efficient in aqueous *** mimicking the cavity feature of bioreceptors,*** Jiang proposed and clarified the concept of“endo-functionalized cavity”.Through situating polar binding sites into a deep hydrophobic cavity,we designed and synthesized several macrocyclic hosts,among which amide naphthotubes are the most *** hosts can selectively recognize various polar molecules including organic micropollutants,drug molecules,and chiral molecules in water by employing the hydrophobic effect and shielded hydrogen *** addition,these biomimetic hosts have been applied in spectroscopic analysis,adsorptive separation and *** this review,we provide an overview of recent advances on amide naphthotubes with special emphasis on the efforts of Jiang's *** are convinced that these biomimetic macrocycles will make further contributions to supramolecular chemistry and beyond.

关键词： Molecular recognition Supramolecular chemistry Amide naphthotube Endo-functionalized cavity Biomimetic macrocycle

Machine learning for fault diagnosis of high-speed train traction systems: A review

在线全文

学校读者我要写书评

暂无评论

Frontiers of Engineering Management 2024年第1期11卷 62-78页

作者： huan WANG Yan-Fu li Jianliang REN Department of Industrial Engineering Tsinghua UniversityBeijing 100084China Zhibo Lucchini Railway Equipment Co. Ltd.Taiyuan 030032China

High-speed trains(HSTs)have the advantages of comfort,efficiency,and convenience and have gradually become the mainstream means of *** the operating scale of HSTs continues to increase,ensuring their safety and reliability has become more *** the core component of HST,the reliability of the traction system has a substantially influence on the *** the long-term operation of HSTs,the core components of the traction system will inevitably experience different degrees of performance degradation and cause various failures,thus threatening the running safety of the ***,performing fault monitoring and diagnosis on the traction system of the HST is *** recent years,machine learning has been widely used in various pattern recognition tasks and has demonstrated an excellent performance in traction system fault *** learning has made considerably advancements in traction system fault diagnosis;however,a comprehensive systematic review is still lacking in this *** paper primarily aims to review the research and application of machine learning in the field of traction system fault diagnosis and assumes the future development ***,the structure and function of the HST traction system are briefly ***,the research and application of machine learning in traction system fault diagnosis are comprehensively and systematically ***,the challenges for accurate fault diagnosis under actual operating conditions are revealed,and the future research trends of machine learning in traction systems are discussed.

关键词： high-speed train traction systems machine learning fault diagnosis

MnO-pillared graphene blocks enabling the ultrastable and ultrafast aqueous zinc ion batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第9期67卷 2930-2940页

作者： Zheng liu Zhipeng Qiu Zhiyuan li Tong Wei Zhuangjun Fan huan Pang School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China School of Materials Science and Engineering China University of PetroleumQingdao 266580China

Due to the low cost,high theoretical capacity,and environmental friendliness,manganese-based cathodes are regarded as promising alternatives for aqueous zinc ion batteries(AZIBs).However,the practicality of the zinc-manganese system is faced with great challenges,such as the inevitable structural collapse of the cathode and controversial energy storage ***,we propose a novel concept of spatial deposition mechanism through the addition of MnSO_(4) additives in the Mn O-pillared graphene blocks(G-MnO).The covalent interface between MnO nanoparticles and multilayered graphene nanosheets can construct an in-built micro-electric field,which is beneficial for consecutive electron transfer(in both horizontal and vertical directions).On this basis,the surficial activity of MnO confined in the interlayered nano-space is greatly enhanced and provides enough spatial deposition and subsequent reaction site for MnSO_(4) additives,thus firstly extending the surficial controlled process to stereoscopic space,effectively improving the electrochemical performance of ***,the assembled Zn//G-Mn O battery exhibits an excellent rate capability of 281.5 mAhg^(-1)at 0.1 A g^(-1)and 106 mAhg^(-1)at 20 Ag^(-1),and impressive cycling stability(93 mAhg^(-1)remaining after 5,000 cycles).This finding may provide a new opportunity for the rational design of surficial controlled energy storage and conversion devices.

关键词： zinc-ion battery manganese monoxide laminated constructure ultrahigh rate performance graphene

Effect of electron beam irradiation on surface molecule and flashover voltage of epoxy composites

在线全文

学校读者我要写书评

暂无评论

High Voltage 2024年第3期9卷 528-536页

作者： Mingru li huan Niu Kai Shang Jianyu Lang Yafang Gao Bingnan li Jiuhui Zhao Zhen li Yang Feng Shengtao li State Key Laboratory of Electrical Insulation and Power Equipment Xi'an Jiaotong UniversityXi'anShaanxiChina Key Laboratory of Engineering Dielectrics and Its Application Ministry of EducationHarbin University of Science and TechnologyHarbinHeilongjiangChina

The unsatisfactory insulating properties of solid–gas interfaces seriously restrict the development of high-voltage electrical equipment and threaten their power supply ***-beam irradiation(EBI)can effectively improve the surface flashover voltage of ***,the underlying mechanism of EBI in tailoring the surface trap and improving the flashover voltage remains *** this study,the surface morphologies and chemical compositions of epoxy composites treated with EBI were *** addition,the surface wetting properties,surface charge migration pa-rameters,and surface flashover voltages were experimentally *** was found that EBI aggravated the surface morphology,changed the surface chemical components,and repressed surface charge *** a result,the contact angle was reduced from 103.7°to 78.43°,and the flashover voltage in SF6 was increased from 35.26 to 38.90 *** calculations showed that the newly generated C–O–H and C=O bonds on the surface molecules after EBI formed charge centres at the molecular electrostatic potential,which enhanced the trapping effect of the surface deep *** a result,surface charge migration was repressed,and the surface flashover voltage was *** study could promote the further development of EBI on materials modification.

关键词： composites surface beam

Temporal changes in mixing effects on litter decay and nitrogen release in a boreal riparian forest in northeastern China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Forestry Research 2024年第2期35卷 33-41页

作者： Simin Wang Bo liu Rui li Xiaoxin Sun rong Mao Key Laboratory of National Forestry and Grassland Administration on Forest Ecosystem Protection and Restoration of Poyang Lake Watershed College of ForestryJiangxi Agricultural UniversityNanchang 330045People’s Republic of China Key Laboratory of Wetland Ecology and Environment Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102People’s Republic of China Key Laboratory of Sustainable Forest Ecosystem Management of Ministry of Education School of ForestryNortheast Forestry UniversityHarbin 150040People’s Republic of China Heilongjiang Sanjiang Plain Wetland Ecosystem Research Station Fuyuan 156500People’s Republic of China

In riparian forests,litter decay provides essential energy and nutrients for both terrestrial and fluvial *** mixing effects(LMEs)are crucial in regulating litter decay and nutrient dynamics,yet how LMEs change over time is unclear in riparian *** this study,leaf litter of three common species(Alnus sibirica *** Turcz,Betula platyphylla Sukaczev,and Betula fruticosa Pall.)were mixed in an equal mass ratio and LMEs were measured for mass and nitrogen(N)remaining in whole litter mixtures over a 3-year period in a boreal riparian forest,northeastern *** were also assessed for component litter mass and N remaining by separating litter mixtures by *** the decay of litter mixtures,antagonistic effects on mass and N remaining were dominant after one and two years of decay,whereas only additive effects were observed after three *** correlated negatively with functional diversity after the first and two years of decay but disappeared after three *** sorting litter mixtures by species,non-additive LMEs on mass and N remaining decreased over incubation ***,non-additive LMEs were more frequent for litter of both *** and *** with lower N concentration than for *** litter with higher N *** results indicate that incubation time is a key determinant of litter mixing effects during decay and highlight that late-stage litter mixture decay may be predicted from single litter decay dynamics in boreal riparian forests.

关键词： Biodiversity litter quality litter mixtures Synergistic effects Functional diversity

Energy release characteristics of PTFE/Al/TiH_(2) reactive jet with different TiH_2 content

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第9期39卷 168-176页

作者： Chunlan Jiang Jingbo Zhang rong Hu liang Mao Ming li State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

Titanium hydride(TiH_(2)), a promising high-energy additive, is doped into PTFE/Al to optimize the energy output structure of the reactive jet and strive for better aftereffect damage ability to the target. Six types of PTFE/Al/TiH_(2) reactive liners with different TiH_(2) content are prepared by the molding and sintering method. The energy release characteristics of PTFE/Al/TiH_(2) reactive jet are tested by the transient explosion energy test, and are characterized from pressure and temperature. The reaction delay time,pressure history, and temperature history of the energy release process are obtained, then the actual value of released energy and reaction efficiency of the reactive jet are calculated. The results show that the peak pressure and temperature of the PTFE/Al/TiH_(2) jet initially increase and then decrease with increasing TiH_(2) content. When the TiH_(2) content is 10%, the actual value of released energy and reaction efficiency increased by 24% and 6.4%, respectively, compared to the PTFE/Al jet. The reaction duration of the reactive material is significantly prolonged as the TiH_(2) content increased from 0% to 30%. Finally,combined with the energy release behaviors of PAT material and the dynamic deformation process of liner, the enhancement mechanism of TiH_(2) on energy release of the reactive jet is expounded.

关键词： PTFE/Al/TiH_(2) Reactive materials Shaped charge Impact energy release characteristics