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Cyro-EM structure of human mGlus:leading therapeutic potential to neurological diseases

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Signal Transduction and Targeted Therapy 2021年第9期6卷 2603-2604页

作者： huan xiao Qiu Sun State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan University and Collaborative Innovation Center for BiotherapyChengduChina

Recently,Lin et al.1 and Du et al.2 have published two papers in Nature,unveiling the full-length structures of metabotropic glutamate receptors(mGlus)of their homologous and heterodimers,and illustrating their conformational change from inactive to fully activated state,which provides a mechanistic basis for a comprehensive understanding of class C G-protein-coupled receptors(GPCRs).

关键词： inactive conformational structure

Bubble Tree ConVergence for the Harmonic Sequence of Harmonic Surfaces in CP^n

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Acta Mathematica Sinica,English Series 2010年第7期26卷 1277-1286页

作者： xiao huan MO Fang SUN Key Laboratory of Pure and Applied Mathematics School of Mathematical Sciences Peking University Beijing 100871 P. R. China

We show that any harmonic sequence determined by a harmonic map from a compact Riemannian surface M to CP^n has a terminating holomorphic （or anti-holomorphic） map from M to CP^n, or a ＂bubble tree limit＂ consisti... 详细信息

关键词： bubble tree harmonic sequence non-isotropic energy identity

Navigation Finsler metrics on a gradient Ricci soliton

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 266-275页

作者： LI Ying MO xiao-huan WANG xiao-yang Department of Applied Mathematics Zhejiang University of TechnologyHangzhou 310023China Key Laboratory of Pure and Applied Mathematics School of Mathematical SciencesPeking UniversityBeijing 100871China School of Mathematics and Statistics Beijing Institute of TechnologyBeijing 100081China

In this paper,we study a class of Finsler metrics defined by a vector field on a gradient Ricci *** obtain a necessary and sufficient condition for these Finsler metrics on a compact gradient Ricci soliton to be of isotropic S-curvature by establishing a new integral *** we determine the Ricci curvature of navigation Finsler metrics of isotropic S-curvature on a gradient Ricci soliton generalizing result only known in the case when such soliton is of Einstein *** its application,we obtain the Ricci curvature of all navigation Finsler metrics of isotropic S-curvature on Gaussian shrinking soliton.

关键词： gradient Ricci soliton navigation Finsler metric isotropic S-curvature Ricci curvature Gaussian shrinking soliton

On the Ricci Curvature of a Randers Metric of Isotropic S-curvature

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Acta Mathematica Sinica,English Series 2008年第6期24卷 911-916页

作者： xiao huan MO Chang Tao YU Key Laboratory of Pure and Applied Mathematics School of Mathematical Sciences Peking University Beijing 100871 P. R. China

We derive the integral inequality of a Randers metric with isotropic S-curvature in terms of its navigation representation. Using the obtained inequality we give some rigidity results under the condition of Ricci curvature. In particular, we show the following result： Assume that an n-dimensional compact Randers manifold （M, F） has constant S-curvature c. Then （M, F） must be Riemannian if its Ricci curvature satisfies that Ric 〈 -（n - 1）c^2.

关键词： Finsler manifold Randers metric Ricci curvature

A promising small molecule binding pocket in class B GPCRs: expanding potential for drug development

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Signal Transduction and Targeted Therapy 2023年第9期8卷 3888-3889页

作者： huan xiao Qian Sun Qiu Sun Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan University/West China School of NursingSichuan UniversityChengdu 610041China West China Medical Publishers West China HospitalSichuan UniversityChengdu 610041China

Recently,Xu et al.1 have published in Nature,solved the high-resolution structure of a small molecule agonist PCO371 and Gs bound human parathyroid hormone receptor 1(PTH1R)by cryo-electron *** study reveals a novel conserved small molecule agonist binding pocket of class B G protein-coupled receptors(GPCRs)and provides new insights into drug develop-ment for various therapeutic *** are a family of receptors with a seven transmembrane(7TM)domains that mediate various downstream signals by activating G proteins or recruitingβ-*** the largest family of cell membrane receptors encoded by the human genome,GPCRs are widely involved in human physiological and patholo-gical processes and have become the most important therapeutic targets.

关键词： expanding insight class

A New Network Coding Mechanism Balancing Coding Opportunities, Energy and QoS in WSNs

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China Communications 2014年第6期11卷 108-118页

作者： ZHENG Kangfeng WANG Xiujuan ZHA Xuan xiao huan School of Computer Science Beijing University of Posts and Telecommunications School of Computer Science Beijing University of Technology

A new Network Coding mechanism in WSNs(Wireless Sensor Networks), which is named COEQ and aims at balancing coding opportunities, energy and QoS, is proposed and analyzed. Implemented on the basis of traditional AODV protocol, COEQ evaluates several metrics of paths comprehensively with TOPSIS method including minimum remaining energy, coding opportunities, QoS and so on, so as to select the optimal transmitting route. Experiments on NS[2] show that COEQ can improve throughput and save energy when the transmitting rate is low.

关键词： network coding wireless sensor network QoS TOPSIS

Control of mould level fluctuation through the modification of steel composition

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International Journal of Minerals,Metallurgy and Materials 2013年第2期20卷 138-145页

作者： Yang Li xiao-huan Zhang Peng Lan Jia-quan Zhang School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

Periodic mould level fluctuation （MLF） during slab casting is a bottleneck for upgrading the surface quality and casting speed especially for hypoperitectic （HP） or ultralow carbon steels. The uneven growth of the initially solidified shell is verified to be one of the important inducements to MLF due to related unsteady bulging in the secondary cooling zone. It is shown that the solidification mode of steels and the contraction behavior can be modified through chemical composition optimization within given composition limits, For high strength low alloy （HSLA） steels, the actual peritectic points calculated by Thermo-Calc software may change remarkably with the slight variations of alloying element contents. Accordingly, the narrow limit of chemical composition of HP steels through optimization is proven to be one of the effective factors to control the popular MLF phenomenon during slab casting.

关键词： low carbon steel continuous casting solidification composition optimization

Facile one-pot hydrothermal method to prepare Sn(Ⅱ) and N co-doped TiO_(2) photocatalyst for water splitting under visible light irradiation

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Rare Metals 2022年第2期41卷 406-414页

作者： xiao-huan Jiang Ying-Nan Duan Yu Tian Meng Chen Mao-Kun Li huan-huan Liu Wan-Liang Yang Meng-Kui Tian School of Chemistry and Chemical Engineering Guizhou UniversityGuiyang 550025China

In this paper,a visible light-responsive Sn^(2+)and N co-doped TiO_(2)photocatalyst was prepared by facile one-pot hydrothermal *** as-prepared samples were characterized in detail by a series of characterization *** results showed that the Sn^(2+)and N elements were co-doped into TiO_(2),while the catalyst still maintains anatase crystal structure and gets irregular little nanocluster in diameter of 9–10 nm with higher specific surface *** absorption edge of Sn^(2+)and N co-doped TiO_(2)extends to the visible light *** with Sn^(2+)-doped TiO_(2)and N-TiO_(2),the absorption edges have obvious red-shift of about 50 and 70 nm,*** synergistic effect of O 2p-N 2p and O 2p-Sn 5s hybridization to form impurity levels is the main reason for the *** hydrogen production performance of the Sn^(2+)and N co-doping TiO_(2)(n(N)/n(Ti)=1)catalyst reached the maximum value of 0.37 mmol·h^(-1)·g^(-1)under visible light,which is higher than that of N-doped TiO_(2)and SnTiO_(2)-doped TiO_(2)*** result is due to the wider visible light region-responsive ability of Sn^(2+)and N codoped into TiO_(2).Furthermore,mild hydrothermal methods will not make the Sn^(2+)oxidized to Sn^(4+),which make the catalysts still maintain high photocatalytic *** work provides a simple and mild method for the preparation of dual-element co-doped TiO_(2)with high crystallinity,excellent performance and broad application prospects.

关键词： Photocatalyst Photocatalytic water splitting Visible light driven Sn^(2+)and N co-doped TiO_(2)

On the Construction of p-Harmonic Morphisms and Conformal Actions

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Acta Mathematica Sinica,English Series 2007年第8期23卷 1475-1484页

作者： xiao huan MO Li Bing huanG Yuan Zheng ZHANG School of Mathematical Sciences Peking University Beijing 100871 P. R. China and Department of Applied Mathematics Shanghai University of Finance and EconomicsShanghai 200433 P. R. China

We produce p-harmonic morphisms by conformal foliations and Clifford systems. First, we give a useful criterion for a foliation on an m-dimensional Riemannian manifold locally generated by conformal fields to produce p-harmonic morphisms. By using this criterion we manufacture conformal foliations, with codimension not equal to p, which are locally the fibres of p-harmonic morphisms. Then we give a new approach for the construction of p-harmonic morphisms from R^m／{0} to R^n. By the well-known representation of Clifford algebras, we find an abundance of the new 2/3 （m ＋ 1）-harmonic morphism Ф： R^m／{0} → R^n where m = 2κδ（n - 1）.

关键词： p-harmonic morphism Clifford system homogeneous function conformal field