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超高效液相色谱-串联质谱法测定红曲中米酵菌酸

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化学分析计量 2024年第9期33卷 38-42页

作者：林华何畅吴易君覃华亮丘莹钟文俊覃冬杰柳州市质量检验检测研究中心广西柳州545006

建立超高效液相色谱-串联质谱测定红曲中米酵菌酸残留的分析方法。样品经80%甲醇水溶液(含1%氨水)超声提取,取上清液5 mL经MAX强阴离子固相萃取小柱净化,采用Welch Botimate C_(18)色谱柱(100 mm×2.1 mm,2.6μm),以乙腈-含0.1%甲酸的10... 详细信息

建立超高效液相色谱-串联质谱测定红曲中米酵菌酸残留的分析方法。样品经80%甲醇水溶液(含1%氨水)超声提取,取上清液5 mL经MAX强阴离子固相萃取小柱净化,采用Welch Botimate C_(18)色谱柱(100 mm×2.1 mm,2.6μm),以乙腈-含0.1%甲酸的10 mmol/L甲酸铵溶液为流动相梯度洗脱,流量为0.3 mL/min,柱温为35℃,进样体积为1μL,采用电喷雾负离子源电离,以多反应监测模式采集信号。米酵菌酸的质量浓度在5.02~1004 ng/mL范围内与定量离子丰度有良好的线性关系,线性相关系数为0.9997。样品加标平均回收率为82.3%~96.1%,测定结果的相对标准偏差为0.6%~4.5%(n=6),方法检出限和定量限分别为0.8 ng/g和2.0 ng/g。该方法快速、准确、灵敏,适用于红曲中米酵菌酸的测定。

关键词：超高效液相色谱-串联质谱法红曲米酵菌酸固相萃取

药物涂层球囊扩张治疗慢性肢体威胁性缺血患者腘动脉病变的效果

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中国临床保健杂志 2024年第3期27卷 293-296页

作者：王盛兴任华亮孙明胜李春民张望德首都医科大学附属北京朝阳医院血管外科北京100020

目的探讨在慢性肢体威胁性缺血(CLTI)患者中运用药物涂层球囊(DCB)扩张治疗腘动脉病变的有效性和安全性。方法回顾性分析2019年6月至2021年6月首都医科大学附属北京朝阳医院血管外科收治的110例CLTI患者病历资料,DCB干预的靶病变为腘动... 详细信息

目的探讨在慢性肢体威胁性缺血(CLTI)患者中运用药物涂层球囊(DCB)扩张治疗腘动脉病变的有效性和安全性。方法回顾性分析2019年6月至2021年6月首都医科大学附属北京朝阳医院血管外科收治的110例CLTI患者病历资料,DCB干预的靶病变为腘动脉。评估患者术后Rutherford分级和肢体威胁程度(WIfI)分期,以及临床驱动的靶血管重建(TLR)。主要安全终点包括全因死亡和截肢。通过多因素生存分析评估影响无截肢生存率的因素。结果患者年龄(72.7±9.2)岁,靶病变长度(127.6±56.8)mm,闭塞性病变和重度钙化分别占79.1%和62.7%,重度肢体威胁患者占20.9%。在12个月的随访中,患者的全因死亡率、无截肢生存率和TLR分别为11.8%、81.8%和12.7%。在3个月和12个月的随访中,Rutherford分级和WIfI分期均得到改善(P均<0.001)。在12个月的随访中,重度肢体威胁患者中有43.5%死亡或截肢。多因素生存分析提示,WIfI分期是患者无截肢生存的独立危险因素。结论DCB扩张治疗CLTI患者的腘动脉病变安全有效。WIfI分期可用于评估CLTI患者预后情况。

关键词：慢性肢体威胁性缺血血管成形术腘动脉危险因素

Organizational Ambidexterity: Balancing Local Knowledge and Global Knowledge 3rd

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Organizational Ambidexterity: Balancing Local Knowledge and ...

An angle-insensitive electromagnetic absorber enabling a wideband absorption

2011 International Conference on Information Management and Engineering(ICIME 2011)

作者： hualiang Zheng Aiqi Wu School of Management Zhejiang University

ISBN: (纸本)9781612842387

Because there are advantages and disadvantages in both local knowledge and global knowledge, for the firms in the cluster, they should balance the relationship but not just focus on either one to achieve good performance while maintain their competitive advantage. However, with the intrinsic tension between local knowledge and global knowledge, it is hard for firms to balance them. Though summarizing the prior research on this area and analyzing the business cases, we found that to balance the local knowledge and global knowledge, firms in the cluster can establish the different structural units, improve the capacity of employees to deal with the different activities and acquire the dynamical decision and support from management team.

关键词： organizational ambidexterity knowledge-based view balance local knowledge global knowledge

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Journal of Materials Science & Technology 2022年第18期113卷 33-39页

作者： Zhichao Lou Qiuyi Wang Xiaodi Zhou Ufuoma I.Kara Rajdeep S.Mamtani hualiang Lv Meng Zhang Zhihong Yang Yanjun Li Chenxuan Wang Solomon Adera Xiaoguang Wang Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry UniversityNanjing 210037China Willian G.Lowrie Department of Chemical and Biomolecular Engineering The Ohio State UniversityColumbusOH43210United States of America Institute of Materials Research and Engineering Agency for SciencesTechnology and ResearchSingapore State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Department of Mechanical Engineering University of MichiganAnn ArborMI48109United States of America Sustainability Institute The Ohio State UniversityColumbusOH43210United States of America School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471023China

Electromagnetic(EM)wave absorbers with wideband absorption capability are proposed as a strategy to mitigate environmental pollution by EM ***,designing an EM absorber with its performance capacity independent of the EM wave incident angle remains elusive to *** this challenge requires development of EM absorbers whose EM absorption performance is insensitive to the EM wave incident ***,we synthesized EM absorbers with a variety of structures with different symme-tries(including micro-/nanospheres,nanoflakes and nanotubes)to study the effect of the EM absorbers’structure and the EM wave incident angle on the EM absorption *** analysis reveals that non-magnetic EM absorbers with spatially symmetric nanostructures exhibit excellent EM wave incident ***,we demonstrate that a class of non-magnetic EM absorbers made from bam-boo derived-carbon nanospheres exhibit EM incident angle-insensitivity and wideband EM absorption performance with an effective absorption band up to 3.5 GHz when the thickness is 1.4 mm,a signif-icant improvement from prior studies which used thicknesses as high as 3-4 mm for comparable EM absorption performance.

关键词： Nanostructure Angle-insensitive EM absorption Biomass derived carbon Wideband

China's reform of the regulatory system for medical products and its impact

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National Science Review 2019年第1期6卷 1-1页

作者： Ruilin Song Guowei Sang Meiyu Geng hualiang Jiang Research Center of National Drug Policy and Ecosystem China Pharmaceutical University Shanghai Institute of Materia Medica Chinese Academy of Sciences

On 9 August 2015, the State Council of the People’s Republic of China issued ‘The Opinions on Reforming Review and Approval Process for Drugs and Medical Devices’(GUOFA[2015] No. 44). This important policy document not only provides the guideline for creating a more scientific and efficient regulatory process for drugs and medical devices, but also initiates the reform of the administration system for medical products in China. In October 2017, the general office of the Communist Party of China Central Committee and the general office

关键词： China’s reform of the regulatory system for medical products and its impact Innovation

Why is the SARS-CoV-2 Omicron variant milder?

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The Innovation 2022年第4期3卷 7-8页

作者： Bingqing Xia Yi Wang Xiaoyan Pan Xi Cheng Hongying Ji Xiaoli Zuo hualiang Jiang Jia Li Zhaobing Gao CAS Key Laboratory of Receptor Research Stake Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences555 Zuchongzhi RoadShanghai 201203China University of Chinese Academy of Sciences 19A Yuquan RoadBeijing 100049China State Key Laboratory of Medical Neurobiology Institutes of Brain ScienceFudan UniversityShanghai 200032China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China Lingang Laboratory Shanghai 201602China

In November 2021,a new SARS-CoV-2 variant emerged in South Africa and was designated the fifth variant of concern and named *** was detected in more than 26 countries worldwide,including *** Omicron variant is highly transmissible and has extensive morbidity,which has raised concerns related to antiviral *** reports have revealed that the Omicron variant exhibits a longer cycle of viral shedding and a decreased replication capacity and results in substantially attenuated lung pathology,indicating that the pathogenic ability of the Omicron variant is lower than that of previous variants.1Omicron has the largest number(>30)of substitutions,deletions,or insertions,with a mutation frequency of higher than 1%in the spike(S)*** studies of the spike protein receptor-binding domain have provided a plausible explanation for the increased transmissibility and antibody resistance of this ***,the molecular basis for its attenuated pathogenicity and replication capacity remains elusive.

关键词： insertion raised explanation

纤维蛋白原与白蛋白比值及CHADS2评分与冠状动脉慢性完全闭塞性病变的相关性研究

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中国临床保健杂志 2024年第4期27卷 520-524页

作者：杨二丽张晶晶朱华良赵宇飞祝小霞黄正安徽医科大学第二附属医院老年心血管内科合肥230601 安徽医科大学第二附属医院心血管内科合肥230601

目的探讨纤维蛋白原与白蛋白比值(FAR)及CHADS2评分与冠状动脉慢性完全闭塞性病变(CTO)的相关性。方法回顾性分析2015年7月至2023年12月于安徽医科大学第二附属医院老年心血管内科行冠状动脉造影术(CAG)检查确诊的244例冠心病患者病历资... 详细信息

目的探讨纤维蛋白原与白蛋白比值(FAR)及CHADS2评分与冠状动脉慢性完全闭塞性病变(CTO)的相关性。方法回顾性分析2015年7月至2023年12月于安徽医科大学第二附属医院老年心血管内科行冠状动脉造影术(CAG)检查确诊的244例冠心病患者病历资料,根据CAG结果将其分为CTO组(142例)和非CTO组(102例)。根据Gensini积分取三分位数分组,将其分为低积分组(82例)、中积分组(82例)和高积分组(80例)。结果CTO和非CTO患者间年龄、高血压、心力衰竭、脑血管事件、吸烟、血红蛋白、白蛋白、尿素氮、纤维蛋白原、FAR、CHADS2评分及Gensini积分比较,差异有统计学意义(P<0.05)。多因素logistic回归分析结果显示,吸烟、FAR及CHADS2评分与CTO相关(P<0.05)。各积分组患者间年龄、心力衰竭比例、吸烟比例、白蛋白、总胆固醇、纤维蛋白原、FAR、CHADS2评分及CTO比例比较,差异均有统计学意义(均P<0.05)。Spearman相关分析显示,FAR和CHADS2评分与Gensini积分均呈正相关(P<0.05)。结论FAR及CHADS2评分与CTO的发生独立相关,对于患者术前冠状动脉病变严重程度的评估有一定的指导意义。

关键词：冠心病心血管造影术纤维蛋白原白蛋白类影响因素分析

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水稻施肥效果及肥料利用率研究

现代农业科技 2024年第6期 12-14,17页

作者：冯伟明吴颖仪郝东川陈育民张均功温华良佛山市农业科学研究所/佛山市农业技术推广中心广东佛山528145

为了明确不同肥料对水稻产量及植株氮磷钾含量的影响,选用天禾水稻专用配方肥(24-7-19)和雅冉复合肥(15-15-15)作为试验材料,进行了施肥效果及肥料利用率研究。结果表明:2种肥料均可以提高水稻产量,各养分元素对产量的贡献率大致表现为... 详细信息

为了明确不同肥料对水稻产量及植株氮磷钾含量的影响,选用天禾水稻专用配方肥(24-7-19)和雅冉复合肥(15-15-15)作为试验材料,进行了施肥效果及肥料利用率研究。结果表明:2种肥料均可以提高水稻产量,各养分元素对产量的贡献率大致表现为氮>钾>磷,表明水稻生产中要特别注意氮素和钾素的投入;总体来看,天禾水稻专用配方肥(24-7-19)的表观利用率、生理效率、农学效率、产量贡献率和偏生产力均高于雅冉复合肥(15-15-15),表明水稻生产中可使用水稻专用配方肥替代普通复合肥。

关键词：水稻天禾水稻专用配方肥(24-7-19) 雅冉复合肥(15-15-15) 产量肥料利用率

Recent progress in fragment-based drug discovery facilitated by NMR spectroscopy

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Magnetic Resonance Letters 2022年第2期2卷 107-118,I0003页

作者： Lei Wang Jia Gao Rongsheng Ma Yaqian Liu Mingqing Liu Fumei Zhong Jie Hu Shuju Li Jihui Wu hualiang Jiang Jiahai Zhang Ke Ruan The First Affiliated Hospital of USTC Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei230001China Ministry of Education Key Laboratory for Membraneless Organelles&Cellular Dynamics Hefei National Laboratory for Physical Sciences at the MicroscaleSchool of Life SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei230027China Drug Discovery and Design Center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences555 Zuchongzhi RoadShanghai201203China

Considerable developments have been observed in fragment-based lead/drug discovery(FBLD/FBDD)recently,with four drugs approved and many others under *** magnetic resonance(NMR)has gained increasing popularity in FBLD due to its intrinsic capability in characterizing protein-ligand interactions in a large dynamic range of affinity,from weak hits to highly potent ***,we summarize NMR applications in fragment-based hit-to-lead evolution,including the construction of a fragment library,screening methods,spectra processing,and the delineation of the protein-ligand binding *** state-of-the-art NMR techniques have been exemplified in the discovery of inhibitors against multiple targets over the past five years,and they are expected to continue to provide new insights in the future.

关键词： Fragment-based lead/drug discovery NMR spectroscopy Protein-ligand interaction Complex structure Hit-to-lead evolution