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Chinese Chemical Letters 2023年第7期34卷 298-302页

作者： Jiaxiang Sun Rongzheng Ren hualiang Yue Wencan Cui Gaige Wang Chunming Xu Jinshuo Qiao Wang Sun Kening Sun Zhenhua Wang Beijing Key Laboratory for Chemical Power Source and Green Catalysis School of Chemistry and Chemical EngineeringBeijing Institute of Technology.Beijing100081China

Reversible protonic ceramic cells(RPCCs) show great potential as new-generation energy conversion and storage devices. However, the mature development of RPCCs is seriously hindered by the inactivity and poor stability of air electrodes exposed to concentrated vapor under operating conditions. Herein, we report a high-entropy air electrode with the composition BaCo_(0.2)Fe_(0.2)Zr_(0.2)Sn_(0.2)Pr_(0.2)O_(3-δ)(BCFZSP), which shows integrated electronic, protonic and oxygenic conduction in a single perovskite phase and excellent structural stability in concentrated steam. Such triple conduction can spread the electrochemically active sites of the air electrode to the overall electrode surface, thus optimizing the kinetics of the oxygen reduction and evolution reactions(0.448 Ω cm^(2) of polarization resistance at 550℃). As-prepared RPCCs with a BCFZSP air electrode at 600℃ achieved a peak power density of 0.68 W/cm^(2) in fuel-cell mode and a current density of 0.92 A/cm^(2) under a 1.3 V applied voltage in electrolysis mode. More importantly, the RPCCs demonstrate an encouragingly high stability during 120 h of reversible switching between the fuelcell and electrolysis modes. Given their excellent performance, high-entropy perovskites can be promising electrode materials for RPCCs.

关键词： High-entropy perovskite oxide Triple-conducting oxide Air electrode Reversible protonic ceramic cells Hydrogen production

Dynamic modifications of biomacromolecules: mechanism and chemical interventions

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Science China(Life Sciences) 2019年第11期62卷 1459-1471页

作者： Chu Wang Peng Zou Caiguang Yang Lei Liu Liang Cheng Xiaopeng He Liang Zhang Yan Zhang hualiang Jiang Peng RChen College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China Department of Chemistry Tsinghua UniversityBeijing 100084China Institute of Chemistry Chinese Academy of SciencesBeijing 100190China School of Chemistry and Molecular Engineering East China University of Science and TechnologyShanghai 200237China Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of MedicineShanghai 200025China National Natural Science Foundation of China Beijing 100085China

Biological macromolecules(proteins,nucleic acids,polysaccharides,etc.)are the building blocks of life,which constantly undergo chemical modifications that are often reversible and spatial-temporally *** dynamic properties of chemical modifications play fundamental roles in physiological processes as well as pathological changes of living *** Major Research Project(MRP)funded by the National Natural Science Foundation of China(NSFC)—"Dynamic modifications of biomacromolecules:mechanism and chemical interventions"aims to integrate cross-disciplinary approaches at the interface of chemistry,life sciences,medicine,mathematics,material science and information science with the following goals:(i)developing specific labeling techniques and detection methods for dynamic chemical modifications of biomacromolecules,(ii)analyzing the molecular mechanisms and functional relationships of dynamic chemical modifications of biomacromolecules,and(iii)exploring biomacromolecules and small molecule probes as potential drug targets and lead compounds.

关键词： chemical biology biomacromolecule dynamic modification modification analysis chemical intervention

基于MATLAB的单相半波可控整流电路仿真分析

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现代工业经济和信息化 2024年第2期14卷 148-150页

作者：张浚李自成李镕杰袁苓芷陈华良成都理工大学工程技术学院四川乐山614000

介绍了MATLAB在电力电子仿真中的应用,包括其基本特点以及在电力电子领域的应用,阐述了单相半波可控整流电路的建模与仿真方法,包括电路拓扑结构和参数设定、控制策略的选择与实现、仿真模型的搭建步骤。通过对不同触发角下的输出电压... 详细信息

介绍了MATLAB在电力电子仿真中的应用,包括其基本特点以及在电力电子领域的应用,阐述了单相半波可控整流电路的建模与仿真方法,包括电路拓扑结构和参数设定、控制策略的选择与实现、仿真模型的搭建步骤。通过对不同触发角下的输出电压和电流波形的仿真结果进行对比和分析,验证了仿真结果与理论分析的一致性。最后,讨论了结果的意义,提出了存在的问题和改进方向,并展望了后续研究的方向。助于理解单相半波可控整流电路的工作原理和性能,同时也为电力电子仿真研究提供了一种有效方法。

关键词：单相半波可控整流电路 MATLAB 仿真

STING agonist-boosted mRNA immunization via intelligent design of nanovaccines for enhancing cancer immunotherapy

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National Science Review 2023年第10期10卷 123-138页

作者： Lei Zhou Wenzhe Yi Zehong Zhang Xiaoting Shan Zitong Zhao Xiangshi Sun Jue Wang Hao Wang hualiang Jiang Mingyue Zheng Dangge Wang Yaping Li State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of Sciences China State Institute of Pharmaceutical Industry Univerisity of Chinese Academy of Sciences Drug Discovery and Design Center State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Precision Research Center for Refractory Diseases Shanghai General HospitalShanghai Jiao Tong University School of Medicine Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery

Messenger RNA(mRNA) vaccine is revolutionizing the methodology of immunization in ***,mRNA immunization is drastically limited by multistage biological barriers including poor lymphatic transport,rapid clearance,catalytic hydrolysis,insufficient cellular entry and endosome ***,we design a mRNA nanovaccine based on intelligent design to overcome these *** efficient nanovaccines are carried out with machine learning techniques from datasets of various nanocarriers,ensuring successful delivery of mRNA antigen and cyclic guanosine monophosphate-adenosine monophosphate(cGAMP) to *** activates stimulator of interferon genes(STING),promotes mRNA-encoded antigen presentation and boosts antitumour immunity in vivo,thus inhibiting tumour growth and ensuring long-term survival of tumour-bearing *** work provides a feasible and safe strategy to facilitate STING agonist-synergized mRNA immunization,with great translational potential for enhancing cancer immunotherapy.

关键词： vaccine mRNA STING cancer immunotherapy nanoparticles

Advancements in compressed air engine technology and power system integration: A comprehensive review

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Energy Reviews 2023年第4期2卷 49-62页

作者： Haifei Tian hualiang Zhang Zhao Yin Yu Liu Xinjing Zhang Yujie Xu Haisheng Chen Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing100190China Nanjing Institute of Future Energy System Institute of Engineering ThermophysicsChinese Academy of SciencesNanjing211135China University of Chinese Academy of Sciences Beijing100049China

The compressed air power system demonstrates the ability to convert the internal energy stored within com-pressed air into mechanical energy,thus facilitating power *** application within specific domains,such as special purpose vehicles,standby power sources,and fire and explosion prevention,holds significant research and practical value owing to its combustion-free operation,zero pollution and *** paper aims to explain the operational principles and unique features of the compressed air engine(CAE).The reasons for selecting volume-type expanders as CAE components are detailed,including an analysis of their technical characteristics and research *** on this foundation,the paper explores the operational characteristics and research status of traditional compressed air power systems installed in vehicles,with a particular focus on their limited range and excessive cold ***,the study presents a comprehensive summary of the research progress made in the last few years relating to hybrid power systems that derive from conventional compressed air power ***,the paper concludes by outlining the expected development trajectory of CAEs and compressed air power systems.

关键词： Compressed air Engine Hybrid Power system Vehicle

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水稻穗型相关基因定位和育种利用研究进展

分子植物育种 2024年第6期22卷 2052-2059页

作者：曾维郭铧艳叶胜海朱国富翟荣荣叶靖巫明明吕华良张小明浙江师范大学化学与生命科学学院金华321004 浙江省农业科学院作物与核技术利用研究所杭州310021 安吉禾盛农业科技有限公司安吉313300

穗型是水稻重要的农艺性状,直接影响水稻产量。水稻穗型按弯曲程度、穗重、着粒密度等不同参数可分成多种类型,如按弯曲程度可分为直立穗、半直立穗和弯曲穗3种类型。不同的水稻穗型对水稻产量、品质和抗病性等都有重要影响。近年来水... 详细信息

穗型是水稻重要的农艺性状,直接影响水稻产量。水稻穗型按弯曲程度、穗重、着粒密度等不同参数可分成多种类型,如按弯曲程度可分为直立穗、半直立穗和弯曲穗3种类型。不同的水稻穗型对水稻产量、品质和抗病性等都有重要影响。近年来水稻穗型遗传调控取得了重要进展,克隆了众多穗型相关基因,并研究了相关基因的功能。本研究的主要概述与课题研究有助于理解水稻穗型的形成与调控机制,为水稻不同穗型高产育种提供理论依据。

关键词：水稻穗型遗传调控基因定位育种

Applying high-performance computing in drug discovery and molecular simulation

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National Science Review 2016年第1期3卷 49-63页

作者： Tingting Liu Dong Lu Hao Zhang Mingyue Zheng Huaiyu Yang Yechun Xu Cheng Luo Weiliang Zhu Kunqian Yu hualiang Jiang State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences

In recent decades, high-performance computing(HPC) technologies and supercomputers in China have significantly advanced, resulting in remarkable achievements. Computational drug discovery and design,which is based on HPC and combines pharmaceutical chemistry and computational biology, has become a critical approach in drug research and development and is financially supported by the Chinese government. This approach has yielded a series of new algorithms in drug design, as well as new software and databases. This review mainly focuses on the application of HPC to the fields of drug discovery and molecular simulation at the Chinese Academy of Sciences, including virtual drug screening, molecular dynamics simulation, and protein folding. In addition, the potential future application of HPC in precision medicine is briefly discussed.

关键词： high-performance computing computational drug discovery and design virtual screening molecular dynamics simulation protein folding

Performance-enhanced and cost-effective triboelectric nanogenerator based on stretchable electrode for wearable SpO2 monitoring

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Nano Research 2022年第3期15卷 2465-2471页

作者： Huamin Chen Wei Yang Cheng Zhang Mingqiang Wu Wenjie Li Yuxiao Zou Longfeng Lv hualiang Yu Huizhen Ke Ruping Liu Yun Xu Jun Wang Zhou Li Fujian Key Laboratory of Functional Marine Sensing Materials Center for Advanced Marine Materials and Smart SensorsMinjiang UniversityFuzhou 350108China CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100083China Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China Beijing Key Laboratory of Inorganic Stretchable and Flexible Information Technology Beijing 100083China Beijing Institute of Graphic Communication Beijing 102600China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China Fujian Key Laboratory of Novel Functional Textile Fibers and Materials Minjiang UniversityFuzhou 350108China

Recently,stretchable and wearable health monitoring equipment has greatly improved human’s daily life,which sets higher demands for portable power source in stretchability,sustainability,and *** this work,we proposed a stretchable triboelectric nanogenerator(teng)based on stretchable poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)(PEDOT:PSS)/porous carbon hybrid for oxyhemoglobin saturation(SpO2)*** combine advantages of carbon material for its high conductivity and organic electrode for its high stretchability,we spin-coated a solution of PEDOT:PSS/porous carbon onto a plasma-treated pre-stretched Ecoflex film to fabricate a stretchable electrode with rough *** to its roughness and high potential difference with the dielectric material,the stretchable-electrode-based teng exhibited better performance compared to the pristine teng based on carbon or PEDOT:PSS *** output voltage and current reached up to 51.5 V and 13.2μA as the carbon concentration *** importantly,the performance further increased under large strain(100%)which is suitable for wearable ***,the device demonstrated its application potential for powering a flexible blood oxygen *** simple and cost-effective method can enhance the stretchability and stability of organic/inorganic electrode-based teng,which paves the development of high-performance stretchable teng.

关键词： triboelectric nanogenerator stretchable porous carbon blood oxygen poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)(PEDOT:PSS) wearable electronic

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白羽肉鸡8层笼养不同层别温差控制关键技术

中国禽业导刊 2024年第4期41卷 53-54页

作者：孙宪法周东崔华良郭栋韩红星钟火娥张文亮山东民和牧业股份有限公司山东烟台265600

在肉鸡养殖中,随着养殖技术的不断进步,多层叠层式鸡舍已成为一种高效、环保的饲养模式。但是,该饲养模式也面临着一些技术难题,其中最关键的问题就是不同层别之间的温差控制,尽管肉鸡对环境温度的变化具有一定的适应能力,但当温差变化... 详细信息

在肉鸡养殖中,随着养殖技术的不断进步,多层叠层式鸡舍已成为一种高效、环保的饲养模式。但是,该饲养模式也面临着一些技术难题,其中最关键的问题就是不同层别之间的温差控制,尽管肉鸡对环境温度的变化具有一定的适应能力,但当温差变化超出其适应范围后就会影响肉鸡的生长性能发挥,给肉鸡生产造成巨大的经济损失。本研究对白羽肉鸡8层叠层笼养鸡舍上下层温差控制技术进行了探讨,通过对鸡舍建筑材料的标准选择与安装方法、鸡舍的供暖方式以及笼上下层温度平衡措施的改进与智能化控制等关键技术与方法,为鸡群创造适宜的生产环境。

关键词：白羽肉鸡饲养模式肉鸡生产环境温度生长性能温差控制智能化控制温度平衡

Drug Discovery based on natural products by using chemical biology approach

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Drug Discovery based on natural products by using chemical b...