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STING agonist-boosted mRNA immunization via intelligent design of nanovaccines for enhancing cancer immunotherapy

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National Science Review 2023年第10期10卷 123-138页

作者： Lei Zhou Wenzhe Yi Zehong Zhang Xiaoting Shan Zitong Zhao Xiangshi Sun Jue Wang Hao Wang hualiang Jiang Mingyue Zheng Dangge Wang Yaping Li State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of Sciences China State Institute of Pharmaceutical Industry Univerisity of Chinese Academy of Sciences Drug Discovery and Design Center State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Precision Research Center for Refractory Diseases Shanghai General HospitalShanghai Jiao Tong University School of Medicine Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery

Messenger RNA(mRNA) vaccine is revolutionizing the methodology of immunization in ***,mRNA immunization is drastically limited by multistage biological barriers including poor lymphatic transport,rapid clearance,catalytic hydrolysis,insufficient cellular entry and endosome ***,we design a mRNA nanovaccine based on intelligent design to overcome these *** efficient nanovaccines are carried out with machine learning techniques from datasets of various nanocarriers,ensuring successful delivery of mRNA antigen and cyclic guanosine monophosphate-adenosine monophosphate(cGAMP) to *** activates stimulator of interferon genes(STING),promotes mRNA-encoded antigen presentation and boosts antitumour immunity in vivo,thus inhibiting tumour growth and ensuring long-term survival of tumour-bearing *** work provides a feasible and safe strategy to facilitate STING agonist-synergized mRNA immunization,with great translational potential for enhancing cancer immunotherapy.

关键词： vaccine mRNA STING cancer immunotherapy nanoparticles

基于MATLAB的单相半波可控整流电路仿真分析

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现代工业经济和信息化 2024年第2期14卷 148-150页

作者：张浚李自成李镕杰袁苓芷陈华良成都理工大学工程技术学院四川乐山614000

介绍了MATLAB在电力电子仿真中的应用,包括其基本特点以及在电力电子领域的应用,阐述了单相半波可控整流电路的建模与仿真方法,包括电路拓扑结构和参数设定、控制策略的选择与实现、仿真模型的搭建步骤。通过对不同触发角下的输出电压... 详细信息

介绍了MATLAB在电力电子仿真中的应用,包括其基本特点以及在电力电子领域的应用,阐述了单相半波可控整流电路的建模与仿真方法,包括电路拓扑结构和参数设定、控制策略的选择与实现、仿真模型的搭建步骤。通过对不同触发角下的输出电压和电流波形的仿真结果进行对比和分析,验证了仿真结果与理论分析的一致性。最后,讨论了结果的意义,提出了存在的问题和改进方向,并展望了后续研究的方向。助于理解单相半波可控整流电路的工作原理和性能,同时也为电力电子仿真研究提供了一种有效方法。

关键词：单相半波可控整流电路 MATLAB 仿真

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水稻穗型相关基因定位和育种利用研究进展

分子植物育种 2024年第6期22卷 2052-2059页

作者：曾维郭铧艳叶胜海朱国富翟荣荣叶靖巫明明吕华良张小明浙江师范大学化学与生命科学学院金华321004 浙江省农业科学院作物与核技术利用研究所杭州310021 安吉禾盛农业科技有限公司安吉313300

穗型是水稻重要的农艺性状,直接影响水稻产量。水稻穗型按弯曲程度、穗重、着粒密度等不同参数可分成多种类型,如按弯曲程度可分为直立穗、半直立穗和弯曲穗3种类型。不同的水稻穗型对水稻产量、品质和抗病性等都有重要影响。近年来水... 详细信息

穗型是水稻重要的农艺性状,直接影响水稻产量。水稻穗型按弯曲程度、穗重、着粒密度等不同参数可分成多种类型,如按弯曲程度可分为直立穗、半直立穗和弯曲穗3种类型。不同的水稻穗型对水稻产量、品质和抗病性等都有重要影响。近年来水稻穗型遗传调控取得了重要进展,克隆了众多穗型相关基因,并研究了相关基因的功能。本研究的主要概述与课题研究有助于理解水稻穗型的形成与调控机制,为水稻不同穗型高产育种提供理论依据。

关键词：水稻穗型遗传调控基因定位育种

Performance-enhanced and cost-effective triboelectric nanogenerator based on stretchable electrode for wearable SpO2 monitoring

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Nano Research 2022年第3期15卷 2465-2471页

作者： Huamin Chen Wei Yang Cheng Zhang Mingqiang Wu Wenjie Li Yuxiao Zou Longfeng Lv hualiang Yu Huizhen Ke Ruping Liu Yun Xu Jun Wang Zhou Li Fujian Key Laboratory of Functional Marine Sensing Materials Center for Advanced Marine Materials and Smart SensorsMinjiang UniversityFuzhou 350108China CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100083China Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China Beijing Key Laboratory of Inorganic Stretchable and Flexible Information Technology Beijing 100083China Beijing Institute of Graphic Communication Beijing 102600China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China Fujian Key Laboratory of Novel Functional Textile Fibers and Materials Minjiang UniversityFuzhou 350108China

Recently,stretchable and wearable health monitoring equipment has greatly improved human’s daily life,which sets higher demands for portable power source in stretchability,sustainability,and *** this work,we proposed a stretchable triboelectric nanogenerator(teng)based on stretchable poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)(PEDOT:PSS)/porous carbon hybrid for oxyhemoglobin saturation(SpO2)*** combine advantages of carbon material for its high conductivity and organic electrode for its high stretchability,we spin-coated a solution of PEDOT:PSS/porous carbon onto a plasma-treated pre-stretched Ecoflex film to fabricate a stretchable electrode with rough *** to its roughness and high potential difference with the dielectric material,the stretchable-electrode-based teng exhibited better performance compared to the pristine teng based on carbon or PEDOT:PSS *** output voltage and current reached up to 51.5 V and 13.2μA as the carbon concentration *** importantly,the performance further increased under large strain(100%)which is suitable for wearable ***,the device demonstrated its application potential for powering a flexible blood oxygen *** simple and cost-effective method can enhance the stretchability and stability of organic/inorganic electrode-based teng,which paves the development of high-performance stretchable teng.

关键词： triboelectric nanogenerator stretchable porous carbon blood oxygen poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)(PEDOT:PSS) wearable electronic

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白羽肉鸡8层笼养不同层别温差控制关键技术

中国禽业导刊 2024年第4期41卷 53-54页

作者：孙宪法周东崔华良郭栋韩红星钟火娥张文亮山东民和牧业股份有限公司山东烟台265600

在肉鸡养殖中,随着养殖技术的不断进步,多层叠层式鸡舍已成为一种高效、环保的饲养模式。但是,该饲养模式也面临着一些技术难题,其中最关键的问题就是不同层别之间的温差控制,尽管肉鸡对环境温度的变化具有一定的适应能力,但当温差变化... 详细信息

在肉鸡养殖中,随着养殖技术的不断进步,多层叠层式鸡舍已成为一种高效、环保的饲养模式。但是,该饲养模式也面临着一些技术难题,其中最关键的问题就是不同层别之间的温差控制,尽管肉鸡对环境温度的变化具有一定的适应能力,但当温差变化超出其适应范围后就会影响肉鸡的生长性能发挥,给肉鸡生产造成巨大的经济损失。本研究对白羽肉鸡8层叠层笼养鸡舍上下层温差控制技术进行了探讨,通过对鸡舍建筑材料的标准选择与安装方法、鸡舍的供暖方式以及笼上下层温度平衡措施的改进与智能化控制等关键技术与方法,为鸡群创造适宜的生产环境。

关键词：白羽肉鸡饲养模式肉鸡生产环境温度生长性能温差控制智能化控制温度平衡

Facing small and biased data dilemma in drug discovery with enhanced federated learning approaches

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Science China(Life Sciences) 2022年第3期65卷 529-539页

作者： Zhaoping Xiong Ziqiang Cheng Xinyuan Lin Chi Xu Xiaohong Liu Dingyan Wang Xiaomin Luo Yong Zhang hualiang Jiang Nan Qiao Mingyue Zheng Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and TechnologyShanghaiTech UniversityShanghai 200031China Drug Discovery and Design Center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China School of Information Science and Technology University of Science and Technology of ChinaHefei 230000China Laboratory of Health Intelligence Huawei Technologies Co.LtdShenzhen 518100China

Artificial intelligence(AI)models usually require large amounts of high-quality training data,which is in striking contrast to the situation of small and biased data faced by current drug discovery *** concept of federated learning has been proposed to utilize distributed data from different sources without leaking sensitive information of the *** emerging decentralized machine learning paradigm is expected to dramatically improve the success rate of AI-powered drug ***,we simulated the federated learning process with different property and activity datasets from different sources,among which overlapping molecules with high or low biases exist in the recorded *** the benefit of gaining more data,we also demonstrated that federated training has a regularization effect superior to centralized training on the pooled datasets with high ***,different network architectures for clients and aggregation algorithms for coordinators have been compared on the performance of federated learning,where personalized federated learning shows promising *** work demonstrates the applicability of federated learning in predicting drug-related properties and highlights its promising role in addressing the small and biased data dilemma in drug discovery.

关键词： federated learning drug discovery Fed AMP Non-IID data

Treg/Th17细胞在溃疡性结肠炎中的作用

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中医学报 2024年第2期39卷 343-348页

作者：赵继亭黄迪闫华栾庆鑫国嵩邓华亮孙轸山东中医药大学附属医院山东济南250011 山东中医药大学山东济南250014

调节性T细胞(regulatory T cell,Treg)/辅助性T细胞17(helper 17 cells,Th17)动态平衡的异常与溃疡性结肠炎的发生发展密切相关,Treg/Th17免疫轴的平衡是维持肠道免疫稳态的关键因素。Th17和Treg细胞在分化上相互联系,在功能上相互抑制... 详细信息

调节性T细胞(regulatory T cell,Treg)/辅助性T细胞17(helper 17 cells,Th17)动态平衡的异常与溃疡性结肠炎的发生发展密切相关,Treg/Th17免疫轴的平衡是维持肠道免疫稳态的关键因素。Th17和Treg细胞在分化上相互联系,在功能上相互抑制,与中医阴阳平衡理论有着高度的相似之处,应用中医阴阳理论指导溃疡性结肠炎的临床治疗,以扶正祛邪、恢复阴阳平衡为主要治则,可以调控Treg/Th17细胞失衡,恢复二者动态“阴阳平衡”,进而干预溃疡性结肠炎的发生与发展,将为临床运用中医药治疗溃疡性结肠炎提供新思路。

关键词：溃疡性结肠炎阴阳理论 Treg细胞 Th17细胞 Treg/Th17细胞平衡以平为期

腔内射频消融术治疗原发性重度大隐静脉曲张的临床疗效研究

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血管与腔内血管外科杂志 2024年第2期10卷 129-133页

作者：孙聪睿孙明胜王盛兴任华亮李春民首都医科大学附属北京朝阳医院血管外科北京100020

目的探讨腔内射频消融术(RFA)与传统高位结扎剥脱术治疗原发性重度大隐静脉曲张的临床疗效差异。方法收集2022年9月至2023年6月于首都医科大学附属北京朝阳医院就诊的65例(65条患肢)原发性重度大隐静脉曲张患者的临床资料,根据手术方式... 详细信息

目的探讨腔内射频消融术(RFA)与传统高位结扎剥脱术治疗原发性重度大隐静脉曲张的临床疗效差异。方法收集2022年9月至2023年6月于首都医科大学附属北京朝阳医院就诊的65例(65条患肢)原发性重度大隐静脉曲张患者的临床资料,根据手术方式的不同将患者分为腔内射频组(n=33,共33条患肢)和高位结扎组(n=32,共32条患肢)。比较两组患者的手术相关指标[手术成功率、术中出血量、手术时间、术后视觉模拟评分法(VAS)评分、总住院时间]、术后2周并发症发生情况[静脉内热诱导血栓形成(EHIT)、深静脉血栓形成(DVT)、血栓性浅静脉炎、皮下血肿或瘀斑、切口感染和隐神经损伤]。采用修订后的静脉临床严重程度评分(VCSS)评估并比较不同时间(术前、术后2周、术后3个月、术后6个月)的静脉曲张严重程度。观察术后6个月腔内射频组患者的大隐静脉主干闭合情况。结果两组患者的技术成功率均为100%。腔内射频组的手术时间和总住院时间均短于高位结扎组患者,术中出血量少于高位结扎组患者,差异均有统计学意义(P0.05),但两组患者术后2周、3个月、6个月的VCSS均低于本组术前,差异均有统计学意义(P<0.05)。术后6个月,腔内射频组患者患肢大隐静脉主干的总闭合率为100%(33/33)。结论与传统高位结扎剥脱术相比,RFA是原发性重度大隐静脉曲张更加安全、有效的治疗方式。

关键词：原发性重度大隐静脉曲张腔内射频消融术高位结扎剥脱术临床疗效

A palaeoearthquake event and its age revealed by the travertine layer along the Litang fault in the southeastern margin of the Qinghai-Tibetan plateau

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Earthquake Research Advances 2023年第3期3卷 53-62页

作者： Yao Yang Mingjian Liang Chao Ma Jun Li hualiang Shen Fang Du Song Luo Shao Liu Xuelian Rui Sichuan Earthquake Agency Chengdu610041China College of Earth Sciences Chengdu University of TechnologyChengdu610059China Zhejiang Earthquake Agency Hangzhou310013China Chengdu Geological Survey Center China Geological SurveyChengdu610081China

The Litang fault(LTF),located in the southeast of the Qinghai-Tibetan Plateau,is known for its high level of present-day seismicity,whereas its Pleistocene activity has been scarcely *** study focused on a tract of banded travertine deposits precipitated from thermal waters along the NW–SE-trending LTF *** role of travertine deposits in recording neotectonic activity has been studied by identifying their internal *** soft-sediment deformation structures observed within the banded travertines include micro folds,liquefied breccia,and liquefied *** deformed structures,which are restricted to a single unit separated unconformably by undeformed layers,can be traced for tens of meters,indicating that they were formed by seismic shaking triggered by LTF *** deformation of the banded travertine layers is attributed to the combined effects of seismic shaking,liquefaction,and fluidization,and it can be related to a paleo earthquake event with a magnitude of MS>*** U-series ages obtained from the banded travertine deposits perturbed by the earthquakes are in the range of 130.59–112.94 ka,indicating an important fault-assisted neotectonic activity that occurred during the Middle–Late *** of such structures,in combination with the use of U-series dating methods,can yield a reliable timing of neotectonic activity and provide new evidence for under-standing the seismotectonic setting of the Litang area.

关键词： Travertine Paleoearthquake Soft-sediment deformation U-series dating Litang fault