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RUNX1 promotes mitophagy and alleviates pulmonary inflammation during acute lung injury

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Signal Transduction and Targeted Therapy 2023年第9期8卷 3917-3919页

作者： Xiaoju Tang Lichun Zhong Xin Tian Ying Zou Silu Hu Jia Liu Ping Li Min Zhu Fengming Luo huajing wan Department of Respiratory and Critical Care Medicine Clinical Research Center for Respiratory DiseasesWest China HospitalSichuan UniversityNo.37 Guo Xue Xiang610041 ChengduChina Laboratory of Pulmonary Immunology and Inflammation Frontiers Science Center for Disease-related Molecular NetworkSichuan UniversityNo.2222 Xin Chuan Road610200 ChengduSichuanChina

Dear Editor,Acute lung injury(ALI)is a significant contributor to the development of acute respiratory distress syndrome(ARDS),which is a severe clinical condition associated with high morbidity and mortality.1 It is increasingly evident that preserving mitochondrial health in alveolar epithelial cells holds great therapeutic potential for ARDS.2 Mitophagy,a cellular process aimed at maintaining mitochondrial health,plays a critical role in this regard.3 Therefore,gaining a comprehensive understanding of the factors that regulate mitophagy in alveolar epithelial cells during ALI could greatly inform the development of future therapeutic approaches for ARDS.

关键词： acute lung inflammation

Regulation of Epithelial Cell Polarity during Respiratory Tubulogenesis

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Regulation of Epithelial Cell Polarity during Respiratory Tu...

第二届全国发育生物学大会

作者： Yong Liao Caijun Liu Jeffrey A.Whitsett Yi Zheng huajing wan Department of Pediatrics West China Second University HospitalSichuan University

Epithelial tubes are a fundamental structural unit of lung,providing tracts for gas *** morphogenesis requires the precise regulation of epithelial cell shape and cell-cell interactions that are strongly influenced by the polarized organization of epithelial *** by which epithelial cell polarity is controlled and contribute to respiratory tubular morphogenesis are incompletely ***,we demonstrate that KLF5-CDC44 signaling cascade is essential for epithelial cell *** cell specific deletion or overexpression of the mouse Klf5 gene disrupted apical polarity required for cell shape modulation during respiratory tubule *** of Klfi induced CDC42-dependent apical cell polarity as evidenced by actin cap formation and the re-distribution of apical polarity proteins PAR3,ZO-1,and PKC,and induced CDC42-dependent change of cell shape,formation of epithelial cysts and tubes in monolayers of cultured epithelial *** conclude that KLF5 is required for regulation of epithelial cell polarity,which is critical for cell shape and coordinate cell-cell interactions essential for formation and maturation of epithelial tubules.

关键词： Tubulogenesis Lung development Epithelial Polarity Rho GTPase Cytoskeleton

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肺发育与相关疾病机制研究进展

中华实用儿科临床杂志 2016年第16期31卷 1201-1204页

作者：万华靖石芳四川大学华西第二医院肺发育与疾病研究实验室出生缺陷与相关妇儿疾病教育部重点实验室成都610041

肺部疾病是危害新生儿及儿童健康的重大疾病。认识其发病机制，实施有效的预防和精准诊疗是儿科医师面临的重要挑战。研究显示肺发育的缺陷是导致新生儿及儿童肺部疾病和引起疾病易感的重要根源。针对肺发育经历的不同时期，现介绍其影... 详细信息

肺部疾病是危害新生儿及儿童健康的重大疾病。认识其发病机制，实施有效的预防和精准诊疗是儿科医师面临的重要挑战。研究显示肺发育的缺陷是导致新生儿及儿童肺部疾病和引起疾病易感的重要根源。针对肺发育经历的不同时期，现介绍其影响因素、关键调控分子和肺发育缺陷引起的相关疾病，为临床医师从发育的角度探索肺部疾病机制提供依据和思路。

关键词：肺发育肺发育调控肺部疾病

一例眼白化病1型患儿G职143基因的新突变

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中华医学遗传学杂志 2017年第2期34卷 224-227页

作者：赵琪关梦龙王玲廖勇李岭万华靖四川大学华西第二医院出生缺陷与相关妇儿疾病教育部重点实验室成都610041 成都新基因格医学检验所 610041 四川大学生命科学学院遗传医学研究所成都610041

目的对1例眼白化病患儿及其父母进行基因检测，了解其基因突变的类型和遗传模式，以对其进行确诊。方法应用PCR扩增患儿及其父母x染色体上GPR143基因的编码区以及侧翼剪接位点，并进行Sanger测序。结果在患儿GPR143基因第6外显子的编码... 详细信息

目的对1例眼白化病患儿及其父母进行基因检测，了解其基因突变的类型和遗传模式，以对其进行确诊。方法应用PCR扩增患儿及其父母x染色体上GPR143基因的编码区以及侧翼剪接位点，并进行Sanger测序。结果在患儿GPR143基因第6外显子的编码区发现一个C．758T〉A突变（半合子），其母亲携带相同的突变（杂合子），其父亲则未检测到突变。该突变使终止密码子提前出现，属于很可能致病的无义突变。上述突变的遗传方式为X染色体连锁隐性遗传，结合其临床表型，将患儿确诊为眼白化病1型。结论对一例X染色体连锁的1型眼白化病患者进行了基因诊断，发现了一个新的致病突变。

关键词：眼白化病 GPR143基因新突变

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气道支架力学设计与数值模拟研究进展

医用生物力学 2022年第6期37卷 1183-1188页

作者：张心远罗凤鸣万华靖赖玉田李梁远陈宇四川大学力学科学与工程系四川省生物力学工程实验室成都610065 四川大学华西医院呼吸与危重症医学科肺免疫炎症研究室成都610041

气道狭窄是一种先天性或由感染、肿瘤、外伤、结核等疾病引起的临床常见疾病,国内常见的病因有气管支气管结核、良性或恶性肿瘤等,植入气道支架已经成为介入治疗气道狭窄的主要方式。气道支架由硅酮支架到激光雕刻、编织支架,其材料与... 详细信息

气道狭窄是一种先天性或由感染、肿瘤、外伤、结核等疾病引起的临床常见疾病,国内常见的病因有气管支气管结核、良性或恶性肿瘤等,植入气道支架已经成为介入治疗气道狭窄的主要方式。气道支架由硅酮支架到激光雕刻、编织支架,其材料与构型一直在不断更替改进。气道支架植入后仍然存在支架发生移位、气管出现肉芽肿、再狭窄等问题未解决,这些问题往往与支架植入后对气管组织整体产生的力学作用相关。本文总结归纳气道支架的力学性能以及支架与气管的典型数值模拟研究。力学性能包括支架的径向力、扭结阻力与屈服应力,其常受支架材质、构型设计、制作工艺等综合影响;而数值模拟方法能高效地对支架研发提供技术支持,为支架材料选取、设计改进与制造工作提供参考。

关键词：气道支架肉芽肿力学性能构型设计数值模拟

Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei Zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

Fault Detection for Networked Systems with Randomly Occurring Nonlinearities Via Switched System Approach

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Fault Detection for Networked Systems with Randomly Occurrin...

Improvement for consensus performance of multi-agent systems based on delayed-state-derivative feedback

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作者： Xiongbo wan huajing Fang Fang Yang College of Engineering Huazhong Agricultural University Department of Control Science and Engineering Huazhong University of Science and Technology

ISBN: (纸本)9781467355322

This paper addresses the fault detection （FD） problem for networked systems with with randomly occurring nonlinearities and incomplete measurements, including transmission time delays, packet dropouts, and signal quantizations which are described by a new switched system model. We aim to design a mode-dependent fault detection filter （FDF） such that, for all external disturbances, incomplete measurements, and the randomly occurring nonlinearities, the error between the residual and weighted fault is made as small as possible. The addressed FD problem is then converted into an auxiliary H∞ filtering problem of switched systems with time-varying delays. By applying Lyapunov-Krasovskii approach, a sufficient condition for the existence of the FDF is derived in terms of certain linear matrix inequalities （LMIs）. When these LMIs are feasible, the explicit expression of the desired FDF can also be characterized. A numerical example is exploited to show the effectiveness of the results obtained.

关键词： Fault detection networked systems time-varying delays packet dropouts randomly occurring nonlinearities

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Journal of Systems Engineering and Electronics 2012年第1期23卷 137-144页

作者： Zhihai Wu huajing Fang Department of Control Science and Engineering Huazhong University of Science and Technology Wuhan 430074 R R. China

The delayed-state-derivative feedback （DSDF） is in- troduced into the existing consensus protocol to simultaneously improve the robustness to communication delay and accele- rate the convergence speed of achieving the consensus. The frequency-domain analysis, together with the algebra graph the- ory, is employed to derive the sufficient and necessary condition guaranteeing the average consensus. It is shown that introduc- ing the DSDF with the proper intensity in the existing consensus protocol can improve the robustness to communication delay. By analyzing the effect of DSDF on the closed-loop poles, this pa- per proves that for a supercritical-delay multi-agent system, this strategy can also accelerate the convergence speed of achieving the consensus with provided the proper intensity of the DSDE Simulations are provided to demonstrate the effectiveness of the theoretical results.

关键词： multi-agent system consensus robustness conver- gence speed delayed-state-derivative feedback.

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肺泡气流空气动力学数值模拟计算研究进展

华西医学 2023年第7期38卷 1107-1112页

作者：欧新颖罗凤鸣万华靖王昭力阮畅陈宇四川大学力学科学与工程系四川省生物力学工程实验室成都610065 四川大学华西医院呼吸与危重症医学科肺免疫炎症研究室成都610041

肺部疾病因其种类繁多、成因复杂、发病率高、治疗困难等,已成为威胁人类生命健康的一大杀手,部分疾病会对肺泡形态学和组织学产生较为明显的影响。基于计算流体力学的肺泡数值模拟,即对肺泡力学响应及肺泡内流场信息、多相流、物质传... 详细信息

肺部疾病因其种类繁多、成因复杂、发病率高、治疗困难等,已成为威胁人类生命健康的一大杀手,部分疾病会对肺泡形态学和组织学产生较为明显的影响。基于计算流体力学的肺泡数值模拟,即对肺泡力学响应及肺泡内流场信息、多相流、物质传递等方面进行数值模拟,对肺部疾病诊断、临床治疗和体外实验有重大意义。该文从几何模型和力学模型的简化及病理差异入手,分析并总结了其在肺泡气流动力学计算方法的条件设置与应用场景,以为肺泡区开展进一步的模拟与应用提供参考。

关键词：肺泡肺部疾病数值模拟计算流体力学几何模型

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