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Force-induced Caspase-1-dependent pyroptosis regulates orthodontic tooth movement

International Journal of Oral Science 2024年第2期16卷 238-250页

作者： Liyuan Chen huajie yu Zixin Li yu Wang Shanshan Jin Min yu Lisha Zhu Chengye Ding Xiaolan Wu Tianhao Wu Chunlei Xun Yanheng Zhou Danqing He Yan Liu Department of Orthodontics Central LaboratoryPeking University School and Hospital for Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental Materials&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijingChina Peking University Hospital of Stomatology Fourth Division BeijingChina

Pyroptosis,an inflammatory caspase-dependent programmed cell death,plays a vital role in maintaining tissue homeostasis and activating inflammatory *** tooth movement(OTM)is an aseptic force-induced inflammatory bone remodeling process mediated by the activation of periodontal ligament(PDL)progenitor ***,whether and how force induces PDL progenitor cell pyroptosis,thereby influencing OTM and alveolar bone remodeling remains *** this study,we found that mechanical force induced the expression of pyroptosis-related markers in rat OTM and alveolar bone remodeling *** or enhancing pyroptosis level could suppress or promote OTM and alveolar bone remodeling *** Caspase-1^(−/−)mice,we further demonstrated that the functional role of the force-induced pyroptosis in PDL progenitor cells depended on ***,mechanical force could also induce pyroptosis in human ex-vivo force-treated PDL progenitor cells and in compressive force-loaded PDL progenitor cells in vitro,which influenced ***,transient receptor potential subfamily V member 4 signaling was involved in force-induced Caspase-1-dependent pyroptosis in PDL progenitor ***,this study suggested a novel mechanism contributing to the modulation of osteoclastogenesis and alveolar bone remodeling under mechanical stimuli,indicating a promising approach to accelerate OTM by targeting Caspase-1.

关键词： homeostasis movement thereby

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Characteristics of the transient thermal load and deformation of the evacuated receiver in solar parabolic trough collector

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Science China(Technological Sciences) 2020年第7期63卷 1188-1201页

作者： LI Lu yu huajie LI YinShi HE Ya-Ling Key Laboratory of Thermo-Fluid Science and Engineering of MOE School of Energy and Power EngineeringXi’an Jiaotong UniversityXi'an 710049China

As a core element in solar parabolic trough collector, the evaluated receiver often runs under severe thermal conditions. Worse still, the transient thermal load is more likely to cause structural deformation and damage. This work develops an efficient transient multi-level multi-dimensional(M2) analysis method to address photo-thermal-elastic problems, thereby estimating transient thermal load and deformation for the receiver:(i) one-dimensional(1-D) thermo-hydraulic model is adopted to determine the transient thermo-hydraulic state,(ii) 3-D finite volume method(FVM) model for the receiver tube is established to obtain the real-time temperature distribution,(iii) 3-D finite element method(FEM) model is employed to make thermoelastic analysis. Based on this M2 method, the typical transient cases are conducted in cold-start, disturbed-operation and regulatedprocess. Three indicators(average temperature of the wall(ATW), radial temperature difference(RTD), circumferential temperature difference(CTD)) are defined for overall analysis of the receiver thermal load. It is found that in the transient process,receivers face response delay and endure significant thermal load fluctuation. The response time for a single HCE(heat collecting element) under lower mass flow rate(1.5 kg s-1) could sustain 280 s. During the cold-start stage(DNI=200 W m-2 to 800 W m-2), the maximum value of CTD in receiver is as high as 11.67℃, corresponding to a maximum deflection of 1.05 *** the mass flow rate decreases sharply by 80%, the CTD reaches 33.04℃, causing a 2.06-cm deflection. It should be pointed out that in the cold-start stage and the lower mass flow rate operation for solar parabolic trough collector, alleviating the transient thermal load and deformation is of importance for safely and efficiently running evaluated receiver.

关键词： solar energy transient thermal load and deformation heat collecting element parabolic trough collector multi-level multi-dimensional analysis method

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Transient Behaviors of Thermo-Hydraulic and Thermal Stratification in the Pressurizer Surgeline for the Nuclear Power Plant

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Journal of Thermal Science 2022年第2期31卷 344-358页

作者： yu huajie LI Lu TANG Qionghui PENG yue LI Yinshi State Key Laboratory of Nuclear Power Safety Monitoring Technology and Equipment Shenzhen 518172China Key Laboratory of Thermo-Fluid Science and Engineering of Ministry of Education School of Energy and Power EngineeringXi’an Jiaotong UniversityXi’an 710049China School of Mechanics and Safety Engineering Zhengzhou UniversityZhengzhou 450001China

In pressurized water reactor(PWR)system,the surgeline plays an important role in bonding the pressurizer and the primary *** considerable problems,including the thermo-hydraulics,the thermal stratification and the accompanying thermal stress under transient conditions,pose risks to the surgeline ***,a fully-coupled flow-heat-thermo-elasticity model was developed to investigate the transient behavior of thermo-hydraulic parameters and the thermal stratification phenomenon in *** evaluate the nonuniformity of the stratified flow,a stratification degree indicatorζis *** is found that during the outsurge flow,the increase of temperature variation will enlarge the temperature gradient on the wall,corresponding to a more serious *** the cases of positive temperature variation,the higher temperature variation causes higher stratification degreeζ,and vice *** mass flow rate m and the stratification degree are in negative *** local deformation can reach 1.802 cm under a 50 K temperature variation,while its location varies from case to *** attention should be paid to the regulation between the highest deformation location and the surgeline thermo-hydraulic parameters.

关键词： pressurized water reactor surgeline transient thermo-hydraulic thermal stratification thermal stress-strain

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Craniofacial therapy:advanced local therapies from nano-engineered titanium implants to treat craniofacial conditions

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International Journal of Oral Science 2023年第1期15卷 33-49页

作者： Karan Gulati Chengye Ding Tianqi Guo Houzuo Guo huajie yu Yan Liu The University of Queensland School of DentistryHerstonQLDAustralia Laboratory of Biomimetic Nanomaterials Department of OrthodonticsPeking University School and Hospital of StomatologyBeijingChina National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental Materials BeijingChina Department of Oral Implantology Peking University School and Hospital of StomatologyBeijingChina Fourth Clinical Division Peking University School and Hospital of StomatologyBeijingChina

Nano-engineering-based tissue regeneration and local therapeutic delivery strategies show significant potential to reduce the health and economic burden associated with craniofacial defects,including traumas and *** to the success of such nano-engineered non-resorbable craniofacial implants include load-bearing functioning and survival in complex local trauma ***,race to invade between multiple cells and pathogens is an important criterion that dictates the fate of the *** this pioneering review,we compare the therapeutic efficacy of nano-engineered titanium-based craniofacial implants towards maximised local therapy addressing bone formation/resorption,soft-tissue integration,bacterial infection and cancers/*** present the various strategies to engineer titanium-based craniofacial implants in the macro-,micro-and nano-scales,using topographical,chemical,electrochemical,biological and therapeutic modifications.A particular focus is electrochemically anodised titanium implants with controlled nanotopographies that enable tailored and enhanced bioactivity and local therapeutic ***,we review the clinical translation challenges associated with such *** review will inform the readers of the latest developments and challenges related to therapeutic nano-engineered craniofacial implants.

关键词： implants titanium local

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不同时机高压氧介入治疗颅脑外伤的疗效研究

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系统医学 2024年第16期9卷 98-100,108页

作者：韩振张本营杨超于华杰郑泽洲济南市章丘区人民医院急诊外科山东济南250200

目的探讨不同时机高压氧(hyperbaric oxygen,HBO)介入治疗颅脑外伤(traumatic brain injury,TBI)的疗效。方法非随机选取2022年8月—2023年7月在济南市章丘区人民医院接受HBO治疗的TBI88例患者为研究对象,根据HBO介入治疗时间进行分组... 详细信息

目的探讨不同时机高压氧(hyperbaric oxygen,HBO)介入治疗颅脑外伤(traumatic brain injury,TBI)的疗效。方法非随机选取2022年8月—2023年7月在济南市章丘区人民医院接受HBO治疗的TBI88例患者为研究对象,根据HBO介入治疗时间进行分组,每组44例。研究组患者在伤后8~15 d接受HBO治疗,对照组患者在伤后16~30 d接受HBO治疗。对比两组疗效、残疾评定量表(Disability Rating Scale,DRS)与改良Barthel指数量表(Modified Barthel Index,MBI)评分。结果研究组治疗总有效率为95.45%(42/44),高于对照组的79.55%(35/44),差异有统计学意义(χ^(2)=5.091,P0.05);随访3个月时与对照组结果相比,研究组DRS评分更低,MBI评分更高,差异有统计学意义(P均<0.05)。结论 TBI患者病情稳定后尽早实施HBO治疗能够有效提高临床疗效,降低病残程度,促进日常生活活动能力的恢复。

关键词：高压氧介入颅脑外伤

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砂岩储层应力敏感性及其对单井产能的影响——以四川盆地JQ气田为例

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天然气勘探与开发 2024年第4期47卷 81-88页

作者：刘婷芝张伟赵丹余华洁严玉霞王艳中国石油西南油气田公司勘探开发研究院四川成都610041

近年来,四川盆地JQ气田致密砂岩储层展现出良好的勘探开发潜力。然而,在油气藏开发实践过程中,致密砂岩储层岩石存在应力敏感伤害,将影响气井产能。为了明确储层岩石应力敏感性及其对单井产能的影响,助力气藏的高效开发,针对四川盆地JQ... 详细信息

近年来,四川盆地JQ气田致密砂岩储层展现出良好的勘探开发潜力。然而,在油气藏开发实践过程中,致密砂岩储层岩石存在应力敏感伤害,将影响气井产能。为了明确储层岩石应力敏感性及其对单井产能的影响,助力气藏的高效开发,针对四川盆地JQ气田中侏罗统沙溪庙组致密砂岩储层,在地层温度下开展变围压和变回压两种方式应力敏感性评价实验。结果表明:①变围压方式下储层岩石渗透率损失率在78.83%~95.85%,应力敏感普遍偏强。②变回压方式下储层岩石渗透率损失率在1.48%~64.02%,渗透率较低的样品,应力敏感表现为无~弱;渗透性越好,应力敏感越强。③6号砂体的应力敏感比8号砂体强。④应力敏感对气井产能有较为严重的影响,产量由1.75×10^(4)m^(3)/d降至0.17×10^(4)m^(3)/d,升降出口压力次数越多,获得的产量越低。因此,在制订生产措施时,渗透能力好的储层或压裂改造后的储层应选择合适的生产压差,防止在过高的生产压差下,喉道、裂缝提前闭合,尽可能降低应力敏感程度,提高单井产能和采收率,保障致密砂岩气藏的长期稳产。

关键词：致密砂岩应力敏感渗透率损失率气井产能

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Biomimetic porous silicon oxycarbide ceramics with improved specific strength and efficient thermal insulation

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Journal of Materials Science & Technology 2024年第1期168卷 185-193页

作者： Zhuoqing Zhang Jinghan Li Lei Cao yu Shi huajie Yang Rui Yang Fan Xie Xing Zhang Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China School of Materials Science and Engineering Shenyang Ligong UniversityShenyang 110159China Shenyang Aircraft Design and Research Institute Shenyang 110035China

Considering the challenge of aerodynamic heating,the development of high-performance insulating ce-ramic materials with lightweight and low thermal conductivity is crucially important for aerospace vehi-cles to achieve flight at high speed for a long *** this work,macro-porous silicon oxycarbide(SiOC)ceramics with directional pores(DP-SiOC)(mean pore size of 88.1μm)were prepared using polysiloxane precursors via freeze casting and photocrosslinking,followed by *** DP-SiOC samples were lightweight(density∼0.135 g cm^(-3))with a porosity of 90.4%,which showed good shapability through the molding of polysiloxane *** DP-SiOC samples also exhibited an ultra-low thermal con-ductivity of 0.048 W(m K)^(-1)at room temperature,which can also withstand heat treatment at 1200°C for 1 *** addition,scaffolds with triply periodic minimal surfaces(TPMS)were fabricated using digital light processing(DLP)printing,which was further filled with polysiloxane precursors for increasing the strength of *** TPMS scaffolds filled with macro-porous SiOC ceramics(TPMS-DP-SiOC)showed good integration between TPMS and macro-pore structures,which had a porosity∼75%and high specific strength of 9.73×10^(3)N m kg^(-1).The thermal conductivity of TPMS-DP-SiOC samples was 0.255 W(m K)^(-1)at room *** biomimetic TPMS-DP-SiOC ceramics developed in this study are likely used for thermal protection systems.

关键词： Thermal insulation Light weight Macro-porous ceramics SiOC

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Assessment of clinical full-crown preparations

Assessment of clinical full-crown preparations

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中华口腔医学会第14次全国口腔医学学术会议（2012年会）

作者： huajie yu School and hospital of stomatology,Peking University

Objective: To compare the preparation of full metal-ceramic crowns in clinical practice with guidelines advocated in ental literatue;Methods: A total of 89 maxillary anterior and premolar teeth preparation were assessed. Occlusal(Incisal),axial wall tooth reduction and finish line depth were measured by three-dimensional reverse engineering software and then compared with guidelines. Result: Cuspal reduction of anterior teeth was much greater than recommended,while cuspal and central fossa reduction were insufficient for premolar *** shoulder width had no significant difference with the guideline,while the lingual shoulder was *** axial wall reduction was generally *** that the difference in labial shoulder width between maxillary anterior and premolar teeth,no significant difference was observed in other measurement between maxillary anterior and premolar teeth. Conclusion: In the clinical practice of finishing tooth preparation,cuspal reduction of anterior teeth was much greater than recommended,while cuspal and central fossa reduction was insufficient for premolar *** that no significant difference between theoretical and clinical preparation was observed in the labial shoulder width,difference in axial and incisal reduction was *** the tooth preparation,which did not fully accord with guidelines in relative literature and textbooks,could be used in clinical practice,its long term prognosis needs further studies.

关键词： tooth preparation database of preparation CAD/CAM-fabricated integrated glass fiber post and core

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四川盆地公山庙油田中侏罗统沙溪庙组一段致密油藏流体渗流特征

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天然气勘探与开发 2024年第1期47卷 73-82页

作者：周克明袁小玲刘婷芝余华洁缪海燕张琳羚王艳何家欢肖红林宋林珂张容中国石油西南油气田公司勘探开发研究院四川成都610041 中国石油西南油气田公司致密油气勘探开发项目部四川成都610051 中国石油川庆钻探工程有限公司地质勘探开发研究院四川成都610051

针对致密油藏岩石孔隙结构复杂、流体渗流阻力大、油气产量低、开发效益较差等问题,以四川盆地中部地区(简称“川中地区”)公山庙油田中侏罗统沙溪庙组一段低渗透、特低渗透致密砂岩油藏为例,在储层岩石润湿性实验基础上,开展了流体低... 详细信息

针对致密油藏岩石孔隙结构复杂、流体渗流阻力大、油气产量低、开发效益较差等问题,以四川盆地中部地区(简称“川中地区”)公山庙油田中侏罗统沙溪庙组一段低渗透、特低渗透致密砂岩油藏为例,在储层岩石润湿性实验基础上,开展了流体低速渗流实验、恒速水驱油实验和自发渗吸实验等多项研究。研究结果表明:①川中地区公山庙油田沙一段致密油藏的储层岩石总体上呈弱亲水性特征,在完全饱和地层水条件下的水相渗流曲线为一条直线,且经过坐标原点,地层水单相渗流符合达西定律且不存在启动压力或启动压力梯度。②在通过油驱水建立束缚水饱和度的条件下,岩石孔隙表面吸附的水膜降低了油相渗流通道,两相渗流存在贾敏效应,增加了油相渗流的附加阻力。油相低速渗流曲线不过坐标原点,存在启动压力或启动压力梯度;储层岩石的渗透率越低,启动压力或启动压力梯度越大。③驱替速度和岩石渗透率对水驱油效果有较大影响,在较高的驱替速度下,注入水在大孔道中发生指进和沿裂缝发生水窜是造成水驱油效率降低的主要原因。④岩石渗透率对渗吸驱油效果有显著影响,且裂缝样品的渗吸驱油效率大于基质样品的渗吸驱油效率。⑤对致密油藏实施大规模压裂改造,所形成的高渗透缝网可有效降低流体渗流的启动压力或启动压力梯度,再辅以单井吞吐(水油渗吸交换)的开采方式,这种组合是保证致密油藏长期稳产的重要技术措施。研究成果对致密油藏以及页岩油的开发具有重要的借鉴意义。

关键词：致密油藏润湿性渗透率低速渗流启动压力渗吸实验水驱油效率

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前牙种植修复体穿龈形态设计的研究进展

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中华口腔医学杂志 2020年第6期55卷 417-420页

作者：王鹃尉华杰邱立新北京大学口腔医学院·口腔医院第四门诊部国家口腔疾病临床医学研究中心口腔数字化医疗技术和材料国家工程实验室口腔数字医学北京市重点实验室100025

在美学区的种植修复中,修复体的形态设计对美学效果有重要影响。龈缘以下修复体的形态,即穿龈形态对种植修复的软组织美学和健康均至关重要。前牙种植修复体的穿龈形态设计方案、适应证、影响因素等相关研究较少且观点不一。多数种植修... 详细信息

在美学区的种植修复中,修复体的形态设计对美学效果有重要影响。龈缘以下修复体的形态,即穿龈形态对种植修复的软组织美学和健康均至关重要。前牙种植修复体的穿龈形态设计方案、适应证、影响因素等相关研究较少且观点不一。多数种植修复体形态设计的理论支持来源于天然牙修复,但种植体和天然牙的修复体设计并不完全相同。本文主要综述前牙种植修复后穿龈形态的设计,以期为临床医师提供参考。

关键词：牙种植美学,牙科穿龈轮廓穿龈角度

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