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Hydrogel-Based Stimuli-Responsive Micromotors for Biomedicine

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Cyborg and Bionic Systems 2022年第1期2022卷 273-284页

作者： huaijuan zhou Guozhao Dong Ge Gao Ran Du Xiaoying Tang Yining Ma Jinhua Li Advanced Research Institute of Multidisciplinary Sciences Bejing Institute of TechnologyBeijing 100081China School of Medical Technology Beijing Institute of TechnologyBeijing 100081China School of Materials Science Engineering Key Laboratory of High Energy Density Materials of the Ministry of EducationBeijing Institute of TechnologyBeijing 100081China School of Life Science Beijing Institute of TechnologyBeijing 100081China Department of Forensic Science Jiangsu Police InstituteNanjing 210031China

The rapid development of medical micromotors draws a beautiful blueprint for the noninvasive or minimally invasive diagnosis and *** combining stimuli-sensitive hydrogel materials,micromotors are bestowed with new characteristics such as stimuli-responsive shape transformation/*** biocompatibility and biodegradability,and drug loading *** by chemical fuels or external fields(eg,magnetic field,ultrasound,light,and electric field),hydrogel-based stimuli-responsive(HBSR)micromotors can be utilized to load therapeutic agents into the hydrogel networks or directly grip the target cargos(eg.,drug-loaded partides,cells,and thrombus),transport them to sites of interest(e.g.,tumor area and diseased tissues),and unload the cargos or execute a specific task(e.g.,cell capture,targeted sampling,and removal of blood dots)in response to a stimulus(eg.,change of temperature,pH,ion strength,and chemicals)in the physiological *** high flexibility,adaptive capacity,and shape morphing property enable the H BSR micromotors to complete specific medical tasks in complex physiological scenarios,especially in confined,hard to-reach tissues,and vessels of the ***,this review summarizes the current progress in hydrogel-based medical micromotors with stimuli *** thermo-responsive,photothermal-responsive,magnetocaloric-responsive,pH-responsive,ionic strength-responsive,and chemoresponsive micromotors are discussed in ***,curent challenges and future perspectives for the development of HBSR micromotors in the biomedical field are discussed.

关键词： diagnosis utilized loaded

Biomembrane-inspired design of medical micro/nanorobots:From cytomembrane stealth cloaks to cellularized Trojan horses

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Aggregate 2023年第5期4卷 63-95页

作者： Jinhua Li huaijuan zhou Chun Liu Shuailong Zhang Ran Du Yulin Deng Xuenong Zou School of Medical Technology Beijing Institute of TechnologyBeijingChina Advanced Research Institute of Multidisciplinary Sciences Beijing Institute of TechnologyBeijingChina Center for Translational Medicine Precision Medicine InstituteThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Orthopedics and Traumatology Department of Spinal SurgeryThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina School of Mechatronical Engineering Beijing Institute of TechnologyBeijingChina School of Materials Science&Engineering Key Laboratory of High Energy Density Materials of the Ministry of EducationBeijing Institute of TechnologyBeijingChina School of Life Science Beijing Institute of TechnologyBeijingChina

Micro/nanorobots are promising for a wide range of biomedical applications(such as targeted tumor,thrombus,and infection therapies in hard-to-reach body sites)because of their tiny size and high maneuverability through the actuation of external fields(e.g.,magnetic field,light,ultrasound,electric field,and/or heat).However,fully synthetic micro/nanorobots as foreign objects are susceptible to phagocytosis and clearance by diverse *** address this issue,researchers have attempted to develop various cytomembrane-camouflaged micro/nanorobots by two means:(1)direct coating of micro/nanorobots with cytomembranes derived from living cells and(2)the swallowing of micro/nanorobots by living immunocytes via *** camouflaging with cytomembranes or living immunocytes not only protects micro/nanorobots from phagocytosis,but also endows them with new characteristics or functionalities,such as prolonging propulsion in biofluids,targeting diseased areas,or neutralizing bacterial *** this review,we comprehensively summarize the recent advances and developments of cytomembrane-camouflaged medical micro/*** first discuss how cytomembrane coating nanotechnology has been employed to engineer synthetic nanomaterials,and then we review in detail how cytomembrane camouflage tactic can be exploited to functionalize micro/*** aim to bridge the gap between cytomembrane-cloaked micro/nanorobots and nanomaterials and to provide design guidance for developing cytomembrane-camouflaged micro/nanorobots.

关键词： camouflage cell membranes immune cells medical micromotors targeted drug delivery

Preparation of microstructure-controllable superhydrophobic polytetrafluoroethylene porous thin film by vacuum thermal-evaporation

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Frontiers of Materials Science 2016年第3期10卷 320-327页

作者： Na YI Shanhu BAO huaijuan zhou Yunchuan XIN Aibin HUANG Yining MA Rong LI PingJIN State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of Sciences Beijing 100049 China Materials Research Institute for Sustainable Development National Institute of Advanced Industrial Science and Technology (AIST) Nagoya 463-8560 Japan

The three-dimensional porous network polytetrafluoroethylene （PTFE） thin films were achieved by a vacuum technique through evaporating the pure PTFE powders. The surfaces of PTFE thin films showed various morphologies by adjusting the evaporation temperature and the corresponding contact angle ranging from 133° to 155°. Further analyses of surface chemical composition and morphology by FTIR and FE-SEM revealed that the origin of hydrophobicity for the PTFE thin films could be ascribed to the fluorine-containing groups and the surface morphologies, indicating that abundant -CF2 groups and network structures with appropriate pore sizes played a vital role in superhydrophobicity. By characterization of UV-Vis, the films also showed high transmittance and antireflection effect. The films prepared by this simple method have potential applications such as waterproof membrane and self-cleaning coating.

关键词： polytetrafluoroethylene (PTFE) vacuum superhydrophobicity

Rational Design of Bioactive Materials for Bone Hemostasis and Defect Repair

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Cyborg and Bionic Systems 2023年第1期4卷 56-69页

作者： Yuqi Gai Yue Yin Ling Guan Shengchang Zhang Jiatian Chen Junyuan Yang huaijuan zhou Jinhua Li School of Medical Technology Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Sciences Beijing Institute of TechnologyBeijing100081China Department of Medicine University of British ColumbiaVancouverBCCanada National Center for Neurological Disorders Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

Everyday unnatural events such as trauma,accidents,military conflict,disasters,and even medical malpractice create open wounds and massive blood loss,which can be *** and large bone defects are among the most common types of *** treatment methods usually involve rapid hemostasis and wound closure,which are convenient and fast but may result in various complications such as nerve injury,deep infection,vascular injury,and deep *** address these complications,various studies have been conducted on new materials that can be degraded in the body and reduce inflammation and abscesses in the surgical *** review presents the latest research progress in biomaterials for bone hemostasis and *** mechanisms of bone hemostasis and bone healing are first introduced and then principles for rational design of biomaterials are *** providing representative examples of hemostatic biomaterials for bone repair,future challenges and opportunities in the field are proposed.

关键词： injuries healing Rational

Injectable body temperature responsive hydrogel for encephalitis treatment via sustained release of nano-anti-inflammatory agents

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Biomaterials Translational 2024年第3期5卷 300-313页

作者： Yuqi Gai huaijuan zhou Yingting Yang Jiatian Chen Bowen Chi Pei Li Yue Yin Yilong Wang Jinhua Li School of Medical Technology Beijing Institute of TechnologyBeijingChina Advanced Research Institute of Multidisciplinary Sciences Beijing Institute of TechnologyBeijingChina Beijing Institute of Technology ZhuhaiBeijing Institute of Technology(BIT)ZhuhaiGuangdong ProvinceChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Advanced Biotechnology&Medicine Rutgers UniversityPiscatawayNJUSA

Skull defects are common in the clinical practice of neurosurgery,and they are easily complicated by encephalitis,which seriously threatens the life and health safety of *** treatment of encephalitis is not only to save the patient but also to benefit the *** on the advantages of injectable hydrogels such as minimally invasive surgery,self-adaptation to irregularly shaped defects,and easy loading and delivery of nanomedicines,an injectable hydrogel that can be crosslinked in situ at the ambient temperature of the brain for the treatment of encephalitis caused by cranial defects is *** hydrogel is uniformly loaded with nanodrugs formed by cationic liposomes and small molecule drugs dexmedetomidine hydrochloride(DEX-HCl),which can directly act on the meninges to achieve sustained release delivery of anti-inflammatory nanodrug preparations and achieve the goal of long-term anti-inflammation at cranial *** is the first time that DEX-HCl has been applied within this therapeutic system,which is ***,this study is expected to alleviate the long-term suffering of patients,improve the clinical medication strategies for anti-inflammatory treatment,promote the development of new materials for cranial defect repair,and expedite the translation of research outcomes into clinical practice.

关键词： anti-inflammatory nanomedicines cranial bone defects encephalitis injectable hydrogels sustained release

Zr含量对大功率0.125PMN 0.875PZT陶瓷压电性能的影响

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南京工业大学学报（自然科学版） 2012年第1期34卷 121-125页

作者：葛宏桂刘云飞吕忆农周怀娟南京工业大学材料科学与工程学院材料化学工程国家重点实验室江苏南京210009

采用二次合成法制备不同zr含量(x=0.46～0.52)的0.125 Pb(Mg_(1/3)Nb_(2/3))O_3-0.875PbZr_xTi_(1-x)O_3(0.125PMN-0.875PZT)三元压电陶瓷。采用x线衍射仪(XRD)、阻抗分析仪等对陶瓷进行表征和性能测试,考察了Zr含量变化对陶瓷烧结相结构、体积密度、介电和压电性能的影响。结果表明:采用二次合成法,制备了纯钙钛矿相结构的陶瓷;当x=0.48～0.50时,0.125PMN-0.875PZT陶瓷处于四方一三方准同型相界(MPB).在x=0.49时制备的0.125PMN-0.875PZT陶瓷性能最佳,体积密度为7.84 g/cm^3,介电损耗低至0.76%,相对介电常数为2 130,压电常数为:320 pC/N,机电耦合系数达0.61,机械品质因数为76。

关键词： 0.125PMN-0.875PZT Zr含量大功率压电性能

Computer-aided diagnosis and decision-making system for medical data analysis: A case study on prostate MR images

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Journal of Management Science and Engineering 2019年第4期4卷 266-278页

作者： Ailian Chen Leilei Zhu huaijuan Zang Zhenglong Ding Shu Zhan School of Computer and Information Hefei University of TechnologyHefei230601China Anhui Institute of Information Technology Wuhu241000China

Prostate cancer is the most common cancer in males and a major cause of cancer-related *** resonance(MR)imaging is recently emerging as a powerful tool for prostate cancer *** clinically diagnose prostate cancer,doctors need to segment the prostate area in the MR ***,manual segmentation is time consuming and influenced by the physician’s ***-aided diagnosis and decision-making systems have shown great effectiveness in assisting doctors for this *** the same time,deep learning based on Generative Adversarial Networks can be applied to the segmentation of prostate MR *** this paper,we propose a new computer-aided diagnosis and decision-making system based on a deep learning model to automatically segment the prostate region from prostate MR ***,receptive field block(RFB)was integrated into the model to enhance the discriminability and robustness of the extracted multi-scale *** also introduced dense upsampling convolution instead of the traditional bilinear interpolation to capture and recover fine-detailed *** training was used to train the model,and the segmentation results were experimentally *** results showed that adversarial training and RFB are indeed effective,and the proposed method is superior to other methods on various evaluation metrics.

关键词： Computer-aided diagnosis Decision-making Prostate MR images Segmentation

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论“东亚福利模式”研究及其存在的问题

浙江大学学报（人文社会科学版） 2010年第5期40卷 64-72页

作者：林卡赵怀娟浙江大学公共管理学院浙江杭州310027 安徽师范大学社会学院安徽芜湖241000

最近十余年来,有关东亚福利的研究已成为一个新的研究领域。这些研究对于认识东亚各国或地区的历史文化传统、经济发展水平以及在此基础上形成的社会政策的特点具有重要意义。在以往的研究中,学者们试图从多个角度归纳东亚福利体制的特... 详细信息

最近十余年来,有关东亚福利的研究已成为一个新的研究领域。这些研究对于认识东亚各国或地区的历史文化传统、经济发展水平以及在此基础上形成的社会政策的特点具有重要意义。在以往的研究中,学者们试图从多个角度归纳东亚福利体制的特点,提出了儒家文化圈中的福利国家、东亚福利模式、生产主义社会政策等概念,并力图从文化、经济、政治等方面揭示东亚福利模式的形成原因。然而,迄今为止人们对于东亚福利体制是否具有为东亚各国或地区所共享的"特质"仍众说纷纭。在东亚福利这一研究领域中,也存在着学理基础欠缺、研究方向模糊、缺乏共同资料平台等方面的问题。由此,应暂时搁置研究概念和研究先设方面的争议,开展诸多专题研究,按研究方向组建团队,按照一定标准采集数据,争取区域组织的合作,以推进东亚福利研究的进一步发展。

关键词：东亚社会保障福利模式社会政策

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基于协作表示残差融合的3维人脸识别

中国图象图形学报 2015年第5期20卷 700-707页

作者：詹曙臧怀娟相桂芳合肥工业大学计算机与信息学院合肥230009

目的针对2维人脸难以克服光照、表情、姿态等复杂问题,提出了一种基于协作表示残差融合的新算法。方法协作表示分类算法是将所有类的训练图像一起协作构成字典,通过正则化最小二乘法代替1范数求解稀疏系数,减小了计算的复杂度,由此系数... 详细信息

目的针对2维人脸难以克服光照、表情、姿态等复杂问题,提出了一种基于协作表示残差融合的新算法。方法协作表示分类算法是将所有类的训练图像一起协作构成字典,通过正则化最小二乘法代替1范数求解稀疏系数,减小了计算的复杂度,由此系数重构测试人脸,根据重构误差最小原则,对测试人脸正确分类。该方法首先在3维人脸深度图上提取Gabor特征和Geodesic特征,然后在协作表示算法的基础上融合两者的残差信息,作为最终差异性度量,最后根据融合残差最小原则,进行人脸识别。结果在不同的训练样本、特征维数条件下,在CIS和Texas 2个人脸数据库上,本文算法的识别率可分别达到94.545%和99.286%。与Gabor-CRC算法相比,本文算法的识别率平均高出了10%左右。结论在实时成像系统采集的人脸库和Texas 3维人脸库上的实验结果表明,该方法对有无姿态、表情、遮挡等变化问题具有较好的鲁棒性和有效性。

关键词：协作表示 Gabor特征 Geodesic特征残差融合人脸识别 3维人脸深度图特征选择