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Acta Metallurgica Sinica(English Letters) 2018年第12期31卷 1311-1316页

作者： Qiang Li Yun-Bo Zhong Chu-Xiong Sun huai Wang Tian-Xiang zheng Wei-Li Ren Zhong-Ming Ren State Key Laboratory of Advanced Special Steels Shanghai University

The voltage was recorded to investigate the influence of the static magnetic field on droplet evolution during the mag-netically controlled electroslag remelting （MC-ESR） process. MC-ESR experiments were carried out under differentremelting current, and transverse static magnetic fields （TSMF） of 85 mT, 130 mT and 160 mT were *** work was performed to obtain the quantitative data of the droplets. The ASPEX Explorer was utilized toinvestigate the inclusions evolution of GCr15 ingots. The number of the droplets was 31 in 20 s during the traditional ESRprocess and reached 50 and 51 under the MC-ESR process with the TSMF of 85 mT and 130 mT, respectively. Whencompared the traditional ESR process with the MC-ESR process, the inclusions amount reduced 67%.

关键词： Electroslag remelting Static magnetic field Droplet transient Inclusions evolution Electromagnetic vibration effect

The fecal shield is a double-edged sword for larvae of a leaf beetle

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Current Zoology 2023年第2期69卷 173-180页

作者： zheng-Zhong Huang Ze-Qun Dong Zu-Long Liang Bin Zhang huai-Jun Xue Si-Qin Ge Institute of Zoology Chinese Academy of SciencesBeijing 100101China College of Life Sciences The Key Laboratory of Zoological Systematics and Application of Hebei ProvinceHebei UniversityBaoding 071002China College of Life Science Institute of Life Science and Green DevelopmentHebei UniversityBaoding 071002China College of Life Sciences Nankai UniversityTianin 300071China

Larvae of some leaf beetles carry masses of feces covering parts or all of the body,which is called a"fecal shield'In general,the shield is thought to be a defense structure against natural ***,some studies have suggested that defense effectiveness varies depending on the natural *** this study,we used a fecal retention leaf beetle Ophrida xanthospilota(Coleoptera:Chrysomelidae),and 2 local generalist predators(an ant,Camponotus japonicus(Hymenoptera:Formicidae)and a stinkbug,Arma custos(Hemiptera:Pentatomidael)as a system to test the hypothesis that the fecal shield of *** plays different roles in predation behavior of different predators and can provide multiple chemical communication signals in predator-prey *** bioassays showed that the fecal shield of *** larvae repelled the ant *** while attracting the stinkbug *** results also strongly demonstrated that hexane extracts of the fecal shield significantly repelled ***,while dichloromethane(DCM)extracts did not inhibit ant ***,DCM extracts attracted ***,but hexane extracts did ***,we suggest that the fecal shield is a double-edged sword for the larvae of *** results also indicated that the risk-benefit tradeoff of an insect should be estimated at a community level involving multiple enemies(predators and parasites)and herbivores,rather than in a single prey-predator pair.

关键词： ant chemical cues kairomone predatory stinkbug predator-prey interactions

Comparison of ocular axis and corneal diameter between entropion and non-entropion eyes in children with congenital glaucoma

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World Journal of Clinical Cases 2021年第18期9卷 4637-4643页

作者： Yue Wang Zhi-Jia Hou huai-Zhou Wang Man Hu Yu-Xin Li zheng Zhang Department of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren Hospital of Capital Medical UniversityBeijing Key Laboratory of Ophthalmology and Visual ScienceBeijing 100730China National Key Discipline of Pediatrics Ministry of EducationDepartment of OphthalmologyBeijing Children’s HospitalCapital Medical UniversityBeijing 100045China

BACKGROUND Children with congenital glaucoma are often accompanied by acquired epiblepharon in the lower eyelid,which causes entropion of the lower eyelid and damages the *** To infer the possible causes of lower eyelid entropion by comparing the difference of ocular axis and corneal diameter between inverted and non-inverted ciliary eyes in children with congenital *** A total of 15 patients(11 males and 4 females)diagnosed with congenital glaucoma between July 2016 and January 2019 at Tongren Hospital were *** patients had bilateral glaucoma,and ten had unilateral *** patient had only one eye with lower eyelid entropion which is associated with congenital *** the patients had no entropion in another *** clinical data were *** outcome measures were the ocular axis and corneal *** The average age of the 15 patients was 1.85±0.49 *** t-test showed that the average ocular axis of congenital glaucoma eyes with lower eyelid entropion(24.86±3.44 mm)was significantly longer than that of congenital glaucoma eyes without lower eyelid entropion(20.79±1.34 mm;P<0.001).The average corneal diameter of congenital glaucoma eyes with lower eyelid entropion(13.61±0.88 mm)was also significantly greater than that of congenital glaucoma eyes without lower eyelid entropion(11.63±0.48;P<0.001).CONCLUSION The rapid growth of the ocular axis and corneal diameter may be the main cause of congenital glaucoma with acquired lower eyelid ***,children with poor control of intraocular pressure and excessive growth of ocular axis and corneal diameter must be observed for the existence of acquired epiblepharon.

关键词： Acquired epiblepharon Congenital glaucoma Entropion Ocular axis Corneal diameter Congenital epiblepharon

Effects of curcumin nanoparticles on proliferation and VEGF expression of human retinal pigment epithelial cells

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International Journal of Ophthalmology(English edition) 2022年第6期15卷 905-913页

作者： Hai-Sheng zheng Yu-Qing Lan Xing-Wu Zhong huai-Sheng Zhou Jia-Yao Xu Hainan Eye Hospital and Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityHaikou 570311Hainan ProvinceChina Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510120Guangdong ProvinceChina Foshan Second People’s Hospital Foshan 528000Guangdong ProvinceChina

AIM:To investigate the effects of curcumin(Cur)nanoparticles loaded with chitosan derivatives grafted by deoxycholic acid(Chit-DC)on human retinal pigment epithelial(h RPE)cell proliferation and vascular endothelial growth factor(VEGF)m RNA ***:Cur nanoparticles were synthesized with Chit-DC as the carrier and Cur as the supported *** counting kit-8(CCK-8)method was used to detect the effects of different concentrations of Cur/Chit-DC,Chit-DC,and Cur on the proliferation of h RPE cells for different *** changes of Cur/Chit-DC and Cur on h RPE cell cycle were determined by flow ***-quantitative reverse transcription-polymerase chain reaction(RT-PCR)was used to detect the m RNA expression levels of VEGF in h RPE cells treated with Cur,Chit-DC and Cur/Chit-DC at 10μg/m L for 24 ***:Different concentrations of Chit-DC nanoparticle treated h RPE cells had no significant difference in terms of optical density(OD)values compared with the control group at 24 h and 48 ***,there was no change in the cell morphology under a light *** 24 h treatment with Cur/Chit-DC and Cur,the percentage of G0-G1 phase cells increased and the percentage of S phase cells decreased in all concentration ***/Chit-DC and Cur in all concentration groups inhibited the proliferation of h RPE cells in a time and dose dependent manner,and reduced the expression level of VEGF m ***:The Cur/Chit-DC nanoparticles can release Cur continuously and have sustained release *** Cur/Chit-DC nanoparticles and Cur could inhibit h RPE cells cultured in vitro,and could reduce the expression level of VEGF m RNA in h RPE cells.

关键词： curcumin retinal pigment epithelial cells vascular endothelial growth factor cell counting kit-8 polymerase chain reaction

An iterative virtual projection method to improve the reconstruction performance for ill-posed emission tomographic problems

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Chinese Physics B 2015年第10期24卷 200-212页

作者：柳华蔚郑树周怀春 Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Thermal EngineeringTsinghua University

In order to improve the reconstruction performance for ill-posed emission tomographic problems with limited projections, a generalized interpolation method is proposed in this paper, in which the virtual lines of projection are fabricated from, but not linearly dependent on, the measured projections. The method is called the virtual projection（VP） ***, an iterative correction method for the integral lengths is proposed to reduce the error brought about by the virtual lines of projection. The combination of the two methods is called the iterative virtual projection（IVP） method. Based on a scheme of equilateral triangle plane meshes and a six asymmetrically arranged detection system, numerical simulations and experimental verification are conducted. Simulation results obtained by using a non-negative linear least squares method,without any other constraints or regularization, demonstrate that the VP method can gradually reduce the reconstruction error and converges to the desired one by fabricating additional effective projections. When the mean square deviation of normal error superimposed on the simulated measured projections is smaller than 0.03, i.e., the signal-to-noise ratio（SNR）for the measured projections is higher than 30.4, the IVP method can further reduce the reconstruction error reached by the VP method apparently. In addition, as the regularization matrix in the Tikhonov regularization method is updated by an iterative correction process similar to the IVP method presented in this paper, or the Tikhonov regularization method is used in the IVP method, good improvement is achieved.

关键词： ill-posed problem emission tomography limited projections Tikhonov regularization

Synthesis of Hierarchical TS-1 and Its Recycling Catalytic Property for Oxidative Desulfurization

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Journal of Renewable Materials 2022年第6期10卷 1711-1726页

作者： Jinglong huai Xiaoxue Liu Yinhai Zhang Yang Yang Yan Gou Li Qin Jinling Shan Yancheng zheng Hao Li College of Chemistry and Environmental Engineering Yangtze UniversityJingzhou434023China College of Agriculture Yangtze UniversityJingzhou434000China

Because of its unique pore structure,good hydrothermal stability and high specific surface area,hierarchical TS-1 zeolite(HTS-1)has become an important catalyst for the deep oxidative desulfurization of fuel *** this work,HTS-1 has been successfully synthesized by a hydrothermal crystallization method using the C-SiO_(2)composite as both silicon source and mesoporous template,tetrapropylammonium hydroxide as microporous template,and tetrabutylorthotitanate as titanium *** C-SiO_(2)composite is obtained by mild carbonization of the SiO_(2)/T-40(Tween 40)xerogel,which is prepared by the two step sol-gel *** reaction conditions for the oxidative desulfurization(ODS)of dibenzothiophene(DBT)and 4,6-dimethyldibenzothiophene(4,6-DMDBT)over HTS-1 are optimized systematically,and the recycling performances of HTS-1 are investigated in *** the 15th run,HTS-1 still maintains high DBT conversion(90.6%)and 4,6-DMDBT conversion(86.0%)without *** samples before and after recycle tests are characterized by XRD,FT-IR,CHN analysis,UV-Vis and SEM *** results indicate that the crystal structure and morphology of regenerated HTS-1 samples are well kept,which accounts for the good structural stability and reusability of *** addition,active intermediates for the ODS of bulky organic sulfides over HTS-1,i.e.,Ti-peroxo(Ti-OOtBu)species,are captured by the UV-Vis ***,a possible reaction mechanism for the ODS process over HTS-1 is proposed.

关键词： Hierarchical TS-1 oxidative desulfurization recycling property Ti-peroxo species

Recombinant adeno-associated virus 8-mediated inhibition of microRNA let-7a ameliorates sclerosing cholangitis in a clinically relevant mouse model

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World Journal of Gastroenterology 2024年第5期30卷 471-484页

作者： Hui Hua Qian-Qian Zhao Miriam Nkesichi Kalagbor Guo-Zhi Yu Man Liu zheng-Rui Bian bei-bei Zhang Qian Yu Yin-Hai Xu Ren-Xian Tang Kui-Yang zheng Chao Yan Jiangsu Key Laboratory of Immunity and Metabolism Department of Pathogenic Biology and ImmunologyNational Demonstration Center for Experimental Basic Medical Science EducationLaboratory of Infection and ImmunityXuzhou Medical UniversityXuzhou 221004Jiangsu ProvinceChina Department of Laboratory Medicine The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221002Jiangsu ProvinceChina

BACKGROUND Primary sclerosing cholangitis(PSC)is characterized by chronic inflammation and it predisposes to cholangiocarcinoma due to lack of effective treatment *** adeno-associated virus(rAAV)provides a promising platform for gene therapy on such kinds of diseases.A microRNA(miRNA)let-7a has been reported to be associated with the progress of PSC but the potential therapeutic implication of inhibition of let-7a on PSC has not been *** To investigate the therapeutic effects of inhibition of a miRNA let-7a transferred by recombinant adeno-associated virus 8(rAAV8)on a xenobiotic-induced mouse model of sclerosing *** A xenobiotic-induced mouse model of sclerosing cholangitis was induced by 0.1% 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine(DDC)feeding for 2 wk or 6 wk.A single dose of rAAV8-mediated anti-let-7a-5p sponges or scramble control was injected in vivo into mice onset of DDC *** sacrifice,the liver and the serum were collected from each *** hepatobiliary injuries,hepatic inflammation and fibrosis were *** targets of let-7a-5p and downstream molecule NF-κB were detected using Western *** rAAV8-mediated anti-let-7a-5p sponges can depress the expression of let-7a-5p in mice after DDC feeding for 2 wk or 6 *** reduced expression of let-7a-5p can alleviate hepato-biliary injuries indicated by serum markers,and prevent the proliferation of cholangiocytes and biliary ***,inhibition of let-7a mediated by rAAV8 can increase the expression of potential target molecules such as suppressor of cytokine signaling 1 and Dectin1,which consequently inhibit of NF-κB-mediated hepatic *** Our study demonstrates that a rAAV8 vector designed for liver-specific inhibition of let-7a-5p can potently ameliorate symptoms in a xenobiotic-induced mouse model of sclerosing cholangitis,which provides a possible clinical translation of PSC of human.

关键词： Primary sclerosing cholangitis Recombinant adeno-associated virus 8 Let-7a-5p Therapeutic effects Inflammation

Regulation of the intestinal microbiota: An emerging therapeutic strategy for inflammatory bowel disease

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World Journal of Gastroenterology 2020年第30期26卷 4378-4393页

作者： bei Yue Zhi-Lun Yu Cheng Lv Xiao-Long Geng zheng-Tao Wang Wei Dou Laboratory of Standardization of Chinese Medicines Shanghai Key Laboratory of Compound Chinese Medicinesand the SATCM key Laboratory of New Resources and Quality Evaluation of Chinese MedicinesInstitute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China

The rapid development of metagenomics,metabolomics,and metatranscriptomics provides novel insights into the intestinal microbiota factors linked to inflammatory bowel disease(IBD).Multiple microorganisms play a role in intestinal health;these include bacteria,fungi,and viruses that exist in a dynamic balance to maintain mucosal *** in the intestinal microbiota disrupt mucosal homeostasis and are closely related to IBD in humans and colitis in ***,preventing or correcting the imbalance of microbiota may serve as a novel prevention or treatment strategy for *** review the most recent evidence for direct or indirect interventions targeting intestinal microbiota for treatment of IBD in order to overcome the current limitations of IBD therapies and shed light on personalized treatment options.

关键词： Inflammatory bowel disease Pro/Prebiotics Fecal microbiota transplantation Herbal medicines Clinical application

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有限元模拟弹性位错的等效体力方法

地球物理学报 2015年第5期58卷 1666-1674页

作者：张贝张怀石耀霖中国科学院大学中国科学院计算地球动力学实验室北京100049

计算地震位错造成的位移场和应力场,对于估计大地震引起的后续地震活动发展趋势十分重要.本文提出在弹性位错问题的有限元模拟中,用等效体力代替位错源,从而在构建几何模型时不用包含断层,却可以处理包含任意复杂断层的问题,极大降低建... 详细信息

计算地震位错造成的位移场和应力场,对于估计大地震引起的后续地震活动发展趋势十分重要.本文提出在弹性位错问题的有限元模拟中,用等效体力代替位错源,从而在构建几何模型时不用包含断层,却可以处理包含任意复杂断层的问题,极大降低建模的难度.使用此方法,本文计算并讨论了在球形地球模型下2011年日本Tohoku-Oki特大地震对华北地区断层的影响,结果表明此次地震使华北主要断层趋于稳定.

关键词：不连续有限元地震位错同震库仑应力 Tohoku-Oki地震华北

A universal calibration method for eliminating topographydependent current in conductive AFM and its application in nanoscale imaging

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Nano Research 2024年第7期17卷 6509-6517页

作者： Chunlin Hao Hao Xu Shiquan Lin Yaju Zhang Jinmiao He bei Liu Yuanzheng Zhang Banghao Wu Guozhen Shen Haiwu zheng Henan Province Engineering Research Center of Smart Micro-nano Sensing Technology and Application School of Physics and ElectronicsHenan UniversityKaifeng 475004China School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081China beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 100083China

The topography and electrical properties are two crucial characteristics that determine the roles and functionalities of *** atomic force microscopy(CAFM)is widely recognized for its ability to independently measure the topography and *** increasing trend towards miniaturization in electrical devices and sensors has encouraged an urgent demand for enhancing the accuracy of CAFM ***,when performing CAFM tests on Bi_(0.5)Na_(0.5)TiO_(3)bulk ceramic,it is interesting to observe significant currents related to the *** do insulators exhibit“conductivity”in CAFM testing?Herein,we thoroughly investigated the topography-dependent current during CAFM testing for the first *** on the linear dependence between the current and the first derivative of topography,the calibration method has been proposed to eliminate the topographic *** method is evaluated on Bi_(0.5)Na_(0.5)TiO_(3)bulk ceramic,one-dimensional(1D)ZnO nanowire,twodimensional(2D)NbOI_(2)flake,and biological lotus *** corresponding results of negligible topography-interference current affirm the feasibility and universality of this calibration *** work effectively addresses the challenge of topographic crosstalk in CAFM characterization,thereby preventing the erroneous estimation of the conductivity of any unknown sample.

关键词： conductive atomic force microscopy topographic crosstalk current error calibration method