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Fufang E’jiao Jiang’s effect on immunity,hematopoiesis,and angiogenesis via a systematic“compound-effect-target”analysis

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Food Science and Human Wellness 2024年第5期13卷 2813-2832页

作者： Xiang Li Xiao Xu Ying Dong Shusheng Fan Xueyang Ren Yuan Zheng Jiamu Ma Feng Zhang qingyue deng Xianxian Li Yingyu He Mengyu Sun Wei Liu Mengxia Li qing Xia Yan Zhang Gaimei She School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102488China Biology Institute Qilu University of Technology(Shandong Academy of Sciences)Jinan 250103China National Engineering Research Center for Gelatin-based Traditional Chinese Medicine Dong-E-E-Jiao Co.Ltd.Liaocheng 252201China

Fufang E’jiao Jiang(FEJ)as a healthy food consisting of medicine food homology materials approved by China’s Ministry of Health has been extensively applied to replenish qi and nourish blood,and it has a positive impact on women’s *** find out the material basis and mechanism of FEJ,a systematic“compoundeffect-target”analysis including chemical composition resolution,zebrafish,network pharmacology,molecular docking,transcriptome,and bibliometric analysis was adopted.124 chemical components including ginsenosides,and phenylethanoid glycosides in FEJ were discovered,and effects of FEJ on promoting the generation of immune cells,erythropoiesis and angiogenesis in zebrafish were *** on network pharmacology,molecular docking and in vivo activity assay,6 compounds including jionoside A1,isoacteoside,echinacoside,acteoside,lobetyolin,and rehmannioside D were identified as active components of *** data showed that several pathways such as complement and coagulation cascades,ECM-receptor interaction,and PI3K-Akt signaling pathway were associated with proangiogenic effect of FEJ.19 common targets were obtained through combined analysis of network pharmacology and transcriptomics,and 5 targets of them were verified by *** bibliometric analysis of these common targets revealed that FEJ was related to energy metabolism,pathway in cancer,etc.,which was consistent with the results of network pharmacology and *** studies suggested that FEJ could replenish qi and nourish blood through multi-compound and multi-targets.

关键词： Fufang E’jiao Jiang Zebrafish(Danio rerio) Network pharmacology Transcriptome Bibliometrics

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Furtherance and Shaping:On the Media-Making of Hankow in the“Foreign Newspaper Era”(1866-1900)

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Cultural and Religious Studies 2024年第8期12卷 528-538页

作者： deng Lin Hubei University WuhanChina

“The Era of Foreign Newspapers”refers to the period from the emergence of the first modern newspaper in Hankow in 1866 to 1900 when Wuhan’s newspaper industry was dominated by foreign *** well-known foreign newspapers in Wuhan during this period mainly included Hankow Times,The New Edition of Tan Dao,and Han *** subjective purpose of foreigners’early endeavors of running newspapers in Wuhan was mainly to use newspapers to convey business information,spread religion,or influence public opinion in order to safeguard their own interests in ***,foreign newspapers in this period played a constructive role in the development of Wuhan’s local society:It gave birth to the emergence and development of the first private and official newspapers in Wuhan and shaped the local social,cultural,and political changes in Wuhan in the late qing *** out and explaining the constructive influence of Hankow’s foreign newspaper in this period has certain significance for restoring the social and political landscape of Wuhan at that time and better understanding the context of historical development.

关键词： “The Era of Foreign Newspapers” semi-colonial Hankow colonial history news history media-making

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Duodenal-jejunal bypass improves hypothalamic oxidative stress and inflammation in diabetic rats via glucagon-like peptide 1-mediated Nrf2/HO-1 signaling

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World Journal of Diabetes 2024年第2期15卷 287-304页

作者： huai-Jie Wang Li-Bin Zhang Si-Peng Sun qing-Tao Yan Zhi-Qin Gao Fang-Ming Fu Mei-Hua Qu Translational Medical Center Weifang Second People's HospitalWeifang 261041Shandong ProvinceChina Department of Endocrinology Weifang Second People's HospitalWeifang 261041Shandong ProvinceChina Department of Pediatric Surgery Weifang People’s HospitalWeifang 261041Shandong ProvinceChina School of Bioscience and Technology Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Department of Endocrinology Jinan Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013Shandong ProvinceChina

BACKGROUND Type 2 diabetes mellitus(T2DM)is often accompanied by impaired glucose utilization in the brain,leading to oxidative stress,neuronal cell injury and *** studies have shown that duodenal jejunal bypass(DJB)surgery significantly improves brain glucose metabolism in T2DM rats,the role and the metabolism of DJB in improving brain oxidative stress and inflammation condition in T2DM rats remain *** To investigate the role and metabolism of DJB in improving hypothalamic oxidative stress and inflammation condition in T2DM *** A T2DM rat model was induced via a high-glucose and high-fat diet,combined with a low-dose streptozotocin injection.T2DM rats were divided into DJB operation and Sham operation *** surgical intervention was carried out on T2DM *** differential expression of hypothalamic proteins was analyzed using quantitative proteomics *** related to oxidative stress,inflammation,and neuronal injury in the hypothalamus of T2DM rats were analyzed by flow cytometry,quantitative real-time PCR,Western blotting,and *** Quantitative proteomics analysis showed significant differences in proteins related to oxidative stress,inflammation,and neuronal injury in the hypothalamus of rats with T2DM-DJB after DJB surgery,compared to the T2DM-Sham groups of *** stress-related proteins(glucagon-like peptide 1 receptor,Nrf2,and HO-1)were significantly increased(P<0.05)in the hypothalamus of rats with T2DM after DJB *** surgery significantly reduced(P<0.05)hypothalamic inflammation in T2DM rats by inhibiting the activation of NF-κB and decreasing the expression of interleukin(IL)-1βand *** surgery significantly reduced(P<0.05)the expression of factors related to neuronal injury(glial fibrillary acidic protein and Caspase-3)in the hypothalamus of T2DM rats and upregulated(P<0.05)the expression of neuroprotective factors(C-fos,Ki67,Bcl-2,and BDNF),thereby reducing hypot

关键词： Duodenal jejunal bypass surgery Type 2 diabetes mellitus Neuron apoptosis Inflammatory Oxidative stress Hypothalamic injury

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Research of caged dynamics of clusters center atoms in Pd_(82)Si_(18) amorphous alloy

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Chinese Physics B 2024年第4期33卷 623-629页

作者：邓永和陈贝祁清华李兵兵高明文大东王小云彭平 School of Computational Science and Electronics Hunan Institute of EngineeringXiangtan 411104China School of Physics and Mechanical&Electrical Engineering Jishou UniversityJishou 416000China School of Materials Science and Engineering Hunan UniversityChangsha 410082China

To date,there is still a lack of a comprehensive explanation for caged dynamics which is regarded as one of the intricate dynamic behaviors in amorphous *** study focuses on Pd_(82)Si_(18)as the research object to further elucidate the underlying mechanism of caged dynamics from multiple perspectives,including the cage's lifetime,atomic local environment,and atomic potential *** results reveal that Si atoms exhibit a pronounced cage effect due to the hindrance of Pd atoms,resulting in an anomalous peak in the non-Gaussian *** in-depth investigation was conducted on the caged dynamics differences between fast and slow Si *** comparison to fast Si atoms,slow Si atoms were surrounded by more Pd atoms and occupied lower potential energy states,resulting in smaller diffusion displacements for the slow Si ***,slow Si atoms tend to be in the centers of smaller clusters with coordination numbers of 9 and *** the isothermal relaxation process,clusters with coordination numbers 9 and 10 have longer lifetimes,suggesting that the escape of slow Si atoms from their cages is more *** findings mentioned above hold significant implications for understanding the caged dynamics.

关键词： caged dynamics Pd_(82)Si_(18) amorphous alloy fast and slow atoms clusters lifetime

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一种针对驻留转换雷达的信号分选算法

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系统工程与电子技术 2024年第6期46卷 1925-1934页

作者：张春杰青松邓志安刘俞辰哈尔滨工程大学信息与通信工程学院黑龙江哈尔滨150001 先进船舶通信与信息技术工业和信息化部重点实验室黑龙江哈尔滨150001 国网黑龙江省电力有限公司哈尔滨供电公司黑龙江哈尔滨150001

复杂电磁环境下驻留转换雷达的信号分选是制约电子侦察技术发展的瓶颈,由于其复杂多变的成形规律,信号子周期难以被检测;脉冲重复周期调制类型不明,脉冲序列无法成功提取;提取的多个子周期脉冲序列无法合并为一部雷达信号,造成虚警。针... 详细信息

复杂电磁环境下驻留转换雷达的信号分选是制约电子侦察技术发展的瓶颈,由于其复杂多变的成形规律,信号子周期难以被检测;脉冲重复周期调制类型不明,脉冲序列无法成功提取;提取的多个子周期脉冲序列无法合并为一部雷达信号,造成虚警。针对以上问题,提出一种针对驻留转换雷达的信号分选算法,利用双门限提高子周期检测概率,通过霍夫变换结合迭代自组织聚类判断信号是否属于驻留转换雷达,改进搜索算法以提取脉冲序列,依据排列熵指标将多脉冲序列合并为一部驻留转换雷达信号。仿真实验结果表明,所提算法在25%脉冲丢失率的复杂电磁环境下,可以将三部驻留转换雷达信号成功分选。

关键词：驻留转换信号分选霍夫变换脉冲序列搜索排列熵

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lncRNA UNC5B-AS1通过NF-κB信号通路调控骨肉瘤细胞的恶性生物学行为

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中国药理学通报 2024年第6期40卷 1082-1088页

作者：阳庆林张怀斌兰志杰秦庆庆王一坤王勇平兰州大学第一临床医学院兰州大学第一医院骨科甘肃兰州730000

目的探讨长链非编码RNA(long non-coding RNA,lncRNA)UNC5B-AS1调控骨肉瘤细胞恶性生物学行为的可能机制。方法通过RT-qPCR检测UNC5B-AS1在骨肉瘤细胞MG63、骨肉瘤细胞U2OS和成骨细胞hFOB1.19中的表达情况;对骨肉瘤细胞中的UNC5B-AS1进... 详细信息

目的探讨长链非编码RNA(long non-coding RNA,lncRNA)UNC5B-AS1调控骨肉瘤细胞恶性生物学行为的可能机制。方法通过RT-qPCR检测UNC5B-AS1在骨肉瘤细胞MG63、骨肉瘤细胞U2OS和成骨细胞hFOB1.19中的表达情况;对骨肉瘤细胞中的UNC5B-AS1进行过表达和敲低后,通过CCK-8实验、Transwell实验以及流式细胞术分别检测骨肉瘤细胞的增殖、迁移和凋亡;同时,通过RT-qPCR和Western blot分别检测过表达和敲低UNC5B-AS1对NF-κB信号通路关键mRNA和蛋白表达的影响。结果相比于正常成骨细胞hFOB1.19,UNC5B-AS1在骨肉瘤细胞MG63和U2OS中的表达有不同程度的升高。过表达UNC5B-AS1明显促进骨肉瘤细胞的增殖能力,同时使骨肉瘤细胞的迁移能力明显升高,而细胞凋亡率明显降低,NF-κB信号通路相关mRNA和蛋白表达明显升高。敲低UNC5B-AS1的表达明显抑制骨肉瘤细胞的增殖能力,同时使骨肉瘤细胞的迁移能力明显降低,而细胞凋亡率明显升高,NF-κB信号通路相关mRNA和蛋白表达明显降低。结论lncRNA UNC5B-AS1在骨肉瘤细胞中呈高表达,且可能通过激活NF-κB信号通路来影响骨肉瘤细胞的恶性生物学行为。

关键词：骨肉瘤 lncRNA UNC5B-AS1 NF-κB信号通路增殖凋亡机制

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基于白箱树突网络的电压灵敏度实时计算方法

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中国电机工程学报 2024年第19期44卷 7503-7514,I0002页

作者：马庆邓长虹龙志君综合能源电力装备及系统安全湖北省重点实验室(武汉大学电气与自动化学院) 湖北省武汉市430072

由于传统电压灵敏度计算需要以知晓精确网络参数为前提,近年来各类基于数据驱动的电压灵敏度拟合方法被相继提出。但现有方法针对新运行场景需要重复所有回归操作才能获得精确的灵敏度值,因此无法真正应用于灵敏度的实时计算。该文提出... 详细信息

由于传统电压灵敏度计算需要以知晓精确网络参数为前提,近年来各类基于数据驱动的电压灵敏度拟合方法被相继提出。但现有方法针对新运行场景需要重复所有回归操作才能获得精确的灵敏度值,因此无法真正应用于灵敏度的实时计算。该文提出一种基于树突网络(dendrite net,DN)的电压灵敏度实时计算方法,基于DN拟合等价于泰勒展开的白箱性质,建立适用于任意运行场景的系统状态参数至节点电压的端到端映射。通过对基于DN的节点电压显性表达式进行提取和求导,最终形成只包含极少计算量的电压灵敏度显性表达式,将灵敏度计算速度提升至微秒级。其次,在基于DN的节点电压显性表达式中,各输入的一阶分量系数在任意运行场景下均保持恒定,可直接作为评判节点电压与状态参数相关性的评价指标。基于IEEE 118节点系统等3个不同规模算例的仿真计算结果证明该文方法的正确性和优越性。

关键词：电压灵敏度树突网络潮流计算输入/输出相关性指标

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数字化时代的企业转型之路:中国上市工业企业的加成率视角

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财经研究 2024年第6期50卷 153-168页

作者：邓石军张卿陈晓霞暨南大学产业经济研究院广东广州510632 中共广东省委党校决策咨询中心广东广州510053 上海财经大学经济学院上海200433

在数字经济发展逐渐深化的背景下,数字化转型是企业顺应时代发展趋势和重塑市场竞争优势的重要举措。基于Melitz和Ottaviano(2008)的研究,文章构建了包含数字化适应成本的模型,分析了数字化转型对企业加成率的影响,并使用2004-2021年中... 详细信息

在数字经济发展逐渐深化的背景下,数字化转型是企业顺应时代发展趋势和重塑市场竞争优势的重要举措。基于Melitz和Ottaviano(2008)的研究,文章构建了包含数字化适应成本的模型,分析了数字化转型对企业加成率的影响,并使用2004-2021年中国上市工业企业数据进行实证检验。研究发现:数字化转型与企业加成率之间存在显著的U形关系,即在低数字化水平时,进行转型会降低企业加成率,而一旦跨过拐点达到较高水平时,持续转型将有力地提升企业加成率。机制检验表明,企业经营成本、维持性投资和生产效率是数字化转型对企业加成率非线性影响的重要渠道。异质性分析发现,对位于西部地区、属于国有性质、较大规模或低人力资本的企业而言,数字化转型对企业加成率并未带来显著U形影响。拓展分析显示,数字化转型有着明显的后动劣势,最早转型并非最佳选择,中期进行转型可以更好发挥数字化的积极作用;从分维度上看,智能制造、数据处理、商业模式和内容数字化领域的数字技术应用均会显著影响企业加成率,尤其是对数据处理领域的影响最大。文章为数字经济相关政策的制定和企业数字化转型路径选择提供了依据和启示。

关键词：数字化转型市场竞争优势企业成本加成率数字经济

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Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer’s disease mice

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Protein & Cell 2024年第4期15卷 261-284页

作者： He-Zhou Huang Wen-qing Ai Na Wei Ling-Shuang Zhu Zhi-Qiang Liu Chao-Wen Zhou Man-Fei deng Wen-Tao Zhang Jia-Chen Zhang Chun-qing Yang Ya-Zhuo Hu Zhi-Tao Han Hong-Hong Zhang Jian-Jun Jia Jing Wang Fang-Fang Liu Ke Li Qi Xu Mei Yuan Hengye Man Ziyuan Guo Youming Lu Kai Shu Ling-Qiang Zhu Dan Liu Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Medical Genetics School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pathology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450002China Department of Pathology School of Basic MedicineZhengzhou UniversityZhengzhou 450002China The Second Affiliated Hospital Department of NeurologyHengyang Medical SchoolUniversity of South ChinaHengyang 421001China Beijing Key Laboratory of Aging and Geriatrics National Clinical Research Center for Geriatric DiseaseInstitute of GeriatricsChinese PLA General Hospital and Chinese PLA Medical AcademyBeijing 100853China Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Neurology Union HospitalHuazhong University of Science and TechnologyWuhan 430022China Department of Biology Boston UniversityBostonMA 02215USA Center for Stem Cell and Organoid Medicine(CuSTOM) Division of Developmental BiologyCincinnati Children’s Hospital Medical CenterCincinnatiOH 45229USA

Sporadic or late-onset Alzheimer’s disease(LOAD)accounts for more than 95%of Alzheimer’s disease(AD)cases without any family *** genome-wide association studies have identified associated risk genes and loci for LOAD,numerous studies suggest that many adverse environmental factors,such as social isolation,are associated with an increased risk of ***,the underlying mechanisms of social isolation in AD progression remain *** the current study,we found that 7 days of social isolation could trigger pattern separation impairments and presynaptic abnormalities of the mossy fibre-CA3 circuit in AD *** also revealed that social isolation disrupted histone acetylation and resulted in the downregulation of 2 dentate gyrus(DG)-enriched miRNAs,which simultaneously target reticulon 3(RTN3),an endoplasmic reticulum protein that aggregates in presynaptic regions to disturb the formation of functional mossy fibre boutons(MFBs)by recruiting multiple mitochondrial and vesicle-related ***,the aggregation of RTN3 also recruits the PP2A B subunits to suppress PP2A activity and induce tau hyperphosphorylation,which,in turn,further elevates RTN3 and forms a vicious ***,using an artificial intelligence-assisted molecular docking approach,we determined that senktide,a selective agonist of neurokinin3 receptors(NK3R),could reduce the binding of RTN3 with its ***,application of senktide in vivo effectively restored DG circuit disorders in socially isolated AD *** together,our findings not only demonstrate the epigenetic regulatory mechanism underlying mossy fibre synaptic disorders orchestrated by social isolation and tau pathology but also reveal a novel potential therapeutic strategy for AD.

关键词： Alzheimer’s disease memory impairment synaptic disorder tau pathology

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专利侵权风险管理对后发企业技术赶超的影响研究

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中国科技论坛 2024年第4期 95-105页

作者：郭青戚湧邓雨亭南京理工大学知识产权学院江苏南京210094 南京理工大学经济管理学院江苏南京210094

本文以中国后发企业2022—2023两年追踪的调研问卷数据为样本,实证分析专利侵权风险管理对后发企业技术赶超的影响,以及技术创新的中介作用,技术能力、知识产权保护的调节作用。研究发现:专利侵权风险管理正向影响后发企业技术赶超;技... 详细信息

本文以中国后发企业2022—2023两年追踪的调研问卷数据为样本,实证分析专利侵权风险管理对后发企业技术赶超的影响,以及技术创新的中介作用,技术能力、知识产权保护的调节作用。研究发现:专利侵权风险管理正向影响后发企业技术赶超;技术创新在专利侵权风险管理与后发企业技术赶超中发挥部分中介作用,且该作用兼具当期效应与时滞效应;技术能力以及知识产权保护能够显著影响专利侵权风险管理对技术创新的作用。研究结果在考虑内生性问题以及稳健性检验后依然成立,为专利侵权风险管理的创新驱动效应提供实证依据,引导中国后发企业在繁茂的“专利丛林”中砥砺前行。

关键词：专利侵权风险管理后发企业技术赶超技术创新

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