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Pancreatic kininogenase improves erectile function in streptozotocin-induced type 2 diabetic rats with erectile dysfunction

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Asian Journal of Andrology 2018年第5期20卷 448-453页

作者： Guo-Tao chen Bai-Bing Yang Jian-huai chen Zheng Zhang Lei-Lei Zhu He-Song Jiang Wen Yu Yun chen Yu-Tian Dai Department of Andrology Nanjing Drum Tower Hospital Affiliated Hospital of Nanjing University Medical School Nanjing 210008 China.

Erectile dysfunction （ED） associated with type 2 diabetes is a severe problem that requires effective treatment. Pancreatic kininogenase （PK） has the potential to improve the erectile function of ED patients. This study aims to investigate the effect of PK on erectile function in streptozotocin-induced type 2 diabetic ED rats. To achieve this goal, we divided male Sprague-Dawley rats into five groups. One group was not treated, and the other four groups were treated with saline, sildenafil, PK or sildenafil, and PK, respectively, for 4 weeks after the induction of type 2 diabetic ED. Then, intracavernous pressure under cavernous nerve stimulation was measured, and penile tissue was collected for further study. Endothelial nitric oxide synthase levels, smooth muscle content, endothelium content, cyclic guanosine monophosphate （cGMP） levels in the corpus cavernosum, and neuronal nitric oxide synthase levels in the dorsal penile nerve were measured. Improved erectile function and endothelium and smooth muscle content in the corpus cavernosum were observed in diabetic ED rats. When treating diabetic ED rats with PK and sildenafil at the same time, a better therapeutic effect was achieved. These data demonstrate that intraperitoneal injection of PK can improve erectile function in a rat model of type 2 diabetic ED. With further research on specific mechanisms of erectile function improvement, PK may become a novel treatment for diabetic ED.

关键词： cyclic guanosine monophosphate endothelial nitric oxide synthase erectile dysfunction intracavernous pressure pancreatic kininogenase type 2 diabetes

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Nitrous oxide emissions from three temperate forest types in the Qinling Mountains,China

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Journal of Forestry Research 2019年第4期30卷 1417-1427页

作者： Wei Xue Changhui Peng huai chen Hui Wang Qiuan Zhu Yanzheng Yang Junjun Zhang Wanqin Yang Institute of Ecology and Forestry Sichuan Agricultural UniversityChengdu 611130People's Republic of China Laboratory for Ecological Forecasting and Global Change College of ForestryNorthwest A&F UniversityYangling 712100People's Republic of China Department of Biology Sciences Institute of Environment SciencesUniversity of Quebec at MontrealCase Postale 888&Succursale Centre-VilleMontreal H3C 3P&Canada chengdu Institute of Biology Chinese Academy of SciencesChengdu 610041People's Republic of China

To understand soil N2O fluxes from temperate forests in a climate-sensitive transitional zone,N2O emissions from three temperate forest types(Pinus tabulaeformis,PTT;Pinus armandii,PAT;and Quercus aliena ***,QAT)were monitored using the static closed-chamber method from June 2013 to May 2015 in the Huoditang Forest region of the Qinling Mountains,*** results showed that these three forest types acted as N2O sources,releasing a mean combined level of 1.35±0.56 kg N2O ha^-1 a^-1,ranging from0.98±0.37 kg N2O ha^-1 a^-1 in PAT to 1.67±0.41 kg N2O ha^-1 a^-1 in QAT.N2O emission fluctuated seasonally,with highest levels during the summer for all three forest types.N2O flux had a significantly positive correlation with soil temperature at a depth of 5 cm or in the water-filled pore space,where the correlation was stronger for temperature than for the water-filled pore space.N2O flux was positively correlated with available soil nitrogen in QAT and *** results indicate that N2O flux is mainly controlled by soil temperature in the temperate forest in the Qinling Mountains.

关键词： Forest types Greenhouse gases N2O fluxes Qinling Mountains Soil temperature

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Quadrupolar matter-wave soliton in two-dimensional free space

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Frontiers of physics 2015年第4期10卷 119-125页

作者： Jia-Sheng Huang Xun-Da Jiang huai-Yu chen Zhi-Wei Fan Wei Pang Yong-Yao Li Department of Applied Physics College of Electronic Engineering South China Agricultural University Guangzhou 510642 China Department of Experiment Teaching Guangdong University of Technology Guangzhou 510006 China

We study two-dimensional （2D） matter-wave solitons in the mean-field models formed by electric quadrupole particles with long-range quadrupoleluadrupole interaction （QQI） in 2D free space. The existence of 2D matter-wave solitons in the free space was predicted using the 2D Gross Pitaevskii Equation （GPE）. We find that the QQI solitoms have a higher mass （smaller size and higher intensity） and stronger anisotropy than the dipol^dipole interaction （DDI） solitons under the same environmental parameters. Anisotropic solitomsoliton interaction between two identical QQI solitons in 2D free space is studied. Moreover, stable anisotropic dipole solitons are observed, to our knowledge, for the first time in 2D free space under anisotropic nonlocal cubic nonlinearity.

关键词： 2D matter-wave solitons quadrupole-quadrupole interaction anisotropy soliton-soliton interaction dipole solitons

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Design,fabrication,and testing of an X-band 9-MeV standing-wave electron linear accelerator

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Nuclear Science and Techniques 2023年第7期34卷 219-230页

作者： Jian Gao Hao Zha Jia-Ru Shi Qiang Gao Xian-Cai Lin Fang-Jun Hu Qing-Zhu Li huai-Bi chen Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle and Radiation Imaging(Tsinghua University) Ministry of EducationBeijing 100084China

In this study,an X-band standing-wave biperiodic linear accelerator was developed for medical radiotherapy that can accel-erate electrons to 9 MeV using a 2.4-MW *** structure works atπ/2 mode and adopts magnetic coupling between cavities,generating the appropriate adjacent mode separation of 10 *** accelerator is less than 600-mm long and constitutes four bunching cells and 29 normal *** optimizations,full-scale radiofrequency(RF)simulations,and beam dynamics calculations were *** accelerator was fabricated and examined using a low-power RF *** cold test results showed a good agreement with the simulation and actual measurement *** the high-power RF test,the output beam current,energy spectrum,capture ratio,and spot size at the accelerator exit were *** the input power of 2.4 MW,the pulse current was 100 mA,and the output spot root-mean-square radius was approximately 0.5 *** output kinetic energy was 9.04 MeV with the spectral FWHM of 3.5%,demonstrating the good performance of this accelerator.

关键词： Standing-wave accelerating structure RF analysis Thermal DC gun Low-power RF test High-power experiment

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A non-invasive diagnostic method of cavity detuning based on a convolutional neural network

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Nuclear Science and Techniques 2022年第7期33卷 25-35页

作者： Liu-Yuan Zhou Hao Zha Jia-Ru Shi Jia-Qi Qiu Chuan-Jing Wang Yun-Sheng Han huai-Bi chen Department of Engineering Physics Tsinghua UniversityBeijing100084China Key Laboratory of Particle and Radiation Imaging Tsinghua UniversityBeijing100084China

As modern accelerator technologies advance toward more compact sizes,conventional invasive diagnostic methods of cavity detuning introduce negligible interference in measurements and run the risk of harming structural *** overcome these difficulties,this study developed a non-invasive diagnostic method using knowledge of scattering parameters with a convolutional neural network and the interior point *** construction and training of the neural network led to remarkable results on three typical acceleration structures:a 13-cell S-band standing-wave linac,a 12-cell X-band traveling-wave linac,and a 3-cell X-band RF *** trained networks significantly reduced the burden of the tuning process,freed researchers from tedious tuning tasks,and provided a new perspective for the tuning of side-coupling,semi-enclosed,and total-enclosed structures.

关键词： Cavity detuning Convolutional neural network Equivalent circuit

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Effect of Ni Interlayer on Cavitation Erosion Resistance of NiTi Cladding by Tungsten Inert Gas(TIG)Surfacing Process

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Acta Metallurgica Sinica(English Letters) 2020年第3期33卷 415-424页

作者： Zhen-Ping Shi Zheng-Bin Wang Ji-Qiang Wang Yan-Xin Qiao huai-Ning chen Tian-Ying Xiong Yu-Gui Zheng CAS Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

The NiTi cladding with/without Ni interlayer was prepared on stainless steel(SS) by tungsten inert gas(TIG) surfacing process,aiming at achieving good cavitation erosion *** ranking according to the cavitation erosion resistance is NiTi plate> NiTi-Ni-TIG cladding> NiTi-TIG cladding> *** better cavitation erosion resistance of NiTi-TIG and NiTi-Ni-TIG claddings than SS substrate is due to their higher micro-hardness and ***,the existence of Ni interlayer can decrease the amount of brittle intermetallic compounds,such as Fe2 Ti,and inhibit the crack generation,which results in the higher cavitation erosion resistance of NiTi-Ni-TIG compared with NiTi-TIG ***,the cavitation erosion resistance of NiTi cladding prepared by TIG surfacing process can be improved by employing Ni interlayer.

关键词： Cavitation erosion NiTi Cladding Tungsten inert gas surfacing process Ni interlayer

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Analytic RF design of a linear accelerator with a SLED-Ⅰ type RF pulse compressor

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Nuclear Science and Techniques 2020年第11期31卷 12-22页

作者： Jia-Yang Liu Jia-Ru Shi Hao Zha Alexej Grudiev Ping Wang Ying-Chao Du huai-Bi chen Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle and Radiation Imaging(Tsinghua University) Ministry of EducationBeijing 100084China European Organization for Nuclear Research(CERN) 1211 GenevaSwitzerland

This study presents the RF design of a linear accelerator(linac)operated in single-bunch *** accelerator is powered by a compressed RF pulse produced from a SLED-I type RF pulse *** compressed RF pulse has an unflattened shape with a gradient distribution which varies over the structure *** analytical study to optimize the accelerating structure together with the RF pulse compressor is *** optimization aims to maximize the efficiency by minimizing the required RF power from the generator for a given average accelerating *** study shows that,owing to the compressed RF pulse shape,the constant-impedance structure has a similar efficiency to the optimal structure using varying iris *** constant-impedance structure is easily fabricated and is favorable for the design of a linac with a pulse *** utilize these findings to optimize the RF design of a X-band linac using the constant-impedance accelerating structure for the Tsinghua Thomson X-ray source facility.

关键词： X-band linac High gradient structure RF pulse compressor Thomson X-ray source Single-bunch mode

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Optimization design of an interior permanent-magnet synchronous machine for a hybrid hydraulic excavator

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Frontiers of Information Technology & Electronic Engineering 2015年第11期16卷 957-968页

作者： Qi-huai chen Qing-feng WANG Tao WANG State Key Laboratory of Fluid Power Transmission and Control Zhejiang University College of Mechanical and Vehicle Engineering Hunan University

A hybrid power transmission system （HPTS） is a promising way to save energy in a hydraulic excavator and the electric machine is one of the key components of the system. In this paper, a design process for permanent-magnet synchronous machines （PMSMs） in a hybrid hydraulic excavator （HHE） is presented based on the analysis of the working conditions and requirements of an HHE. A parameterized design approach, which combines the analytical model and the 2D finite element method （FEM）, is applied to the electric machine to improve the design efficiency and accuracy. The analytical model is employed to optimize the electric machine efficiency and obtain the statordimension and flux density distribution. The rotor is designed with the FEM to satisfy the flux requirements obtained in stator design. The rotor configuration of the PMSM employs an interior magnet structure, thus resulting in some inverse saliency, which allows for much higher values in magnetic flux density. To reduce the rotor leakage, a disconnected type silicon steel block structure is adopted. To improve the air gap flux density distribution, the trapezoid permanent magnet （PM） and centrifugal rotor structure are applied to PMSM. Demagnetization and armature reactions are also taken into consideration and calculated by the FEM. A prototype of the newly designed electric machine has been fabri- cated and tested on the experimental platform. The analytical design results are validated by measurements.

关键词： Analysis Design Hybrid hydraulic excavator (HHE) Finite element method (FEM) Interior permanent-magnet(PM) motor PM synchronous machine (PMSM)

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Serum Levels of Interleukin-1 Beta, Interleukin-6 and Melatonin over Summer and Winter in Kidney Deficiency Syndrome in Bizheng Rats

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Chinese Medical Sciences Journal 2014年第2期29卷 107-111页

作者： Miao Zhang Tong Wang huai-min chen Yan-qin chen Yang-chun Deng Ya-tian Li School of Basic Medical Sciences Beijing University of Chinese Medicine

Objective To observe the seasonal changes in serum levels of interleukin-1 beta(IL-1β), interleukin-6(IL-6) and melatonin(MT) in Bizheng rat model, and explore the relationship between MT and the pathogenesis of rheumatoid arthritis. Methods One hundred and sixty Sprague-Dawley rats were randomly divided into four groups in summer(n=80) and winter(n=80) respectively: normal group, collagen-induced arthritis(CIA) model group, operation group, and sham-operation group(n=20 in each group). The CIA model group was injected with collagen emulsion at the base of the tail to induce arthritis. The rats in the operation group received pineal gland resection, and 7 days after the first operation, underwent testectomy or oophorectomy. The rats in the sham-operation group were operated to ligature the sagittal sinus, without extracting the pineal gland. After the operations, the operation group and the sham-operation group both were immunized as the CIA group was. The serum levels of IL-1β, IL-6 and MT in different groups were measured by radioimmunoassay. Results Compared with the normal group, the serum levels of IL-1β and IL-6 increased in the CIA model, operation, and sham-operation groups both in summer and in winter(IL-1β in summer, P=0.008, P<0.01, P=0.012; IL-1β in winter, P=0.019, P<0.01, P=0.027; IL-6 in summer, P=0.028, P<0.01, P=0.024; IL-6 in winter, P=0.006, P<0.01, P=0.008). In the operation group, the serum levels of IL-1β and IL-6 in winter were higher than in summer, but with no statistically significant differences(P=0.844, 0.679). Compared with the normal group, the serum level of MT significantly increased in summer and winter in both the CIA model group(P=0.002, 0.008) and the sham-operation group(P=0.003, 0.007), while significantly decreased in the operation group(P=0.023, 0.003). There was no significant difference in MT level in the operation group between summer and winter(P=0.947). Conclusions The increase of serum levels of IL-1β and IL-6 may exacer

关键词： correspondence between human and nature kidney corresponding with winter kidney deficiency syndrome in Bizheng cytokines melatonin

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Laser-RF synchronization based on digital phase detector

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Nuclear Science and Techniques 2017年第4期28卷 97-102页

作者： Jin Yang Ying-Chao Du Li-Xin Yan Gang Huang Qiang Du Yi-Lun Xu Wen-Hui Huang huai-Bi chen Department of Engineering Physics Tsinghua UniversityBeijing 100084 China Key Laboratory of Particle and Radiation Imaging (Tsinghua University) Ministry of Education Beijing 100084 China Lawrence Berkeley National Laboratory BerkeleyCA 94720 USA

Laser oscillator synchronization with RF reference signal is ultra-important for a modern light source based on the *** Tsinghua Thomson scattering X-ray source,we have synchronized the mode-locked laser oscillator to RF reference signal with 48.2 fs RMS relative *** fundamental and harmonic signals derived from photo diode detection are used for laser-RF synchronization in our *** fundamental signal is for coarse laser-RF synchronization and multiple laser oscillator *** harmonic signal is for high precise phase *** digital phase detector is implemented in the synchronization scheme for less noise,replacing the mixing to DC phase detection *** digital processing algorithm for synchronization is commonly used in low-level RF control *** order to test the phase locking loop logic without damaging the real laser oscillator,a laser oscillator emulator was developed for phase *** paper will report the laser-RF synchronization scheme and its *** laser oscillator emulator system will also be introduced here.

关键词： Laser oscillator Synchronization RF LLRF Emulator

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