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Significance of monitoring imatinib plasma concentration in secondline treatment decisions for c-kit 11 gene-mutated gastrointestinal stromal tumors

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 81-90页

作者： Hai-Tao Li yun-yun Du Zhen huang Jin-Jin Li Jun Zhang Department of Gastrointestinal Surgery Nanchuan Hospital of Chongqing Medical UniversityChongqing 408400China Department of Oncology Nanchuan Hospital of Chongqing Medical UniversityChongqing 408400China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND For patients with advanced gastrointestinal stromal tumors(GISTs)carrying the ckit exon 11 mutation,imatinib(IM)at a standard dosage of 400 mg per day is the preferred first-line *** cases where treatment with IM fails,there is an urgent need for a more precise assessment method to determine whether to switch therapies or escalate the IM *** approach will enhance clinical decision-making and optimize patient *** To investigate IM plasma concentration’s role in second-line treatment decisions for c-kit 11-mutated advanced GISTs post-IM *** Patients with advanced GIST harboring c-kit 11 mutation who experienced failure with IM 400 mg per day as first-line treatment at our hospital were retrospectively *** were categorized into a low plasma(LP)concentration group(LP group,0.05).For the HP group(n=47),Group B(n=18)had a higher DCR and longer PFS than Group A(n=29)(P=0.008 and P=0.03,respectively).No difference in OS was observed between the two subgroups(P>0.05).CONCLUSION Increasing IM dosage for c-kit 11-mutated advanced GISTs post-IM failure may prolong OS if plasma concentration is<1100 ng/*** tyrosine kinase inhibitors may improve DCR and PFS if≥1100 ng/mL.

关键词： Gastrointestinal stromal tumor C-kit exon 11 Imatinib Plasma concentration Second-line treatment

Optimized reinforcement of granite residual soil using a cement and alkaline solution: A coupling effect

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Journal of Rock Mechanics and Geotechnical Engineering 2025年第1期17卷 509-523页

作者： Bingxiang Yuan Jingkang Liang Baifa Zhang Weijie Chen Xianlun huang Qingyu huang yun Li Peng Yuan School of Civil and Transportation Engineering Guangdong University of TechnologyGuangzhou510006China School of Environmental Science and Engineering Guangdong University of TechnologyGuangzhou510006China Shenzhen Key Laboratory of Natural Gas Hydrates Academy for Advanced Interdisciplinary StudiesSouthern University of Science and TechnologyShenzhen518055China

Granite residual soil (GRS) is a type of weathering soil that can decompose upon contact with water, potentially causing geological hazards. In this study, cement, an alkaline solution, and glass fiber were used to reinforce GRS. The effects of cement content and SiO_(2)/Na2O ratio of the alkaline solution on the static and dynamic strengths of GRS were discussed. Microscopically, the reinforcement mechanism and coupling effect were examined using X-ray diffraction (XRD), micro-computed tomography (micro-CT), and scanning electron microscopy (SEM). The results indicated that the addition of 2% cement and an alkaline solution with an SiO_(2)/Na2O ratio of 0.5 led to the densest matrix, lowest porosity, and highest static compressive strength, which was 4994 kPa with a dynamic impact resistance of 75.4 kN after adding glass fiber. The compressive strength and dynamic impact resistance were a result of the coupling effect of cement hydration, a pozzolanic reaction of clay minerals in the GRS, and the alkali activation of clay minerals. Excessive cement addition or an excessively high SiO_(2)/Na2O ratio in the alkaline solution can have negative effects, such as the destruction of C-(A)-S-H gels by the alkaline solution and hindering the production of N-A-S-H gels. This can result in damage to the matrix of reinforced GRS, leading to a decrease in both static and dynamic strengths. This study suggests that further research is required to gain a more precise understanding of the effects of this mixture in terms of reducing our carbon footprint and optimizing its properties. The findings indicate that cement and alkaline solution are appropriate for GRS and that the reinforced GRS can be used for high-strength foundation and embankment construction. The study provides an analysis of strategies for mitigating and managing GRS slope failures, as well as enhancing roadbed performance.

关键词： Granite residue soil(GRS) Reinforcement Coupling effect Alkali activation Mechanical properties

耐重金属细菌对土壤胶体及矿物体系吸附镉的影响

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湖北农业科学 2010年第4期49卷 855-858页

作者：谢朝阳黄巧云黄敏武汉生物工程学院环境工程系武汉430415 华中农业大学资源与环境学院武汉430070 武汉理工大学资源与环境工程学院武汉430063

以从大冶铜矿区土壤筛选的耐重金属细菌NTG-01为试验菌株,研究在不同pH值及不同菌量条件下该细菌对土壤胶体和粘土矿物体系吸附Cd2+的影响。结果表明,土壤胶体、矿物与细菌的共存体系对Cd2+的吸附仍符合Langmuir方程,相关系数为0.99以... 详细信息

以从大冶铜矿区土壤筛选的耐重金属细菌NTG-01为试验菌株,研究在不同pH值及不同菌量条件下该细菌对土壤胶体和粘土矿物体系吸附Cd2+的影响。结果表明,土壤胶体、矿物与细菌的共存体系对Cd2+的吸附仍符合Langmuir方程,相关系数为0.99以上。在细菌NTG-01的存在下,土壤胶体、矿物对Cd2+的吸附量较无菌时增加,且在一定菌量范围内,随着体系中细菌量的增加,体系对镉的吸附量增加。红壤胶体、褐土胶体和针铁矿体系对Cd2+的pH—吸附率曲线与无菌时相比整体左移。

关键词：细菌土壤胶体矿物镉吸附

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一种监督型的连续属性离散化算法的研究

三明学院学报 2015年第4期32卷 60-64,82页

作者：黄巧云福州大学至诚学院计算机工程系福建福州350002

提出一种监督型的连续属性离散化算法,利用云模型实现对属性区域的划分,以此引入边界的模糊性;再利用属性对类别的决定作用,判断是否对云模型进行归并操作,从而选择出合适的云模型集合,以实现离散化的目的。实验结果表明,该算法具有较... 详细信息

提出一种监督型的连续属性离散化算法,利用云模型实现对属性区域的划分,以此引入边界的模糊性;再利用属性对类别的决定作用,判断是否对云模型进行归并操作,从而选择出合适的云模型集合,以实现离散化的目的。实验结果表明,该算法具有较少的离散化区间数以及较高的分类精度。

关键词：云模型信息熵离散化

Understanding and probing progression of localized corrosion on inner walls of steel pipelines:an overview

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Journal of Iron and Steel Research International 2025年第1期32卷 1-18页

作者： Ming-yu Wang Hai-yuan Yao Yong-fei Liu Ye-sen Zhu Wan-bin Chen yun-ze Xu Yi huang School of Naval Architecture and Ocean Engineering Dalian University of TechnologyDalian 116024LiaoningChina China National Offshore Oil Corporation Research Institute Co. Ltd.Beijing 100028China State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of TechnologyDalian 116024LiaoningChina

Corrosion poses a major threat to the safety of transportation ***,it is crucial to have an in-depth understanding of corrosion mechanisms in pipeline steels for the effective management of pipeline *** research on corrosion mechanisms relies on the use of efficient and reliable corrosion monitoring and analysis *** advancements in corrosion monitoring techniques specifically designed for the localized corrosion monitoring were aimed to be introduced,and a comprehensive overview of recent progress in understanding the localized corrosion mechanisms in pipeline steels was *** on the different corrosive environments encountered,the localized corrosion issues inside pipelines are classified into two categories:localized corrosion primarily influenced by electrochemical processes and localized corrosion controlled by both electrochemical and mechanical ***,a thorough analysis of the synergistic effects between micro-cell and macro-cell currents,as well as the interplay of mechanics and electrochemistry is ***,recommendations for future research on the mechanisms of internal localized corrosion in pipelines are provided.

关键词： Pipeline steel Localized corrosion Corrosion type Corrosion monitoring Corrosion mechanism

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医院报表信息公开对药品费用的影响研究

中国卫生资源 2017年第6期20卷 455-459页

作者：何运臻应晓华黄巧云复旦大学公共卫生学院上海200032

目的 :通过实证分析,研究福建省三明市医院报表信息公开对门诊及住院药费的影响,并探讨其原因。方法 :三明于2013出台政策以控制药费,其效果在2014年趋于平稳,而后三明开始推出医院报表信息公开。研究基于"健康三明"信息平台所公示的25... 详细信息

目的 :通过实证分析,研究福建省三明市医院报表信息公开对门诊及住院药费的影响,并探讨其原因。方法 :三明于2013出台政策以控制药费,其效果在2014年趋于平稳,而后三明开始推出医院报表信息公开。研究基于"健康三明"信息平台所公示的25家医院报表数据,构建分段时间序列模型,评估信息公开对药品费用的影响。结果 :医院报表信息公开之前,医院门诊次均药费和住院人均药费呈现上升趋势。报表公开后,短期内门诊与住院次均药费绝对值无显著变化。长期来看,次均药费上涨趋势得到控制,且这种影响在不同医院间各不相同。结论 :医院报表信息公开短期内不会影响医院门急诊次均药费和住院人均药费,但长期来看能控制药费上涨速度。

关键词：信息公开医院信息医疗费用三明医改

草木灰污泥联合施用对Cd污染土壤中Cd形态变化的影响

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华中农业大学学报 2010年第4期29卷 447-451页

作者：朱雅兰李明黄巧云湖北省黄石理工学院环境科学与工程学院黄石435003 华中农业大学农业部亚热带农业资源与环境重点实验室武汉430070

利用盆栽小白菜试验研究了施入草木灰、污泥和草木灰污泥混合物对镉污染土壤中Cd形态的影响。结果表明:草木灰、污泥和草木灰污泥混合物的施用导致了土壤中Cd的重新分配;土壤中生物有效性较高的有效态Cd含量明显降低,并转化为不易被植... 详细信息

利用盆栽小白菜试验研究了施入草木灰、污泥和草木灰污泥混合物对镉污染土壤中Cd形态的影响。结果表明:草木灰、污泥和草木灰污泥混合物的施用导致了土壤中Cd的重新分配;土壤中生物有效性较高的有效态Cd含量明显降低,并转化为不易被植物吸收的惰性态Cd。土壤水溶态和交换态Cd含量较对照最大降低56.60%～68.38%;有机结合态Cd含量显著升高,最大升幅较对照升高166.7%～281.1%;无机结合态Cd最大升幅达72.60%～73.20%,残渣态Cd含量较对照升高,最大升幅为37.93%～112.50%。因此,可以通过施入草木灰、污泥、草木灰污泥混合物来修复Cd污染土壤。

关键词：草木灰污泥 Cd形态

细菌表面展示技术及其在环境重金属污染修复中的意义

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生态与农村环境学报 2006年第4期22卷 74-79页

作者：路延笃黄巧云陈雯莉李林华中农业大学农业微生物学国家重点实验室湖北武汉430070

从细菌表面展示系统构成、载体蛋白的选择和细菌表面展示策略等方面综述了细菌表面展示技术及其发展,分析了它们的优缺点,指出了细菌表面展示技术用于重金属污染修复存在的问题,提出了解决问题的思路和方法。

关键词：细菌表面展示重金属修复金属螯合肽吸附

英语专业低年级学生学习自主性的思考——基于自主性培训教学实验的发现

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海外英语 2010年第5X期 19-23页

作者：黄巧云湛江师范学院英语系广东湛江524048

如何培养英语专业低年级学生的学习自主性?在培训中他们遇到的主要问题是什么?作者在"基础英语"课程中对低年级学生进行了为期两年的课内和课外相结合的学习策略培训的实验。主要通过学生的学习汇报,以及课堂观察、访谈,获取第一手资料... 详细信息

如何培养英语专业低年级学生的学习自主性?在培训中他们遇到的主要问题是什么?作者在"基础英语"课程中对低年级学生进行了为期两年的课内和课外相结合的学习策略培训的实验。主要通过学生的学习汇报,以及课堂观察、访谈,获取第一手资料,从而发现培训过程中他们所遇到的问题。从学生的角度深入分析问题的原因,并提出应对的教学策略。

关键词：自主性低年级学生学习策略策略培训