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Efficacy and safety of Nafamostat mesylate in patients with endstage renal failure

World Journal of Clinical Cases 2024年第1期12卷 68-75页

作者： Kun liu zhen-hua li Department of Critical Care Medicine The Third People's Hospital Of Hubei ProvinceWuhan 430030Hubei ProvinceChina Department of Critical Care Medicine General Hospital of The Yangtze River ShippingWuhan Brain HospitalWuhan 430015Hubei ProvinceChina

BACKGROUND Recent studies on dialysis anticoagulation therapy in patients with renal failure have shown that Nafamostat mesylate,a broad-spectrum potent serine protease inhibitor,has strong anticoagulation and anti-fiber *** To evaluate the efficacy and safety of Nafamostat mesylate in patients with end-stage renal *** Seventy-five patients with end-stage renal failure who received hemodialysis at our hospital between January 2020 and August 2021 were selected and divided into the observation group(Nafamostat mesylate for injection,n=33)and control group(heparin sodium injection,n=32).General patient data,indicators of clinical efficacy,dialyzer hemocoagulation parameters,coagulation function indices,and hemoglobin concentration and platelet count before and after treatment,and the occurrence of adverse reactions after treatment were compared between the two *** The two groups showed no significant differences in general patient data(P>0.05).The post-treatment effectiveness rate in the control group was lower than that in the observation group(P0.05),while the number of patients in grade 0 was lower in the control group,and the number of patients in grades II and III was higher in the control group(Plized ratio values in the control group were higher than those in the observation group,while the fibrinogen level in the control group was lower than that in the observation group(P0.05).The total number of post-treatment adverse reactions in the observation group was lower than that in the control group(P<0.05).CONCLUSION Treatment of patients showing end-stage renal failure with Nafamostat mesylate can s

关键词： End-stage renal failure Nafamostat mesylate Effectiveness Safety study Chronic kidney diseases

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Microstructural evolution and mechanical properties of aging high nitrogen austenitic stainless steels

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International Journal of Minerals,Metallurgy and Materials 2010年第6期17卷 729-736页

作者： Zhou-hua Jiang Zu-rui Zhang hua-bing li zhen li Qi-feng Ma School of Materials and Metallurgy Northeastern University Shenyang 110819 China

The microstructural evolution of 18Crl 8Mn2Mo0.77N high nitrogen austenitic stainless steel in aging treatment was investigated by optical microscopy （OM）, scanning electron microscopy （SEM）, and transmission electron microscopy （TEM）. The results show that hexagonal intergranular and cellular Cr2N with a=0.478 nm and c=0.444 nm and body-centered cubic intermetaUic X phase with a=0.892 nm precipitate gradually in the isothermal aging treatment. The matrix nitrogen depletion due to the intergranular Cr2N precipitation induces the decay of Vickers hardness, and the formation of cellular Cr2N and X phase causes the increase in the values. The impact toughness presents a monotonic decrease and SEM morphologies show the leading brittle intergranular fracture. The tensile strength and elongation deteriorate obviously except for the sample aged for 1 h in yield strength. Stress concentration occurs when the matrix dislocations pile up at the pre- cipitation and matrix interfaces, and the interracial dislocations may become precursors to the misfit dislocations, which can form small cleavage steps and accelerate the formation of cracks.

关键词： microstructural evolution aging mechanical properties austenitic stainless steel secondary phase

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Zero-energy modes in serially coupled double quantum dots

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Chinese Physics B 2020年第6期29卷 441-445页

作者： Fu-li Sun zhen-hua li Jian-hua Wei Department of Physics&Beijing Key Laboratory of Optoelectronic Functional Materials and Micro-nano Devices Renmin University of ChinaBeijing 100872China School of Physical Science and Technology&Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education Lanzhou UniversityLanzhou 730000China

We investigate symmetrically coupled double quantum dots via the hierarchical equations of motion method and propose a novel zero-energy mode(ZEM) at a temperature above the spin singlet–triplet transition temperature. Owing to the resonance of electron quasi-particle and hole quasi-particle, ZEM has a peak at ω = 0 in the spectral density *** further examine the effect of the magnetic field on the ZEM, where an entanglement of spin and charge has been determined;therefore, the magnetic field can split the ZEM in the spectra.

关键词： zero-energy mode quantum dot temperature

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Solid-liquid Metastable Equilibria in Quaternary System li_2SO_4+li_2CO_3+li_2B_4O_7+H_2O at 288 K

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Chemical Research in Chinese Universities 2009年第5期25卷 740-743页

作者： SANG Shi-hua ZHANG zhen-lei li Ming College of Materials and Chemistry ＆ Chemical Engineering Chengdu University of Technology Chengdu 610059 P. R. China

Metastable equilibrium solubilities and densities of quaternary system li2SO4＋li2CO3＋ li2B4O7＋H2O at 288 K were determined by isothermal evaporation method. According to the experimental data, the metastable equilibrium phase diagram was plotted. The metastable phase diagram had one invariant point F, three double saturated liquid curves ElF, E2F and E3F, and three crystallization fields corresponding to li2SO4·H2O, li2CO3 and liBO2·8H2O. It was found that lithium sulphate（li2SO4） had the highest concentration and strong salting-out effects on the other salts. There were no solid solutions or double salts formed in the quaternary system at 288 K.

关键词： Metastable equilibrium lithium Quaternary system

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Self-assembly of metalla[3]catenanes, Borromean rings and ring-in-ring complexes using a simple π-donor unit

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National Science Review 2020年第10期7卷 1548-1556页

作者： Ye Lu Dong liu Yue-Jian lin zhen-hua li Guo-Xin Jin State Key Laboratory of Molecular Engineering of Polymers Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsDepartment of Chemistry Fudan University

Despite extensive research and several stunning breakthroughs in the synthesis of interlocked molecular species, [3]catenanes, Borromean rings and ring-in-ring complexes are exceedingly rare and their targeted synthesis remains a formidable challenge. Herein, a series of Cp*Rh-based homogeneous and heterogeneous interlocked structures have been prepared by coordination-driven self-assembly, not only including metalla[2]catenanes and molecular Borromean rings, but also linear metalla[3]catenanes and ring-in-ring complexes. The interlocked structures are all based on bithiophenyl groups. The bithiophenyl groups effectively enhance the strength of the inter-ring interactions and play a crucial role in the formation of these interlocked structures. By taking advantage of the strong interaction between π-donor(D) andπ-acceptor(A) groups, the electron-deficient methylviologen cation was introduced into a cationic metallarectangle based on bithiophenyl groups. Taking inspiration from these results, a cationic metallarectangle based on A units was threaded into a metallarectangle based on D units, leading to a heterogeneous D–A ring-in-ring structure.

关键词： coordination-driven self-assembly supramolecular chemistry interlocked structure metallacatenanes molecular Borromean rings ring-in-ring complex

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Influence of Oxide Morphologies on Galvanizability of Third Generation Automotive Steel

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Journal of Iron and Steel Research International 2014年第11期21卷 1059-1064页

作者： She-ming JIANG Shi-jie FENG Xun-hua YUAN Yuan-peng li zhen-hua li Qi-fu ZHANG National Engineering Laboratory of Advanced Coating Technology for Metal Materials Central Iron and Steel Research Institute Faculty of Material Science and Engineering Kunming University of Science and Technology

Focusing on improving the galvanizability of the third generation automotive steel, the effect of surface ox ide morphologies on the galvanizability was studied. The results show that the surface oxide types of sample steels by X ray photoelectron spectroscopy （XPS） analysis after annealing in different conditions are the same. Only MnO, MnO2 and Cr2O3 were detected and no complex oxide exists on the surface. Morphologies of surface oxides can greatly influence the galvanizability of the third generation automotive steel. Nodule-like oxide surface can contribute to better wettability and inhibition layer than vitreous film like oxide surface. Galvanized panels of nodule-like oxide surface steels only show pinhole sized bare spots, while panels galvanized from vitreous film-like oxide surface steels reveal larger areas of bare spots and uncoated areas. Inhibition layer observed in galvanized panels of nodule-like oxide surface steels is compact but not homogeneous; some inhibition layer grains are fine, and others are coarse, while the inhibition layer grains of panels galvanized from vitreous film-like oxide surface steels have a non-compact morphology with some particularly fine equiaxed crystals which developed deficiently.

关键词： galvanizing third generation automotive steel oxide morphology galvanizability

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Recent advances in CRISPR-based genome editing technology and its applications in cardiovascular research

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Military Medical Research 2023年第6期10卷 862-880页

作者： zhen-hua li Jun Wang Jing-Ping Xu Jian Wang Xiao Yang State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein SciencesBeijing Institute of LifeomicsBeijing 100071China Yaneng BIOScience(Shenzhen)Co. Ltd.Shenzhen 518102GuangdongChina

The rapid development of genome editing technology has brought major breakthroughs in the fields of life science and medicine. In recent years, the clustered regularly interspaced short palindromic repeats(CRISPR)-based genome editing toolbox has been greatly expanded, not only with emerging CRISPR-associated protein(Cas) nucleases, but also novel applications through combination with diverse effectors. Recently, transposon-associated programmable RNA-guided genome editing systems have been uncovered, adding myriads of potential new tools to the genome editing toolbox. CRISPR-based genome editing technology has also revolutionized cardiovascular research. Here we first summarize the advances involving newly identified Cas orthologs, engineered variants and novel genome editing systems, and then discuss the applications of the CRISPR-Cas systems in precise genome editing, such as base editing and prime editing. We also highlight recent progress in cardiovascular research using CRISPR-based genome editing technologies, including the generation of genetically modified in vitro and animal models of cardiovascular diseases(CVD) as well as the applications in treating different types of CVD. Finally, the current limitations and future prospects of genome editing technologies are discussed.

关键词： Genome editing CRISPR-Cas system Base editing Prime editing Transposon-associated genome editing Cardiovascular disease Heart Blood vessel Gene therapy

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Effect of Short Chain Alcohols upon Viscosity of TTAB Solution

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Chinese Journal of Chemical Physics 2008年第2期21卷 169-173页

作者： Yun-fei Yan hua-zhen li Hai-yang Yang Jia-sheng Qian Ping-ping Zhu Ping-sheng He Department of Polymer Science and Engineering University of Science and Technology of China Hefei 230026 China

The effect of ethanol （C2H5OH）, propanol （C3H7OH）, and butanol （C4H9OH） upon the viscosity of tetradecyltrimethylammonium bromide （TTAB） solution in the presence or absence of KBr at 30℃was investigated, where the surfactant concentration CS is kept constant. In the absence of KBr, the relative viscosity ηr of TTAB solution increases linearly with the alcohol concentration CA, indicating that the alcohols do not promote micelle formation of TTAB. In the presence of KBr, ηr linearly decreases with CA for C2H5OH, but it exhibits a maximum with increasing CA for C3H7OH or C4H9OH. The facts reveal that C2H5OH or C4H9OH promotes the micelle formation of TTAB. A possible explanation is that the hydrophobicity of the mieellar interior is enhanced by KBr, so that C2H5OH or C4H9OH can dissolve in micelle and promotes micelle formation. In the presence of KCl, which is less efficient in promoting the micelle formation of cationic surfactant, both C3H7OH and C4H9OH have only a slight effect on the micelle formation. In contrast, due to the hydrophilicity, C2H5OH cannot dissolve in micelles in the presence of KBr or KCl.

关键词： Relative viscosity Cationic surfactant Organic additive Hydrophobic interaction

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Chahine algorithm to invert light scattering spectroscopy of epithelial dysplasia

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Optoelectronics Letters 2007年第5期3卷 397-400页

作者： WANG Qing-hua li zhen-hua LAI Jian-cheng HE An-zhi Department of Information Physics and Engineering Nanjing University of Science and Technology Nanjing 210094China

To perceive the epithelial dysplasia from the light scattering spectroscopy (LSS) is an inverse problem, which can be transformed into the inversion of the size distribution of epithelial-cell nuclei. Based on the simulation of single polarized LSS for epithelial-cell nuclei, Chahine algorithm is adopted to retrieve the size distribution. Numerical results show that Chahine algorithm has high inversion precision for both single-peaked and bimodal models, which implies the potential to increase diagnostic resolution of LSS.

关键词：激光技术医疗应用光散射上皮发育异常

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Modified insulin-like growth factor 1 containing collagen-binding domain for nerve regeneration

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Neural Regeneration Research 2018年第2期13卷 298-303页

作者： Jian-an li Chang-fu Zhao Shao-jun li Jun Zhang zhen-hua li Qiao Zhang Xiao-yu Yang Chun-fang Zan Department of Orthopedics Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Orthopedics China-lapan Union Hospitallilin UniversityChangchunlilin ProvinceChina Department of Orthopedics Affiliated Hospital of Changchun University of Traditional Chinese MedicineChangchunlilin ProvinceChina

Insulin-like growth factor 1 （IGF-I） is a potential nutrient for nerve repair. However, it is impractical as a therapy because of its limited half- life, rapid clearance, and limited target specificity. To achieve targeted and long-lasting treatment, we investigated the addition of a binding structure by fusing a collagen-binding domain to IGF- 1. After confirming its affinity for collagen, the biological activity of this construct was examined by measuring cell proliferation after transfection into PC12 and Schwann cells using a 3-（4,5-dimethyl-2-thiazolyl）-2,5-di- phenyl-2-H-tetrazolium bromide assay. Immunofluorescence staining was conducted to detect neurofilament and microtubule-associated protein 2 expression, while real time-polymerase chain reaction was utilized to determine IGF-1 receptor and nerve growth/actor mRNA expression. Our results demonstrate a significant increase in collagen-binding activity of the recombinant protein compared with IGF-1. Moreover, the recombinant protein promoted proliferation of PC12 and Schwann cells, and increased the expression of neurofilament and microtubule-associated protein 2. Importantly, the recombinant protein also stimulated sustained expression of IGF-1 receptor and nerve growth factor mRNA for days. These results show that the recombinant protein achieved the goal of targeting and long-lasting treatment, and thus could become a clinically used factor for promoting nerve regeneration with a prolonged therapeutic effect.

关键词： nerve regeneration insulin-like growth factor I collagen-binding domain fusion protein collagenase targeted therapy neural regeneration

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