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Electroacupuncture activates AMPKa1 to improve learning and memory in the APP/PS1 mouse model of early Alzheimer's disease by regulating hippocampal mitochondrial dynamics

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Journal of Integrative Medicine 2024年第5期22卷 588-599页

作者： wei-wei Jia hua-wei lin Min-guang Yang Ya-ling Dai Yan-yi Ding Wen-shan Xu Si-nuo Wang Ya-jun Cao Sheng-xiang Liang Zhi-fu Wang Cong Chen wei-lin Liu College of Rehabilitation Medicine Fujian University of Traditional Chinese Medicine The Institute of Rehabilitation Industry Fujian University of Traditional Chinese Medicine National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology Fujian University of Traditional Chinese Medicine Traditional Chinese Medicine Rehabilitation Research Center of State Administration of Traditional Chinese Medicine Fujian University of Traditional Chinese Medicine

Objective: Studies have shown that electroacupuncture(EA) can alleviate cognitive impairments from Alzheimer's disease(AD) by regulating the expression of adenosine monophosphate-activated protein kinase(AMPK), but the specific mechanism involved remains to be elucidated. Therefore, this study explores the potential mechanism by which EA improves cognitive function from the perspective of mitochondrial ***: The four-month-old transgenic mice with amyloid precursor protein(APP)/presenilin 1(PS1)and AMPKa1-subunit conditional knockout(AMPKa1-cKO) were used for experiments. To evaluate the effects of EA treatment on cognitive function, the T-maze and Morris water maze were used. In addition,chemical exchange saturation transfer, thioflavin staining, transmission electron microscopy, mitochondrial membrane potential, and Western blotting were used to examine the potential mechanisms underlying the effects of EA on APP/PS1 ***: Both APP/PS1 mice and AMPKa1-cKO mice exhibited dysfunction in mitochondrial dynamics accompanied by learning and memory impairment. Inactivation of the AMPK/peroxisome proliferatoractivated receptor-γ coactivator-1a(PGC-1a) pathway increased pathological amyloid-β(Aβ) deposition and aggravated the dysfunction in mitochondrial dynamics. In addition, EA rescued learning and memory deficits in APP/PS1 mice by activating the AMPK/PGC-1a pathway, specifically by reducing pathological Aβ deposition, normalizing energy metabolism, protecting the structure and function of mitochondria,increasing the levels of mitochondrial fusion proteins, and downregulating the expression of fission proteins. However, the therapeutic effect of EA on cognition in APP/PS1 mice was hindered by ***: The regulation of hippocampal mitochondrial dynamics and reduction in Aβ deposition via the AMPK/PGC-1a pathway are critical for the ability of EA to ameliorate cognitive impairment in APP/PS1 mice.

关键词： Adenosine monophosphate-activated protein kinase Alzheimer’s disease Cognitive impairment Electroacupuncture Hippocampus Mitochondrial dynamics

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AN ANT COLONY ALGORITHM FOR YARD TRUCK SCHEDUlinG AND YARD LOCATION ASSIGNMENT PROBLEMS WITH PRECEDENCE CONSTRAINTS

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Journal of Systems Science and Systems Engineering 2013年第1期22卷 21-37页

作者： Zhaojie XUE Canrong ZHANG Lixin MIAO wei-hua lin Research Center of Modern Logistics Tsinghua Campusthe University Town Systems and Industrial Engineering Department University of Arizona

This paper examines the yard truck scheduling,the yard location assignment for discharging containers,and the quay crane scheduling in container *** into account the practical situation,we paid special attention to the loading and discharging precedence relationships between containers in the quay crane operations.A Mixed Integer Program（MIP） model is constructed,and a two-stage heuristic algorithm is *** the first stage an Ant Colony Optimization（ACO） algorithm is employed to generate the yard location assignment for discharging *** the second stage,the integration of the yard truck scheduling and the quay crane scheduling is a flexible job shop problem,and an efficient greedy algorithm and a local search algorithm are proposed. Extensive numerical experiments are conducted to test the performance of the proposed algorithms.

关键词： Container terminal yard truck scheduling yard location assignment quay crane scheduling precedence constraints ant colony optimization

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Emerging blood exosome-based biomarkers for preclinical and clinical Alzheimer's disease:a meta-analysis and systematic review

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Neural Regeneration Research 2022年第11期17卷 2381-2390页

作者： wei-lin Liu hua-wei lin Miao-Ran lin Yan Yu huan-huan Liu Ya-ling Dai Le-Wen Chen wei-wei Jia Xiao-Jun He Xiao-ling Li Jing-Fang Zhu Xie-hua Xue Jing Tao Li-Dian Chen Academy of Rehabilitation Industry Fujian University of Traditional Chinese MedicineFuzhouFujian ProvinceChina Department of Biochemistry and Molecular Biology University of Oklahoma Health Sciences CenterOklahoma CityOKUSA National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology Fujian University of Traditional Chinese MedicineFuzhouFujian ProvinceChina Affiliated Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine FuzhouFujian ProvinceChina

Blood exosomes,which are extracellular vesicles secreted by living cells into the circulating blood,are regarded as a relatively noninvasive novel tool for monitoring brain physiology and disease *** increasing number of blood cargo-loaded exosomes are emerging as potential biomarkers for preclinical and clinical Alzheimer's *** re,we conducted a meta-analysis and systematic review of molecular biomarkers derived from blood exosomes to comprehensively analyze their diagnostic performance in preclinical Alzheimer's disease,mild cognitive impairment,and Alzheimer's *** performed a literature search in PubMed,Web of Science,Embase,and Cochrane Library from their inception to August 15,*** research subjects mainly included Alzheimer's disease,mild cognitive impairment,and preclinical Alzheimer's *** identified 34 observational studies,of which 15 were included in the quantitative analysis(Newcastle-Ottawa Scale score 5.87 points)and 19 were used in the qualitative *** meta-analysis results showed that core biomarkers including Aβ_(1-42),P-T181-tau,P-S396-tau,and T-tau were increased in blood neuro nderived exosomes of preclinical Alzheimer's disease,mild cognitive impairment,and Alzheimer's disease patients.M olecules related to additional risk facto rs that are involved in neuroinflammation(C1q),metabolism disorder(P-S312-IRS-1),neurotrophic deficiency(HGF),vascular injury(VEGF-D),and autophagy-lysosomal system dysfunction(cathepsin D)were also *** the gene level,the differential expression of transc ription-related factors(REST)and microRNAs(miR-132)also affects RNA splicing,transport,and *** pathological changes contribute to neural loss and synaptic *** data confirm that the above-mentioned core molecules and additional ris k-related factors in blood exosomes can serve as candidate biomarkers for preclinical and clinical Alzheimer's *** findings support further development of

关键词： Alzheimer's disease amyloid-β biomarkers blood exosomes extracellular vesicles meta-analysis mild cognitive impairment systematic review tau protein

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THEORETICAL AND EXPERIMENTAL STUDIES OF HYDRAULIC CHARACTERISTICS OF DISCHARGE TUNNEL WITH VORTEX DROP

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Journal of Hydrodynamics 2010年第4期22卷 582-589页

作者： CHEN hua-yong XU wei-lin DENG Jun NIU Zhi-pan LIU Shan-jun WANG wei State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University Chengdu 610065 China

The velocities at given points in the volute chamber,the contracted section and the vertical dropshaft of a discharge tunnel with vortex drop were measured by a small specially designed L-shaped tube,as Laser Doppler Velocimetry（LDV） or Particle Image Velocimetry（PIV） would not work there due to the special structure of the discharge tunnel with vortex *** empirical formulas were proposed to predict the velocities and the angles of the velocities made with the vertical direction θ.The theoretical analysis results were in good agreement with experimental ***,the method proposed in this paper can be used to analyze related characteristics of discharge tunnels with vortex ***,different model scales were considered to predict the cavitation characteristics on the wall of a dropshaft in practical engineering.

关键词： discharge tunnel with vortex drop dropshaft velocity wall pressure cavitation

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Convergence analysis for complementary-label learning with kernel ridge regression

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Applied Mathematics(A Journal of Chinese Universities) 2024年第3期39卷 533-544页

作者： NIE wei-lin WANG Cheng XIE Zhong-hua School of Mathematics and Statistics Huizhou UniversityHuizhou 516007China School of Computer Science and Engineering Huizhou UniversityHuizhou 516007China

Complementary-label learning(CLL)aims at finding a classifier via samples with complementary *** data is considered to contain less information than ordinary-label *** transition matrix between the true label and the complementary label,and some loss functions have been developed to handle this *** this paper,we show that CLL can be transformed into ordinary classification under some mild conditions,which indicates that the complementary labels can supply enough information in most *** an example,an extensive misclassification error analysis was performed for the Kernel Ridge Regression(KRR)method applied to multiple complementary-label learning(MCLL),which demonstrates its superior performance compared to existing approaches.

关键词： multiple complementary-label learning partial label learning error analysis reproducing kernel Hilbert spaces

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山楂叶类保健食品中总黄酮的提取及抗氧化活性研究

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食品安全质量检测学报 2024年第13期15卷 89-98页

作者：王雅楠黄姗尹玉云魏华琳陶健河南省食品和盐业检验技术研究院郑州450003 国家市场监管重点实验室(食品安全快速检测与智慧监管技术) 郑州450003 河南省检验检测研究院集团有限公司郑州450000

目的建立有效测定山楂叶类保健食品中总黄酮含量的方法 ,同时研究山楂叶总黄酮的抗氧化功效。方法以胶囊剂为例,研究山楂叶总黄酮提取的料液比例、溶剂乙醇体积分数和水浴蒸发温度,并采用响应面分析法优化最佳提取条件。验证方法的... 详细信息

目的建立有效测定山楂叶类保健食品中总黄酮含量的方法 ,同时研究山楂叶总黄酮的抗氧化功效。方法以胶囊剂为例,研究山楂叶总黄酮提取的料液比例、溶剂乙醇体积分数和水浴蒸发温度,并采用响应面分析法优化最佳提取条件。验证方法的线性、重复性、精密度、稳定性、准确度。对抗氧化性进行研究,测定山楂叶总黄酮的1,1-二苯基-2-三硝基苯肼(1,1-diphenyl-2-picrylhydrazine,DPPH)自由基清除率、羟基自由基清除率、超氧阴离子自由基清除率。结果建立以料液比0.025 (g/m L)、溶剂乙醇体积分数65%、水浴温度65℃的山楂叶总黄酮提取处理方法。建立的方法总黄酮重复性良好,平均含量为1.3 g/100 g,相对标准偏差(relative standard deviation,RSD)为2.6%,仪器精密度为0.02%(n=6)。实验方法总黄酮回收率在90.57%~94.18%之间,RSD为1.3%。山楂叶总黄酮DPPH自由基、羟基自由基、超氧阴离子自由基清除效率分别能达到88.92%、84.46%、70.95%。结论本研究建立的山楂叶总黄酮检测方法结果准确,得出山楂叶总黄酮具有较强的抗氧化功效,为高效快速测定以山楂叶为原料的保健食品中总黄酮的含量提供理论依据。

关键词：总黄酮山楂叶响应面抗氧化活性

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Current opinion on human leukocyte antigen-G in China

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Chinese Medical Journal 2007年第14期120卷 1260-1265页

作者： YAN wei-hua lin Ai-fen Medical Research Center Taizhou Hospital of Zhejiang Province Linhai 317000 China

Since discovery and cloning of the non-classical human leukocyte antigen （HLA） class Ⅰ antigen HLA-G by Geraghty et al in 1987, a large number of studies have been carried out. HLA-G has a low polymorphism, limited distribution to normal tissues and seven isoforms resulting from its primary mRNA alternative splicing. HLA-G expression was first found on the extravillous cytotrophoblasts, at the fetal-maternal interface during normal pregnancy, which lacks the expression of HLA-A, -B and HLA Ⅱ antigens. Initial studies on HLA-G mainly addressed its function in fetal-maternal immunotolerance. Two decades later, HLA-G is now considered to be a very important immune molecule which plays a vital immune inhibitory role in the context of reproduction, oncology, transplantation, infection and also in autoimmune disease. A number of Chinese research teams are interested in, and have contributed to, the publication of more than 80 peer-reviewed articles and reviews on HLA-G over the past ten years. We summarize the key points in this field that were presented and discussed by them.

关键词： HLA-G antigen China

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Micro segment analysis of supercritical methane thermal-hydraulic performance and pseudo-boiling in a PCHE straight channel

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Petroleum Science 2024年第2期21卷 1275-1289页

作者： Qian Li Zi-Jie lin Liu Yang Yue Wang Yue Li wei-hua Cai Laboratory of Thermo-Fluid Science and Nuclear Engineering Northeast Electric Power UniversityJilin132000JilinChina School of Energy and Power Engineering Northeast Electric Power UniversityJilin132000JilinChina

The printed circuit heat exchanger(PCHE) is receiving wide attention as a new kind of compact heat exchanger and is considered as a promising vaporizer in the LNG process. In this paper, a PCHE straight channel in the length of 500 mm is established, with a semicircular cross section in a diameter of 1.2 *** simulation is employed to investigate the flow and heat transfer performance of supercritical methane in the channel. The pseudo-boiling theory is adopted and the liquid-like, two-phase-like, and vapor-like regimes are divided for supercritical methane to analyze the heat transfer and flow *** results are presented in micro segment to show the local convective heat transfer coefficient and pressure drop. It shows that the convective heat transfer coefficient in segments along the channel has a significant peak feature near the pseudo-critical point and a heat transfer deterioration when the average fluid temperature in the segment is higher than the pseudo-critical point. The reason is explained with the generation of vapor-like film near the channel wall that the peak feature related to a nucleateboiling-like state and heat transfer deterioration related to a film-boiling-like state. The effects of parameters, including mass flow rate, pressure, and wall heat flux on flow and heat transfer were *** calculating of the averaged heat transfer coefficient of the whole channel, the traditional method shows significant deviation and the micro segment weighted average method is adopted. The pressure drop can mainly be affected by the mass flux and pressure and little affected by the wall heat flux. The peak of the convective heat transfer coefficient can only form at high mass flux, low wall heat flux, and near critical pressure, in which condition the nucleate-boiling-like state is easier to appear. Moreover,heat transfer deterioration will always appear, since the supercritical flow will finally develop into a filmboiling-like state. So hea

关键词： Printed circuit heat exchanger Vaporization Supercritical methane Pseudo-boiling Micro segment analysis

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Autofocus by Lissajous scanning in time reversal optical scanning holography

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CHINESE OPTICS LETTERS 2024年第8期22卷 080501-080501页

作者： Liu, Jie Ou, Haiyan Wang, hua Peng, lin Shao, wei Univ Elect Sci & Technol China Shenzhen Inst Adv Study Shenzhen 518000 Peoples R China Univ Elect Sci & Technol China Sch Phys Chengdu 611731 Peoples R China Guilin Univ Elect Technol Key Lab Cognit Radio & Informat Proc Guilin 541004 Peoples R China

In this Letter, an autofocusing method in optical scanning holography (OSH) system is proposed. By introducing Lissajous scanning into multiple signal classification (MUSIC) method in time-reversal (TR) OSH, the axial locations of the targets can be retrieved with better resolution and the peak prominence increases from 0.21 to 0.34. The feasibility of this method is confirmed by simulation as well as experiment.

关键词： digital holography Lissajous scanning image reconstruction axial localization SECTIONAL IMAGE-RECONSTRUCTION SCATTERING MICROSCOPY TARGETS

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Synergistic catalysis of the N-hydroxyphthalimide on flower-like bimetallic metal-organic frameworks for boosting oxidative desulfurization

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Petroleum Science 2024年第1期21卷 674-682页

作者： Jing He Kun Zhu wei Jiang Dong-Ao Zhu lin-hua Zhu Hai-Yan huang Wen-Shuai Zhu hua-Ming Li Institute for Energy Research Jiangsu UniversityZhenjiang212013JiangsuChina College of Chemistry and Chemical Engineering Hainan Normal UniversityKey Laboratory of Water Pollution Treatment and Resource Reuse of Hainan ProvinceHaikou571158HainanChina

Synergic catalytic effect between active sites and supports greatly determines the catalytic activity for the aerobic oxidative desulfurization of fuel *** this work,Ni-doped Co-based bimetallic metal-organic framework(CoNi-MOF)is fabricated to disperse N-hydroxyphthalimide(NHPI),in which the whole catalyst provides plentiful synergic catalytic effect to improve the performance of oxidative desulfurization(ODS).As a bimetallic MOF,the second metal Ni doping results in the flower-like morphology and the modification of electronic properties,which ensure the exposure of NHPI and strengthen the synergistic effect of the overall *** with the monometallic Co-MOF and naked NHPI,the NHPI@CoNi-MOF triggers the efficient activation of molecular oxygen and improves the ODS performance without an *** sulfur removal of dibenzothiophene-based model oil reaches 96.4%over the NHPI@CoNi-MOF catalyst in 8 h of ***,the catalytic product of this aerobic ODS reaction is sulfone,which is adsorbed on the catalyst surface due to the difference in *** work provides new insight and strategy for the design of a strong synergic catalytic effect between NHPI and bimetallic supports toward high-activity aerobic ODS materials.

关键词： Metal-organic frameworks Doped Bimetallic N-hydroxyphthalimide Aerobic processes Oxidative desulfurization

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