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Achievable dual-strategy to stabilize Li-rich layered oxide interface by a one-step wet chemical reaction towards long oxygen redox reversibility

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Journal of Energy Chemistry 2025年第2期101卷 120-131页

作者： Bin He Yujie dai Shuai Jiang Dawei Chen Xilong Wang Jie Song Dan Xiao Qian Zhao Yan Meng Wei Feng School of Mechanical Engineering Chengdu University Chongqing Institute of Metrology and Quality Inspection Institute of New Energy and Low-Carbon Technology Sichuan University

Oxygen release and electrolyte decomposition under high voltage endlessly exacerbate interfacial ramifications and structu ral degradation of high energy-density Li-rich layered oxide（LLO）,leading to voltage and capacity ***,the dual-strategy of Cr,B complex coating and local gradient doping is simultaneously achieved on LLO surface by a one-step wet chemical reaction at room *** functional theory（DFT） calculations prove that stable B-O and Cr-O bonds through the local gradient doping can significantly reduce the high-energy O 2p states of interfacial lattice O,which is also effective for the near-surface lattice O,thus greatly stabilizing the LLO surface,Besides,differential electrochemical mass spectrometry（DEMS） indicates that the CrxB complex coating can adequately inhibit oxygen release and prevents the migration or dissolution of transition metal ions,including allowing speedy Li+migration,The voltage and capacity fading of the modified cathode（LLO-CrB） are adequately suppressed,which are benefited from the uniformly dense cathode electrolyte interface（CEI） composed of balanced organic/inorganic ***,the specific capacity of LLO-CrB after 200 cycles at 1C is 209.3 mA h g-1（with a retention rate of 95.1%）.This dual-strategy through a one-step wet chemical reaction is expected to be applied in the design and development of other anionic redox cathode materials.

关键词： Interfacial oxygen Lithium-rich layered oxide cathode Local gradient doping One-step wet chemical reaction Surface coating

Peripheral blood RNA biomarkers can predict lesion severity in degenerative cervical myelopathy

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Neural Regeneration Research 2025年第6期20卷 1764-1775页

作者： Zhenzhong Zheng Jialin Chen Jinghong Xu Bin Jiang Lei Li Yawei Li Yuliang dai Bing Wang Department of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse *** numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical *** study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic *** analysis identified 128 differentially expressed genes that were enriched in patients with neurological *** least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,*** of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%*** results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.

关键词： biomarkers candidate genes degenerative cervical myelopathy gene expression analysis immune cell types neurological disabilities peripheral blood RNA profiles spinal cord injury

Efficiency improvement for post-sulfurized CIGS solar cells enabled by in situ Na doping

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Journal of Energy Chemistry 2025年第2期101卷 324-332页

作者： Zeran Gao Yuchen Xiong Jiawen Wang Shanshan Tian Wanlei dai Haoyu Xu Xinzhan Wang Chao Gao Yali Sun Wei Yu National-Local Joint Engineering Laboratory of New Energy Photovoltaic Devices Key Laboratory of Brain-like Neuromorphic Devices and Systems of Hebei Province Hebei University

Despite sulfurization offers the advantage of improving the photovoltaic performance in preparing Cu（In,Ga）Se2（CIGS） absorbers,deep level defects in the absorber and poor energy level alignment on the front surface are still main obstacles limiting the improvement of power co nversion efficiency（PCE） in sulfided CIGS solar ***,an in-situ Na doping strategy is proposed,in which the tailing effect of crystal growth is used to promote the sulfurization of CIGS *** is found that the grain growth is supported by Na incorporating due to the enrichment of NaSexnear the upper *** high soluble Na during grain growth can not only suppress intrinsic InCudonor defects in the absorber,but also tailor S distribution in bulk and the band alignment at the heterojunction,which are both beneficial for the effective electron ***,the Na aggregation near the bottom of the absorber also contributes to the crystalline quality increasing and favorable ultra-thin MoSe2formation at back contact,resulting in a reduced barrier height conducive to hole *** of the champion device is as high as 16.76% with a 28% *** research offers new insights into synthesizing CIGS solar cells and other chalcogenide solar cells with superior cell performance when using an intense sulfurization process.

关键词： CBO CIGS Defect In situ doping Sulfurization

C-X-C chemokine receptor type 5+CD8+T cells as immune regulators in hepatitis Be antigen-positive chronic hepatitis B under interferonalpha treatment

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World Journal of Gastroenterology 2025年第3期31卷 73-83页

作者： Zhen-Yu Xu Zhong-Shang dai Guo-Zhong Gong Min Zhang Department of Infectious Diseases Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Institute of Hepatology and Department of Infectious Diseases The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND C-X-C chemokine receptor type 5(CXCR5)^(+)CD8^(+)T cells represent a unique immune subset with dual roles,functioning as cytotoxic cells in persistent viral infections while promoting B cell *** their importance,the specific role of CXCR5^(+)CD8^(+)T cells in chronic hepatitis B(CHB),particularly during interferon-alpha(IFN-α)treatment,is not fully *** study aims to elucidate the relationship between CXCR5^(+)CD8^(+)T cells and sustained serologic response(SR)in patients undergoing 48 weeks of pegylated IFN-α(peg-IFN-α)treatment for *** To elucidate the relationship between CXCR5^(+)CD8^(+)T cells and sustained SR in patients undergoing 48 weeks of peg-IFN-αtreatment for *** This study enrolled 60 patients with hepatitis Be antigen(HBeAg)-positive CHB undergoing 48 weeks of peg-IFN-α*** were assessed for eligibility based on criteria such as persistent HBsAg-positive status for at least six months,HBeAb-negative,hepatitis B virus DNA levels exceeding 2×10^(4) copies/mL,and alanine aminotransferase(ALT)levels between 2 and 10 times the upper limit of *** samples were collected at baseline and at weeks 12,24,48,and a 24-week treatment-free follow-up(week 72)to measure serum interleukin(IL)-21 concentration via ELISA and to analyze CXCR5 and programmed death-ligand 1(PD-L1)expression on CD8^(+)T cells by flow cytometry,CXCR5 is a chemokine receptor that directs immune cells to specific tissues,while PD-L1 is a protein that regulates immune responses by inhibiting T cell *** Patients with CHB exhibited significantly lower levels of circulating CXCR5^(+)CD8^(+)T cells compared to healthy controls(P<0.01).Notably,CXCR5^(+)CD8^(+)T cells were prominently expressed in patients who achieved sustained SR compared to non-SR(NSR).A significant correlation was observed between CXCR5 and PD-L1 expression(r=-0.189,P=0.002).However,there was no significant correlation between serum IL-21 level

关键词： C-X-C chemokine receptor type 5 Programmed death-ligand 1 Interleukin-21 Pegylated interferon-alpha Chronic hepatitis B

Zinc finger transcription factors BnaSTOP2s regulate sulfur metabolism and confer Sclerotinia sclerotiorum resistance in Brassica napus

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Journal of Integrative Plant Biology 2025年第1期67卷 101-116页

作者： Lihong dai Zhaoqi Xie Tianxu Ai Yushun Jiao Xiaoyi Lian Angchen Long Jinyun Zhang Guangsheng Yang Dengfeng Hong National Key Laboratory of Crop Genetic Improvement College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Lushan Botanical Garden Chinese Academy of SciencesJiujiang 332900China Hubei Hongshan Laboratory Wuhan 430070China Yazhouwan National Laboratory Sanya 572024China

Rapeseed(Brassica napus L.)exhibits high-sulfur requirements to achieve optimal growth,development,and pathogen *** the importance of sulfur,the mechanisms regulating its metabolism and disease resistance are not fully *** this study,we found that the zinc finger transcription factors BnaSTOP2s play a pivotal role in sulfur metabolism and Sclerotinia sclerotiorum *** findings indicate that BnaSTOP2s are involved in sulfur metabolism,as evidenced by extensive protein interaction ***2s knockout reduced the content of essential sulfurcontaining metabolites,including glucosinolate and glutathione,which is consistent with the significantly lowered transcriptional levels of BnaMYB28s and BnaGTR2s,key factors involved in glucosinolate synthesis and transportation,*** RNA-seq analysis revealed the substantial effect of BnaSTOP2s on sulfur metabolism from roots to siliques,which serve as pivotal sources and sinks for sulfur metabolism,***,we found that leaf lesion size significantly decreased and increased in the BnaSTOP2-OE and Bnastop2 mutants,respectively,compared with the wild-type during *** infection,suggesting a vital role of BnaSTOP2s in plant defense *** conclusion,BnaSTOP2s act as global regulators of sulfur metabolism and confer resistance to *** infection in ***,they have potential implications for improving crop resilience.

关键词： BnaSTOP2 Brassica napus CRISPR/Cas9 glucosinolate Sclerotinia sclerotiorum sulfur metabolism

The assembly and activation of the PANoptosome promote porcine granulosa cell programmed cell death during follicular atresia

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Journal of Animal Science and Biotechnology 2025年第1期16卷 121-135页

作者： Hao Wu Yingxue Han Jikang Liu Rong Zhao Shizhen dai Yajun Guo Nan Li Feng Yang Shenming Zeng National Engineering Laboratory for Animal Breeding Key Laboratory of Animal Genetics and Breeding of the Ministry of AgricultureCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China Department of Clinical Sciences College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China College of Animal Science and Technology Henan Agricultural UniversityZhengzhou 450046China

Background Follicular atresia significantly impairs female fertility and hastens reproductive *** of granulosa cells is the primary cause of follicular *** and necroptosis,as additional forms of pro-grammed cell death,have been reported in mammalian ***,the understanding of pyroptosis and necrop-tosis pathways in granulosa cells during follicular atresia remains *** study explored the effects of pro-grammed cell death in granulosa cells on follicular atresia and the underlying *** The results revealed that granulosa cells undergo programmed cell death including apoptosis,pyroptosis,and necroptosis during follicular *** the first time,we identified the formation of a PANoptosome com-plex in porcine granulosa *** complex was initially identified as being composed of ZBP1,RIPK3,and RIPK1,and is recruited through the RHIM ***,we demonstrated that caspase-6 is activated and cleaved,interacting with RIPK3 as a component of the *** stress may exacerbate the activation of the PANop-tosome,leading to programmed cell death in granulosa *** Our data identified the formation of a PANoptosome complex that promoted programmed cell death in granulosa cells during the process of follicular *** findings provide new insights into the molecular mechanisms underlying follicular atresia.

关键词： Follicular atresia Granulosa cells PANoptosome Programmed cell death

Unleashing the Spark South China’s Shenzhen has emerged as one of the leading cities in the low-altitude economy

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ChinAfrica 2025年第3期17卷 32-33页

作者： dai XIAORONG Shenzhen Special Zone daily

At Shenzhen’s renowned theme park,Window of the World,drones illuminated the night sky alongside fireworks during the Spring Festival holiday,creating a breathtaking *** Longgang District’s central area,citizens enjoyed panoramic views of the city from above through helicopter ***,in Dapeng New District,low-altitude rescue aircraft remained on standby 24/7 to ensure the safety of hikers in the mountains.

关键词： Spark altitude mountains

Is intraperitoneal isoperistaltic side-to-side anastomosis a safe surgical procedure in radical colon cancer surgery

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 133-143页

作者： Bin Wu Jing-Tao Zhu He-Xin Lin Yu-hua dai Tian-Sheng Lin An-Le huang Yi-Nan Chen Yong-Wen Li Hai-Bin Wang Yi-Fu Chen Dong-Han Chen huang-Dao Yu Jun You Qing-Qi Hong Department of Gastrointestinal Oncology Surgery The First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361003Fujian ProvinceChina

BACKGROUND Colorectal cancer,one of the most common malignancies,is primarily treated through *** the widespread use of laparoscopy,gastrointestinal reconstruction remains a key area of *** choice between intraperitoneal anastomosis(IA)and extraperitoneal anastomosis(EA)remains a subject of considerable *** study uses intraperitoneal isoperistaltic side-to-side anastomosis(IISSA)with hand-sewn closure of the common opening to evaluate its safety and short-term *** is hypothesized that this technique may offer better short-term outcomes than *** To investigate the safety and short-term outcomes of IISSA with hand-sewn closure of the common opening compared to *** Patients who underwent laparoscopic radical colon cancer surgery between January 2018 and June 2022 at the First Affiliated Hospital of Xiamen University were retrospectively ***,postoperative,and pathological features of the IA and EA groups were observed before and after propensity score *** with right-sided and left-sided colon cancer were separated,each further divided into IA and EA groups(R-IA vs R-EA for right-sided,L-IA vs L-EA for left-sided),for stratified analysis of the aforementioned *** After propensity score matching,63 pairs were matched in each *** surgical characteristics,the IA group exhibited less blood loss and shorter incisions than the EA *** postoperative recovery,the IA group showed earlier recovery of gastrointestinal ***,the IA group had greater lymph node *** to the R-EA group,the R-IA group experienced reduced blood loss,shorter assisted incisions,earlier recovery of gastrointestinal functions and greater lymph node *** compared to the L-EA group,the L-IA group demonstrated earlier postoperative anal exhaust and defecation,along with a reduced length of *** postoperative complications,no statistically signific

关键词： Colon cancer Laparoscopic surgery Intraperitoneal anastomosis Extraperitoneal anastomosis Isoperistaltic sideto-side anastomosis Hand-sewn

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng Zhao Bin dai Lei Ye Tao Song Shuai huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2