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Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng Zhao Bin dai Lei Ye Tao Song Shuai huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits

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Neural Regeneration Research 2025年第5期20卷 1431-1444页

作者： Yuehua Cui Xiaokuang Ma Jing Wei Chang Chen Neha Shakir Hitesch Guirram Zhiyu dai Trent Anderson Deveroux Ferguson Shenfeng Qiu Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZUSA Department of Medicine University of Arizona College of Medicine-PhoenixPhoenixAZUSA

Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse *** have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine *** investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing *** found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection *** findings are further corroborated by increased synaptic activity and transient generation of immature silent *** MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and *** data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult *** findings may have implications for regenerative therapy in aging and neurodegeneration conditions.

关键词： aging circuit connectivity cortical circuits molecular mechanisms neural regeneration neurodegeneration synapses

Brain-derived neurotrophic factor and neural plasticity in a rat model of spinal cord transection

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Neural Regeneration Research 2011年第13期6卷 1017-1022页

作者： Ruxin Xing Jia Liu hua Jin ping dai Tinghua Wang Department of Neurosurgery West China Hospital of Sichuan University Chengdu 610041 Sichuan Province China Institute of Neuroscience Kunming Medical College Kunming 650031 Yunnan Province China Laboratory of Neurological Disease West China Hospital of Sichuan University Chengdu 610041 Sichuan Province China

The present study employed a rat model of T10 spinal cord transection. Western blot analyses revealed increased brain-dedved neurotrophic factor （BDNF） expression in spinal cord segments caudal to the transection site following injection of replication incompetent herpes simplex virus vector （HSV-BDNF） into the subarachnoid space. In addition, hindlimb locomotor functions were improved. In contrast, BDNF levels decreased following treatment with replication defective herpes simplex virus vector construct small interference BDNF （HSV-siBDNF）. Moreover, hindlimb locomotor functions gradually worsened. Compared with the replication incompetent herpes simplex virus vector control group, extracellular signal regulated kinasel/2 expression increased in the HSV-BDNF group on days 14 and 28 after spinal cord transection, but expression was reduced in the HSV-siBDNF group. These results suggested that BDNF plays an important role in neural plasticity via extracellular signal regulated kinasel/2 signaling pathway in a rat model of adult spina cord transection.

关键词： spinal cord transection brain-dedved neurotrophic factor neuroplasticity extracellular-signal regulated kinasel/2 replication-incompetent herpes simplex virus vector replication-defective herpes simplex virus vector

Amorphous transformation of ternary Cu_(45)Zr_(45)Ag_(10) alloy under microgravity condition

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Chinese Physics B 2022年第9期31卷 587-591页

作者： Ming-hua Su Fu-ping dai Ying Ruan School of Physical Science and Technology Northwestern Polytechnical UniversityXi'an 710072China

The influences of undercooling rate and cooling rate on the microstructural evolution of ternary Cu_(45)Zr_(45)Ag_(10) alloy using single-roller melt spinning and drop tube are *** rapidly quenched alloy ribbons achieve a homogeneous glass *** microstructure of the droplets transforms from the Cu_(10)Zr_(7) dendrites plus(Cu_(10)Zr_(7)+AgZr)eutectic into Cu_(10)Zr_(7) dendrite with the decrease of droplet *** the diameter decreases to 180μm,the Cu_(45)Zr_(45)Ag_(10) alloy changes from crystal to amorphous structure,showing that the cooling rate is not the only influence factor and the undercooling play a certain role in the forming of the amorphous alloy at the same time under microgravity condition.

关键词： Cu-Zr-Ag rapid solidification microgravity glass transformation

Practical Green’s function for the thermal stress field induced by a heat source in plane thermoelasticity

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Applied Mathematics and Mechanics(English Edition) 2020年第4期41卷 543-550页

作者： Jian hua Ming dai State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China

The classical Green’s functions used in the literature for a heat source in a homogeneous elastic medium cannot lead to ?nite remote thermal stresses in the medium,so that they may not work well in practical thermal stress analyses. In this paper, we develop a practical Green’s function for a heat source disposed eccentrically into an elastic disk/cylinder subject to plane deformation. The edge of the disk/cylinder is assumed to be thermally permeable and traction-free. The full thermal stress ?eld induced by the heat source in the disk/cylinder is determined exactly and explicitly via the Cauchy integral techniques. In particular, a very simple formula is obtained to describe the hoop thermal stress on the edge of the disk/cylinder, which may be conveniently useful for analyzing the thermal stresses in microelectronic components.

关键词： heat source Green’s function thermal stress finite matrix

The Origin and Acceleration of ~3He and Heavy Ions in the 2000 July 14 Event

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Chinese Journal of Astronomy and Astrophysics 2007年第1期7卷 141-147页

作者： Gui-ping Wu Guang-Li huang Yu-hua Tang Yu dai Department of Physics Southeast University Nanjing 210096 Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210008 Department of Astronomy Nanjing University Nanjing 210093

According to the evolutionary properties of the flare, halo coronal mass ejection （CME）, enrichments of 3He ions in the energy range of 3.5-26 MeV nucl^-1 and Ne, Mg, Si and Fe ions in the energy range of 8.5-15 MeV nucl^- 1, we argue that the 3He and heavy ions originate in the middle corona （-0.1-1 R⊙） with well-connected open field lines to the Earth, where the magnetic reconnection leads to acceleration of the electrons and the production of type-ll burst during the decay phase of the soft X-ray emission. The acceleration of 3He and heavy ions may have been accomplished in two stages： first H-He ion-ion hybrid waves may be easily excited by the energetic electron beams produced in the middle corona, and these waves are preferentially absorbed by ZHe and heavy ions due to their frequency being near the fundamental gyro frequency of the ZHe ions and harmonic gyro frequency of Ne, Mg, Si and Fe ions. These preheated ions escape into interplanetary space along the open field lines and may be further accelerated to tens of MeV nucl^- 1 by CME-driven shock. The theoretical calculations show that the ZHe and heavy ions may be accelerated to the energy of - MeV nucl^-1 by the ion-ion hybrid waves and be further accelerated to the energy of -100 MeV nucl^-1 by the shock wave： these are basically consistent with the observations.

关键词： Sun abundances-waves-shock wave-acceleration of particles

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女性盆腔结核误诊18例分析

临床误诊误治 2017年第1期30卷 3-6页

作者：杨艳艳韩华褚兆苹代聪伟秦英河北省人民医院妇二科石家庄050051 河北省人民医院妇一科石家庄050051

目的分析女性盆腔结核的临床特点及误诊原因,以提高确诊率。方法对我院2010年3月—2016年3月收治的女性盆腔结核误诊病例资料进行回顾性分析。结果本组18例,首发症状主要为腹胀、腹痛,伴有食欲缺乏及发热,主要体征为盆腹腔积液。2例有... 详细信息

目的分析女性盆腔结核的临床特点及误诊原因,以提高确诊率。方法对我院2010年3月—2016年3月收治的女性盆腔结核误诊病例资料进行回顾性分析。结果本组18例,首发症状主要为腹胀、腹痛,伴有食欲缺乏及发热,主要体征为盆腹腔积液。2例有明确结核感染史。首诊误诊为卵巢肿瘤及腹腔积液原因待查各7例,盆腔炎性肿物2例,不全肠梗阻及急性阑尾炎各1例。8例经手术病理检查确诊;5例通过临床表现结合CT、MRI和腹腔积液检查结果以及血红细胞沉降率、癌抗原125升高,并经多科室会诊后确诊;3例因同时合并肺结核或腰椎结核而确诊;2例经结核感染T细胞斑点试验确诊。18例均予抗结核治疗后临床症状明显改善,腹腔积液减少或消失。随访3个月~6年,4例失访,余未见结核复发。结论女性盆腔结核临床表现不典型,极易误诊。临床医师要提高对该病的警惕性,综合运用各种医技检查手段,减少误诊的发生。

关键词：结核泌尿生殖系统女性误诊卵巢肿瘤

Multiphysics simulation and optimization of the in-situ beneficiation process of ilmenite minerals from lunar regolith

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Science China Earth Sciences 2025年第1期68卷 195-207页

作者： Peng ZHANG Xin LIU Guanghui LIU Wei dai Hanzhe YANG Haibo ZHENG Zhi WANG Ran NIU Yifan BAI Yang ZHANG Chengbao LIU Ge YANG Junwei YANG Guang ZHANG Technology and Engineering Center for Space Utilization Chinese Academy of Sciences Beijing Hegong Simulation Co. Ltd

The exploration and utilization of lunar resources have become the major objectives of future lunar exploration missions. The classified collection and processing of lunar minerals is the basic prerequisite for the in-situ exploration and utilization of lunar resources. In this study, we propose a scheme for in-situ separation of magnetic minerals from lunar soils using the dry magnetic separation method. The scheme can realize the purpose of separating magnetic minerals from lunar regolith by altering the motion trajectory of lunar regolith particles with different magnetic properties. Detailed modeling of the dry magnetic separation device is conducted, and the three-dimensional distribution of magnetic parameters is calculated and analyzed. Based on the characterization and analysis of the Chang E-5's samples, the morphologies and physical parameters of lunar regolith particles are modeled and simulated. A discrete element simulation of the motion process of lunar regolith particles under multi-physical field conditions is performed, and the influences of key parameters on the beneficiation performance of lunar magnetic minerals are investigated. Our results indicate that optimal separation and beneficiation of lunar regolith particles can be achieved under specific conditions of magnetic field strength and drum speed. Additionally, we analyze the effects of lunar weak gravity conditions and the charged nature of lunar particles on the beneficiation process, showing that these factors can obviously enhance the beneficiation process of lunar ilmenites. This study demonstrates the feasibility of using the dry magnetic separation method for the beneficiation of magnetic minerals from lunar regolith, providing a theoretical basis for the scientific tasks of collecting, processing, and utilizing lunar mineral resources.

关键词： Lunar regolith In-situ resource utilization Magnetic separation Classified sampling

PRECONDITIONING BLOCK LANCZOS ALGORITHM FOR SOLVING SYMMETRIC EIGENVALUE PROBLEMS

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Journal of Computational Mathematics 2000年第4期18卷 365-374页

作者： hua dai Peter Lancaster Nanjing University of Aeronautics and Astronautics Naming210018China University of Calgary CalgaryCanada

A preconditioned iterative method for computing a few eigenpairs of large sparse symmetric matrices is presented in this paper. The proposed method which combines the preconditioning techniques with the efficiency of block Lanczos algorithm is suitable for determination of the extreme eigenvalues as well as their multiplicities. The global convergence and the asymptotically quadratic convergence of the new method are also demonstrated. [ABSTRACT FROM AUTHOR]

关键词： eigenvalue eigenvector sparse matrices Lanczos method preconditioning