检索结果-南通市图书馆

Coronavirus disease 2019-associated pulmonary fibrosis:clinical findings,pathogenesis,and potential treatment

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2021年第15期134卷 1792-1794页

作者： Ya-Le Jiang hua-ping dai Chen Wang School of Medicine Tsinghua UniversityBeijing 100084China Department of Pulmonary and Critical Care Medicine China-Japan Friendship HospitalNational Center for Respiratory MedicineInstitute of Respiratory MedicineChinese Academy of Medical SciencesNational Clinical Research Center for Respiratory DiseaseBeijing 100029China Tsinghua University-Peking University Joint Center for Life Sciences Peking Union Medical CollegeBeijing 100730China

An outbreak of coronavirus disease 2019(COVID-19)has caught global attention and caused enormous damage.2019 novel coronavirus,also known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),shares remarkable homology with severe acute respiratory syndrome(SARS)coronavirus and Middle East respiratory syndrome(MERS)*** the follow-up studies,62%of SARS and 33%of MERS patients,who tended to be older and have longer intensive care unit admissions,had radiographic evidence of pulmonary fibrosis(PF)after hospital discharge.11,21 The repercussions of COVID-19 may also lead to PF,impair pulmonary function,and threaten life quality.

关键词： acute pathogenesis finding

Expert Consensus on the Diagnosis and Treatment of Anticancer Drug-Induced Interstitial Lung Disease

在线全文

学校读者我要写书评

暂无评论

Current Medical Science 2023年第1期43卷 1-12页

作者：无 Fei MA hua-ping dai Anticancer Drug-induced Interstitial Lung Disease Diagnosis and Treatment Group China Interstitial Lung Diseases Panel Chinese Medical Association-Chinese Thoracic Society and Chinese Medical Doctor Association-Chinese Association of Chest PhysiciansChina Department of Medical Oncology National Cancer CenterNational Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 10021China Department of Pulmonary and Critical Care Medicine China-Japan Friendship HospitalNational Center for Respiratory MedicineChinese Academy of Medical SciencesBeijing 100029China

Drug-induced interstitial lung disease(DILD)is the most common pulmonary adverse event of anticancer *** recent years,the incidence of anticancer DILD has gradually increased with the rapid development of novel anticancer *** to the diverse clinical manifestations and the lack of specific diagnostic criteria,DILD is difficult to diagnose and may even become fatal if not treated ***,a multidisciplinary group of experts from oncology,respiratory,imaging,pharmacology,pathology,and radiology departments in China has reached the“expert consensus on the diagnosis and treatment of anticancer DILD”after several rounds of a comprehensive *** consensus aims to improve the awareness of clinicians and provide recommendations for the early screening,diagnosis,and treatment of anticancer *** consensus also emphasizes the importance of multidisciplinary collaboration while managing DILD.

关键词： drug-induced interstitial lung disease anticancer drug diagnosis treatment

Current therapies for patients with acute exacerbation of idiopathic pulmonary fibrosis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2020年第12期133卷 1470-1472页

作者： Li-Li Zhu hua-ping dai Chen Wang Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalCapital Medical UniversityNational Clinical Research Center for Respiratory DiseasesChinese Academy of Medical Sciences Institute of Respiratory MedicineBeijing 100029China Chinese Academy of Medical Sciences Peking Union Medical CollegeBeijing 100730China

Idiopathic pulmonary fibrosis(IPF)is a chronic,progressive,and generally fatal fibrotic lung disease with a median survival of 2 to 3 years after diagnosis.[1,2]Acute exacerbation of IPF(AE-IPF)is defined as an acute,clinically significant respiratory deterioration characterized by evidence of new widespread alveolar *** 46%of deaths in IPF are caused by AE-IPF,and the median survival of patients with AE-IPF is approximately 3 to 4 months.[3]Over the past 27 years,great efforts have been paid to find therapies that might work for patients with this *** herein summarize current therapies for patients with AE-IPF.

关键词： patients acute exacerbation

Mass Spectrometry-based Proteomics in Acute Respiratory Distress Syndrome： A Powerful Modality for Pulmonary Precision Medicine

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2016年第19期129卷 2357-2364页

作者： Xue-Feng Xu hua-ping dai Yan-Ming Li Fei Xiao Chen Wang Department of Surgical Intensive Care Medicine Beijing Anzhen Hospital Capital Medical University Beijing 100029 China National Clinical Research Centre for Respiratory Medicine Beijing Hospital Beijing 100730 China Department of Respiratory and Critical Care Medicine China-Japan Friendship Hospital Beijing 100029 China

Objective：Acute respiratory distress syndrome （ARDS） is an acute and lethal clinical syndrome that is characterized by hypoxemic respiratory failure and diffuse alveolar inflammatory *** review aimed to search and discuss the mass spectrometry （MS）-based proteomic studies on different subsets of ARDS *** Sources：Original research articles were collected from the PubMed database published in English up to December *** Selection：The literature search was done using the term ＂（acute lung injury OR acute respiratory distress syndrome）AND （proteomics OR proteome OR mass spectrum OR differential in-gel electrophoresis OR two-dimensional polyacrylamide gel electrophoresis）＂.Related original research articles were included and were carefully ***：Eight original proteomic researches on ARDS patients were *** common proteomic modalities were two-dimensional （2D）high-performance liquid chromatography-based electronic spray ion-MS/MS and 2D-polyacrylamide gel electrophoresis/differential in-gel electrophoresis-based matrix-assisted laser desorption ionization-time of flight/*** compared the proteome between ARDS patients and normal controls and analyzed the dynamic changes ofproteome at different ARDS stages or *** disturbed proteome in ARDS patients includes plasma acute-phase proteins,inflammatory/immune-associated proteins,and coagulation ***：Although several previous studies have provided some useful information about the lung proteome in ARDS patients and gained several interesting disease-associated biomarkers,clinical proteomic studies in ARDS patients are still in the initial *** increased cooperation is still needed to establish a global and faithful database containing disease-specific proteome from the largest ARDS subsets.

关键词： Acute Respiratory Distress Syndrome Biomarkers Mass Spectrometry Proteomics

Foreign Body Aspiration-induced Unusual Exacerbation o Chronic Obstructive Pulmonary Disease

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2016年第6期129卷 755-756页

作者： Xiao-Xia Ren Yan Liu Ting Yang hua-ping dai Department of Pulmonary and Critical Care Medicine China-Japan Friendship Hospital Beijing 100029 China Department of Pulmonary and Critical Care Medicine Beijing Institute of Respiratory Medicine Beijing Key Laboratory of Respiratory and Puimonary Circulation Disorders Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China

To the Editor： Chronic obstructive puhnonary disease （COPD） is a common preventable and treatable disease, characterized by persistent and progressive airflow limitation due to abnormal inflammation in the airways and lung to noxious particles or gases. Exacerbation of COPD is rarely induced by foreign body aspiration. In the present report, we described a male patient with acute exacerbation of COPD caused by foreign body aspiration.

关键词：

A Novel Case of Pulmonary Nocardiosis with Secondary Hemophagocytic Lymphohistiocytosis

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2017年第17期130卷 2128-2129页

作者： Teng Han Ying-Mei Liu Ting Yang hua-ping dai Xiao-Lei Zhang Center for Respiratory Diseases China-Japan Friendship Hospital Beijing 100029 China Department of Pulmonary and Critical Care Medicine China-Japan Friendship Hospital Beijing 100029 China National Clinical Research Center for Respiratory Diseases Beijing 100029 China

Pulmonary nocardiosis is an opportunistic infection,especially in immunocompromised *** lymphohistiocytosis （HLH） is a rare but potentially fatal *** report a case of pulmonary nocardiosis with secondary HLH.

关键词： Hemophagocytic Lymphohistiocytosis Infection Pulmonary Nocardiosis

Follistatin-Like 1 Promotes Bleomycin-lnduced Pulmonary Fibrosis through the Transforming Growth Factor Beta 1/Mitogen-Activated Protein Kinase Signaling Pathway

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2018年第16期131卷 1917-1925页

作者： Yan-Kun Jin Xiao-He Li Wang Wang Jie Liu Wei Zhang Yin-Shan Fang Zhi-Fei Zhang hua-ping dai Wen Ning Chen Wang Department of Respiratory and Critical Care Medicine Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China Department of Respiratory Disease Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders Capital Medical University Beijing 100020 China Department of Respiratory Disease Capital Medical University Beijing 100020 China Department of Life Sciences State Key Laboratory of Medicinal Chemical Biology College of Life Sciences Nankai University Tianjin 300071 China Department of Physiology and Pathophysiology Capital Medical University Beijing 100069 China

Background： Follistatin-like I （FSTL 1） is a novel profibrogenic factor that induces pulmonary fibrosis （PF） through the transforming growth factor-beta 1 （TGF-[B 1 ）/Smad signaling. Little is known about its effects on PF through the non-Smad signaling, like the mitogen-activated protein kinase （MAPK） pathway. Therefore, this study aimed to investigate the role ofFSTL 1 in PF through the MAPK signaling pathway and its mechanisms in lung fibrogenesis. Methods： PF was induced in Fstll~ and wild-type （WT） C57BL/6 mice with bleomycin. After 14 days, the mice were sacrificed, and lung tissues were stained with hematoxylin and eosin; the hydroxyproline content was measured to confirm PF. The mRNA and protein level of FSTLI and the change of MAPK phosphorylation were measured by quantitative polymerase chain reaction and Western blotting. The effect of Fst11 deficiency on fibroblasts differentiation was measured by Western blotting and cell immunofluorescence. MAPK signaling activation was measured by Western blotting in Fst11＋/ and WT fibroblasts treated with recombinant human FSTLI protein. We pretreated mouse lung fibroblast cells with inhibitors of the extracellular signal-regulated kinase （ERK）, p38, and Jun N-terminal kinase （JNK） signaling and analyzed their differentiation, proliferation, migration, and invasion by Western blotting, 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide analysis, and transwell assays. The Student＇s t-test was used to compare the differences between two groups. Results： Fstll deficiency attenuated phosphorylation of the ERK, p38, and JNK signaling in bleomycin-induced fibrotic lung tissue 14 days after injury （0.67 ± 0.05 vs. 1.22 ± 0.03, t = 14.92, P = 0.0001; 0.41 ± 0.01 vs. 1.15 ± 0.07; t = 11.19; P = 0.0004; and 0.41 ± 0.01 vs. 1.07± 0.07, t = 8.92, P = 0.0009; respectively）, compared with WT lungs at the same time and in primary lung fibroblasts （0.82 ± 0.01 vs. 1.01 ±0.04, t = 4.06, P = 0.0150; 1.04 ±0.03 vs. 1.24 ± 0.0

关键词： Follistatin-Like 1 Mitogen-Activated Protein Kinase Pulmonary Fibrosis Transforming Growth Factor Beta 1

Incidence and Clinical Characteristics of Pulmonary Hypertension in Patients with Idiopathic Pulmonary Fibrosis

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2015年第7期128卷 896-901页

作者： Wei Yan Li-Ying Peng Cheng-Jun Ban Xue-Feng Xu Min Zhu Yan Liu Shu Zhang Zhen-Guo Zhai Chen Wang hua-ping dai Department of Respiratory and Critical Care Medicine Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China Beijing Key Laboratory of Respiratory and Pulmonary Circulation Beijing Institute of Respiratory Medicine Beijing 100020 China

Background： Pulmonary hypertension （PH） frequently complicates the course of idiopathic pulmonary fibrosis （IPF） patients and is associated with significantly worse outcomes. The aim of the present study was to investigate the incidence of PH in IPF patients and evaluate the correlation between clinical parameters and systolic pulmonary artery pressure （sPAP）. Methods： Hospitalized patients with IPF, who were evaluated for sPAP by Doppler echocardiography from January 2004 to December 2011, were enrolled in our study. Patients were defined as PH by an estimated sPAP 〉 50 mmHg and graded as PH likely, PH possible and PH unlikely, based on the 2009 European Society of Cardiology/European Respiratory Society PH Guidelines. The correlations between clinical parameters and sPAP were analyzed by multiple linear regression. Results： Totally, 119 IPF patients were enrolled in our study and 28 （23.5%）, 20 （16.8%） and 71 （59.7%） patients were PH likely, PH possible and PH unlikely, respectively. Borg dyspnea score was positively correlated with sPAP, r = 0.467, P 〈 0.001. Oxygen saturation was negatively correlated with sPAP, r = -0.416, P 〈 0.001. Diffusing capacity of the lung for carbon monoxide percentage predicted was negatively correlated with sPAP, r = -0.424, P = 0.003. N-terminal fragment of pro-brain natriuretic peptide and pulmonary artery width was positively correlated with sPAP, r = 0.452, P = 0.011 and r= 0.513, P 〈 0.001, respectively. Conclusions： The incidence of PH in IPF patients was 23.5% in a single center of China. PH may worsen the dyspnea, right heart dysfunction and decrease the life quality of the patients with IPF.

关键词： Idiopathic Pulmonary Fibrosis: Incidence Pulmonary Hypertension

Direct medical costs of hospitalized patients with idiopathic pulmonary fibrosis in a tertiary hospital in China

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2020年第20期133卷 2498-2500页

作者： Xiao-Fen Zheng Bing-Bing Xie Yan Liu Ming Zhu Shu Zhang Cheng-Jun Ban Jing Geng Ding-Yuan Jiang Yan-Hong Ren hua-ping dai Chen Wang Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100029China The Second Affiliated Hospital of Zhejiang Chinese Medical University HangzhouZhejiang 310000China Department of Pulmonary and Critical Care Medicine Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100012China Department of Respiratory Medicine Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China

Idiopathic pulmonary fibrosis(IPF)incidence shows wide variations in different countries,ranging from 3 to 9 per 100,000 inhabitants per year in North America and Europe,while in South America and Asia,incidence is lo... 详细信息

关键词： patients pulmonary Idiopathic