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Repeated measurement of growth-differentiation factor-15in Chinese Han patients with post-myocardial infarction chronic heart failure

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Journal of Geriatric Cardiology 2018年第10期15卷 618-627页

作者： Ji-Xuan LIU Yan-Ping LI Bo-Han LIU Xiao-Jing ZHAO Ze-Yu zhang Jin-Da WANG Qian JIA Chun-Lei LIU Xiao-Jian GAO Zhen-Guo XU hua-wei zhang Lin-Nan SONG Zhi-Jun SUN Kun-Lun HE Beijing Key Laboratory of Chronic Heart Failure Precision Medicine Chinese PLA General HospitalBeijingChina Transformation Medicine Centre Chinese PLA GeneraI HospitalBeijingChina Department of Cardiovascular Chinese PLA General HospitalBeijingChina Department of Geriatric Cardiology Chinese PLA General HospitalBeijingChina Outpatient Department of North China Military Materials Procurement Bureau TianjinChina Queen Mary College of Nanchang University NanchangChina

Background Growth-differentiation factor-15(GDF-15)is a promising prognostic biomarker in patients with chronic heart failure (CHF).Comparatively little is known about the value of repeated measurement of GDF-15with CI-IF in Chinese Han *** study sought to identify the clinical value of repeated measurement of GDF-15in Chinese Han patients with post-myocardial infarction CHF. Methods In total,232consecutive Chinese Hart patients with post-myocardial infarction CHF were enrolled prospectively from January 2014to June *** plasma concentration of GDF-15was determined on admission and over *** were followed up for all-cause death and a composite outcome of major adverse cardiac events (MACE)included all-cause death,myocardial infarction and first heart failure (HF)*** with other clinical variables and adverse outcomes of repeated measurement of GDF-15 was *** The median baseline GDF-15level was 2025ng/*** GDF-15was moderately associated with baseline N-terminal pro-B type nalriuretic peptide (NT-proBNP)(coefficient 0.561,P <0.001).During a median follow-up of 20months,there were 53deaths and ***-I5remained an independent predictor of all-cause death (adjusted hazard ratio 1.826per 1Ln U,95%CI: 1.037-8.360;P =0.037)and MACE (adjusted hazard ratio 2.243per I Ln U,95%CI:1.181-1.775;P <0.001)adjusted for established risk *** measurement of GDF-15was performed in 173survivals over *** of GDF-15over 12months was associ- ated with dilatation of left ventricle and acted as an independent predictor of subsequent all-canse death (adjusted HR =3.164,95%CI: 1.245~.041;P =0.015).In the joint model,GDF-15was also shown to be a risk factor for all-cause death (HR =2.749,95%CI: 1.667-3.831;P <0.001)and MACE (FIR =2.434,95%CI:1.425-3.443;P <0.001).Conclusions Repeated measurements of GDF-15 have promising prognostic value of the risk of all-cause death in Chinese Han patients

关键词： Chronic heart failure Growth-differentiation factor-15 Left ventricular remodeling Myocardial infarction Prognosis

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Evaluation of the therapeutic efficiency of mandibular anterior implant-supported fixed bridges with cantilevers

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Chinese Medical Journal 2013年第24期126卷 4665-4669页

作者： WU Min-jie WANG Xiao-jing ZOU Li-dong XU wei-hua zhang Xiang-hao Second Dental Center Peking University School and Hospital of Stomatology Beijing 100101 China

Background Dental implant technology has developed rapidly in recent years. However, the use of implant-supported fixed bridges with cantilevers has been controversial. The purpose of this study was to evaluate the clinical results of the mandibular anterior implant-supported fixed bridges with a cantilever. Method Thirty-three patients （15 males, 18 females; mean age, 42.6 years; range 20-54 years） with two missing anterior mandibular teeth had single implant-supported fixed bridges with a cantilever. Clinical examination was recorded and radiographs were taken. The mean duration of follow-up was 30 months （15-44 months）. Results All implants survived. Loosening or fracture of the prosthesis was not observed. All patients were satisfied with the treatment. The mean bone resorption values after 12, 24, and 36 months of implant loading were 0.94, 1.18 and 1.35 mm respectively. The changes of gingival papilla height ranged from 0 to 0.5 mm. There was significant difference between 1-year and 2 or 3 years restoration groups regarding the average gingival height changes （P 〈0.05）. Conclusion After careful and precise selection of patients, restoration with a single implant-supported fixed bridge with a cantilever can be recommended if two anterior mandibular teeth are missing.

关键词： dental implant fixed partial denture, mandibular prostheses bone resorption

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Fabrication of lotus-type porous Mg−Mn alloys by metal/gas eutectic unidirectional solidification

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Transactions of Nonferrous Metals Society of China 2020年第6期30卷 1524-1534页

作者： Can-xu ZHOU Yuan LIU hua-wei zhang Xiang CHEN Yan-xiang LI School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationTsinghua UniversityBeijing 100084China

Lotus-type porous Mg–xMn(x=0,1,2 and 3 wt.%)alloys were fabricated by metal/gas eutectic unidirectional solidification(the Gasar process).The effects of Mn addition and the fabrication process on the porosity,pore diameter and microstructure of the porous Mg-Mn alloy were *** addition improved the Mn precipitates and increased the porosity and pore *** increasing hydrogen pressure from 0.1 to 0.6 MPa,the overall porosity of the Mg-2wt.%Mn ingot decreased from 55.3%to 38.4%,and the average pore diameter also decreased from 2465 to 312μ*** on a theoretical model of the change in the porosity with the hydrogen pressure,the calculated results were in good agreement with the experimental *** is shown that this technique is a promising method to fabricate Gasar Mg–Mn alloys with uniform and controllable pore structure.

关键词： porous material Mg-Mn alloy porosity Gasar process directional solidification

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Binary Star Fractions from the LAMOST DR4

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Research in Astronomy and Astrophysics 2018年第5期 49-60页

作者： Zhi-Jia Tian Xiao-wei Liu Hai-Bo Yuan Bing-Qiu Chen Mao-Sheng Xiang Yang huang Chun Wang hua-wei zhang Jin-Cheng Guo Juan-Juan Ren Zhi-Ying Huo Yong Yang Meng zhang Shao-Lan Bi Wu-Ming Yang Kang Liu Xian-Fei zhang Tan-Da Li Ya-Qian Wu Jing-hua zhang Department of Astronomy Peking University LAMOST Department of Astronomy Yunnan University Department of Astronomy Beijing Normal University National Astronomical Observatories Chinese Academy of Sciences

Stellar systems composed of single, double, triple or higher-order systems are rightfully regarded as the fundamental building blocks of the Milky Way. Binary stars play an important role in formation and evolution of the Galaxy. Through comparing the radial velocity variations from multiepoch observations, we analyze the binary fraction of dwarf stars observed with LAMOST. Effects of different model assumptions, such as orbital period distributions on the estimate of binary fractions,are investigated. The results based on log-normal distribution of orbital periods reproduce the previous complete analyses better than the power-law distribution. We find that the binary fraction increases with Teff and decreases with [Fe/H]. We first investigate the relation between α-elements and binary fraction in such a large sample as provided by LAMOST. The old stars with high [α/Fe] dominate with a higher binary fraction than young stars with low [α/Fe]. At the same mass, earlier forming stars possess a higher binary fraction than newly forming ones, which may be related with evolution of the Galaxy.

关键词： binaries:general binaries:spectroscopic Galaxy:stellar content stars:statistics surveys

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Optimized cardiac resynchronization therapy in patients with congestive heart failure

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Chinese Medical Journal 2007年第7期120卷 605-607页

作者： NIU Hong-xia hua wei zhang Shu SUN Xin CHEN Ke-ping WANG Fang-zheng CHEN Xin Center of Arrhythmia Diagnosis and Treatment Fuwai Hospital and Cardiovascular Institute Chinese Academy and Medical Sciences ＆ Peking Union Medical College Beijing 100037 China

Heart failure was a major and increasing public health problem, with an almost ＂epidemic＂ increase in the number of patients. Despite recent advances in pharmacotherapy, the prognosis remains poor. Cardiac resynchronization therapy （CRT）, by pacing right and left ventricles, has been proved to improve symptoms and reduce mortality for heart failure patients with cardiac dyssynchrony, However, 20% to 30% of patients did not respond to CRT. The good cardiac synchronicity before CRT and the remaining atrioventficular, inter- and intra-ventricular dyssynchrony after CRT may explain the non-response. New echocardiographic techniques, and in particular tissue Doppler imaging （TDI） analysis, has been proved to be a helpful tool in evaluating cardiac dyssynchrony, as well as in assessing the degree of cardiac resynchronization after biventricular device implantation. So, in this study, we optimized the pacing parameters to determine whether echo-guided optimizing of AV/VV delays would enhance the effect of CRT on cardiac function and synchronicity.

关键词： heart failure dysynchrony cardiac resynchronization therapy atrioventricular delay interventricular delay tissue Doppler imaging

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Clinical effects of phospholipase D2 in attenuating acute pancreatitis

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World Journal of Gastroenterology 2025年第2期31卷 52-60页

作者： Jin-wei Niu Guo-Chao zhang Wu Ning Hai-Bin Liu hua Yang Chao-Feng Li Department of General Surgery China-Japan Friendship HospitalBeijing 100029China

BACKGROUND The objective of the current study was to elucidate the clinical mechanism through which phospholipase D2(PLD2)exerted a regulatory effect on neutrophil migra-tion,thereby alleviating the progression of acute *** To elucidate the clinical mechanism through which PLD2 exerted a regulatory effect on neutrophil migration,thereby alleviating the progression of acute *** The study involved 90 patients diagnosed with acute pancreatitis,admitted to our hospital between March 2020 and November 2022.A retrospective analysis was conducted,categorizing patients based on Ranson score severity into mild(n=25),moderate(n=30),and severe(n=35)*** data was collected for each *** blot analysis assessed PLD2 protein expression in patient ***-time reverse transcription polymerase chain reaction was used to evaluate the mRNA expression of chemokine receptors associated with neutrophil *** levels of inflammatory factors in patients were detected using enzyme-linked immunosorbent *** migration tests were conducted to compare migration of neutrophils across groups and analyze the influence of PLD2 on neutrophil *** Overall data analysis did not find significant differences between patient groups(P>0.05).The expression of PLD2 protein in the severe group was lower than that in the moderate and mild groups(P<0.05).The expression level of PLD2 in the moderate group was also lower than that in the mild group(P<0.05).The severity of acute pancreatitis is negatively correlated with PLD2 expression(r=-0.75,P=0.002).The mRNA levels of C-X-C chemokine receptor type 1,C-X-C chemokine receptor type 2,C-C chemokine receptor type 2,and C-C chemokine receptor type 5 in the severe group are significantly higher than those in the moderate and mild groups(P<0.05),and the expression levels in the moderate group are also higher than those in the mild group(P<0.05).The levels of C-reactive protein,tumo

关键词： Phospholipase D2 Neutrophil migration Acute pancreatitis Retrospective analysis Inflammatory response

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论中国政治话语体系的认知建构——以习近平2017年瑞士两场演讲为例

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南京师大学报（社会科学版） 2017年第5期 146-153页

作者：汪少华张薇南京师范大学外国语学院南京审计大学文学院

本文以习近平在瑞士的两场演讲为例,依据认知科学中架构理论所揭示的政治话语规律,探讨该话语的主要认知特征及其对中国政治话语体系建构的重大指导意义;并以此为范例,从认知和社会的视角衍生出全球视野下中国政治话语建构的首要原则、... 详细信息

本文以习近平在瑞士的两场演讲为例,依据认知科学中架构理论所揭示的政治话语规律,探讨该话语的主要认知特征及其对中国政治话语体系建构的重大指导意义;并以此为范例,从认知和社会的视角衍生出全球视野下中国政治话语建构的首要原则、基本特征、主要机制、话语架构模式和对外交流主要策略。

关键词：政治话语体系建构架构模式

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Influence of polymer additives on turbulent energy cascading in forced homogeneous isotropic turbulence studied by direct numerical simulations

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Chinese Physics B 2012年第11期21卷 306-320页

作者：李凤臣蔡伟华张红娜王悦 School of Energy Science and Engineering Harbin Institute of Technology

Direct numerical simulations （DNS） were performed for the forced homogeneous isotropic turbulence （FHIT） with/without polymer additives in order to elaborate the characteristics of the turbulent energy cascading influenced by drag-reducing effects. The finite elastic non-linear extensibility-Peterlin model （FENE-P） was used as the conformation tensor equation for the viscoelastic polymer solution. Detailed analyses of DNS data were carried out in this paper for the turbulence scaling law and the topological dynamics of FHIT as well as the important turbulent parameters, including turbulent kinetic energy spectra, enstrophy and strain, velocity structure function, small-scale intermittency, etc. A natural and straightforward definition for the drag reduction rate was also proposed for the drag-reducing FHIT based on the decrease degree of the turbulent kinetic energy. It was found that the turbulent energy cascading in the FHIT was greatly modified by the drag-reducing polymer additives. The enstrophy and the strain fields in the FH1T of the polymer solution were remarkably weakened as compared with their Newtonian counterparts. The small-scale vortices and the small-scale intermittency were all inhibited by the viscoelastic effects in the FHIT of the polymer solution. However, the scaling law in a fashion of extended self-similarity for the FHIT of the polymer solution, within the presently simulated range of weissenberg numbers, had no distinct differences compared with that of the Newtonian fluid case.

关键词： forced homogenous isotropic turbulence polymer additives turbulent energy cascading drag reduction

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三相法制备木瓜蛋白酶的过程研究

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现代化工 2017年第10期37卷 114-117页

作者：魏胜华周清华钱伟张驰安徽工程大学生物与化学工程学院安徽芜湖241000 微生物发酵安徽省工程研究中心安徽芜湖241000

为了高效制备木瓜蛋白酶,利用三相分离法对番木瓜乳粉进行分离纯化。对影响分离纯化的主要因素有机溶剂种类及浓度、硫酸铵质量分数、三相成相时间及pH等进行了研究。实验结果表明,该酶的最佳分离条件为:粗酶液与叔丁醇的体积比为1∶1.5... 详细信息

为了高效制备木瓜蛋白酶,利用三相分离法对番木瓜乳粉进行分离纯化。对影响分离纯化的主要因素有机溶剂种类及浓度、硫酸铵质量分数、三相成相时间及pH等进行了研究。实验结果表明,该酶的最佳分离条件为:粗酶液与叔丁醇的体积比为1∶1.5,硫酸铵质量分数为50%,成相时间为60 min,体系pH为7.0。在此条件下使用三相法分离出的木瓜蛋白酶纯化倍数为2.98倍,酶活回收率为76%。

关键词：木瓜蛋白酶三相分离分离纯化

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Influence of increased epicardial adipose tissue volume on 1-year in-stent restenosis in patients who received coronary stent implantation

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Journal of Geriatric Cardiology 2016年第9期13卷 768-775页

作者： Ying ZHOU hua-wei zhang Feng TIAN Jin-Song CHEN Tian-Wen HAN Ya-Hang TAN Jia ZHOU Tao zhang Jing JING Yun-Dai CHEN Department of Cardiology Chinese PLA General Hospital Beijing China VIP Medical Service Department Beijing SHIJITAN Hospital Belling China Department of Cardiology Chinese PLA 175 Hospital Fujian China School of Medicine Nankai University Tianjin China Department of Cardiology Tianjin Chest Hospital Tianjin China

Background Epicardial adipose tissue （EAT） is significantly associated with the formation and composition of coronary atherosclerotic plaque, cardiac events and the clinical prognosis of coronary heart disease. But, whether increased EAT deposition may affect the incidence of in-stent restenosis （ISR） is currently unclear. This study used coronary computed tomography angiography （CCTA） as a mean to investigate whether increased EAT volume was associated with ISR. Methods A total of 364 patients who underwent 64-slice CCTA examination for the evaluation of suspected coronary artery disease, and subsequently underwent percutaneous coronary intervention （PCI） for the first time, and then accepted coronary angiography （CA） follow-up for ISR examination in one year, were retrospectively included in this study. EAT volume was measured by CCTA examination. CA follow-up was obtained between 9 and 15 months. ISR was defined as 〉 50% kuninal diameter narrowing of the stent segment or peri-stent segment. EAT volume was compared between patients with and without ISR and additional well-known predictors of ISR were compared. Results EAT volume was significantly increased in patients with ISR compared with those without ISR （154.5 ± 74.6 mL vs. 131.0 ± 52.2 mL, P 〈 0.001）. The relation between ISR and EAT volume remained significant after adjustment for conventional cardiovascular risk factors and angiographic parameters. Conclusions EAT volume was related with ISR and may provide additional information for future ISR.

关键词： Computed tomography Drug-eluting stents Epicardial adipose tissue In-stem restenosis

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