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Erratum to:Toxic aldehyde-scavenging polypeptides mitigate secondary injury after spinal cord injury(vol 66,issue 7,page 2931,2023)

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Science China Materials 2024年第10期67卷 3426-3426页

作者： Yixuan Liu Feng lin Tianhui Zhang Cheng Wu Wanguo Liu Hao Wang Chunsheng Xiao Xuesi Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Science and Technology of China Hefei 230026China Department of Orthopaedic Surgery China-Japan Union Hospital of Jilin UniversityChangchun 130033China Jilin Biomedical Polymers Engineering Laboratory Changchun 130022China

In the version of the article originally published in the volume 66,issue 7,2023 of Sci China Mater(pages 2925–2937,https://***/10.1007/s40843-022-2409-4),the images reported in Fig.2d showing the resulting cell morphologies after incubation with PPAH at the concentrations of 0,125,and 250μg mL^(−1)were *** corrected Fig.2 is given *** corrections do not change or affect the results or conclusions of the paper.

关键词： injury correction after

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钒钛磁铁矿还原-磨选工艺分离铁钛试验

钢铁 2024年第8期59卷 13-18,49页

作者：罗林根庞建明李新宋耀欣王华林银河郑权柴先义中国钢研科技集团有限公司资源应用与合金材料事业部北京100081 马鞍山钢铁股份有限公司特钢公司安徽马鞍山243000 长江师范学院化学化工学院重庆408100 中冶华天南京工程技术有限公司钢铁设计研究总院江苏南京210000 安徽首矿大昌金属材料有限公司炼钢事业部安徽六安237400

以攀西钒钛磁铁矿为研究对象,分析了攀西钒钛磁铁矿综合利用工艺方案现状。考虑到传统工艺采用碳质还原剂或加入添加剂还原后产品中有过量的碳和添加剂残留,将对制得的产品造成污染,尤其是钠盐添加剂更是一种环境污染因子,工业化处理成... 详细信息

以攀西钒钛磁铁矿为研究对象,分析了攀西钒钛磁铁矿综合利用工艺方案现状。考虑到传统工艺采用碳质还原剂或加入添加剂还原后产品中有过量的碳和添加剂残留,将对制得的产品造成污染,尤其是钠盐添加剂更是一种环境污染因子,工业化处理成本较高等弊端,提出采用氢气还原-磨选工艺处理钒钛磁铁矿以实现铁、钛2种元素的分离。研究过程先对钒钛磁铁矿用氢气还原,使矿中的铁氧化物绝大部分还原为金属铁,再通过细磨磁选分离钛和铁元素。研究表明,在1200℃还原4 h,钒钛磁铁矿金属化率可达86.21%;还原钒钛磁铁矿经细磨60 min,得到粒度D_(50)约为10.5μm的微粒,在磁场强度为80 m T条件下进行湿式磁选,可得到TFe质量分数为89.34%、TiO_(2)质量分数为0.83%、V_(2)O_(5)质量分数为0.33%的金属铁粉和TFe质量分数为6.22%、TiO_(2)质量分数为36.82%、V_(2)O_(5)质量分数为2.35%的非磁性物,从而实现铁钛元素的分离。还原-磨选工艺应用于钒钛磁铁矿的铁、钛元素分离有较好的效果,获得的金属铁粉铁含量高、铁收率高,同时渣中钒、钛元素得到有效富集有利于后续提取钒、钛元素;氢气作为还原剂不会带来二次污染。还原-磨选工艺有望实现钒钛磁铁矿综合利用,有较好的应用前景,可进一步开展更大规模试验研究。

关键词：氢还原直接还原铁钛分离钒钛磁铁矿磁选

Magnetic resonance imaging for local complications of acute pancreatitis: A pictorial review

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World Journal of Gastroenterology 2010年第22期16卷 2735-2742页

作者： Xiao, Bo Zhang, Xiao-Ming Tang, Wei Zeng, Nan-lin Zhai, Zhao-hua N Sichuan Med Coll Affiliated Hosp Dept Radiol Sichuan Key Lab Med Imaging Nanchong 637000 Sichuan Prov Peoples R China

Acute pancreatitis is a common disease characterized by sudden upper abdominal pain and vomiting. Alcoholism and choledocholithiasis are the most common factors for this disease. The choice of treatment for acute pancreatitis might be affected by local complications, such as local hemorrhage in or around the pancreas, and peripancreatic infection or pseudoaneurysm. Diagnostic imaging modalities for acute pancreatitis have a significant role in confirming the diagnosis of the disease, helping detect the extent of pancreatic necrosis, and for diagnosing local complications. Magnetic resonance imaging (MRI) might be indicated in acute pancreatitis for detecting and characterizing local complications of acute pancreatitis that involve necrotic, hemorrhagic, infectious, vascular, and pseudocyst disorders. The general MRI sequences for pancreatitis require the combined use of T1-weighted, T2-weighted sequences, and magnetic resonance chol-angiopancreatography. For imaging of pancreatic necrosis, the combination of T1-weighted and T2-weighted findings with dynamic contrast-enhanced imaging gives a comprehensive evaluation of the extent of necrosis and full range of inflammatory extension. For imaging of infectious complications, dynamic contrast-enhanced examinations might help differentiate pancreatic cellulitis or abscesses, from pancreatic fluid collection or simple pseudocysts. For vascular abnormalities, the combination of cross-sectional pancreatic parenchyma imaging with MRA represents a single diagnostic modality for the full evaluation of peripancreatic artery and vein involvement, such as arterial pseudoaneurysms and venous thromboses. The purpose of this pictorial review is to examine the MRI appearances of various local complications of acute pancreatitis and to discuss the practical setup of MRI in local complications of acute pancreatitis.

关键词： Pancreas Pancreatitis Complication Magnetic resonance imaging Pictorial review

Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity

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Signal Transduction and Targeted Therapy 2024年第1期9卷 259-270页

作者： Yan Sun Xiu-Na Yang Shuang-Shuang Yang Yi-Zhu Lyu Bing Zhang Kai-Wen Liu Na Li Jia-Chen Cui Guang-Xiang huang Cheng-lin Liu Jie Xu Jian-Qing Mi Zhu Chen Xiao-Hu Fan Sai-Juan Chen Shuo Chen Shanghai Institute of Hematology National Research Center for Translational MedicineState Key Laboratory of Medical GenomicsRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Department of Hematology Second Hospital of Dalian Medical UniversityDalian 116023China National Facility for Protein Science Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Legend Biotech China Nanjing 211112China Shanghai Immune Therapy Institute Shanghai Cancer InstituteState Key Laboratory of Oncogenes and Related GenesRenji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Wondercel Biotechnology Shenzhen 518052China

Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity,safeguarding receptor activation,and facilitating amplification of signal transduction across the cellular ***,cell-surface antigeninduced multimerization(dubbed AIM herein)has not yet been consciously leveraged in chimeric antigen receptor(CAR)engineering for enriching T cell-based *** co-developed ciltacabtagene autoleucel(cilta-cel),whose CAR incorporates two B-cell maturation antigen(BCMA)-targeted nanobodies in tandem,for treating multiple *** we elucidated a structural and functional model in which BCMA-induced cilta-cel CAR multimerization amplifies myeloma-targeted T cell-mediated *** analysis of BCMA–nanobody complexes revealed atomic details of antigen–antibody hetero-multimerization whilst analytical ultracentrifugation and small-angle X-ray scattering characterized interdependent BCMA apposition and CAR juxtaposition in ***-induced nanobody CAR multimerization enhanced cytotoxicity,alongside elevated immune synapse formation and cytotoxicity-mediating cytokine release,towards myeloma-derived *** results provide a framework for contemplating the AIM approach in designing next-generation CARs.

关键词： cytotoxicity Antigen elevated

苹果之夜欢笑之夜——记沉浸式歌剧《苹果之夜》广州首演

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人民音乐 2024年第3期 16-20页

作者：林海鹏华南师范大学音乐学院

继2022年沉浸式歌剧《丽塔》(Rita)的大获成功后,广州大剧院与星海音乐学院在2023年6月再度推出一部全新制作的沉浸式歌剧——奥芬巴赫轻歌剧《苹果之夜》(Pomme d'Api)。

关键词：星海音乐学院奥芬巴赫沉浸式歌剧苹果

IL-31及其受体在皮肤病发生及治疗中的研究进展

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中国皮肤性病学杂志 2024年第6期38卷 696-699,704页

作者：孙小洁林彤北京协和医学院/中国医学科学院/皮肤病医院/皮肤病研究所激光科江苏南京210042

IL-31是一种神经免疫因子,可由Th2型淋巴细胞、单核/巨噬细胞、树突状细胞、肥大细胞、嗜酸性粒细胞、嗜碱性粒细胞等细胞分泌;主要通过与IL-31受体A(IL-31RA)和瘤抑素M受体β(OSMRβ)偶联形成的异二聚体受体复合体结合,发挥相应的生物... 详细信息

IL-31是一种神经免疫因子,可由Th2型淋巴细胞、单核/巨噬细胞、树突状细胞、肥大细胞、嗜酸性粒细胞、嗜碱性粒细胞等细胞分泌;主要通过与IL-31受体A(IL-31RA)和瘤抑素M受体β(OSMRβ)偶联形成的异二聚体受体复合体结合,发挥相应的生物学作用。近年来,对于IL-31及其受体引发相关疾病的机制研究取得了一些进展。研究表明,一方面,IL-31通过激活瞬时受体电位香草酸受体1(TRPV1)、瞬时受体电位受体A1(TRPA1)上调神经元兴奋性等方式参与瘙痒形成;另一方面,通过激活JAK/STAT、PI3K/AKT等信号通路,招募多种细胞因子促进炎症形成。IL-31参与特应性皮炎、结节性痒疹、大疱性类天疱疮等多种皮肤疾病的发生发展。同时针对IL-31受体的生物制剂奈莫利珠单抗,已经批准上市,用于辅助治疗当前治疗无效的特应性皮炎的瘙痒。本文主要围绕IL-31及其受体在皮肤科疾病发生及治疗中取得的相关进展进行综述。

关键词：白介素31 白介素31受体α 皮肤疾病发生机制治疗

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灵芝多糖的化学研究进展

菌物研究 2024年第1期22卷 9-21页

作者：林树钱王赛贞王联福林冬梅福建农林大学国家菌草工程研究中心福州350002

多糖类化合物是灵芝主要的有效成分,具有免疫调节、抗肿瘤、抗氧化、抗衰老等药理学作用,目前已从灵芝分离出200余种多糖(包括灵芝多糖和多糖肽等)。灵芝多糖是灵芝的重要生物活性成分。文中综述灵芝多糖化学的研究进展,包括灵芝多糖提... 详细信息

多糖类化合物是灵芝主要的有效成分,具有免疫调节、抗肿瘤、抗氧化、抗衰老等药理学作用,目前已从灵芝分离出200余种多糖(包括灵芝多糖和多糖肽等)。灵芝多糖是灵芝的重要生物活性成分。文中综述灵芝多糖化学的研究进展,包括灵芝多糖提取与分离、纯度鉴定、单糖组成、糖与肽连接方式、各组分活性多糖的结构和构象表征及构效关系等,并对灵芝的质量控制指标、有效成分的标准样品研制、检测方法及对灵芝提取物与产品的质量控制的研究进展进行了概述。

关键词：灵芝多糖药物化学糖苷键结构表征质量控制

^(68)Ga-FAPI PET显像用于心血管疾病研究进展

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中国医学影像技术 2024年第7期40卷 1096-1099页

作者：林学智张国建内蒙古医科大学第一临床医学院内蒙古呼和浩特010050 内蒙古医科大学附属医院核医学科内蒙古呼和浩特010050 内蒙古自治区分子影像重点实验室内蒙古呼和浩特010050

心肌纤维化与多种心血管疾病(CVD)发生、发展密切相关,而成纤维细胞激活蛋白(FAP)在其中发挥关键作用。^(68)Ga-FAP抑制剂(FAPI)对FAP具有高亲和力及特异度,现已逐渐用于心血管PET显像。本文围绕^(68)Ga-FAPI PET显像用于CVD研究进展进... 详细信息

心肌纤维化与多种心血管疾病(CVD)发生、发展密切相关,而成纤维细胞激活蛋白(FAP)在其中发挥关键作用。^(68)Ga-FAP抑制剂(FAPI)对FAP具有高亲和力及特异度,现已逐渐用于心血管PET显像。本文围绕^(68)Ga-FAPI PET显像用于CVD研究进展进行综述。

关键词：成纤维细胞激活蛋白α 心血管疾病正电子发射断层显像

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Effect of Warm-Rolled Pearlite Microstructural Features on Austenitic Transformation

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Journal of Iron and Steel Research International 2009年第4期16卷 55-59页

作者： YAO Sheng-jie DU lin-xiu LIU Xiang-hua WANG Guo-dong State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 Liaoning China

The austenite transformation characteristics for various warm-rolled pearlite during rapid heating were investigated. The results indicate that the start temperature （Ts） is sensitive to the microstructural feature of pearlite, whereas the dislocation plays an important role in the transformation rate; at the same time, the uniformity of austenite grains is more or less affected by the amount of spheroidized pearlite. A critical effect on the state of austenite grain is created through the influence of initial microstructures on the start temperature of transformation.

关键词： warm rolling pearlite dislocation austenite transformation