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Icariin accelerates bone regeneration by inducing osteogenesisangiogenesis coupling in rats with type 1 diabetes mellitus

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World Journal of Diabetes 2024年第4期15卷 769-782页

作者： sheng Zheng Guan-Yu Hu Jun-hua Li Jia Zheng Yi-Kai Li Department of Traditional Chinese Orthopedics and Traumatology Center for Orthopedic SurgeryThe Third Affiliated Hospital of Southern Medical UniversityGuangzhou 510630Guangdong ProvinceChina School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Endocrinology Peking University First HospitalBeijing 100034China

BACKGROUND Icariin(ICA),a natural flavonoid compound monomer,has multiple pharmacological ***,its effect on bone defect in the context of type 1 diabetes mellitus(T1DM)has not yet been *** To explore the role and potential mechanism of ICA on bone defect in the context of *** The effects of ICA on osteogenesis and angiogenesis were evaluated by alkaline phosphatase staining,alizarin red S staining,quantitative real-time polymerase chain reaction,Western blot,and ***-related assays were conducted to investigate the relationship between osteogenesis and angiogenesis.A bone defect model was established in T1DM *** model rats were then treated with ICA or placebo and micron-scale computed tomography,histomorphometry,histology,and sequential fluorescent labeling were used to evaluate the effect of ICA on bone formation in the defect *** ICA promoted bone marrow mesenchymal stem cell(BMSC)proliferation and osteogenic *** ICA treated-BMSCs showed higher expression levels of osteogenesis-related markers(alkaline phosphatase and osteocalcin)and angiogenesis-related markers(vascular endothelial growth factor A and platelet endothelial cell adhesion molecule 1)compared to the untreated *** was also found to induce osteogenesis-angiogenesis coupling of *** the bone defect model T1DM rats,ICA facilitated bone formation and CD31hiEMCNhi type H-positive capillary ***,ICA effectively accelerated the rate of bone formation in the defect *** ICA was able to accelerate bone regeneration in a T1DM rat model by inducing osteogenesis-angiogenesis coupling of BMSCs.

关键词： Icariin Osteogenesis-angiogenesis coupling Type 1 diabetes mellitus Bone defect Bone regeneration

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Investigating the Mechanism of Qu Du Qiang Fei 1 Hao Fang Formula against Coronavirus Disease 2019 Based on Network Pharmacology Method

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 93-103页

作者： Yuan-hua Wang He-Yang Zhou Jin-Yun Ma Gui-Qing Ding hua Yu Yong-sheng Jin Xiao-Dong Cheng Institute of Clinical Immunology Yue-Yang Hospital of Integrative MedicineShanghai University of Traditional Chinese MedicineShanghaiChina School of Pharmacy Naval Medical UniversityShanghaiChina

Objective:Qu Du Qiang Fei 1 Hao Fang(QDQF1)is a novel Chinese herbal medicine formula used to treat coronavirus disease 2019(COVID-19).However,the pharmacological mechanisms of action of QDQF1 remain *** objective of this study was to identify the effective ingredients and biological targets of QDQF1 for COVID-19 *** and Methods:The effective ingredients and mechanisms of action of QDQF1 were analyzed by using network pharmacology methods,which included an analysis of the effective ingredients and corresponding targets,COVID-19-related target acquisition,compound-target network analyses,protein-protein interaction network analysis,Kyoto Encyclopedia of Genes and Genomes(KEGG)and Gene Ontology(GO)enrichment analyses,and molecular docking ***:In total,288 effective QDQF1 ingredients were *** identified 51 core targets from the 148 targets through an overlap between putative QDQF1 targets and COVID-19-related *** key components,including formononetin,kaempferol,luteolin,naringenin,quercetin,and wogonin were identified through component-target network *** functional enrichment analysis of the core targets revealed 1296 items,while KEGG pathway enrichment analysis identified 148 signaling *** central targets(CCL2,CXCL8,IL1B,IL6,MAPK1,MAPK3,MAPK8,STAT3,and TNF)related to the COVID-19 pathway were identified in the KEGG pathway enrichment ***,molecular docking analysis suggested that the docking scores of the six key components to the nine central targets were better than those to ***:QDQF1 may regulate multiple immune-and inflammation-related targets to inhibit the progression of severe acute respiratory syndrome coronavirus 2,and thus,may be suitable for the treatment of COVID-19.

关键词： Coronavirus disease 2019 molecular docking molecular mechanism network pharmacology Qu Du Qiang Fei 1 Hao Fang formula

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Pulsations of Three Rapidly Oscillating Ap Stars TIC 96315731,TIC72392575,and TIC 318007796

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Research in Astronomy and Astrophysics 2024年第8期24卷 157-168页

作者： Hai-Jian zhong Dong-Xiang Shen Chun-hua Zhu He-Lei Liu Su-Fen Guo Guo-Liang Lü School of Physical Science and Technology Xinjiang UniversityUrumqi 830046China Xinjiang Astronomical Observatory National Astronomical ObservatoriesChinese Academy of SciencesUrumqi 830000China

We analyze the frequencies of three known roAp stars,TIC 96315731,TIC 72392575,and TIC 318007796,using the light curves from the Transiting Exoplanet Survey *** TIC 96315731,the rotational and pulsational frequencies are 0.1498360 day^(-1)and 165.2609 day^(-1),*** the case of TIC 72392575,the rotational frequency is 0.25551 day^(-1).We detect a quintuplet of pulsation frequencies with a center frequency of135.9233 day^(-1),along with two signals within the second pair of rotational sidelobes of the quintuplet separated by the rotation *** two signals may correspond to the frequencies of a dipole *** TIC318007796,the rotational and pulsational frequencies are 0.2475021 day^(-1),192.73995 day^(-1),and196.33065 day^(-1),*** on the oblique pulsator model,we calculate the rotation inclination(i)and magnetic obliquity angle(b)for the stars,which provide the geometry of the pulsation *** the phases of the frequency quintuplets,the pulsation amplitude and phase modulation curves,and the results of spherical harmonic decomposition,we conclude that the pulsation modes of frequency quintuplets in TIC96315731,TIC 72392575,and TIC 318007796 correspond to distorted dipole mode,distorted quadrupole mode,and distorted dipole mode,respectively.

关键词： asteroseismology-techniques photometric-stars oscillations(including pulsations)-stars chemically peculiar

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Full waveform inversion based on hybrid gradient

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Petroleum Science 2024年第3期21卷 1660-1670页

作者： Chuang Xie Zhi-Liang Qin Jian-hua Wang Peng Song Heng-Guang Shen sheng-Qi Yu Ben-Jun Ma Xue-Qin Liu Qingdao Innovation and Development Base Harbin Engineering UniversityQingdao266000ShandongChina Qingdao Innovation and Development Center Harbin Engineering UniversityQingdao266000ShandongChina CNOOC Research Institute Co. Ltd.Beijing100028China College of Marine Geoscience Ocean University of ChinaQingdao266100ShandongChina Weihai Sunfull Geophysical Exploration Equipment Co. Ltd.Weihai264209ShandongChina

The low-wavenumber components in the gradient of full waveform inversion(FWI)play a vital role in the stability of the ***,when FWI is implemented in some high frequencies and current models are not far away from the real velocity model,an excessive number of low-wavenumber components in the gradient will also reduce the convergence rate and inversion *** solve this problem,this paper firstly derives a formula of scattering angle weighted gradient in FWI,then proposes a hybrid *** hybrid gradient combines the conventional gradient of FWI with the scattering angle weighted gradient in each inversion frequency band based on an empirical formula derived *** weighted hybrid mode,we can retain some low-wavenumber components in the initial lowfrequency inversion to ensure the stability of the inversion,and use more high-wavenumber components in the high-frequency inversion to improve the convergence *** results of synthetic data experiment demonstrate that compared to the conventional FWI,the FWI based on the proposed hybrid gradient can effectively reduce the low-wavenumber components in the gradient under the premise of ensuring inversion *** also greatly enhances the convergence rate and inversion accuracy,especially in the deep part of the *** the field marine seismic data experiment also illustrates that the FWI based on hybrid gradient(HGFWI)has good stability and adaptability.

关键词： Full waveform inversion Hybrid gradient Scattering angle weighted Low-wavenumber component

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考虑质量风险时供应链订货批量的博弈分析

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系统工程理论方法应用 2005年第4期14卷 303-307,312页

作者：华中生陈晓伶中国科学技术大学商学院合肥230026

中间产品的质量缺陷给供应链的订货过程带来质量风险。提出了一种综合质量风险和采购库存成本的供应链订货批量模型,比较了考虑质量风险与不考虑质量风险时的供应链订货批量的差异。研究结果表明,无论在非合作还是在一体化的情况下,考... 详细信息

中间产品的质量缺陷给供应链的订货过程带来质量风险。提出了一种综合质量风险和采购库存成本的供应链订货批量模型,比较了考虑质量风险与不考虑质量风险时的供应链订货批量的差异。研究结果表明,无论在非合作还是在一体化的情况下,考虑质量风险时的订货批量都比不考虑质量风险时的批量小。

关键词：质量风险成本订货批量供应链

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Flexible MXene/sodium alginate composite fabric with high structural stability and oxidation resistance for electromagnetic interference shielding

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Nano Research 2024年第6期17卷 5326-5335页

作者： Hao-Wen Zhang Lu-Yao Yang Meng-Lin huang Ming-hua Cheng Zhe-sheng Feng Fanbin Meng Zifeng Lin Yan Wang School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 610054China Laboratory of Advanced Technologies of Materials(Ministry of Education) School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China College of Materials Science and Engineering Sichuan UniversityChengdu 610065China

Wearable electromagnetic interference(EMI)shielding fabrics with excellent electromagnetic shielding performance,oxidation resistance,and structural stability are highly demanded for the rapid development of electronic devices and wireless *** are metallic conductive materials with exceptional EMI shielding properties,but they are prone to oxidation in air and have poor structural stability and durability on fabric ***,we present a one-step assembly method to fabricate fabrics coated with MXenes and polymeric sodium alginate(SA)composite(MXene-SA).SA protects MXenes from oxidation and forms a stable interlayer structure by bonding to *** MXene-SA coated fabrics are breathable and flexible,and have a low sheet resistance of 2.12±0.08Ω/sq and a high EMI shielding performance of 37.05 dB at X-band,which is comparable to the best 42.31 ***,the MXene-SA coated fabrics exhibit high structural stability and oxidation resistance under various conditions of sonication disintegration,mechanical abuse,chemical corrosion,and humidity,compared to pure MXenes coated *** believe that the wearable and high-performance MXene-SA fabrics have great potential for the next generation of ultra-portable and wearable EMI shielding products.

关键词： MXenes electromagnetic interference shielding fabric one-step assembly

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Super P and MoO2/MoS2 co-doped gradient nanofiber membrane as multi-functional separator for lithium–sulfur batteries

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Rare Metals 2024年第9期43卷 4263-4273页

作者： Xin Liang Dong-Qing Zhao Qian-Qian huang sheng Liang Li-Li Wang Lei Hu Ling-Li Liu Kun-Hong Hu Chong-Hai Deng sheng Cheng Er-Tao Zhu hua-Xia Deng School of Energy Materials and Chemical Engineering LIB Technology Center of Anhui ProvinceHefei University Instrumental Analysis Centre Hefei University of Technology Hefei Youngy Energy Materials Co. Ltd. Department of Modern Mechanics University of Science and Technology of China

Lithium-sulfur battery is one of the most promising battery systems for industrialization due to its high theoretical specific capacity and high energy ***,the??shuttle effect??has restrained the advancement of lithium-sulfur *** this work,a gradient-structured nanofiber membrane with pure gelatin on one side and Super P-MoO2/MoS2-gelatin on the other side was created using a multi-step electrostatic spinning technique,which was applied for multi-functional separator for lithium-sulfur *** pure gelatin layer facing the anode side primarily homogenizes the lithium flux,whereas the Super P-MoO2/MoS2-gelatin layer facing the cathode side primarily adsorbs polysulfides by physical and chemical adsorption and enhancing polysulfide conversion *** findings demonstrate that even after 150 cycles at 0.2C,the lithium-sulfur battery can still sustain a discharge-specific capacity of 572.3 mAh·*** used with Li||Li symmetric batteries,it has a cycle life of more than 1200 *** commercialization of lithium-sulfur batteries is given a fresh idea by this straightforward preparation technique.

关键词： Li–S battery Membrane MoO2/MoS2 Nanofiber

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间断需求预测方法综述

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预测 2005年第5期24卷 70-75页

作者：杨杰张斌华中生中国科学技术大学商学院安徽合肥230052

间断需求是一种随机需求,需求数据中存在着大量的零值。具有间断需求的物资如备件、贵重设备等对于企业生产运作非常重要,需要精确的预测才能很好地进行管理,但目前研究间断需求预测方法的文献不多,已有的间断需求预测方法适用范围有限... 详细信息

间断需求是一种随机需求,需求数据中存在着大量的零值。具有间断需求的物资如备件、贵重设备等对于企业生产运作非常重要,需要精确的预测才能很好地进行管理,但目前研究间断需求预测方法的文献不多,已有的间断需求预测方法适用范围有限,还缺少比较通用的预测方法。本文对现有的间断需求预测方法进行了回顾,分析了当前间断需求预测方法存在的问题,并提出了未来可能的研究方向。

关键词：间断需求需求间隔 0—1序列

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Exosome-Transmitted miR-224-5p Promotes Colorectal Cancer Cell Proliferation via Targeting ULK2 in p53-Dependent Manner

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Biomedical and Environmental Sciences 2024年第1期37卷 71-84页

作者： YANG Le Mei ZHENG Qi LIU Xiao Jia LI Xian Xian Veronica Lim CHEN Qi ZHAO zhong hua WANG Shu Yang Department of Pathology School of Basic MedicineFudan UniversityShanghai 200032China Department of Pathology Dunedin School of MedicineUniversity of OtagoDunedin 9054New Zealand Department of Pathology Huashan HospitalFudan UniversityShanghai 200040China Shanghai Cancer Institute Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Teladoc Health Inc Shanghai 200335China Shanghai Medical College Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Shanghai 200032China

Objective To investigate the role and molecular mechanism of exosomal miR-224-5p in colorectal cancer(CRC).Methods The miR-224-5p expression in CRC patient tissues and cell-derived exosomes was measured by laser capture microdissection and qRT-PCR,***-luciferase reporter gene assay was used to determine the target gene of *** protein expressions of p53 and unc-51 like kinase 2(ULK2)in CRC cells were detected by western *** cytometry was used to detect cell cycle and *** proliferation was measured by CCK8 and EdU *** The miR-224-5p expression was upregulated in CRC tissues and increased progressively with the rise of CRC *** cells secreted extracellular miR-224-5p mainly in an exosome-dependent manner,and then miR-224-5p could be transferred to surrounding tumor cells to regulate cell proliferation in the form of autocrine or ***,ULK2 was characterized as a direct target of miR-224-5p and was downregulated in CRC ***,ULK2 inhibited CRC cell proliferation in a p53-dependent ***,exosome-derived miR-224-5p partially reversed the proliferation regulation of ULK2 on CRC *** Our findings demonstrate that exosome-transmitted miR-224-5p promotes p53-dependent cell proliferation by targeting ULK2 in CRC,which may offer promising targets for CRC prevention and therapy.

关键词： miR-224-5p Exosome ULK2 p53 Cell proliferation Colorectal cancer

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Enhanced recovery after surgery in elderly patients with non-small cell lung cancer who underwent video-assisted thoracic surgery

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World Journal of Clinical Cases 2024年第12期12卷 2040-2049页

作者： Mei-hua Sun Liu-sheng Wu Ying-Yang Qiu Jun Yan Xiao-Qiang Li Department of Thoracic Surgery Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina School of Medicine Tsinghua UniversityBeijing 100084China Yong Loo Lin School of Medicine National University of SingaporeSingapore 119077Singapore

BACKGROUND This study was designed to investigate the clinical outcomes of enhanced recovery after surgery(ERAS)in the perioperative period in elderly patients with nonsmall cell lung cancer(NSCLC).AIM To investigate the potential enhancement of video-assisted thoracic surgery(VATS)in postoperative recovery in elderly patients with *** We retrospectively analysed the clinical data of 85 elderly NSCLC patients who underwent ERAS(the ERAS group)and 327 elderly NSCLC patients who received routine care(the control group)after VATS at the Department of Thoracic Surgery of Peking University Shenzhen Hospital between May 2015 and April *** propensity score matching of baseline data,we analysed the postoperative stay,total hospital expenses,postoperative 48-h pain score,and postoperative complication rate for the 2 groups of patients who underwent lobectomy or sublobar *** After propensity score matching,ERAS significantly reduced the postoperative hospital stay(6.96±4.16 vs 8.48±4.18 d,P=0.001)and total hospital expenses(48875.27±18437.5 vs 55497.64±21168.63 CNY,P=0.014)and improved the satisfaction score(79.8±7.55 vs 77.35±7.72,P=0.029)relative to those for routine *** significant between-group difference was observed in postoperative 48-h pain score(4.68±1.69 vs 5.28±2.1,P=0.090)or postoperative complication rate(21.2%vs 27.1%,P=0.371).Subgroup analysis showed that ERAS significantly reduced the postoperative hospital stay and total hospital expenses and increased the satisfaction score of patients who underwent lobectomy but not of patients who underwent sublobar *** ERAS effectively reduced the postoperative hospital stay and total hospital expenses and improved the satisfaction score in the perioperative period for elderly NSCLC patients who underwent lobectomy but not for patients who underwent sublobar resection.

关键词： Enhanced recovery after surgery Non-small cell lung cancer Perioperative care Propensity score Video-assisted thoracic surgery

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