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Prevalence and clinical impact of sarcopenia in liver transplant recipients:A meta-analysis

World Journal of Gastroenterology 2024年第8期30卷 956-968页

作者： Min-Jie Jiang Mu-Chen Wu Zhong-Hui Duan Jing Wu Xiao-Tong Xu Juan Li qing-hua meng Department of Hepatology Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Department of Emergency Beijing You-An HospitalCapital Medical UniversityBeijing 100069China

BACKGROUND The prevalence of sarcopenia in patients undergoing liver transplantation(LT)remains to be determined partly because of different diagnostic *** has recently been recognized as a new prognostic factor for predicting outcomes in LT *** To estimate the prevalence of sarcopenia and evaluate its clinical effect on LT *** This systematic search was conducted in PubMed,Web of Science,Embase,and Cochrane Library for original English-language articles that investigated the prevalence and influence of sarcopenia in patients undergoing LT from database inception to November 30,*** studies of the definition of sarcopenia that estimate sarcopenia prevalence and evaluate its effect on clinical outcomes and the risk of mortality were *** Twenty-five studies involving 7760 patients undergoing LT were *** pooled prevalence of sarcopenia in patients undergoing LT was 40.7%[95%confidence intervals(95%CI):32.1-49.6].The 1-,3-,and 5-year cumulative probab-ilities of post-LT survival in patients with preoperative sarcopenia were all lower than those without sarcopenia(P<0.05).Sarcopenia was associated with an increased risk of post-LT mortality in patients undergoing LT(adjusted hazard ratio:1.58;95%CI:1.21-2.07).Patients with preoperative sarcopenia had a longer intensive care unit stay,a high risk ratio of sepsis,and serious post-LT complications than those without *** Sarcopenia is prevalent in a substantial proportion of patients undergoing LT and is strongly and independently associated with higher a risk of mortality risk.

关键词： Sarcopenia Liver transplantation Mortality Clinical outcomes

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Identifying the risk factors for pancreatic fistula after laparoscopic pancreaticoduodenectomy in patients with pancreatic cancer

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1609-1617页

作者： Hang Xu qing-Cai meng Jie hua Wei Wang Department of Pancreatic Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China

BACKGROUND Laparoscopic pancreaticoduodenectomy(LPD)is a surgical procedure for treating pancreatic cancer;however,the risk of complications remains high owing to the wide range of organs involved during the surgery and the difficulty of *** fistula(PF)is a major complication that not only increases the risk of postoperative infection and abdominal hemorrhage but may also cause multi-organ failure,which is a serious threat to the patient’s *** study hypothesized the risk factors for PF after *** To identify the risk factors for PF after laparoscopic pancreatoduodenectomy in patients with pancreatic *** We retrospectively analyzed the data of 201 patients admitted to the Fudan University Shanghai Cancer Center between August 2022 and August 2023 who underwent LPD for pancreatic *** the basis of the PF’s incidence(grades B and C),patients were categorized into the PF(n=15)and non-PF groups(n=186).Differences in general data,preoperative laboratory indicators,and surgery-related factors between the two groups were compared and analyzed using multifactorial logistic regression and receiver-operating characteristic(ROC)curve *** The proportions of males,combined hypertension,soft pancreatic texture,and pancreatic duct diameter≤3 mm;surgery time;body mass index(BMI);and amylase(Am)level in the drainage fluid on the first postoperative day(Am>1069 U/L)were greater in the PF group than in the non-PF group(P24.91 kg/m²[odds ratio(OR)=13.978,95%confidence interval(CI):1.886-103.581],hypertension(OR=8.484,95%CI:1.22-58.994),soft pancreatic texture(OR=42.015,95%CI:5.698-309.782),and operation time>414 min(OR=15.41,95%CI:1.63-145.674)were risk factors for the development of PF after LPD for pancreatic cancer(all P<0.05).The areas under the ROC curve for BMI,

关键词： Pancreatic cancer Laparoscopy Pancreaticoduodenectomy Pancreatic fistula Risk factors Receiver-operating characteristic curve

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Current understanding of the metabolism of micronutrients in chronic alcoholic liver disease

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World Journal of Gastroenterology 2020年第31期26卷 4567-4578页

作者： Jing Wu qing-hua meng Department of Critical Care Medicine of Liver Disease Beijing You-An HospitalCapital Medical UniversityBeijing 100069China

Alcoholic liver disease(ALD)remains an important health problem *** of micronutrients has been broadly reported to be a common characteristic in patients with ALD,given the fact that micronutrients often act as composition or coenzymes of many biochemical enzymes responsible for the inflammatory response,oxidative stress,and cell *** the metabolic pattern and the function of these micronutrients is a prerequisite before targeted intervention can be delivered in clinical *** years have registered a significant improvement in our understanding of the role of micronutrients on the pathogenesis and progression of ***,how and to what extent these micronutrients are involved in the pathophysiology of ALD remains largely *** the current study,we provide a review of recent studies that investigated the imbalance of micronutrients in patients with ALD with a focus on zinc,iron,copper,magnesium,selenium,vitamin D and vitamin E,and determine how disturbances in micronutrients relates to the pathophysiology of ***,zinc,selenium,vitamin D,and vitamin E uniformly exhibited a deficiency,and iron demonstrated an elevated *** for copper,both an elevation and deficiency were observed from existing *** importantly,we also highlight several challenges in terms of low sample size,study design discrepancies,sample heterogeneity across studies,and the use of machine learning approaches.

关键词： Alcoholic liver disease Metabolism Trace elements Vitamins Malnutrition Oxidative stress

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Synthesis of a novel pyrrolo-benzoxaborole scaffold and its derivatization via Friedel-Crafts reaction catalyzed by anhydrous stannic chloride

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Chinese Chemical Letters 2011年第12期22卷 1411-1414页

作者： Pu hua Wu qing qing meng Hu Chen Zhou School of Pharmacy Shanghai Jiaotong University Shanghai 200240 China

A novel pyrrolo-benzoxaborole,6-（pyrrol-1-yl）-1,3-dihydro-1-hydroxy-2,1-benzoxaborole,was synthesized with 27%overall yield over six steps from 2-bromo-1-methyl-4-nitrobenzene as starting *** derivatization was achieved via Friedel-Crafts reaction catalyzed by anhydrous stannic chloride with various acyl chlorides giving 3-acyl-1-phenylpyrroles as the main products.

关键词： Benzoxaborole Friedel-Crafts reaction Stannic chloride 3-Acyl-1-arylpyrrole

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Influence of underground space development mode on the groundwater flow field in Xiong’an new area

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Journal of Groundwater Science and Engineering 2023年第1期11卷 68-80页

作者： Yi-hang Gao Jun-hui Shen Lin Chen Xiao Li Shuang Jin Zhen Ma qing-hua meng Tianjin Geological Survey Center China Geological SurveyTianjin 300000China State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China College of Environment and Civil Engineering Chengdu University of TechnologyChengdu 610059China Shenyang Geological Survey Center China Geological SurveyShenyang 110034China Fifth Geological Brigade Hebei Bureau of Geology and Mineral ResourcesTangshan 063000Hebei ProvinceChina

The degree and scale of underground space development are growing with the continuous advancement of urbanization in *** lack of research on the change of the groundwater flow field before and after the development of underground space has led to various problems in the process of underground space development and *** paper took the key development zone of the Xiong’an New Area as the study area,and used the Groundwater modeling system software(GMS)to analyse the influence on the groundwater flow field under the point,line,and surface development *** main results showed that the underground space development would lead to the expansion and deepening of the cone of depression in the *** groundwater level on the upstream face of the underground structure would rise,while the water level on the downstream face would ***“line”concurrent development has the least impact on the groundwater flow field,and the maximum rise of water level on the upstream side of the underground structure is expected to be approximately 3.05 ***“surface”development has the greatest impact on the groundwater flow field,and the maximum rise of water level is expected to be 7.17 m.

关键词： Xiong’an new area Groundwater flow field Underground space GMS

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Current understanding of mesenchymal stem cells in liver diseases

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World Journal of Stem Cells 2021年第9期13卷 1349-1359页

作者： Mu-Chen Wu qing-hua meng Department of Medical Oncology You An HospitalCapital Medical UniversityBeijing 100069China

Liver diseases caused by various factors have become a significant threat to publichealth worldwide. Liver transplantation has been considered as the only effectivetreatment for end-stage liver diseases;however, it is limited by the shortage ofdonor organs, postoperative complications, long-term immunosuppression, andhigh cost of treatment. Thus, it is not available for all patients. Recently,mesenchymal stem cells (MSCs) transplantation has been extensively explored forrepairing hepatic injury in various liver diseases. MSCs are multipotent adultprogenitor cells originated from the embryonic mesoderm, and can be found inmesenchymal tissues including the bone marrow, umbilical cord blood, adiposetissue, liver, lung, and others. Although the precise mechanisms of MSC transplantationremain mysterious, MSCs have been demonstrated to be able toprevent the progression of liver injury and improve liver function. MSCs can selfrenewby dividing, migrating to injury sites and differentiating into multiple celltypes including hepatocytes. Additionally, MSCs have immune-modulatoryproperties and release paracrine soluble factors. Indeed, the safety and effectivenessof MSC therapy for liver diseases have been demonstrated in ***, pre-clinical and clinical trials are largely required to confirm its safetyand efficacy before large scale clinical application. In this review, we will explorethe molecular mechanisms underlying therapeutic effects of MSCs on liverdiseases. We also summarize clinical advances in MSC-based therapies.

关键词： Mesenchymal stem cell Liver disease Clinical trial Treatment Safety Efficacy

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TRAIL and Celastrol Combinational Treatment Suppresses Proliferation, Migration, and Invasion of Human Glioblastoma Cells via Targeting Wnt/β-catenin Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 322-329页

作者： QIN Jing-jing NIU meng-da CHA Zhe GENG qing-hua LI Yu-lin REN Chun-guang David P.Molloy YU hua-rong Research Center of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China Laboratory of Developmental Biology Department of Cell Biology and GeneticsSchool of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China

Objective To investigate the mechanistic basis for the anti-proliferation and anti-invasion effect of tumor necrosis factor-related apoptosis-induced ligand(TRAIL)and celastrol combination treatment(TCCT)in glioblastoma *** Cell counting kit-8 was used to detect the effects of different concentrations of celastrol(0-16µmol/L)and TRAIL(0-500 ng/mL)on the cell viability of glioblastoma cells.U87 cells were randomly divided into 4 groups,namely control,TRAIL(TRAIL 100 ng/mL),Cel(celastrol 0.5µmol/L)and TCCT(TRAIL 100 ng/mL+celastrol 0.5µmol/L).Cell proliferation,migration,and invasion were detected by colony formation,wound healing,and Transwell assays,*** reverse transcription polymerase chain reaction and Western blotting were performed to assess the levels of epithelial-mesenchymal transition(EMT)markers(zona occludens,N-cadherin,vimentin,zinc finger E-box-binding homeobox,Slug,and β-catenin).Wnt pathway was activated by lithium chloride(LiCl,20 mol/L)and the mechanism for action of TCCT was *** Celastrol and TRAIL synergistically inhibited the proliferation,migration,invasion,and EMT of U87 cells(P<0.01).TCCT up-regulated the expression of GSK-3β and down-regulated the expression of β-catenin and its associated proteins(P<0.05 or P<0.01),including c-Myc,Cyclin-D1,and matrix metalloproteinase(MMP)-*** addition,LiCl,an activator of the Wnt signaling pathway,restored the inhibitory effects of TCCT on the expression of β-catenin and its downstream genes,as well as the migration and invasion of glioblastoma cells(P<0.05 or P<0.01).Conclusions Celastrol and TRAIL can synergistically suppress glioblastoma cell migration,invasion,and EMT,potentially through inhibition of Wnt/β-catenin *** underlies a novel mechanism of action for TCCT as an effective therapy for glioblastoma.

关键词： celastrol Chinese medicine tumor necrosis factor-related apoptosis-induced ligand glioblastoma β-catenin Tripterygium wilfordii

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Escape probability for isotropic emitters near Kerr black hole with astrometric

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Communications in Theoretical Physics 2024年第5期76卷 128-133页

作者： Yu-Xuan Han qing-hua Zhu qing-Guo huang CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesNo.19A Yuquan RoadBeijing 100049China Department of Physics Chongqing UniversityChongqing 401331China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced Study UCASHangzhou 310024China

The paper investigates the escape probability for isotropic emitters near a Kerr black *** propose a new approach to obtain the escape probability in a general manner,going beyond previous case-by-case *** approach is based on studies of the black hole shadow with astrometric observable and can be applied to emitters with an arbitrary 4-velocities and locations,even to the emitters outside of the equatorial *** also consider representative examples illustrating how escape probabilities vary with distance,velocity,and inclination ***,this new approach provides an effective method for studying escape probabilities near Kerr black holes.

关键词： Kerr black hole photon escape probability isotropic emitters

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An-Luo-hua-Xian Pill Improves the Regression of Liver Fibrosis in Chronic Hepatitis B Patients Treated with Entecavir

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Journal of Clinical and Translational Hepatology 2023年第2期11卷 304-313页

作者： Yi-Qi Liu Chi Zhang Jia-Wen Li Li-hua Cao Zhan-qing Zhang Wei-Feng Zhao qing-hua Shang Da-Zhi Zhang An-Lin Ma qing Xie Hong-Lian Gui Guo Zhang Ying-Xia Liu Jia Shang Shi-Bin Xie Jun Li Xu-qing Zhang Zhi-Qiang Zou Yu-Ping Chen Zong Zhang Ming-Xiang Zhang Jun Cheng Fu-Chun Zhang Li-hua huang Jia-Bin Li qing-hua meng Hai-Bin Yu Yu-Qiang Mi Yan-Zhong Peng Zhi-Jin Wang Li-Ming Chen Fan-Ping meng Wan-hua Ren Lang Bai Yi-Lan Zeng Rong Fan Xian-Zhi Lou Wei-Feng Liang Hui Liu Hui Zhuang Hong Zhao Gui-Qiang Wang Department of Infectious Disease Center for Liver DiseasePeking University First HospitalBeijingChina Department of Hepatology The Third Hospital of QinhuangdaoQinhuangdaoHebeiChina Department of Infectious Disease Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina Department of Infectious Disease Xinxiang Medical University Affiliated Third HospitalXinxiangHenanChina No.88 Hospital of Chinese People’s Liberation Army(PLA) JinanShandongChina Department of Infectious Diseases The Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Infectious Disease China-Japan Friendship HospitalBeijingChina Department of Infectious Diseases Ruijin HospitalSchool of MedicineShanghai Jiaotong UniversityShanghaiChina Department of Gastroenterology The People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxiChina Department of Infectious Diseases The Third People’s Hospital of ShenzhenShenzhenGuangdongChina Department of Infectious Diseases The People’s Hospital of Henan ProvinceZhengzhouHenanChina Department of Infectious Disease The Third Affiliated Hospital of Sun-Yat Sen UniversityGuangzhouGuangdongChina Department of Infectious Diseases Jiangsu Province HospitalThe First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Infectious Diseases The Southwest Hospital of Army Medical UniversityChongqingChina Yantai Infectious Diseases Hospital YantaiShandongChina Department of Hepatology Baoding Infectious Diseases HospitalBaodingHebeiChina Department of Integrated Traditional Chinese Medicine(TCM)and Western Medicine Jinan Infectious Diseases HospitalShandong UniversityJinanShandongChina Department of Integrated TCM and Western Medicine in Hepatology The Sixth People’s Hospital of ShenyangShenyangLiaoningChina Beijing Ditan Hospital Capital Medical UniversityBeijingChina Department of Infectious Diseases Guangzhou Eighth People’s HospitalGuangzhou Medical UniversityGuangzhouGuangdon

Background and Aims:Chronic hepatitis B(CHB)can cause liver fibrosis and lead to cirrhosis and *** the effectiveness of antiviral therapy to reverse liver fibrosis is limited,We aimed to evaluate the effect of An-Luo-hua-Xian pill(ALHX)on fibrosis regression in CHB patients treated with entecavir(ETV).Methods:Treatment-naïve patients with CHB were randomly treated with ETV alone or combined with ALHX(ETV+ALHX)between October 1,2013 and December 31,***,laboratory,and liver histology data before and after 78 weeks of treatment were *** Ishak fibrosis score(F)was used and fibrosis regression required a decrease in F of≥1 after ***:A total of 780 patients were enrolled,and 394 with a second liver biopsy after treatment were included in the per-protocol population,132 in ETV group and 262 in ETV+ALHX *** 78 weeks of treatment,the fibrosis regression rate in the ETV+ALHX group was significantly higher than that of the ETV group at baseline F≥3 patients:124/211(58.8%)vs.45/98(45.9%),p=*** percentage of patients with a decreased liver stiffness measurement(LSM)was higher in the ETV+ALHX group:156/211(73.9%)vs.62/98(63.%),p=*** regression analysis showed that ETV combined with ALHX was associated with fibrosis regression[odds ratio(OR)=1.94,p=0.018],and a family history of hepatocellular carcinoma was on the contrary.(OR=0.41,p=0.031).Conclusions:ETV combined with ALHX increased liver fibrosis regression in CHB patients.

关键词： Chronic hepatitis B Liver fibrosis Regression Randomized controlled trial

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Structure and 2p decay mechanism of^(18)Mg

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Nuclear Science and Techniques 2024年第6期35卷 145-154页

作者： Long Zhou De-qing Fang Si-Min Wang Hui hua Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics NSFC and Fudan UniversityShanghai 200438China School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijing 100871China

The recently discovered,extremely proton-rich nuclide 18 Mg exhibits ground-state decay via two sequential two-proton(2p)emissions through the intermediate nucleus,*** study investigates the structure and the initial 2p decay mechanism of^(18)Mgby examining the density and correlations of the valence protons using a three-body Gamow coupled-channel *** results show that the ground state of^(18)Mgis significantly influenced by the continuum,resulting in a significant s-wave ***,based on the current framework,this does not lead to a significant deviation in mirror symmetry in either the structure or spectroscopy of the 18Mg-18C ***,the time evolution analysis of the^(18)Mgground state suggests a simultaneous 2p emission during the first step of *** observed nucleon-nucleon correlations align with those of the light-mass 2p emitters,indicating a consistent decay behavior within this nuclear region.

关键词： Structure of^(18)Mg Two-proton decay Proton-proton correlation

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