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Curcumin for gastric cancer:Mechanism prediction via network pharmacology,docking,and in vitro experiments

World Journal of Gastrointestinal Oncology 2024年第8期16卷 3635-3650页

作者： Peng-Hui Yang Ya-Nan Wei Bi-Juan Xiao Si-Yi Li Xin-Long Li Liang-Jun Yang hua-feng pan Geng-Xin Chen The Second School of Clinical Medicine Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Department of Traditional Chinese Medicine The People's Hospital of LonghuaShenzhen 518109Guangdong ProvinceChina Department of Gastroenterology Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Centre for Translational Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina

BACKGROUND Curcumin originates from the natural herb turmeric,and its antitumor effects have been known about for a long ***,the mechanism by which curcumin affects gastric cancer(GC)has not been *** To elucidate the potential mechanisms of curcumin in the treatment of *** Network pharmacological approaches were used to perform network analysis of *** first analyzed Lipinski’s Rule of Five for the use of *** latent targets were predicted using the PharmMapper,SwissTargetPrediction and DrugBank network *** disease targets were mined through the GeneCard,OMIM,DrugBank and TTD network ***,GO enrichment,KEGG enrichment,protein-protein interaction(PPI),and overall survival analyses were *** results were further verified through molecular docking,differential expression analysis and cell *** We identified a total of 48 curcumin-related genes with 31 overlapping GC-related *** intersection targets between curcumin and GC have been enriched in 81 GO biological processes and 22 significant *** PPI analysis,6 hub targets were identified,namely,estrogen receptor 1(ESR1),epidermal growth factor receptor(EGFR),cytochrome P450 family 3 subfamily A member 4(CYP3A4),mitogen-activated protein kinase 14(MAPK-14),cytochrome P450 family 1 subfamily A member 2(CYP1A2),and cytochrome p450 family 2 subfamily B member 6(CYP2B6).These factors are correlated with decreased survival rates among patients diagnosed with *** docking analysis further substantiated the strong binding interactions between Curcumin and the hub target *** experimental findings demonstrated that curcumin not only effectively inhibits the growth of BGC-823 cells but also suppresses their *** levels of hub targets CYP3A4,MAPK14,CYP1A2,and CYP2B6 in BGC-823 cells were significantly increased in each dose *** Curcumin can play an anti-GC role through a variety of

关键词： Curcumin Gastric cancer Network pharmacology Molecular docking Survival analysis

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Real-time motion deblurring algorithm with robust noise suppression

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第5期11卷 375-380页

作者： hua-jun feng Yong-pan WANG Zhi-hai XU Qi LI hua LEI Ju-feng ZHAO State Key Lab of Modern Optical Instrumentation Zhejiang University Hangzhou 310027 China

In an image restoration process,to obtain good results is challenging because of the unavoidable existence of noise even if the blurring information is already *** suppress the deterioration caused by noise during the image deblurring process,we propose a new deblurring method with a known ***,the noise in the measurement process is assumed to meet the Gaussian distribution to fit the natural noise ***,the first and second orders of derivatives are supposed to satisfy the independent Gaussian distribution to control the non-uniform *** results show that our method is obviously superior to the Wiener filter,regularized filter,and Richardson-Lucy(RL) ***,owing to processing in the frequency domain,it runs faster than the other algorithms,in particular about six times faster than the RL algorithm.

关键词： Motion blurring Motion kernel Gaussian distribution

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Mechanism of local solidification time variations with melt rate during vacuum arc remelting process of 8Cr4Mo4V high-strength steel

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Journal of Iron and Steel Research International 2024年第2期31卷 377-388页

作者： Tao pan Hong-chun Zhu Zhou-hua Jiang hua-bing Li Rui Zhang Hao feng School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819LiaoningChina

A 2D axisymmetric numerical model was established to investigate the variations of molten pool with different melt rates during the vacuum arc remelting of 8Cr4Mo4V high-strength steel,and the ingot growth was simulated by dynamic mesh *** results show that as the ingot grows,the molten pool profile changes from shallow and flat to V-shaped,and both the molten pool depth and the mushy width ***,the variation of both the molten pool shape and the mushy width melt rate is clarified by the thermal equilibrium *** melt rate increases,both the molten pool depth and the mushy width *** is caused by the increment in sensible heat stored in the ingot due to the limitation of the cooling capacity of the *** nonlinear increment in sensible heat leads to a nonlinear increase in the mushy *** addition,as melt rate increases,the local solidification time(LST)of ingot decreases obviously at first and then *** melt rate is controlled in a suitable range,LST is the lowest and the secondary dendrite arm spacing of the ingot is the smallest,which can effectively improve the compactness degree of 8Cr4Mo4V high-strength steel.

关键词： 8Cr4Mo4V high-strength steel Vacuum arc remelting process Melt rate Molten pool Local solidification time

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Full robot-assisted gastrectomy with intracorporeal robot-sewn anastomosis produces satisfying outcomes

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World Journal of Gastroenterology 2013年第38期19卷 6427-6437页

作者： Xin-Xin Liu Zhi-Wei Jiang Ping Chen Yan Zhao hua-feng pan Jie-Shou Li Department of Gastrointestinal Surgery Subei People’s Hospital of Jiangsu Province Post-doctoral Mobile Stations of Nanjing University Clinical Medical College of Yangzhou University Department of General Surgery Jinling HospitalSchool of MedicineNanjing University

AIM:To evaluate the feasibility and safety of full robotassisted gastrectomy with intracorporeal robot handsewn anastomosis in the treatment of gastric ***:From September 2011 to March 2013,110consecutive patients with gastric cancer at the authors’institution were enrolled for robotic *** to tumor location,total gastrectomy,distal or proximal subtotal gastrectomy with D2 lymphadenectomy was fully performed by the da Vinci Robotic Surgical *** construction,including Roux-en-Y jejunal limb,esophagojejunal,gastroduodenal and gastrojejunal anastomoses were fully carried out by the intracorporeal robot-sewn *** the end of surgery,the specimen was removed through a 3-4 cm incision at the umbilicus trocar *** details of the surgical technique are well *** benefits in terms of surgical and oncologic outcomes are well documented,as well as the failure rate and postoperative ***:From a total of 110 enrolled patients,radical gastrectomy could not be performed in 2 patients due to late stage disease;1 patient was converted to laparotomy because of uncontrollable hemorrhage,and1 obese patient was converted due to difficult exposure;2 patients underwent extra-corporeal anastomosis by minilaparotomy to ensure adequate tumor ***-sewn anastomoses were successfully performed for 12 proximal,38 distal and 54 total *** average surgical time was 272.52±53.91 min and the average amount of bleeding was 80.78±32.37 *** average number of harvested lymph nodes was 23.1±*** specimens showed adequate surgical *** regard to tumor staging,26,32 and 46 patients were staged asⅠ,ⅡandⅢ,*** average hospitalization time after surgery was 6.2 *** patient experienced a duodenal stump anastomotic leak,which was mild and treated *** patient was readmitted for intra-abdominal infection and was treated *** afferent loop obstruction occurred i

关键词： Robotic surgery Gastric cancer Total gastrectomy Esophagojejunal anastomosis

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Barrier-focused intervention to increase colonoscopy attendance among nonadherent high-risk populations

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World Journal of Gastroenterology 2009年第31期15卷 3920-3925页

作者： Wen Meng Xi-Wen Bi Xiao-Yin Bai hua-feng pan Shan-Rong Cai Qi Zhao Su-Zhan Zhang Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education Key Laboratory of Molecular Biology in Medical Sciences Zhejiang Province China The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310009 Zhejiang Province China Department of Cardiothoracic Surgery Hangzhou No. 1 People Hospital Hangzhou 310006 Zhejiang Province China Xiacheng District Center for Disease Control and Prevention Hangzhou 310003 Zhejiang Province China

AIM： To increase attendance tor colonoscopy among nonadherent high-risk individuals for colorectal cancer （CRC） screening in China. METHODS： During the first 12 mo without intervention, only 428 of the 2398 high-risk subjects attended a scheduled colonoscopy examination. The 1970 subjects who did not attend for CRC screening were enrolled in the present study. Prior barrier investigation was performed to ascertain the reasons for nonadherence. A barrier-focused intervention program was then established and implemented among eligible nonadherent subjects by telephone interviews and on-site consultations. The completion rates of colonoscopy during the first 12 mo without intervention and the second 12 mo with intervention were compared. Variations in the effect of the intervention on some high-risk factors and barrier characteristics were analyzed using logistic regression. RESULTS： 540 subjects who were not eligible were excluded from the study. The colonoscopy attendance rate was 23.04% （428/1858） during the first 12 mo without intervention, and 37.69% （539/1430） during the second 12 mo with intervention （P 〈 0.001）. Logistic regression analysis showed that the intervention was more effective among subjects with only objective barriers （OR： 34.590, 95% CI： 23.204-51.563） or subjects with some specific highrisk characteristics： first-degree relatives diagnosed with CRC （OR： 1.778, 95% CI： 1.010-3.131）, personal history of intestinal polyps （OR： 3.815, 95% CI： 1.994-7.300） and positive result for immunochemical fecal occult blood testing （OR： 2.718, 95% CI： 1.479-4.996）. CONCLUSION： The barrier-focused telephone or on- site consultation intervention appears to be a feasible means to improve colonoscopy attendance among nonadherent high-risk subjects for CRC screening in China.

关键词： Colorectal cancer Screening Intervention Colonoscopy Attendance

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Avoidance of urinary drainage during perioperative period of open elective colonic resection within enhanced recovery after surgery programme

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Gastroenterology Report 2021年第6期9卷 589-594页

作者： Yun Li Zhi-Wei Jiang Xin-Xin Liu hua-feng pan Guan-Wen Gong Cheng Zhang Zheng-Rong Li Department of Gastrointestinal Surgery The First Affiliated Hospital of Nanchang UniversityNanchangJiangxiP.R.China Jiangxi Institute of Digestive surgery NanchangJiangxi 330006P.R.China Department of General Surgery The Affiliated Hospital of Nanjing University of Chinese MedicineNanjingJiangsuP.R.China

Background:Urinary catheterization(UC)is a conventional perioperative measure for major abdominal *** of perioperative catheter management is an essential component of the enhanced recovery after surgery(ERAS)*** aimed to investigate the risk factors of urinary retention(UR)after open colonic resection within the ERAS protocol and to assess the feasibility of avoiding urinary drainage during the perioperative ***:A total of 110 colonic-cancer patients undergoing open elective colonic resection between July 2014 and May 2018 were enrolled in this *** patients were treated within our ERAS protocol during the perioperative *** on patients’demographics,clinicopathologic characteristics,and perioperative outcomes were collected and analysed ***:Sixty-eight patients(61.8%)underwent surgery without any perioperative *** patients(27.3%)received indwelling UC during the surgical ***(10.9%)cases developed UR after surgery necessitating *** patients with intraoperative UC had a lower incidence of post-operative UR[0%(0/30)vs 15%(12/80),P=0.034],intraoperative UC was not testified as an independent protective factor inmultivariate logistic *** history of prostatic diseases and the body mass index were strongly associated with post-operative *** patients were diagnosed with post-operative urinary-tract infection,among whom two had intraoperative UC and four were complicated with post-operative UR requiring ***:Avoidance of urinary drainage for open elective colonic resection is feasible with the implementation of the ERAS programme as the required *** and a history of prostatic diseases are significant predictors of postoperative UR.

关键词： colectomy urinary catheterization urinary retention enhanced recovery after surgery

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Hydrodynamic Characteristics of Undular Tidal Bores in the Qiantang River Based on Field Observations

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China Ocean Engineering 2024年第3期38卷 505-518页

作者： ZHANG Shu-yu pan Cun-hong ZHANG Shen-yang LI Ruo-hua CHENG Wenlong XIE Dong-feng Zhejiang Tongji Vocational College of Science and Technology Hangzhou 311231China Zhejiang Institute of Hydraulics and Estuary Hangzhou 310020China

Understanding the undular tidal bores in the Qiantang River is essential for effective river management and *** breaking tidal bores have been studied extensively, reports on undular tidal bores in the Qiantang Riverremain limited. Furthermore, observed data on undular tidal bores fulfilling the requirements of short measurementtime intervals, and spring, medium, and neap tide coverage, and providing detailed data for the global vertical stratificationof flow velocity are quite limited. Based on field observations at Qige in the Qiantang estuary, we analyzedthe characteristics of undular tidal bores. The results showed that the flooding amplitude (a) of the first wave isalways larger than its ebbing amplitude (b). Moreover, the vertical distribution of the maximum flood velocity exhibitesthree shapes, influenced by the tidal range, while that of the maximum ebb velocity exhibites a single shape. Duringthe initial phase of the flood tide in the spring and medium tides, the upper water body experiences multiple oscillatingchanges along the flow direction, corresponding to the alternating process of the crest and trough of the tide levelupon the arrival of the tidal bore. The tidal range is a crucial parameter in tidal bore hydrodynamics. By establishingthe relationship between hydrodynamic parameters and tidal range, other hydrodynamic parameters, such as the tidalbore height, maximum flood depth–averaged velocity, maximum flood stratified velocity at the measurement points,and duration of the flood tide current, can be effectively predicted, thereby providing an important reference for rivermanagement and maintenance.

关键词： tidal bores Qiantang Estuary tidal bore height tidal bore velocity propagation speed

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Dissipation source function and an improvement to LAGFD-WAM model

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Acta Oceanologica Sinica 1992年第4期11卷 471-481页

作者： Yuan Yeli, hua feng, pan Zengdi and Sun Letao 1. First Institute of Oceanography, State Oceanic Administration, Qingdao 266003, China First Institute of Oceanography State Oceanic Administration Qingdao 266003 China China

In this paper, a new theoretical expression of dissipation term is presented on the basis of statistical model of breaking wave, which is an improvement to LAGFD-WAM wave model. The computational results in three typical wind fields show a good improvement to LAGFD-WAM model and a better accuracy in comparison with the observed data in the South China Sea.

关键词： WAM mode Dissipation source function and an improvement to LAGFD-WAM model

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Unstructured Road Extraction in UAV Images based on Lightweight Model

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 372-384页

作者： Di Zhang Qichao An Xiaoxue feng Ronghua Liu Jun Han feng pan School of Automation Beijing Institute of TechnologyBeijing 100081China Tianjin Institute of Maritime Navigation Instruments Tianjin 300130China The 716th Research Institute of China Shipbuilding Group Co. LtdJiangsu 222061China

There is no unified planning standard for unstructured roads,and the morphological structures of these roads are complex and *** is important to maintain a balance between accuracy and speed for unstructured road extraction *** road extraction algorithms based on deep learning have problems such as high model complexity,high computational cost,and the inability to adapt to current edge computing ***,it is best to use lightweight network *** the need for lightweight models and the characteristics of unstructured roads with different pattern shapes,such as blocks and strips,a TMB(Triple Multi-Block)feature extraction module is proposed,and the overall structure of the TMBNet network is *** TMB module was compared with SS-nbt,Non-bottleneck-1D,and other modules via *** feasibility and effectiveness of the TMB module design were proven through experiments and *** comparison experiment,using multiple convolution kernel categories,proved that the TMB module can improve the segmentation accuracy of the *** comparison with different semantic segmentation networks demonstrates that the TMBNet network has advantages in terms of unstructured road extraction.

关键词： Unstructured road Lightweight model Triple Multi-Block(TMB) Semantic segmentation net

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Deep insight of unique phase transition behaviors and mechanism in Zr_(2)Co-H isotope system with ultra-low equilibrium pressure

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Rare Metals 2024年第1期43卷 212-224页

作者： Yang Liu pan-pan Zhou Xue-Zhang Xiao Jia-Cheng Qi Jia-Peng Bi Tiao Ying Xing-Wen feng Yan Shi Wen-hua Luo Li-Xin Chen State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Institute of Materials China Academy of Engineering PhysicsMianyang 621907China Key Laboratory of Advanced Materials and Applications for Batteries of Zhejiang Province Hangzhou 310013China

Efficient capture,safe storage and release of tritium from the international thermonuclear experimental reactor(ITER) reaction exhaust gas is a perplexing problem,and the development of an efficient tritium-getter material with ultra-low hydrogenation equilibrium pressure is considered as a reliable *** this work,Zr_(2)Co alloy was selected as a tritium-getter material and prepared through induction levitation *** performance test results show that Zr_(2)Co exhibits an ultra-low hydrogenation equilibrium pressure of 3.22 × 10^(-6) Pa at 25℃ and excellent hydriding kinetics under a low hydrogen pressure of 0.005 ***,unique phase transition behaviors were presented in Zr_(2)Co-H ***,Zr_(2)CoH_(5) formed by Zr_(2)Co hydrogenated at room temperature is initially decomposed into ZrH_(2) and ZrCoH_(3) at200 ℃.With the temperature increasing to 350 ℃,ZrCoH_(3)is dehydrogenated to ZrCo,and then ZrCo further reacts with ZrH_(2) at 650 ℃ to reform Zr_(2)Co and *** the staged phase transition pathways during dehydrogenation,the decomposition of Zr_(2)CoH_(5) occurs preferentially,which is well accordance with both the smallest reaction energy barrier and the maximum reaction spontaneity that are determined respectively from kinetics activation energy and thermodynamics Gibbs free ***,first principles calculation results indicate that the stronger binding of hydrogen in interstitial environments of ZrCoH_(3)and ZrH_(2) triggers the hydrogen-stabilized phase transformation of Zr_(2)CoH_(5).The unique phase transition mechanisms in Zr_(2)Co-H system can shed light on the further exploration and regulation of analogous staged phase transition of hydrogen storage materials.

关键词： Zr_(2)Co alloy Tritium-getter materials Ultralow equilibrium hydrogen pressure Phase transition mechanism

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