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Chinese Chemical Letters 2024年第10期35卷 241-243页

作者： Yu Pang Min wang Ning-{1. Yang Min Xue Yong Yang School of Science Department of PhysicsKey Laboratory of Optical Field Manipulation of Zhejiang ProvinceZhejiang Sci-Tech UniversityHangzhou 310018China School of Chemistry and Chemical Engineering Key Laboratory of Surface&Interface Science of Polymer Materials of Zhejiang ProvinceZhejiang Sci-Tech UniversityHangzhou310018China

Trifluoroacetic acid(TFA)catalyzed condensation reaction between tetraaminooxacalix[4]arene and N-alkylcarbazole-3,6-dicarbaldehyde in CH_(2)Cl2afforded a single product in 87%–89%***-defined yet undissolvable1. NMR spectra suggested formation of robust and discrete structures in solution.X-ray single crystal analysis further revealed a giant twisted double-layer chiral macrocycle in the solid state,which was formed from[4+8]condensation of the two reactants via 1. imine *** calculations discovered that only the[4+8]twisted product is thermodynamically favorable,which accounts for its highly selective and efficient formation out of a library of many other combinations.

关键词： One-pot synthesis Oxacalixarene Dynamic covalent chemistry Chiral macrocycle X-ray single crystal

Impact of thoracic paravertebral block and sufentanil on outcomes and postoperative cognitive dysfunction in thoracoscopic lung cancer surgery

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World Journal of Psychiatry 2024年第6期14卷 894-903页

作者： Dan-Dan wang Hong-Yu wang Yan Zhu Xi-hua Lu Department of Anesthesiology The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhou 450008Henan ProvinceChina

BACKGROUND Postoperative pain management and cognitive function preservation are crucial for patients undergoing thoracoscopic surgery for lung cancer(LC).This is achieved using either a thoracic paravertebral block(TPVB)or sufentanil(SUF)-based multimodal ***,the efficacy and impact of their combined use on postoperative pain and postoperative cognitive dysfunction(POCD)remain *** To explore the analgesic effect and the influence on POCD of TPVB combined with SUF-based multimodal analgesia in patients undergoing thoracoscopic radical resection for LC to help optimize postoperative pain management and improve patient *** This retrospective analysis included 1.7 patients undergoing thoracoscopic radical resection for LC at The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital between May 2021.and January *** receiving SUF-based multimodal analgesia(n=50)and patients receiving TPVB+SUF-based multimodal analgesia(n=57)were assigned to the control group and TPVB group,*** compared the Ramsay Sedation Scale and visual analog scale(VAS)scores at rest and with cough between the two groups at 2,1.,and 24 h after *** levels of epinephrine(E),angio-tensin Ⅱ(Ang Ⅱ),norepinephrine(NE),superoxide dismutase(SOD),vascular endothelial growth factor(VEGF),transforming growth factor-β1.TGF-β1.,tumor necrosis factor-α(TNF-α),and S-1.0 calcium-binding proteinβ(S-1.0β)were measured before and 24 h after *** Mini-Mental State Examination(MMSE)was administered 1.day before surgery and at 3 and 5 days after surgery,and the occurrence of POCD was monitored for 5 days after *** reactions were also *** There were no significant time point,between-group,and interaction effects in Ramsay sedation scores between the two groups(P>0.05).Significantly,there were notable time point effects,between-group differences,and interaction effects observed in VAS scores both at rest

关键词： Thoracic paravertebral block Sufentanil Thoracoscope Radical resection of lung cancer Postoperative cognitive dysfunction

Intestinal microecological transplantation for a patient with chronic radiation enteritis:A case report

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World Journal of Gastroenterology 2024年第19期30卷 2603-2611页

作者： Lin wang Yan Li Yu-Jing Zhang Li-{1. Peng Department of Gastroenterology and Hepatology The First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Gastroenterology and Hepatology Chinese PLA Medical SchoolBeijing 100853China

BACKGROUND The gut microbiota is strongly associated with radiation-induced gut *** study aimed to assess the effectiveness and safety of intestinal microecological transplantation for treating patients with chronic radiation *** SUMMARY A 64-year-old female with cervical cancer developed abdominal pain,diarrhea,and blood in the stool 1.year after *** electronic colonoscopy was performed to diagnose chronic radiation *** courses of intestinal microecological transplantation and full-length 1.S rRNA microbiological analysis were *** patient experienced short-and long-term relief from symptoms without adverse *** 1.S rRNA sequencing revealed significant differences in the intestinal flora’s composition between patient and healthy *** bacteria,such as Escherichia fergusonii and Romboutsia timonensis,were more in the *** bacteria such as Faecalibacterium prausnitzii,Fusicatenibacter saccharivorans,Ruminococcus bromii,and Bifidobacterium longum were more in the healthy *** microbiota transplantation resulted in a significant change in the patient's intestinal flora *** composition converged with the donor's flora,with an increase in core beneficial intestinal bacteria,such as Eubacterium rectale,and a decrease in pathogenic *** in the intestinal flora corresponded with the patients'alleviating clinical *** Intestinal microecological transplantation is an effective treatment for relieving the clinical symptoms of chronic radiation enteritis by altering the composition of the intestinal *** study provides a new approach for treating patients with chronic radiation enteritis.

关键词： Chronic radiation enteritis Gut microbial transplantation Intestinal microecology Cancer Quality of life Case report

Neutrophil extracellular traps induced by interleukin 8 via CXCR1.2 promote the progression of gastric carcinoma through transcription factor IIB-related factor 1.and cyclin

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Genes & Diseases 2024年第2期11卷 575-578页

作者： Qianling wang Yiyin Zhang Wenxi Ding Cheng Feng Yuyan wang Xiaoli Wei Ziting Qu Hui wang Xiaoying Liu hua wang Kangsheng Gu Department of Oncology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China School of Life Sciences Anhui Medical UniversityHefeiAnhui 230032China

Neutrophils constitute a significant portion of the immune cells present within the tumor *** generated by our group has confirmed neutrophils to be an adverse independent prognostic factor affecting the disease-free survival of gastric carcinoma(GC)patients.1.Neutrophil extracellular traps(NETs),protein-covered DNA webs that interact with tumor cells in the tumor microenvironment,were detected in GC tissues and found to clinically associated with disease progression in our previous study.2 NETosis could be mediated by a series of agonists,such as interleukin 8(IL-8).3 However,the mechanism of IL-8 in the progression of GC occurs via NETs remains *** this study,we identified that IL-8-mediated NETosis can promote the proliferation,migration,and invasion of GC cells in vitro,which can be abrogated by NET degradation through deoxyribonucleaseI(DNase I)or IL-8 suppression through neutralizing *** of NETs by DNase I or blockade of the IL-8-CXC chemokine receptor 2(CXCR2)axis could result in growth retardation in mouse *** also confirmed that NETs may influence the biological behavior of GC cells by up-regulating the expression of transcription factor IB-related factor 1.BRF1.and cyclin p21.p27.

关键词： invasion gastric progression

Predictive modeling for postoperative delirium in elderly patients with abdominal malignancies using synthetic minority oversampling technique

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1227-1235页

作者： Wen-Jing Hu Gang Bai Yan wang Dong-Mei Hong Jin-{1. Jiang Jia-Xun Li Yin {1. Xin-Yu wang Ying Chen Intensive Care Unit Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of Anesthesia and Perioperative Medicine Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of Nursing Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of Thyroid Breast and Vascular SurgeryShanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China

BACKGROUND Postoperative delirium,particularly prevalent in elderly patients after abdominal cancer surgery,presents significant challenges in clinical *** To develop a synthetic minority oversampling technique(SMOTE)-based model for predicting postoperative delirium in elderly abdominal cancer *** In this retrospective cohort study,we analyzed data from 61. elderly patients who underwent abdominal malignant tumor surgery at our hospital between September 2020 and October *** incidence of postoperative delirium was recorded for 7 d *** were divided into delirium and non-delirium groups based on the occurrence of postoperative delirium or not.A multivariate logistic regression model was used to identify risk factors and develop a predictive model for postoperative *** SMOTE technique was applied to enhance the model by oversampling the delirium *** model’s predictive accuracy was then *** In our study involving 61. elderly patients with abdominal malignant tumors,multivariate logistic regression analysis identified significant risk factors for postoperative *** included the Charlson comorbidity index,American Society of Anesthesiologists classification,history of cerebrovascular disease,surgical duration,perioperative blood transfusion,and postoperative pain *** incidence rate of postoperative delirium in our study was 22.91..The original predictive model(P1.exhibited an area under the receiver operating characteristic curve of *** comparison,the SMOTE-based logistic early warning model(P2),which utilized the SMOTE oversampling algorithm,showed a slightly lower but comparable area under the curve of 0.856,suggesting no significant difference in performance between the two predictive *** This study confirms that the SMOTE-enhanced predictive model for postoperative delirium in elderly abdominal tumor patients shows performance equivalent to that of tradi

关键词： Elderly patients Abdominal cancer Postoperative delirium Synthetic minority oversampling technique Predictive modeling Surgical outcomes

“三hua雷锋”进社区 “伙伴计划”展风采

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中国共青团 2024年第10期 36-37页

作者： 1.团沈阳市委 2.沈阳市一滴水公益服务中心团沈阳市委沈阳市一滴水公益服务中心

2024年3月4日,在沈阳市铁西区红梅社区的“青年之家”,刚刚结束了一堂形式新颖的沉浸式宣讲课。“在社区里就能通过视频‘云游’雷锋班,听雷锋班班长给我们讲‘老三宝’和‘新三宝’的故事。我一定要努力学习,长大后像雷锋叔叔那样,做... 详细信息

2024年3月4日,在沈阳市铁西区红梅社区的“青年之家”,刚刚结束了一堂形式新颖的沉浸式宣讲课。“在社区里就能通过视频‘云游’雷锋班,听雷锋班班长给我们讲‘老三宝’和‘新三宝’的故事。我一定要努力学习,长大后像雷锋叔叔那样,做一个对国家、对社会、对家乡有用的人!”家住红梅社区的小学二年级学生张恩睿诚挚地说。

关键词：雷锋叔叔沈阳市铁西区沉浸式雷锋班青年之家伙伴计划小学二年级形式新颖

High-resolution remote thermometry based on Bi^(3+)-doped 0D zinc halide hybrids

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Science China Chemistry 2024年第8期67卷 2599-2605页

作者： Cui-Mi Shi Shu-hua Xue Jin-Yun {1. Liang-Jin Xu Zhong-Ning Chen State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Fujian Science Technology Innovation Laboratory for Optoelectronic Information of ChinaFuzhou 350108China University of Chinese Academy of Sciences Beijing 100049China

Developing highly sensitive optical thermometers is of great significance due to their capability to enable remote and non-contact temperature measurements, rendering them highly applicable in diverse and harsh environments. Herein we report a temperature-dependent phosphor of 0D metal halide hybrid by incorporating Bi^(3+)into the(MePPh_(3))_(2)ZnCl_(4) matrix. Through Bi^(3+)doping,the initially non-luminescent(MePPh_(3))_(2) ZnCl_(4) matrix exhibits a deep-blue emission centered at 453 nm, with a photoluminescence quantum yield(PLQY) of 5.71. and a Stokes shift of 75 nm at room temperature. Experimental characterization demonstrates that exciton-like luminescence of Bi^(3+)is mainly responsible for the blue emission. Single crystals of Bi^(3+)-doped(MePPh_(3))_(2)ZnCl_(4) show an unusual correlation between photoluminescence(PL) lifetime and temperature. Particularly, the dependence of luminescence lifetime on temperature is most remarkable in the temperature range of 80 to 1.0 K with an exceptional sensitivity up to 0.09 K^(-1., representing one of the best levels for thermometry based on PL decay lifetime. Our work not only provides a viable strategy for designing a novel, environmentally friendly, and stable blue emitter, but also paves the way for precise thermometric application at low temperature.

关键词： lead-free hybrids Bi^(3+)doping blue emission temperature sensing

High-Performanceα-Diimine Nickel Complexes for Facile Access of PE Elastomers with Exceptional Material Properties

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Chinese Journal of Polymer Science 2024年第5期42卷 620-635,I0008页

作者： Li-Dong Qin Xin-Yu wang Qaiser Mahmood Zhi-Xin Yu Yi-Zhou wang Song Zou Tong-Ling Liang Wen-hua Sun School of Pharmaceutical Sciences Changchun University of Chinese MedicineChangchun130117China Chemistry and Chemical Engineering Guangdong Laboratory Shantou515031China Key Laboratory of Engineering Plastics and Beijing National Laboratory for Molecular Science Institute of ChemistryChinese Academy of SciencesBeijing100190China

For practicable elastomeric polyethylene,achieving high catalyst thermal stability and activity,along with precise control of polymer properties such as branching density,molecular weights,and distribution,is crucial but *** this study,two sets of symmetricalα-diimine nickel complexes,each comprising four nickel bromide or chloride complexes,were synthesized and investigated their performance for ethylene polymerization under various reaction *** activation with either Et2AlCl or MMAO cocatalysts,these complexes displayed not only high activity but also generated high molecular weight polyethylenes with controlled polydispersity and a substantial number of *** catalyst with the least steric hindrance displayed the remarkable high activity(up to 1.2×1.^(7) g·mol^(-1.·h^(-1.).Notably,nickel bromides demonstrated higher activity compared to their chloride *** investigation into the effect of reaction temperature on catalytic performance revealed that NiBrMe-MMAO system displayed high thermal stability(activity up to 2.51.1.^(6) g·mol^(-1.·h^(-1. at 1.0℃)and consistently yielded high polymer molecular weights with narrow polydispersity over a broad temperature range of 30-1.0℃.Of significant note,mechanical analysis of the resulting polyethylene demonstrated excellent ultimate tensile strength and high strain at ***,the polyethylene sample prepared at 1.0℃exhibited ultimate tensile strength up to 1. MPa with 1.63%maximum strain at break and a strain recovery of up to 54.9%after ten cycles at a fixed strain of 300%,indicating excellent material properties of prepared thermoplastic polyethylene elastomers(TPE).

关键词： Thermoplastic polyethylene elastomers α-Diimine nickel pre-catalysts Ethylene polymerization Mechanical properties Highly branched polyethylene

Early changes in corneal densitometry after FS-LASIK combined with accelerated corneal cross-linking for correction of high myopia

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1307-1312页

作者： Qing-Bao wang Hong-Sheng Bi Xiao-Fan wang hua Fan Li Li Peng Ji Shandong University of Traditional Chinese Medicine Jinan 250014Shandong ProvinceChina Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine Shandong Clinical Medicine Research CenterJinan 250002Shandong ProvinceChina Shandong Academy of Eye Disease Prevention and Therapy Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular DiseasesJinan 250002Shandong ProvinceChina

AIM:To observe the effects of femtosecond laserassisted excimer laser in situ keratomileusis combined with accelerated corneal cross-linking(FS-LASIK Xtra)on corneal densitometry after correcting for high ***:In this prospectively study,1.0 patients underwent FS-LASIK or FS-LASIK Xtra for high *** right eyes were selected for inclusion in the study,of which 65 cases of 65 eyes in the FS-LASIK group,65 patients with 65 eyes in the FS-LASIK Xtra *** were evaluated for corneal densitometry at 1.3,and 6mo postoperatively using Pentacam Scheimpflug ***:Preoperative differences in corneal densitometry between the FS-LASIK and FS-LASIK Xtra groups in different ranges were not statistically significant(P>0.05).Layer-by-layer analysis revealed statistically significant differences in the anterior(1.0μm),central,and total layer corneal densitometry between the FS-LASIK and FS-LASIK Xtra groups at 1.and 3mo postoperatively(all P1.o postoperatively in the ranges of 0–2,2–6,and 6–1. mm(both P0.05).CONCLUSION:There is an increase in internal corneal densitometry during the early postoperative period after FS-LASIK Xtra for correction of high ***,the densitometry values decreased to the level of conventional FS-LASIK at 6mo after surgery,with the most significant changes observed in the superficial central zone.

关键词： femtosecond laser accelerated corneal cross-linking corneal densitometry high myopia femtosecond laser in situ keratomileusis

Zinc glycine chelate ameliorates DSS‑induced intestinal barrier dysfunction via attenuating TLR4/NF‑κB pathway in meat ducks

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Journal of Animal Science and Biotechnology 2024年第2期15卷 765-778页

作者： Yaqi Chang Ke wang Guangmang Liu {1. Zhao Xiaoling Chen Jingyi Cai Gang Jia Institute of Animal Nutrition Key Laboratory for Animal Disease‑Resistance Nutrition of ChinaMinistry of EducationSichuan Agricultural UniversityChengdu 611130SichuanChina

Background Zinc glycine chelate(Zn-Gly)has anti-inflammation and growth-promoting properties;however,the mechanism of Zn-Gly contribution to gut barrier function in Cherry Valley ducks during intestinal inflammation is ***-hundred 1.day-old ducks were divided into 5 groups(6 replicates and 1. ducks per replicate)in a completely randomized design:the control and dextran sulfate sodium(DSS)groups were fed a corn-soybean meal basal diet,and experimental groups received supplements of 70,1.0 or 1.0 mg/kg Zn in form of *** DSS and treatment groups were given 2 mL of 0.45 g/mL DSS daily during d 1.–21.and the control group received normal *** experiment lasted 21.*** Compared with DSS group,70,1.0 and 1.0 mg/kg Zn significantly increased body weight(BW),villus height and the ratio of villus to crypt,and significantly decreased the crypt depth of jejunum at 21.*** number of goblet cells in jejunal villi in the Zn-Gly group was significantly increased by periodic acid-Schiff *** with control,the content of intestinal permeability marker D-lactic acid(D-LA)and fluxes of fluorescein isothiocyanate(FITC-D)in plasma of DSS group significantly increased,and 1.0 mg/kg Zn supplementation significantly decreased the D-LA content and FITC-D *** with control,contents of plasma,jejunum endotoxin and jejunum pro-inflammatory factors IL-1.,IL-6 and TNF-αwere significantly increased in DSS group,and were significantly decreased by 1.0 mg/kg Zn *** Zn significantly increased the contents of anti-inflammatory factors IL-1.,IL-22 and sIgA and IgG in ***-time PCR and Western blot results showed that 1.0 mg/kg Zn supplementation significantly increased mRNA expression levels of CLDN-1.and expression of OCLN protein in jejunum,and decreased gene and protein expression of CLDN-2 compared with DSS *** 1.0 mg/kg Zn significantly promoted the expressions of IL-22 and *** Zn-Gly supplementation sign

关键词： Cherry Valley ducks Growth performance Gut inflammation Intestinal barrier Zn-Gly