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Tumour response following preoperative chemotherapy is affected by body mass index in patients with colorectal liver metastases

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 331-342页

作者： hua-chuan Song Hang-Cheng Zhou Ping Gu Bing Bao Quan sun Tian-Ming Mei Wei Cui Kang Yao huan-Zhang Yao Shen-Yu Zhang Yong-Shuai Wang Rui-Peng Song Ji-Zhou Wang Department of General Surgery Provincial Hospital Affiliated to Anhui Medical UniversityHefei 230001Anhui ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Pathology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Gastrointestinal Surgery Tongcheng People’s HospitalTongcheng 231400Anhui ProvinceChina Department of Gastrointestinal Surgery Suzhou Hospital Affiliated to Anhui Medical UniversitySuzhou 234000Anhui ProvinceChina Department of General Surgery Xuancheng People’s HospitalXuancheng 242000Anhui ProvinceChina

BACKGROUND Colorectal cancer is the third most prevalent malignancy globally and ranks second in cancer-related mortality,with the liver being the primary organ of *** chemotherapy is widely recommended for initially or potentially resectable colorectal liver metastases(CRLMs).Tumour pathological response serves as the most important and intuitive indicator for assessing the efficacy of ***,the postoperative pathological results reveal that a considerable number of patients exhibit a poor response to preoperative *** mass index(BMI)is one of the factors affecting the tumori-genesis and progression of colorectal cancer as well as prognosis after various antitumour *** studies have indicated that overweight and obese patients with metastatic colorectal cancer experience worse prognoses than those with normal weight,particularly when receiving first-line chemotherapy regimens in combination with *** To explore the predictive value of BMI regarding the pathologic response following preoperative chemotherapy for *** A retrospective analysis was performed in 126 consecutive patients with CRLM who underwent hepatectomy following preoperative chemotherapy at four different hospitals from October 2019 to July *** and multivariate logistic regression models were applied to analyse potential predictors of tumour pathological *** Kaplan-Meier method with log rank test was used to compare progression-free survival(PFS)between patients with high and low ***<24.0 kg/m^(2) was defined as low BMI,and tumour regression grade 1-2 was defined as complete tumour *** Low BMI was observed in 74(58.7%)patients and complete tumour response was found in 27(21.4%)*** rate of complete tumour response was significantly higher in patients with low BMI(29.7%vs 9.6%,P=0.007).Multivariate analysis revealed that low BMI[odds ratio(OR)=4.56,95%confidence interval(CI):1

关键词： Colorectal liver metastases Body mass index Tumour regression grade Preoperative chemotherapy Hepatectomy

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Identification of LPV system using locally weighted technique

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Applied Mathematics(A Journal of Chinese Universities) 2010年第4期25卷 411-419页

作者： ZENG Jiu-sun GAO chuan-hou LUO Shi-hua Department of Mathematics Zhejiang University Hangzhou 310027 China School of Management Jiangxi University of Finance and Economics Nanchang 331300 China

The problem of linear parameter varying （LPV） system identification is considered based on the locally weighted technique which provides estimation of the LPV model parameters at each distinct data time point by giving large weights to measurements that are ＂close＂ to the current time point and small weights to measurements ＂far＂ from the current time point. Issues such as choice of distance function, weighting function and bandwidth selection are discussed. The developed method is easy to implement and simulation results illustrate its efficiency.

关键词： Linear parameter varying system locally weighted technique identification.

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Idealized Experiments for Optimizing Model Parameters Using a 4D-Variational Method in an Intermediate Coupled Model of ENSO

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Advances in Atmospheric Sciences 2018年第4期35卷 410-422页

作者： chuan GAO Rong-hua ZHANG Xinrong WU Jichang sun Key Laboratory of Ocean Circulation and Waves Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China Qingdao National Laboratory for Marine Science and Technology Qingdao 266237 China Institute of Oceanographic Instrumentation Shandong Academy of Sciences Qingdao 266001 China University of Chinese Academy of Sciences Beijing 100029 China Key Laboratory of Marine Environmental Information Technology State Oceanic Administration National Marine Data and Information Service Tianjin 300000 China

Large biases exist in real-time ENSO prediction, which can be attributed to uncertainties in initial conditions and model parameters. Previously, a 4D variational （4D-Vat） data assimilation system was developed for an intermediate coupled model （ICM） and used to improve ENSO modeling through optimized initial conditions. In this paper, this system is further applied to optimize model parameters. In the ICM used, one important process for ENSO is related to the anomalous temperature of subsurface water entrained into the mixed layer （Te）, which is empirically and explicitly related to sea level （SL） variation. The strength of the thermocline effect on SST （referred to simply as ＂the thermocline effect＂） is represented by an introduced parameter, （l＇Te. A numerical procedure is developed to optimize this model parameter through the 4D-Var assimilation of SST data in a twin experiment context with an idealized setting. Experiments having their initial condition optimized only, and having their initial condition plus this additional model parameter optimized, are compared. It is shown that ENSO evolution can be more effectively recovered by including the additional optimization of this parameter in ENSO modeling. The demonstrated feasibility of optimizing model parameters and initial conditions together through the 4D-Var method provides a modeling platform for ENSO studies. Further applications of the 4D-Vat data assimilation system implemented in the ICM are also discussed.

关键词： intermediate coupled model ENSO modeling 4D-Var data assimilation system optimization of model param- eter and initial condition

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Zn和Gd元素含量和比例对铸态和挤压态Mg-8Li合金显微组织和力学性能的影响

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Transactions of Nonferrous Metals Society of China 2024年第3期34卷 798-811页

作者：黄玉川张泉达欧阳思杰孙福臻孙家伟李蕙宇吴国华陈培军刘文才中国机械科学研究总院集团有限公司先进成形技术与装备国家重点实验室北京100083 北京机科国创轻量化科学研究院有限公司北京100083 上海交通大学材料科学与工程学院轻合金精密成型国家工程中心和金属基复合材料重点实验室上海200240 洛阳晟雅镁合金科技有限公司洛阳471921

研究Zn和Gd元素含量及其质量比对铸态和挤压态Mg-8Li合金显微组织和力学性能的影响。挤压后,析出相破碎。β-Li中分散着粒径约100 nm的球形微粒。形成了由长条状α-Mg粗晶和再结晶β-Li细晶组成的双峰结构。挤压后合金的强度和塑性显著... 详细信息

研究Zn和Gd元素含量及其质量比对铸态和挤压态Mg-8Li合金显微组织和力学性能的影响。挤压后,析出相破碎。β-Li中分散着粒径约100 nm的球形微粒。形成了由长条状α-Mg粗晶和再结晶β-Li细晶组成的双峰结构。挤压后合金的强度和塑性显著提高,且屈服强度和极限抗拉强度随Zn和Gd含量的增加而增加。Mg-8Li-8Zn-2Gd合金表现出最优的综合性能,其屈服强度、极限抗拉强度和伸长率分别为274 MPa、283 MPa和39.9%。挤压态合金主要强化机制为由β-Li的细晶强化和α-Mg的织构强化组成的双模态结构强化和析出相的弥散强化。

关键词：镁锂合金挤压变形双峰结构弥散强化

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Regenerating gene 4 promotes chemoresistance of colorectal cancer by affecting lipid droplet synthesis and assembly

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世界胃肠病学杂志:英文版 2023年第35期29卷 5104-5124页

作者： Cong-Yu Zhang Rui Zhang Li Zhang Zi-Mo Wang Hong-Zhi sun zheng-Guo Cui hua-chuan zheng Cancer Center The First Affiliated Hospital of Jinzhou Medical UniversityJinzhou 121001Liaoning ProvinceChina Department of Colorectal Surgery Liaoning Cancer HospitalShenyang 110042Liaoning ProvinceChina Department of Oncology The Affiliated Hospital of Chengde Medical UniversityChengde 067000Hebei ProvinceChina Department of Environmental Health University of Fukui School of Medical SciencesFukui 910-1193Japan

BACKGROUND Regenerating gene 4(REG4)has been proved to be carcinogenic in some cancers,but its manifestation and possible carcinogenic mechanisms in colorectal cancer(CRC)have not yet been *** previous study found that the drug resistance of CRC cells may be closely linked to their fat *** To explore the role of REG4 in CRC and its association with lipid droplet formation and *** We conducted a meta-analysis and bioinformatics and pathological analyses of REG4 expression in *** effects of REG4 on the phenotypes and related protein expression were also investigated in CRC *** detected the impacts of REG4 on the chemoresistance and lipid droplet formation in CRC ***,we analyzed how REG4 regulated the transcription and proteasomal degradation of lipogenic enzymes in CRC *** Compared to normal mucosa,REG4 mRNA expression was high in CRC(P<0.05)but protein expression was *** inverse correlation existed between lymph node and distant metastases,tumor-node-metastasis staging or short overall survival and REG4 mRNA overexpression(P<0.05),but vice versa for REG4 protein ***4-related genes included:Chemokine activity;taste receptors;protein-DNA and DNA packing complexes;nucleosomes and chromatin;generation of second messenger molecules;programmed cell death signals;epigenetic regulation and DNA methylation;transcription repression and activation by DNA binding;insulin signaling pathway;sugar metabolism and transfer;and neurotransmitter receptors(P<0.05).REG4 exposure or overexpression promoted proliferation,antiapoptosis,migration,and invasion of DLD-1 cells in an autocrine or paracrine manner by activating the epidermal growth factor receptor-phosphoinositide 3-kinase-Akt-nuclear factor-κB ***4 was involved in chemoresistance not through de novo lipogenesis,but lipid droplet ***4 inhibited the transcription of acetyl-CoA carboxylase 1(ACC1)and ATP-citrate lyase(ACLY)by disas

关键词： Colorectal cancer Regenerating gene 4 Aggressive behavior Prognosis Chemoresistance Lipid droplet formation Epidermal growth factor receptor signal

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Screening of Serum Biomarkers for Distinguishing between Latent and Active Tuberculosis Using Proteome Microarray

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Biomedical and Environmental Sciences 2018年第7期31卷 515-526页

作者： CAO Shu Hui CHEN Yan Qing sun Yong LIU Yang zheng Su hua ZHANG Zhi Guo LI chuan You Department of Bacteriology and Immunology Beijing Key Laboratory on Drug-Resistant Tuberculosis Research Beijing Tuberculosis and Thoracic Tumor Research Institute/Beijing Chest Hospital Capital Medical University. Beijing 101149 China Department of Laboratory Center Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing 100045 China Department of Clinical Laboratory Beijing Tuberculosis and Thoracic Tumour Research Institute/Beijing Chest Hospital Capital Medical University Beijing 101149 China Department of Epidemiological Research Beijing Tuberculosis and Thoracic Tumour Research lnstitute/Beijing Chest Hospital Capital Medical University Beijing 101149 China Institute of Tuberculosis Prevention and Control of District Changping Beijing 102200 China

Objective To identify potential serum biomarkers for distinguishing between latent tuberculosis infection（LTBI） and active tuberculosis（TB）. Methods A proteome microarray containing 4,262 antigens was used for screening serum biomarkers of 40 serum samples from patients with LTBI and active TB at the systems level. The interaction network and functional classification of differentially expressed antigens were analyzed using STRING 10.0 and the TB database, respectively. Enzyme-linked immunosorbent assays（ELISA） were used to validate candidate antigens further using 279 samples. The diagnostic performances of candidate antigens were evaluated by receiver operating characteristic curve（ROC） analysis. Both antigen combination and logistic regression analysis were used to improve diagnostic ability. Results Microarray results showed that levels of 152 Mycobacterium tuberculosis（Mtb）-antigenspecific IgG were significantly higher in active TB patients than in LTBI patients（P 〈 0.05）, and these differentially expressed antigens showed stronger associations with each other and were involved in various biological processes. Eleven candidate antigens were further validated using ELISA and showed consistent results in microarray analysis. ROC analysis showed that antigens Rv2031 c, Rv1408, and Rv2421 c had higher areas under the curve（AUCs） of 0.8520, 0.8152, and 0.7970, respectively. In addition, both antigen combination and logistic regression analysis improved the diagnostic ability. Conclusion Several antigens have the potential to serve as serum biomarkers for discrimination between LTBI and active TB.

关键词： LTBI Active TB Proteome microarray Serum biomarkers

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含钴三元硫化物常压硫酸浸出钴的动力学研究

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Transactions of Nonferrous Metals Society of China 2024年第5期34卷 1669-1680页

作者：张丁川孙丰龙赵中伟刘旭恒陈星宇李江涛何利华中南大学冶金与环境学院长沙410083 中南大学稀有金属冶金与材料加工重点实验室长沙410083

开展含钴三元硫化物常压硫酸浸出的实验研究。考察搅拌速度、浸出温度、硫酸浓度和粒度对钴浸出率的影响,并分析从含钴三元硫化物中浸出钴的动力学。结果表明,在最佳条件下,钴和铁被选择性浸出,且浸出率均大于99%,而钼和铜则富集于浸出... 详细信息

开展含钴三元硫化物常压硫酸浸出的实验研究。考察搅拌速度、浸出温度、硫酸浓度和粒度对钴浸出率的影响,并分析从含钴三元硫化物中浸出钴的动力学。结果表明,在最佳条件下,钴和铁被选择性浸出,且浸出率均大于99%,而钼和铜则富集于浸出渣。通过对实验数据的分析可知,钴的浸出符合由固体产物层产生的收缩核模型,且浸出过程受内扩散控制。浸出反应的活化能为49.86k J/mol,硫酸浓度和粒度的反应级数分别为0.57和-1.4。

关键词：钴白合金含钴三元硫化物钴硫酸浸出动力学

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内源营养负荷对4种常见沉水植物生长、形态和资源分配策略的影响

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水生生物学报 2024年第3期48卷 426-435页

作者：庞伟程付贵萍沈哲文孙尚省马巾华兆晖丑庆川深圳大学生命与海洋科学学院海洋生物资源与生态环境重点实验室深圳518055 上海海洋大学环境DNA技术与水生态健康评估工程中心上海201306 中国科学院水生生物研究所淡水生态和生物技术国家重点实验室武汉430072

为探明内源营养负荷对沉水植物生长、形态和资源分配的影响,研究通过控制沉积物的营养浓度,探究4种常见沉水植物苦草(Vallisneria natans)、黑藻(Hydrilla verticillata)、穗状狐尾藻(Myriophyllum spicatum)和竹叶眼子菜(Potamogeton w... 详细信息

为探明内源营养负荷对沉水植物生长、形态和资源分配的影响,研究通过控制沉积物的营养浓度,探究4种常见沉水植物苦草(Vallisneria natans)、黑藻(Hydrilla verticillata)、穗状狐尾藻(Myriophyllum spicatum)和竹叶眼子菜(Potamogeton wrightii)的多种功能性状对沉积物营养浓度的响应。结果表明:(1)内源营养负荷的增加促进了4种沉水植物的生长,其中苦草的种群数量和总生物量均高于其他沉水植物。然而,当沉积物营养含量过高时(C:73.33 mg/g;N:4.94 mg/g;P:0.68 mg/g)4种沉水植物的种群数量均有所下降。(2)沉水植物形态特征对沉积物营养含量变化的响应趋势并不一致,所有物种株高均逐渐升高,根长则无显著变化规律;苦草和竹叶眼子菜的单株鲜重持续升高,黑藻和穗状狐尾藻的单株鲜重先升高后降低。(3)内源营养物质含量的变化使4种植物的资源分配发生了显著变化,随着沉积物营养含量上升4种沉水植物的地上生物量占比显著升高(根冠比显著下降),光合色素含量显著升高,但过高的营养含量对光合色素合成产生负效应。总之,本研究结果表明苦草对沉积物营养负荷变化的适应能力最强,因此在富营养化水体的生态修复中选择苦草作为先锋种能有效提高沉水植物的修复效率。

关键词：沉水植物内源营养负荷形态特征资源分配

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Id2 regulates the proliferation of squamous cell carcinoma in vitro via the NF-κB/Cyclin D1 pathway

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Chinese Journal of Cancer 2012年第9期31卷 430-439页

作者： chuan Wang Qiang Chen Yuki Hamajima Wei sun Yi-Qing zheng Xiao-hua Hu Frank G. Ondrey Ji-Zhen Lin The Cancer Center and Fujian Key Laboratory of Translational Cancer Medicine Union Hospital Fujian Medical University Fuzhou Fujian 350001 P. R. China Department of Otolaryngology Head and Neck Surgery University of Nagoya City Nagoya 460-0002 Japan Department of Otolaryngology Sun Yat-sen Memorial Hospital Sun Yat-sen University Guangzhou Guangdong 510120 P. R. China Department of Otolaryngology and Cancer Center University of Minnesota Minneapolis MN 55455 USA

Squamous cell carcinoma (SCC) is a significant cause of cancer morbidity and mortality worldwide, with an incidence of up to 166 cases per 100 000 population. It arises in the skin, upper aerodigestive tract, lung, and cervix and affects more than 200 000 Americans each year. We report here that a microarray experiment comparing 41 SCC and 13 normal tissue specimens showed that Id2, a gene that controls the cell cycle, was significantly up-regulated in SCC. Enforced expression of Id2 in vitro stimulated the proliferation of SCC cells and up-regulated the transcription of nuclear factor kappa B (NF-κB) and cyclin D1. Enhancement of the NF-κB activity with p65 significantly increased the cell proliferation and the transcription of cyclin D1, whereas inhibition of the NF-κB activity with I kappa B alpha mutant (IκBα M) and pyrroline dithiocarbamate (PDTC) abrogated cell proliferation and transcription of cyclin D1. Furthermore, a mutated NF-κB binding site in the cyclin D1 promoter fully abrogated the Id2-induced transcription of cyclin D1. Taken together, these data indicate that Id2 induces SCC tumor growth and proliferation through the NF-κB/cyclin D1 pathway.

关键词：鳞状细胞癌体外增殖细胞周期蛋白D1 核因子kappa 二硫代氨基甲酸盐 cyclin NF-KB NF-kB

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Study on the corrosion behavior of 316H stainless steel in molten NaCl–KCl–MgCl_(2) salts with and without purification

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Nuclear Science and Techniques 2023年第12期34卷 123-132页

作者： hua Ai Xin‑Mei Yang hua‑Jian Liu Bing‑chuan Chen Ling Han hua sun Yan‑Jun Chen Yuan Qian Jian‑Qiang Wang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Key Laboratory of Interfacial Physics and Technology Chinese Academy of ScienceShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

The corrosion behavior of 316H stainless steel(SS)in the impure and purified Na Cl–KCl–Mg Cl_(2) salt was investigated at700°*** indicate that the main deleterious impurity induced corrosion in the impure salt was the absorbed moisture,present in the form of Mg Cl_(2)·6H_(2)O.316H SS occurred severe intergranular corrosion with a corrosion depth of 130μm for1000 h in the impure Na Cl–KCl–Mg Cl_(2) *** contrast,the purification treatment of molten chloride salt by the dissolved Mg metal can remove the absorbed moisture,and the corresponding reactions were also *** a result,the corrosiveness of Na Cl–KCl–Mg Cl_(2) salt is reduced significantly.316H SS occurred slight uniform corrosion with a depth of less than 5μm for 3000 h in the purified Na Cl–KCl–Mg Cl_(2) salt.

关键词： Stainless steel Alloy Chloride salt Molten salt corrosion High-temperature corrosion

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