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A Facile Synthesis of 3,5-Diaryl 1,2,4-Selenadiazoles from Aryl Selenoamides

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Chinese Chemical Letters 2002年第8期13卷 729-730页

作者： hua rong zhao Qing Sen YU Department of Chemistry Zhejiang UniversityHangzhou 310027

A facile synthesis of 3,5-diaryl 1,2,4-selenadiazoles was provided by treatment of aryl selenoamides with p-methylphenyl sulfonyl chloride in chloroform.

关键词： Diaryl-1,2,4-selenadiazoles aryl selenoamides p-methylphenyl sulfonyl chloride synthesis.

A Convenient Synthesis of Diacyl Selenides by Selenium Transfer Reaction of Primary Selenoamides

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Chinese Chemical Letters 2001年第10期12卷 873-874页

作者： hua rong zhao Xin Jian zhao Xian huaNG Department of Chemistry Zhejiang UniversityHangzhou 310027 Zhejiang Institute of Calibaration and Testing for Technical Superision Hangzhou 310013

As a selenium transfer reagent, arylselenoamides react with acyl chlorides in chloroform to give diacyl selenides conveniently in good yield.

关键词： diacyl selenides selenium transfer reaction

Substrate Selectivity of Glycerol-3-phosphate Acyl Transferase in Rice

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Journal of Integrative Plant Biology 2009年第11期51卷 1040-1049页

作者： Su-Qin Zhu hua zhao rong Zhou Ben-hua Ji Xiao-Yan Dan School of Life Sciences Nantong University Nantong 226007 China

Substrate selectivity of glycerol-3-phosphate acyltransferase （EC 2. 3. 1. 15） of rice （Oryza sativa L.） was explored in a comparative study of acyltransferases from seven plant species. In vitro labeling of acyl carrier protein （ACP） with ^14C or 3H showed that acyltransferase from chill-sensitive plants, such as rice that uses either oleic （18：1） or palmitic acid （16：0） as acyl donor at comparable rates, displays lower selectivity than the enzyme from chill-resistant plants, such as spinach, which preferentially uses oleic acid （18：1） rather than palmitic acid （16：0） as an acyl donor. This may be a result of the size and character of the substrate-binding pocket of acyltransferase. Homology modeling and protein structure-based sequence alignment of acyltransferases revealed that proteins from either chill-sensitive or chill-tolerant plants shared a highly conserved domain containing the proposed substrate-binding pocket. However, the aligned residues surrounding the substrate-binding pocket are highly heterogeneous and may have an influence mainly on the size of the substrate binding pockets of acyltransferases. The substrate selectivity of acyltransferase of rice can be improved by enlarging the substrate-binding pocket using molecular biological methods.

关键词： glycerol-3-phosphate acyt transferase homology modeling rice substrate selectivity.

Patterns of lymph node metastasis are different in colon and rectal carcinomas

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World Journal of Gastroenterology 2010年第42期16卷 5375-5379页

作者： Hao Wang Xian-zhao Wei Chuan-Gang FU Fu-Ao Cao rong-hua zhao Department of Colorectal Surgery Changhai Hospital Second Military Medical University Shanghai 200433 China Department of Surgery College of Medicine University of Saskatchewan Saskatoon SK S7N0W8Canada

AIM:To describe patterns of lymph node metastasis in invasive colon and rectal ***:Clinical data of 2340 patients with colorectal carcinoma(stageⅠ to Ⅲ) who received radical resection,was retrospectively *** the 2340 patients,1314 patients suffered from rectal carcinoma and 1026 from colon *** with rectal cancer who received neoadjuvant chemoradiation therapy were *** analysis was performed using MannWhitney,χ 2 and Cochran's and Mantel-Haenszel tests(SPSS 15.0).A two-tailed P < 0.05 was considered statistically ***:Lymph node retrieval in the rectal carcinoma group was significantly lower than that in the colon carcinoma group(P < 0.001),while positive lymph node retrieval in the rectal carcinoma group was significantly higher than that in the colon carcinoma group(P < 0.001).The proportion of lymph node positive(N+) cases was higher(patients with one or more positive lymph nodes) in the rectal carcinoma group(P = 0.004).The number of N+ cases was compared at different T stages(T1-T4) to eliminate background bias and the results were confirmed(P < 0.001).In addition,the lymph node ratio(the ratio of number of positive lymph nodes over the number of lymph nodes examined) of stage Ⅲ cases in the rectal carcinoma group was significantly higher than that in the colon carcinoma group(P < 0.001).CONCLUSION:Rectal carcinomas seem more prone to metastasize to the lymph nodes than colon carcinomas,which may be of potential clinical significance.

关键词： Lymph node Metastasis Colon Rectum Neoplasms

Concomitant lung metastasis in patients with advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第20期18卷 2533-2539页

作者： Tian Yang Jun-hua Lu Chuan Lin Song Shi Ting-Hao Chen rong-hua zhao Yi Wang Meng-Chao Wu Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China Department of Hepatobiliary Surgery the First People＇s Hospital of Ziyang Ziyang 641205 Sichuan Province China Department of Surgery Royal University Hospital College of Medicine University of Saskatchewan Saskatoon SK S7NOWS Canada

AIM:To investigate the clinical features and prognostic factors of advanced hepatocellular carcinoma (HCC)patients presenting with lung metastasis at initial diagnosis. METHODS:Between 2001 and 2010,we recruited 76 consecutive HCC patients initially presenting with lung metastasis,without co-existing metastasis from other *** patients were divided into three groups:untreated group(n=22),single treatment group(n= 19),and combined treatment group(n=35). RESULTS:Metastasis of bilateral lung lobes was common and noted in 35 patients(46.1%),and most of patients(59/76,77.6%)presented with multiple lung metastatic *** patients(25.0%) received single-method treatment,including hepatectomy in 4,transcatheter arterial chemoembolization in 6,radiotherapy in 5,and oral sorafenib in ***-five patients(46.1%)received combined treatment *** overall median survival of the all patients was 8.7±0.6 mo;4.1±0.3,6.3±2.5 and 18.6±3.9 mo, respectively in the untreated group,single treatment group and combined treatment group,respectively, with a significant difference(log-rank test,P<0.001). Multivariate analysis revealed that Child-Pugh score, the absence or presence of portal vein tumor thrombus,and treatment modality were three independent prognostic factors affecting survival of patients with advanced HCC and concomitant lung metastasis. CONCLUSION:Combined treatment modalities tend to result in a better survival as compared with the conservative treatment or single treatment modality for HCC patients initially presenting with lung metastasis.

关键词： Hepatocellular carcinoma Lung metastasis Prognosis Survival Prognostic factor

Investigation of diagnosis and treatment of hemolysis-elevated liver enzymes-low platelet counts （HELLP） syndrome： clinical analysis of 59 cases

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Chinese Medical Journal 2010年第10期123卷 1273-1277页

作者： WANG Yong-qing WANG Jing YE rong-hua zhao Yang-yu Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China

Background Hemolysis-elevated liver enzymes-low platelet counts （HELLP） syndrome is a clinical condition occurring in middle and late stage pregnancy. It is characterized by hemolysis, elevated liver enzymes and low platelet counts. This study involves the analysis of the diagnosis, clinical characteristics and treatment of 59 cases of HELLP syndrome as well as the clinical classification, method of delivery and gestational age at delivery. Methods Clinical data from 59 cases of HELLP syndrome occurring from January 2000 to December 2009 were analyzed retrospectively. Thirty-five cases were classified as complete HELLP syndrome and 24 cases were considered partial HELLP syndrome. Results Twenty-six of the 59 analyzed patients （44%） with complete HELLP syndrome showed rapid onset, severe signs, symptoms, and complications in addition to a poor clinical outcome. Complications included multiple organ dysfunction syndrome （MODS） occurring in 18 cases, eclampsia （3 cases）, placental abruption （3 cases）, and perinatal death （4 cases）. The remaining 33 cases （24 with partial and 9 with complete HELLP） were characterized by less severe signs, symptoms, complications and progression of the condition. Two of these cases were complicated with MODS （6.1%）, and 1 with perinatal death （3.0%）.Twelve non-radical-type cases received conservative treatment. The remaining 4 patients had recurring HELLP syndrome （6.78%）. Conclusions HELLP syndrome is classified as the radical type and non-radical-type according to clinical characteristics and outcome. Classification of HELLP syndrome cases according to clinical features can help in the monitoring and treatment of the disease. Active termination of pregnancy should be considered for radical-type cases. Non-radical-type cases can undergo conservative treatment with close monitoring in an attempt to improve perinatal outcome without increasing maternal morbidity.

关键词： HELLP syndrome severe preeclampsia diagnosis treatment

A Convenient Preparation of Enantiopure 1,1'-bi-2-naphthols via an Inclusion Complexation in the Solid State

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Wuhan University Journal of Natural Sciences 2000年第4期5卷 469-473页

作者： Shan Zi-xing, Xiong Ying, huang Shi-wen, Yun hua-rong, zhao De-jie College of Chemistry and Environmental Science, Wuhan University, Wuhan, 430072, China College of Chemistry and Environmental Science Wuhan University Wuhan China

Inclusion reaction of reaction 1, 1'-bi-2-naphthol and (S)-proline was examined uuder the solid state and the solid-liquid conditions. The results indicated that a solid mixture of racemic 1, 1'-bi-2-naphthol and (S)-proline in a 1 : 1 molar ratio was kept at 50-80 for 3-4 h, followed by treatment with benzene to give an insoluble solid and a benzene solution, from which (S)- (- )- and (R)-(+)-1, 1'-bi-2-naphthols of a modest level or optical purity were obtained. Arter 'kinetic' crystallization, both essentially enantiopure iso- mers were provided in 15%-35 % overall yields ,respectively.

关键词： 1,1'-bi-2-naphthol enantiomer preparation inclusion reaction

Patient with antiphospholipid syndrome accompanied by pre-eclampsia who developed hellp syndrome and eclampsia after abortion

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Chinese Medical Journal 2012年第22期125卷 4142-4144页

作者： WANG Yong-qing NIU Ji-hong WANG Jia-lue YE rong-hua zhao Yang-yu Peking Univ Dept Obstet & Gynecol Hosp 3 Beijing 100191 Peoples R China

Antiphospholipid syndrome （APS） refers to a group of clinical symptoms and signs caused by antiphospholipid antibody （aPLA）. We reported a rare case of poor outcome of a pregnant woman with APS. The pregnant woman had APS, hemolytic anemia, elevated liver function and low platelet count （HELLP） syndrome, and eclampsia and had a poor outcome from a second pregnancy. She was treated with antispasmodics, sedatives, and anti-hypertensive agents, along with anticoagulant therapy and infusion of immunoglobulin. APS during pregnancy often makes pregnancy even more complex and risky. Obstetricians should carry out anticoagulation treatment throughout the perinatal period.

关键词： antiphospholipid syndrome pre-eclampsia, eclampsia

Pharmacodynamic study in multi-animal models on the efficacy and optimal dosage of antiviral oral liquid for children

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Traditional Medicine Research 2023年第11期8卷 34-44页

作者： Ying-Li Xu Jia-Min Cao Lin Zhang rong-hua zhao Lei Bao Shan-Shan Guo Zhi Dai Xiao-Lan Cui Liang Wang Jing Sun Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Department of Neurology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China State Key Laboratory of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China China Resources Sanjiu Medical&Pharmaceutical Co. Ltd.Shenzhen 518000China.

Antiviral Oral Liquid(AOL)is an adult medicine in the Chinese Pharmacopoeia used to treat upper respiratory infections such as *** has shown promising clinical efficacy in relieving flu-like symptoms such as fever,inflammation,and pharyngalgia both in adults and ***,the instruction manual does not specify the exact usage and dosage of AOL for *** this article,we set 6 dosage ranges:0.2,0.5,0.7,0.9,1.1,1.4 mL/kg/d,according to its dosage for adults and the conversion method between adult and children *** six animal models were used to evaluate the effectiveness of AOL in different *** results indicated that AOL could reduce the lung index,virus load,and expression of proinflammatory cytokines in the *** could improve pathological changes and prolong the survival time of mice infected by the Influenza A virus(H1N1)A/PR/8/34 strains at 0.5–0.9 mL/kg/d concentrations in different *** four dose groups of 0.7–1.4 mL/kg/d could significantly inhibit the ear shell swelling caused by xylene and reduce the rabbit body temperature induced by lipopolysaccharide(P<0.01,P<0.05).All the five dosage groups of 0.2–1.1 mL/kg/d could inhibit the increase of peritoneal capillary permeability induced by glacial acetic acid(P<0.01).AOL at 0.7 and 0.9 mL/kg/d reduced the painful writhing times in young mice induced by glacial acetic(P<0.01).These results indicated that the optimal dose of AOL in antiviral,antipyretic,anti-inflammatory,and analgesic effects is 0.7 mL/kg/d.

关键词： antiviral oral liquid clinical application in children antiviral activity anti-inflammatory activity analgesic activity