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Efficient synthesis of 4-substituted pyrazole via microwave-promoted Suzuki cross-coupling reaction

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Chinese Chemical Letters 2014年第5期25卷 705-709页

作者： hua cheng Qiong-You Wu Fan Han Guang-Fu Yang Key Laboratory of Pesticide & Chemical Biology Ministry of EducationCollege of ChemistryCentral China Normal University

Pyrazoles and their derivatives are important heterocycles found in nature and present in numerous bioactive *** contrast to 3 or 5-aryl pyrazole,the preparation of 4-aryl pyrazole is fairly *** microwave irradiation,the synthesis of 4-substituted-arylpyrazole via Suzuki cross-coupling has been developed with a wide range of *** remarkable advantages of this method are mild reaction conditions,simple operation,high yield,and short reaction *** structures were identified by MS 1H NMR 13C NMR,and elemental analysis.

关键词： 4-Aryl pyrazoles Suzuki cross-coupling reactions 4-Iodo-1-methyl-1H-pyrazole Microwave irradiation

Cell Fate Switch during In Vitro Plant Organogenesis

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Journal of Integrative Plant Biology 2008年第7期50卷 816-824页

作者： Xiang Yu Zhao Ying hua Su ZhiJuan cheng Xian Sheng Zhang State Key Laboratory of Crop Biology College of Life Sciences Shandong Agricultural University Tai'an 271018 China

Plant mature cells have the capability to reverse their state of differentiation and produce new organs under cultured conditions. Two phases, dedifferenUation and redifferentiation, are commonly characterized during in vitro organogenesis. In these processes, cells undergo fate switch several times regulated by both extrinsic and intrinsic factors, which are associated with reentry to the cell cycle, the balance between euchromatin and heterochromatin, reprogramming of gene expression, and so forth. This short article reviews the advances in the mechanism of organ regeneration from plant somatic cells in molecular, genomic and epigenetic aspects, aiming to provide important information on the mechanism underlying cell fate switch during in vitro plant organogenesis.

关键词： cell fate dedifferentiation plant organogenesis redifferentiation regeneration.

CONSTRAINED RATIONAL CUBIC SPLINE AND ITS APPLICATION

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Journal of Computational Mathematics 2001年第2期19卷 143-150页

作者： Qi Duan huan-ling Zhang Xiang Lai Nan Xie Fu-hua(Frank)cheng Department of Applied Mathematics Shandong University of TechnologyJinan 250061China Department of Computer Science University of KentuckyLexingtonKY 40506USA

In this paper, a kind of rational cubic interpolation function with linear denominator is constructed. The constrained interpolation with constraint on shape of the interpolating curves and on the second-order derivative of the interpolating function is studied by using this interpolation, and as the consequent result, the convex interpolation conditions have been derived.

关键词： rational spline constrained design constrained interpolation convex interpolation shape control

K doping stabilizes three-dimensional K_(0.2)Na_(1.3)Mn_(0.5)O_(2-δ)as high-performance cathode for sodium-ion batteries

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Rare Metals 2024年第10期43卷 5030-5038页

作者： Jia-Hao Xu You-huan Zhu Wei-Min Yang hua cheng Zhou-Guang Lu Industrial Training Center Shenzhen Polytechnic UniversityShenzhen 518055China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China School of Materials Science and Environmental Engineering Shenzhen Polytechnic UniversityShenzhen 518055China

It is a difficult challenge to simultaneously employ the cationic and anionic redox chemistry in cathode materials for sodium-ion batteries with high *** though layered oxides(classified as two-dimensional oxides)demonstrate excellent promise in the high discharge capacity,their poor oxygen transformation via redox reactions is limited by crystal ***,a doping strategy was conceived to tackle this issue and increase redox efficiency.K doping was applied to transform the two-dimensional Na_(1.3)Mn_(0.7)O_(2)(NMO)to threedimensional K_(0.2)Na_(1.3)Mn_(0.5)O_(2)(KNMO),preventing the irreversible phase shift and preserving the crystal structure’s stability while *** this modification treatment,KNMO features manganese and oxygen reactive sites,delivering a promising energy density of 190mAh·g^(-1)at 5 mA·g^(-1)in the 2.0–4.5 V voltage range(vs71.4 mAh·g^(-1)for the pristine NMO).Moreover,it displays improved capacity retention of more than 83.5%after 50cycles at 50 mA·g^(-1).The results demonstrated that doped intercalation oxides were promising for redox oxygen transformation in sodium-ion batteries.

关键词： High-performance cathode Metal ion dopings Sodium-ion batteries Three-dimensional structure

N-acetylcysteine protects against cadmium-induced germ cell apoptosis by inhibiting endoplasmic reticulum stress in testes

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Asian Journal of Andrology 2013年第2期15卷 290-296,I0010页

作者： Yan-Li Ji hua Wang cheng Zhang Ying Zhang Mei Zhao Yuan-hua Chen De-Xiang Xu Department of Toxicology School of Public Health Anhui Medical University Hefei 230032 China

Cadmium （Cd） is a reproductive toxicant that induces germ cell apoptosis in the testes. Previous studies have demonstrated that endoplasmic reticulum （ER） stress is involved in Cd-induced germ cell apoptosis. The aim of the present study was to investigate the effects of N-acetylcysteine （NAC）, an antioxidant, on Cd-induced ER stress and germ cell apoptosis in the testes. Male CD-1 mice were intraperitoneally injected with CdCl2 （2.0 mg kg^-1）. As expected, acute Cd exposure induced germ cell apoptosis in the testes, as determined by terminal dUTP nick-end labelling （TUNEL）. However, the administration of NAC alleviated Cd-induced germ ceil apoptosis in the testes. Further analysis showed that NAC attenuated the Cd-induced upregulation of testicular glucose-regulated protein 78 （GRP78）, an important ER molecular chaperone. Moreover, NAC inhibited the Cd-induced phosphorylation of testicular eukaryotic translation initiation factor 2a （elF2a）, a downstream target of the double-stranded RNA-activated kinase-like ER kinase （PERK） pathway. In addition, NAC blocked the Cd-induced activation of testicular X binding protein （XBP）-1, indicating that NAC attenuates the Cd-induced ER stress and the unfolded protein response （UPR）. Interestingly, NAC almost completely prevented the Cd-induced elevation of C/EBP homologous protein （CHOP） and phosphorylation of c-Jun N-terminal kinase （.INK）, two components of the ER stress-mediated apoptotic pathway. In conclusion, NAC protects against Cd-induced germ cell apoptosis by inhibiting endoplasmic reticulum stress in the testes.

关键词： antioxidant apoptosis cadmium endoplasmic reticulum stress N-acetylcysteine (NAC) testis unfolded protein response

ROS-mediated BNIP3-dependent mitophagy promotes coelomocyte survival in Apostichopus japonicus in response to Vibrio splendidus infection

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Zoological Research 2022年第2期43卷 285-300页

作者： Lian-Lian Sun Yi-Na Shao Mei-Xiang You cheng-hua Li State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Ningbo UniversityNingboZhejiang 315211China Laboratory for Marine Fisheries Science and Food Production Processes Qingdao National Laboratory for Marine Science and TechnologyQingdaoShandong 266071China State-Province Joint Laboratory of Marine Biotechnology and Engineering Ningbo UniversityNingboZhejiang 315211China

Organisms produce high levels of reactive oxygen species(ROS)to kill pathogens or act as signaling molecules to induce immune responses;however,excessive ROS can result in cell *** maintain ROS balance and cell survival,mitophagy selectively eliminates damaged mitochondria via mitophagy receptors in *** marine invertebrates,however,mitophagy and its functions remain largely *** the current study,Vibrio splendidus infection damaged mitochondrial morphology in coelomocytes and reduced mitochondrial membrane potential(ΔΨm)and mitophagosome *** colocalization of mitochondria and lysosomes further confirmed that lipopolysaccharide(LPS)treatment increased mitophagy *** explore the regulatory mechanism of mitophagy,we cloned Bcl2/adenovirus E1 B 19 kDa protein-interacting protein 3(BNIP3),a common mitophagy receptor,from sea cucumber Apostichopus japonicus(Aj BNIP3)and confirmed that Aj BNIP3 was significantly induced and accumulated in mitochondria after *** infection and LPS *** the mitochondrial membrane,Aj BNIP3 interacts with microtubule-associated protein 1 light chain 3(LC3)on phagophore membranes to mediate *** Aj BNIP3 interference,mitophagy flux decreased ***,Aj BNIP3-mediated mitophagy was activated by ROS following the addition of exogenous hydrogen peroxide(H2 O2),ROS scavengers,and ROS ***,inhibition of BNIP3-mediated mitophagy by Aj BNIP3 small interfering RNA(si RNA)or high concentrations of lactate increased apoptosis and decreased coelomocyte *** findings highlight the essential role of Aj BNIP3 in damaged mitochondrial degradation during *** mitophagy activity is required for coelomocyte survival in *** against *** infection.

关键词： Apostichopus japonicus Mitophagy Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3 Reactive oxygen species Microtubule-associated protein 1 light chain 3

Choline dehydrogenase interacts with SQSTM1 to activate mitophagy and promote coelomocyte survival in Apostichopus japonicus following Vibrio splendidus infection

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Zoological Research 2023年第5期44卷 905-918页

作者： Lian-Lian Sun Ying-Fen Dai Mei-Xiang You cheng-hua Li State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Ningbo UniversityNingboZhejiang 315211China Laboratory for Marine Fisheries Science and Food Production Processes Qingdao National Laboratory for Marine Science and TechnologyQingdaoShandong 266071China

Previous studies have shown that Vibrio splendidus infection causes mitochondrial damage in Apostichopus japonicus coelomocytes,leading to the production of excessive reactive oxygen species(ROS)and irreversible apoptotic cell *** evidence suggests that mitochondrial autophagy(mitophagy)is the most effective method for eliminating damaged mitochondria and ROS,with choline dehydrogenase(CHDH)identified as a novel mitophagy receptor that can recognize non-ubiquitin damage signals and microtubule-associated protein 1 light chain 3(LC3)in ***,the functional role of CHDH in invertebrates is largely *** this study,we observed a significant increase in the mRNA and protein expression levels of *** CHDH(AjCHDH)in response to *** infection and lipopolysaccharide(LPS)challenge,consistent with changes in mitophagy under the same ***,AjCHDH was localized to the mitochondria rather than the cytosol following *** ***,AjCHDH knockdown using si RNA transfection significantly reduced mitophagy levels,as observed through transmission electron microscopy and confocal *** investigation into the molecular mechanisms underlying CHDH-regulated mitophagy showed that AjCHDH lacked an LC3-interacting region(LIR)for direct binding to LC3 but possessed a FB1 structural domain that binds to *** interaction between AjCHDH and SQSTM1 was further confirmed by immunoprecipitation ***,laser confocal microscopy indicated that SQSTM1 and LC3 were recruited by AjCHDH in coelomocytes and HEK293T *** contrast,AjCHDH interference hindered SQSTM1 and LC3 recruitment to the mitochondria,a critical step in damaged mitochondrial ***,AjCHDH interference led to a significant increase in both mitochondrial and intracellular ROS,followed by increased apoptosis and decreased coelomocyte ***,these findings indicate that AjCHDH-mediated mitophagy plays a

关键词： Choline dehydrogenase Mitophagy SQSTM1 Microtubule-associated protein 1 light chain 3 Apostichopus japonicus

Modified strict sperm morphology threshold aids in the clinical selection of conventional in vitro fertilization(IVF)or intracytoplasmic sperm injection(ICSI)

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Asian Journal of Andrology 2022年第1期24卷 62-66页

作者： Yong Zhu Feng Zhang hua cheng Xiao-Xi Sun Feng Jiang Obstetrics and Gynecology Hospital Fudan UniversityShanghai 200011China Shanghai Ji Ai Genetics and IVF Institute Obstetrics and Gynecology HospitalFudan UniversityShanghai 200011China

For infertility treatment,the selection of in vitro fertilization(IVF)or intracytoplasmic sperm injection(ICSI)is decided by multiplying indicators(including fallopian tube factors,semen count,and semen motility),except for sperm *** this study,we conducted a retrospective analysis,from implantation to birth,over a period of 5 years.A total of 1873 couples with primary or secondary fallopian tube factors and an increased defective sperm morphology rate(DSMR)were divided into different groups to receive IVF or ICSI *** comparing the outcomes,we found that the F1 group(DSMR98%,IVF group 3;P98%,ICSI group 3)had higher cleavage rate(P<0.001),biochemical pregnancy rate(P<0.05),clinical pregnancy rate(P<0.05)and live birth rate(P<0.05)than the F3 ***,the ICSI subgroup had a lower two pronuclei fertilization rate than the IVF subgroup(P<0.05).Our data suggest that the sperm morphology should also be considered when selecting IVF or ICSI combined with other semen parameters before the first assisted reproductive technologies(ART)cycle,especially for males with severe sperm defects.

关键词： clinical outcome in vitro fertilization intracytoplasmic sperm injection sperm morphology

The trend of the APRGP velocity field and plates movement derived from GPS data

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Science China(Physics,Mechanics & Astronomy) 2010年第4期53卷 767-772页

作者： cheng PengFei , WANG hua, cheng YingYan, WEN HanJiang & CAI YanHui Chinese Academy of Surveying and Mapping, Beijing 100039, China 1. Chinese Academy of Surveying and Mapping Beijing 100039 China

High-precision data processing theories and methods for the wide area GPS network–––Asia Pacific Regional Geodesy Project (APRGP), are systematically discussed in this article. With the software bernese5.0 update, the annual results of APRGP coordinate, velocity field and the trend of plate movement are reestimated, and the corresponding accuracy of adjustment with different constraints, also the velocity field of APRGP, are presented and analyzed. Conclusions could be drawn that Eurasian plate (EURA) rotates clockwise, the Australian plate (AUST) and the Indian plate (INDI) move from southwest to northeast, while the Pacific plate (PCFC) is drifting to northwest, which shows agreement with those of IGS results.

关键词： APRGP Bernese5.0 GPS Data processing velocity field plate movement