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Role of gut microbiota in ischemic stroke:A narrative review of human and animal studies

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Neuroprotection 2024年第2期2卷 120-136页

作者： Guangtang Chen Xiaolin Du Junshuan Cui Jiaquan Song Mingsong xiong Xi Zeng hua Yang Kaya Xu Department of Neurosurgery The Affiliated Hospitalof Guizhou Medical UniversityGuiyangGuizhouChina Department of Neurosurgery The Jinyang Hospital Affiliated to Guizhou Medical UniversityGuiyangGuizhouChina Department of Hyperbaric Oxygen The Affiliated Hospitalof Guizhou Medical UniversityGuiyangGuizhouChina

The high incidence,mortality,and disability associated with ischemic stroke pose a significant threat to human *** intestinal microbiota significantly influences the onset,progression,and prognosis of ischemic *** flora plays a pivotal role in brain-gut *** reflection of changes in the gut and brain caused by gut microbes faciltates the investigation of early warning biomarkers and potential therapeutic targets for ischemic *** this narrative review of the relationship between gut microbiota and ischemic stroke,we primarily discuss three topics,grounded in real-world human and animal ***,we examined the relationship between ischemic stroke and intestinal microbiota and its metabolites,delineate the overall characteristics of intestinal microbiota dysregulation in ischemic stroke,and assess the potential clinical value,prevailing research controversies,and unique phenomena of intestinal microbiota metabolites such as trimethylamine N-oxide and short-chain fatty acids in ischemic ***,we explored the potential communication pathways between intestinal flora and ischemic stroke based on the brain-gut axis,encompassing metabolic pathways,immune pathways,and neural ***,we encapsulated the factors influencing the severity of ischemic stroke via intestinal flora,the pharmacological and nonpharmacological interventions that modulate intestinal flora in treating ischemic stroke,and the current research landscape of intestinal flora in the context of ischemic stroke sequelae.

关键词： animal study gut microbiota human study ischemic stroke short-chain fatty acid trimethylamine oxide

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基于集群机并行绘制的三角形条带压缩

计算机辅助设计与图形学学报 2007年第7期19卷 898-906页

作者：秦爱红熊华石教英浙江大学CAD & CG国家重点实验室

提出一个适用于集群机并行绘制的三角形条带数据压缩框架——视点连贯性的分片条带压缩(VCPSC),有效地克服了传统几何数据压缩算法存在的问题.VCPSC包括3步核心算法:基于空间和法向连贯性分片方法;基于同心圆全局路径控制的三角形单条带... 详细信息

提出一个适用于集群机并行绘制的三角形条带数据压缩框架——视点连贯性的分片条带压缩(VCPSC),有效地克服了传统几何数据压缩算法存在的问题.VCPSC包括3步核心算法:基于空间和法向连贯性分片方法;基于同心圆全局路径控制的三角形单条带化;ETSC三角形条带压缩算法.通过把每个压缩的三角形条带映射为一个支持随机存取的虚拟三角形,VCPSC实现了几何模型压缩域的基于视点的归属判断和分片随机存取.实验结果表明:VCPSC有效地改善了集群机绘制性能.

关键词：集群机并行绘制 GPU 三角形条带几何压缩网格分割

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基于面积分布的3D模型检索技术

计算机工程 2008年第12期34卷 257-258,261页

作者：熊华西华师范大学数学与信息学院南充637002

基于内容的3D模型检索技术难以提取形状特征,该文通过提取表面面积分布来表示3D模型的形状特征,采用主分量分析方法确保特征满足平移不变性、旋转不变性、对称不变性。以切分块内三角面片面积和与总面积的比值作为特征,确保缩放不变性... 详细信息

基于内容的3D模型检索技术难以提取形状特征,该文通过提取表面面积分布来表示3D模型的形状特征,采用主分量分析方法确保特征满足平移不变性、旋转不变性、对称不变性。以切分块内三角面片面积和与总面积的比值作为特征,确保缩放不变性。二次型形式的距离公式计算的相似度能够有效地区分特征分量的空间位置。实验表明,基于面积分布的检索技术具有较好的检索效果。

关键词：基于内容检索基于面积分布检索 3D模型检索

剪切增稠流体浸渍Kevlar复合材料的防刺性能

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南京理工大学学报 2010年第2期34卷 271-274页

作者：刘君熊党生熊华超南京理工大学材料科学与工程系江苏南京210094

利用自制落锤式冲击试验装置,该文研究了剪切增稠流体(STF)浸渍Kevlar复合材料防刺性能的瞬态受力响应过程和刺穿深度,以及STF-Kevlar复合材料的吸能机理。实验结果表明,经浸渍的Kevlar织物防刺穿力峰值提高到约400 N,复合材料的第一层... 详细信息

利用自制落锤式冲击试验装置,该文研究了剪切增稠流体(STF)浸渍Kevlar复合材料防刺性能的瞬态受力响应过程和刺穿深度,以及STF-Kevlar复合材料的吸能机理。实验结果表明,经浸渍的Kevlar织物防刺穿力峰值提高到约400 N,复合材料的第一层受力响应时间缩短到3.5 ms,而刺穿深度降低较小。其中以120 nm SiO2配制的中间浓度的分散体系浸渍后,复合材料的防刺效果最好,防刺穿力提高至约2.7倍,刺穿深度降低了10%左右。

关键词：剪切增稠流体复合材料防刺浸渍

Changes of Survivin mRNA and Protein Expression during Paclitaxel Treatment in Breast Cancer Cells

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Journal of huazhong University of Science and Technology(Medical Sciences) 2007年第1期27卷 65-67页

作者：熊慧华于世英庄亮熊华 Cancer Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

In order to investigate the role of antiapoptosis gene, survivin in the resistance to palcitaxel, the expression of survivin mRNA and protein in the process of paclitaxel treatment in breast cancer cell line MCF-7 was detected. MCF-7 cells were incubated with paclitaxel at different concentrations. The growth inhibition rate of MCF-7 was investigated by tetrazolium bromide （MTT） colorimetry. The change of apoptosis was detected by Annexin-V/PI methods. The changes in the expression of survivin mRNA and protein were studied by reverse transcription polymerase chain reaction （RT-PCR） and Western-blot assay respectively. The growth inhibition rate of MCF-7 was increased in a concentration- and time-dependent manner. Paclitaxel of higher concentration could effectively induce apoptosis in MCF-7 cells after 48 h, while the expression of survivin was increased at early time （within 6 h） and decreased after 24 h regardless of treatment concentrations of paclitaxel. It suggested that tumor cells might evade the paclitaxel-induced cell cycle arrest and apoptosis by increasing the level of survivin at early treatment time.

关键词： breast cancer survivin apoptosis paclitaxel

三阶非线性发展方程的线性化有理逼近方法(英文)

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计算力学学报 2006年第1期23卷 34-39页

作者：沈烨吴雄华同济大学应用数学系上海200092

研究了三阶非线性发展方程的初边值问题的解。采用基于Sinc函数的微分求积法发展了线性化有理逼近方法。通常的配点法不适用于上述三阶问题的求解。本文把提出的方法用于求解KdV方程,取得了良好的效果。

关键词：线性化有理逼近方法 Sinc函数的微分求积法 KdV(Korteweg-de Vries)方程

吉非替尼对晚期非小细胞肺癌患者生活质量的改善(英文)

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The Chinese-German Journal of Clinical Oncology 2009年第9期8卷 495-497页

作者： Yanmei Zou hua xiong Shiying Yu Cancer Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan430030 China

Objective:The aim of this study was to evaluate the effect of gefitinib on improvement of quality of life (QoL) of patients with advanced non-small cell lung cancer (NSCLC). Methods:There were 70 patients with advanced NSCLC. One oral gefitinib tablet (250 mg) was administered every day without interruption unless disease progression or unacceptable toxicity occurred. The impact of treatment on disease-related symptoms and QoL was evaluated with the Chinese versions of European Organization for Research and Treatment of Cancer Quality of Life Questionnaires (EORTC QLQ-C30 and QLQ-LC13). Results: Fifty-eight patients had finished the questionnaires. The mean scores of five functioning scales (physical, role, emotional, cognitional and social) were 62.64, 56.03, 68.41, 64.67, 60.63 respectively after eight weeks of treatment, which were 52.30, 49.43, 64.39, 59.79, 52.30 respectively before treatment, and the mean score of global QoL after and before treatment was 60.17 and 52.70 respectively. There was statistical difference in five functioning scales and global QoL (P < 0.05). Mean scores of main general symptoms (fatigue and appetite loss) were 57.66 and 48.08 respectively after eight weeks of treatment, which were 61.11 and 51.72 respectively before treatment, and mean scores of disease-related symptoms (dyspnoea, coughing, empsyxis, pain in chest) were 48.66, 47.13, 26.82, 24.71 respectively after eight weeks of treatment, which were 54.98, 53.64, 27.78, 28.54 respectively before treatment. There was statistical difference in fatigue, dyspnoea, cough and pain in chest (P < 0.05). Response rate of five functioning and global QoL were all more than 50% after gefitinib treatment. Response rate of main general symptoms and disease-related symptoms were all more than 40%. QoL and symptom response correlated with disease control. The patients with better QoL had longer survival. Conclusion: gefitinib treatment can improve the QoL and symptoms of advanced NSCLC patients.

关键词：肺癌治疗方法临床分析症状

Navier-Stokes方程的线性化微分求积法(英文)

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计算物理 2006年第1期23卷 10-18页

作者：李晨吴雄华同济大学应用数学系上海200092

提出一种新的线性化微分求积法(LDQM),将这种方法应用到流函数和涡量形式的Navier-Stokes方程.通过LDQM,非线性方程很容易被解出来,并且容易处理压力的边界条件.为检验本方法,计算了两个数值算例.

关键词： Navier—Stokes方程微分求积法线性化方法

基于CiteSpace的法医齿科学研究发展态势分析

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法医学杂志 2023年第1期39卷 18-26页

作者：马浩天熊华烨卢烨李兵赖江华西安交通大学医学部法医学院陕西西安710061 西南大学资源环境学院重庆400700 山西医科大学法医学院山西太原030001

目的基于文献计量学方法,实现法医齿科学研究动态可视化,以期捕捉研究热点,明确未来发展趋势。方法在Web of Science核心数据集中依据特定主题词搜索1995年1月—2020年12月发表的文献,采用CiteSpace 5.7.R5W软件对发文国家、机构、学科... 详细信息

目的基于文献计量学方法,实现法医齿科学研究动态可视化,以期捕捉研究热点,明确未来发展趋势。方法在Web of Science核心数据集中依据特定主题词搜索1995年1月—2020年12月发表的文献,采用CiteSpace 5.7.R5W软件对发文国家、机构、学科领域、作者、共被引期刊、关键词等进行可视化分析。结果发文年度分析表明法医齿科学研究文献呈现逐年上升趋势,最近5年年度发文量达110篇以上。发达国家是主要的供稿来源,平均中心度>0.2。法医齿科学研究涉及口腔医学、生物、计算机、医学影像学等多个学科,学科交叉明显。关键词聚类分析共获得115个节点,主要以个体识别、年龄推断为主线,关键词热点突现与新技术密切相关。基于群体的齿科学调查、对传统牙龄推断法的改善、基于新技术的牙龄推断是当前法医齿科学较热门的研究方向。结论发展中国家亟须提高相关研究的关注度。建立并充实本地区齿科数据库,结合前沿高端技术开发新型齿科鉴定方法,基于先进信息技术开发识别程序,可能是未来法医齿科学学科发展的重要方向。

关键词：法医学法医齿科学文献计量学 Web of Science数据库 Citespace