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Potential applications of single-incision laparoscopic totally preperitoneal hernioplasty

World Journal of Gastrointestinal Surgery 2024年第7期16卷 2202-2210页

作者： Xiao-Jun Wang Ting Fei xiong-hua Xiang Quan Wang En-Cheng Zhou Department of Gastrointestinal Surgery The First Affiliated Hospital of Ningbo UniversityNingbo 315020Zhejiang ProvinceChina Ambulatory Surgery Center Xijing HospitalAir Force Military Medical UniversityXi’an 710032Shaanxi ProvinceChina

BACKGROUND The totally preperitoneal(TPP)approach is a new concept that was recently *** the TPP approach combined with single-incision laparoscopic hernia repair has its own advantages,there is little evidence reflecting the characteristics and feasibility of either *** To analyze the potential applications of single-incision laparoscopic TPP(SILTPP)inguinal hernia hernioplasty for the treatment of inguinal *** A total of 152 SIL-TPP surgeries were performed at the First Affiliated Hospital of Ningbo University from February 2019 to November 2022.A single-port,named Iconport,and standard laparoscopic instruments were used during the *** data,intraoperative parameters and short-term postoperative outcomes were collected and retrospectively *** The demographic data of 152 patients underwent SIL-TPP were shown in Table *** average age was 49.5 years(range from 21 to 81 years).The average body mass index was 27.7 kg/m^(2)(range from 17.7 kg/m^(2) to 35.6 kg/m^(2)).SIL-TPP were conducted successfully in 147 *** patients were converted to the SILtransabdominal preperitoneal laparoscopic herniorrhaphy at the initial stage of the study due to a lack of *** 2 patients with incisional hernias,an auxiliary operation hole was added during the SIL-TPP procedure,as required for *** mean operative time was 64.5 minutes(range:36.0-110.0 minutes)for unilateral direct and femoral hernias and 81.6 minutes for indirect hernias(range:40.0-150.0 minutes).The mean postoperative hospital stay was 3.4 *** SIL-TPP is feasible and has advantages for inguinal hernia ***-TPP has potential benefits for patients with various abdominal wall ***,doctors should be encouraged to actively apply the TPP approach combined with a single incision in their daily work.

关键词： Totally preperitoneal hernioplasty Iconport Single incision laparoscopic Totally extraperitoneal herniorrhaphy Single incision laparoscopic totally preperitoneal hernioplasty

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Modification of food protein fibrils: During and after fibrillization

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Food Science and Human Wellness 2024年

作者： Kefan Ouyang Hexiang Xie hua xiong Qiang Zhao Wenjun Wang State Key Laboratory of Food Science and Resources Nanchang University Jiangxi Key Laboratory of Natural Products and Functional Food College of Food Science and Engineering Jiangxi Agricultural University

Fibrillization endows food proteins with anisotropic nanostructures， significantly enhancing their functional properties. The resultant food protein fibrils (FPFs) have garnered attention for their diverse applications across the food industry. However， the full potential of FPFs is hindered by inherent challenges， particularly their limited stability. This review critically examines the formation of FPFs in food processing， the new protein sources， and on the modification strategies of FPFs， thereby unlocking new avenues for FPF utilization in food processing. In particular， the strategies during and after fibrillization are highlighted. The first strategy is to modify the structure and function of protein fibrils by influencing fibrillization， such as through pretreatment， incubation conditions， nuclei induction， and ingredient interactions. The second strategy is to modify the mature FPFs by regulating their properties and interactions with other components. The review also discusses the potential applications and challenges of FPFs in food systems， such as food preservation， functional food design， and novel delivery carriers.

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Research progress on lung cancer stem cells in epidermal growth factor receptor–tyrosine kinase inhibitor targeted therapy resistance in lung adenocarcinoma

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Oncology and Translational Medicine 2024年第1期10卷 42-46页

作者： Hong Zhang Yanbin Wang Xianglin Yuan Yanmei Zou hua xiong Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina

Lung cancer is the leading cause of cancer-related deaths *** recent years,with the widespread use of genetic testing,epidermal growth factor receptor–tyrosine kinase inhibitor(EGFR-TKI)–targeted drugs have been efficacious to patients with lung adenocarcinoma exhibiting EGFR ***,resistance to treatment is inevitable and eventually leads to tumor progression,recurrence,and reduction in the overall treatment *** cancer stem cells play a crucial role in the development of resistance toward EGFR-TKI–targeted therapy for lung *** cancer stem cells possess self-renewal,multilineage differentiation,and unlimited proliferation capabilities,which efficiently contribute to tumor formation and ultimately lead to tumor recurrence *** this study,we evaluated the origin,markers,stemness index,relevant classic studies,resistance mechanisms,related signaling pathways,and strategies for reversing lung cancer stem cell resistance to EGFR-TKIs to provide new insights on delaying or reducing resistance and to improve the treatment efficacy of patients with EGFR-mutated lung adenocarcinoma in the future.

关键词： Drug resistance EGFR-TKIs Lung cancer stem cells Lung adenocarcinoma

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电磁耦合场对星载弹性元件结构和性能的影响

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中国空间科学技术 2024年第1期44卷 89-98页

作者：华雄肖勇高翔王辉邱冬生王勇中国空间技术研究院西安分院西安710199 武汉晶泰科技股份有限公司 430056

星载可展天线广泛使用了弹性元件,这些弹性元件机械性能的一致性和稳定性对天线的展开和正常服役至关重要,是可展天线产品满足形面精度指标要求的重要支撑。采用宏观和微观试验相结合的方法,旨在探究电磁场对弹性元件结构和性能的影响,... 详细信息

星载可展天线广泛使用了弹性元件,这些弹性元件机械性能的一致性和稳定性对天线的展开和正常服役至关重要,是可展天线产品满足形面精度指标要求的重要支撑。采用宏观和微观试验相结合的方法,旨在探究电磁场对弹性元件结构和性能的影响,分析其影响机制,为提升星载弹性元件机械性能的一致性和稳定性提供新的途径。研究发现电磁耦合场能够在不改变原有产品精度等级及内部成分的情况下,将星载弹性元件刚度提升2.11%,刚度分布方差降低一个数量级;显微硬度最大可提升8.42%,硬度方差分布下降40.79%;抗蠕变性能提高45.76%,在强化机械性能的同时提高弹簧刚度分布和硬度分布的均匀性,减小个体差异。另外金相微观组织的观测结果显示电磁耦合场对弹簧机械性能的改善具有细晶强化和沉淀强化的作用。电磁耦合强化对提高星载弹性元件结构的性能稳定性和一致性具有重要影响,该技术在未来航天领域具有良好前景。

关键词：星载弹性元件电磁耦合细晶强化沉淀强化位错

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Clinical manifestation,lifestyle,and treatment patterns of chronic erosive gastritis:A multicenter real-world study in China

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World Journal of Gastroenterology 2024年第9期30卷 1108-1120页

作者： Ying-Yun Yang Ke-Min Li Gui-Fang Xu Cheng-Dang Wang hua xiong Xiao-Zhong Wang Chun-Hui Wang Bing-Yong Zhang Hai-Xing Jiang Jing Sun Yan Xu Li-Juan Zhang Hao-Xuan Zheng Xiang-Bin Xing Liang-Jing Wang Xiu-Li Zuo Shi-Gang Ding Rong Lin Chun-Xiao Chen Xing-Wei Wang Jing-Nan Li Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China Department of Gastroenterology Nanjing Drum Tower HospitalNanjing 21000Jiangsu ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005Fujian ProvinceChina Department of Gastroenterology Renji HospitalShanghai 200127China Department of Gastroenterology Union Hospital of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Gastroenterology West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Gastroenterology and Hepatology The People’s Hospital of Zhengzhou UniversityThe Henan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai Jiao Tong UnivesrityRuijin HospitalSchool MedicineShanghai 200025China Department of Gastroenterology and Hepatology China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Gastroenterology Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina Department of Gastroenterology Nanfang HospitalGuangzhou 510080Guangdong ProvinceChina Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina Department of Gastroenterology The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Gastroenterology Shandong University Qilu HospitalJinan 250012Shandong ProvinceChina Department of Gastroenterology Peking University Third HospitalBeijing 100191China Department of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei Pr

BACKGROUND Although chronic erosive gastritis(CEG)is common,its clinical characteristics have not been fully *** lack of consensus regarding its treatment has resulted in varied treatment *** To explore the clinical characteristics,treatment patterns,and short-term outcomes in CEG patients in *** We recruited patients with chronic non-atrophic or mild-to-moderate atrophic gastritis with erosion based on endoscopy and *** and treating physicians completed a questionnaire regarding history,endoscopic findings,and treatment plans as well as a follow-up questionnaire to investigate changes in symptoms after 4 wk of *** Three thousand five hundred sixty-three patients from 42 centers across 24 cities in China were *** pain(68.0%),abdominal distension(62.6%),and postprandial fullness(47.5%)were the most common presenting *** was classified as chronic non-atrophic in 69.9%of *** those with erosive lesions,72.1%of patients had lesions in the antrum,51.0%had multiple lesions,and 67.3%had superficial flat *** patients with epigastric pain,the combination of a mucosal protective agent(MPA)and proton pump inhibitor was more *** those with postprandial fullness,acid regurgitation,early satiety,or nausea,a MPA appeared more *** CEG is a multifactorial disease which is common in Asian patients and has non-specific *** may play a major role in its detection and *** should be individualized based on symptom profile.

关键词： Chronic erosive gastritis Symptom Endoscopic findings Treatment pattern Real-world

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重庆市一起鹦鹉热衣原体肺炎疫情流行病学调查分析

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疾病预防控制通报 2024年第3期39卷 10-12,16页

作者：马兰熊华利重庆市荣昌区疾病预防控制中心重庆402460 重庆市荣昌区卫生健康委员会重庆402460 重庆市荣昌区精神卫生中心重庆402460

目的了解2022年1月重庆市荣昌区1例鹦鹉热衣原体肺炎病例的流行病学特征,探索病因及影响因素,为鹦鹉热的防控提供参考依据。方法通过电话调查和现场流行病学调查的方法,对病例开展流行病学调查,对病例、密切接触者、环境样本、动物粪便... 详细信息

目的了解2022年1月重庆市荣昌区1例鹦鹉热衣原体肺炎病例的流行病学特征,探索病因及影响因素,为鹦鹉热的防控提供参考依据。方法通过电话调查和现场流行病学调查的方法,对病例开展流行病学调查,对病例、密切接触者、环境样本、动物粪便样本开展病原学检测。结果病例男,78岁,超重,患有高血压和血脂异常,因发热、畏寒、咳嗽、全身肌肉酸痛、呼吸困难2 d入院,胸部CT检查提示肺部感染,病例血液和痰培养样本经聚合酶链式反应检测鹦鹉热衣原体阳性;病例有可疑的鸟类交易市场暴露史,潜伏期20 d。共发现密切接触者3人,经7 d居家医学隔离观察后,均未见异常。共检测外环境样本22份,鹦鹉热衣原体核酸检测结果均为阴性。结论该病例可能是因暴露在被鹦鹉热衣原体污染的鸟类交易市场外环境而导致感染;应加强畜禽市场,尤其是鸟类市场的鹦鹉热衣原体监测,加强健康宣传教育,提高公众对鹦鹉热等人兽共患病的知晓率。

关键词：鹦鹉热鹦鹉热衣原体流行病学调查人兽共患病

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基于生物信息学与网络药理学分析薯蓣皂苷治疗阿尔茨海默病和新型冠状病毒肺炎的靶点研究

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海南医学院学报 2024年第1期30卷 39-49页

作者：张华雄张明惠李红燕新疆维吾尔自治区人民医院神经内科新疆乌鲁木齐830000 新奇康药业股份有限公司新疆乌鲁木齐830000

目的:基于生物信息学、网络药理学及分子对接技术探究薯蓣皂苷治疗阿尔茨海默病(alzheimer disease,AD)和新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)的靶点。方法:利用生物信息学对AD和COVID-19的共有的差异表达基因(differe... 详细信息

目的:基于生物信息学、网络药理学及分子对接技术探究薯蓣皂苷治疗阿尔茨海默病(alzheimer disease,AD)和新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)的靶点。方法:利用生物信息学对AD和COVID-19的共有的差异表达基因(differential expression gene,DEGs)进行富集分析。接着,通过转录因子(transcription Factor,TF)调控网络分析,并利用Cytoscape使其网络可视化,进一步通过DGIdb数据库预测能同时治疗AD和COVID-19的药物,与CTD数据库中AD、COVID-19相关治疗药物进行韦恩图分析,确定薯蓣皂苷作为治疗AD、COVID-19的潜在药物。使用SEA、SuperPred、SwissTargetPrediction、TCMSP对薯蓣皂苷进行靶点预测,并将其分别与AD、COVID-19的DEGs进行韦恩图交集分析,确定薯蓣皂苷治疗AD、COVID-19的靶点,对其进行基因本体论(Gene Ontology,GO)、京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)富集分析,并构建这些药物靶点的蛋白相互作用(Protein Protein Interaction,PPI)网络,筛选出关联度最高的核心靶点。利用分子对接分析薯蓣皂苷与这些核心靶点的结合情况。结果:通过富集和聚类分析,发现AD、COVID-19共有DEGs所富集的生物过程、通路、疾病均与炎症和免疫调节相关。利用这些共有DEGs与Trust数据库构建了AD和COVID-19 TFs调控网络。通过网络药理学预测到薯蓣皂苷是治疗AD和COVID-19的潜在药物,并揭示了薯蓣皂苷治疗AD的36个靶点和27个治疗COVID-19的靶点。用CytohHubba计算得分,分别选取各自关联度最高的6个的核心靶点与薯蓣皂苷进行分子对接。结论:本研究首次揭示了AD和COVID-19共有TFs调控网络,预测并验证了薯蓣皂苷是治疗AD和COVID-19的潜在药物。且通过分子对接确定了薯蓣皂苷与治疗AD和COVID-19的核心药理靶点的结合情况,为开辟临床治疗AD和COVID-19新的途径提供了理论依据。

关键词：生物信息学网络药理学薯蓣皂苷阿尔茨海默病新型冠状病毒肺炎

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一种无机改性导电共聚酯的研究

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聚酯工业 2024年第2期37卷 29-32页

作者：琚雷龙熊华俊浙江永盛科技有限公司浙江绍兴312000

涤纶是聚酯纤维习惯叫法,具有强度高、易清洗、染色牢度高、技术成熟、生产成本低的优点,是理想的纺织品原料,但它的缺点也很明显,其分子结构中缺少亲水性基团,因此纤维的公定回潮率低,纤维互相摩擦产生的静电不容易快速消散,积累的静... 详细信息

涤纶是聚酯纤维习惯叫法,具有强度高、易清洗、染色牢度高、技术成熟、生产成本低的优点,是理想的纺织品原料,但它的缺点也很明显,其分子结构中缺少亲水性基团,因此纤维的公定回潮率低,纤维互相摩擦产生的静电不容易快速消散,积累的静电到一定程度时会击穿空气瞬间释放产生火花,危害生产安全。本研究以硅藻土、海藻酸钠分散在乙二醇中配制成吸湿改进剂,在分子链中接枝少量亲水性的磺酸基团,增加纤维的吸湿率,从源头降低体积比电阻。

关键词：共聚酯静电亲水性吸湿性电阻

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牙根发育不良病因及分子机制的研究进展

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北京口腔医学 2024年第1期32卷 65-69页

作者：雷彬熊华翠陈柯广州中医药大学深圳医院(福田) 深圳518000 南方医科大学口腔医院海珠广场院区儿童口腔科

牙根发育不良(HTR)是指发生于牙齿根部的先天性发育障碍的一种疾病,国外学者称其为短根异常疾病(SRA),乳、恒牙列均可发生,其发生通常无任何临床症状,且牙冠色泽正常,但偶有牙齿异常的松动,影像学可见诸如短锥状牙根等。该病诊断具有一... 详细信息

牙根发育不良(HTR)是指发生于牙齿根部的先天性发育障碍的一种疾病,国外学者称其为短根异常疾病(SRA),乳、恒牙列均可发生,其发生通常无任何临床症状,且牙冠色泽正常,但偶有牙齿异常的松动,影像学可见诸如短锥状牙根等。该病诊断具有一定的挑战性。本文就牙根发育不良的发病因素、分子机制作一简要综述。

关键词：牙根发育不良短根症发病因素分子机制

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高校青年教师教学能力发展的自我评价及影响因素分析

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当代教师教育 2024年第2期17卷 48-54页

作者：熊华军耿笠博广东技术师范大学教育科学学院广东广州510665 西北师范大学教育科学学院甘肃兰州730070

通过问卷调查和深度访谈的方式,以17所高校1456名教师为样本,从人口统计学特征、学校特征、学术特征、教学荣誉特征四个方面对高校青年教师教学能力发展的自我评价和影响因素进行独立样本T检验、单因素方差分析和Logistic回归分析。研... 详细信息

通过问卷调查和深度访谈的方式,以17所高校1456名教师为样本,从人口统计学特征、学校特征、学术特征、教学荣誉特征四个方面对高校青年教师教学能力发展的自我评价和影响因素进行独立样本T检验、单因素方差分析和Logistic回归分析。研究发现,促进高校青年教师教学能力发展,需要大力加强教学师资培训与管理、着力减少青年教师的行政工作、殚力关注新入职教师发展、通力提升新建本科院校青年教师教学能力。

关键词：高校青年教师教学能力发展自我评价影响因素

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