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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng wu Wen-Jia Chen Xin-Ning Yu hua-Tao wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

ON THE CELL ENTROPY INEQUALITY FOR THE FULLY DISCRETE RELAXING SCHEMES

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Journal of Computational Mathematics 2001年第5期19卷 511-518页

作者： hua-zhong Tang hua-mo wu School of Mathematical Sciences Peking UniversityBeijing 100871China LSEC JCMSECAcademy of Mathematics and Systems SciencesChinese Academy of SciencesBeijing 100080China

Presents a study on the cell entropy inequality for two classes of fully discrete relaxing schemes approximating scalar conservation laws. Main advantage of the schemes; Review of the construction of the relaxing syst... 详细信息

关键词： the relaxing schemes entropy inequality conservation laws

ON THE CONVERGENCE OF IMPLICIT DIFFERENCE SCHEMES FOR HYPERBOLIC CONSERVATION LAWS

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Journal of Computational Mathematics 2002年第2期20卷 121-128页

作者： hua-zhong Tang hua-mo wu School of Mathematical Sciences Peking UniversityBeijing 100871China LSEC ICMSECAcademy of Mathematics and System SciencesChinese Academy of SciencesBeijing 100080China

Discusses the treatment of implicit difference approximations to hyperbolic conservation laws with non-convex flux. Information on weighted implicit difference schemes; Convergence of difference scheme; Establishment ... 详细信息

关键词： conservation laws weighted implicit schemes entropy solution

Gelation of polymeric nanoparticles

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Particuology 2014年第3期12卷 1-11页

作者： hua wu Massimo Morbidelli Institute for Chemical and Bioengineering.Department of Chemistry and Applied Biosciences ETH Zurich8093 ZurichSwitzerland

We review how, starting from polymeric nanoparticles, to generate clusters of fractal morphology and to expand the entire space and interconnect to form gels, through either Brownian motion or intense shear-induced aggregation. In the case of Brownian motion-induced gelation, specific techniques developed to obtain uniform structure of gels under both reaction-limited and diffusion-limited cluster aggregation conditions have been described. In the case of intense shear-induced gelation as a newly developed technique, our focus is on its principle, theoretical development and advantages with respect to Brownian motion-induced gelation in practical applications. We consider gelation of both rigid and soft particles. As a physical process, the bonding between the particles within gels is owed to van der Waals attractions, thus being easily broken. However, in the case of soft particles that can coalesce upon contact, the coalescence can allow the particles to stick together forming permanent gels. In this case, the gel structure can be controlled by controlling the degree of coalescence. Techniques used to control the degree of coalescence have also been described.

关键词： Structured material Fractal Gelation Gel Polymer

Microstructure and Microhardness of Tempered Ni-Al Alloyed Layer

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Journal of Materials Science & Technology 2012年第10期28卷 937-940页

作者： Yue Yang hua wu College of Materials Science and Engineering Changchun University of TechnologyChangchun130012China

A Nd：YAG pulsed laser was used to alloy the Ni-P electroless deposited coating with aluminum substrate under the condition of scanning speed of 3.0 mm/s and power density of 5.36×10^9 W/m^2. Subsequently, the samples were heat treated at 300, 400 and 500 ℃ for 2.5 h, respectively. The phase composition and microstructure of the tempered layers treated at different temperature were identified by X-ray diffraction （XRD）, scanning electron microscopy （SEM） and transmission electron microscopy （TEM）. The results showed that the phase constituents of the alloyed zones were intermetallic compounds of NiAI, AI3Ni, Ni3P and AINi3. As a result, the microhardness of the alloyed layer after heat treatment was improved obviously compared to untreated samoles, and the laver obtained at teml0erature 400 ℃ reached HVn.1 430.

关键词： Laser alloying Nickel-aluminum intermetallics Heat treatment Microhardness

Effects of Current Density on Microstructure of Titania Coatings by Micro-arc Oxidation

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Journal of Materials Science & Technology 2012年第4期28卷 321-324页

作者： Yue Yang hua wu Key Laboratory of Advanced Structural Materials Ministry of EducationChangchun University of TechnologyChangchun130012China

In the present study, titania coatings were prepared under different current density conditions in micro-arc oxidation （MAO） process on titanium alloy in NaAlO2 solution. The aim of this work was to study the effects of current density on the microstructure of titania coatings. The morphology and phase composition of the coatings were investigated by field emission scanning electron microscopy （FESEM）, X-ray diffraction （XRD） and Raman spectra. The thickness and surface roughness of the coatings were characterized by confocal laser Scanning Microscopy （CLSM）. The results showed that the coatings were composed of crystalline anatase and rutile phases of TiO2, and contain a network of evenly distributed small pores. It has also shown that an increase in current density leads to an increase in rutile content.

关键词： Titanium alloy Micro-arc oxidation Raman spectra Current density

Local scour by multiple slit-type energy dissipaters

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Journal of Hydrodynamics 2020年第6期32卷 1221-1224页

作者： Li Yao Jian-hua wu College of Water Conservancy and Ecological Engineering Nanchang Institute of TechnologyNanchang330099China College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing210098China

Energy dissipation and scour control are all the key issues for the design of hydraulic *** the basis of the high energy dissipation for the multiple slit-type energy dissipaters(M-STED)developed by the authors,in this work,the characteristics of the scour hole for the M-STED were experimentally investigated through three sets of those physical models with five cases and a scour hole form index was *** results show that,the M-STED results in not only the high energy dissipation but also the mild upstream slope of the scour hole thanks to the scour hole form index of larger than 0.5,which is in favor of the safety of the release works.

关键词： Energy dissipation scour scour hole form index multiple slit-type energy dissipater

ON ENTROPY CONDITIONS OF HIGH RESOLUTION SCHEMES FOR SCALAR CONSERVATION LAWS

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Journal of Computational Mathematics 2001年第4期19卷 371-384页

作者： Ning Zhao hua-mu wu Department of Aerodynamics Nanjing University of Aeronautics and AstronauticsNanjing 210016China LSEC ICMSECAcademy of Mathematics and Systems SciencesChinese Acaderny of SciencesBeijing 100080China

Presents a method of proof which improves the estimates of entropy production for general total variation diminishing (TVD) schemes. Elements of the general theory of TVD schemes; Basis for obtaining the entropy inequality of a class of second order resolution-TVD schemes for strict convex conservation laws; Definition of discrete entropy inequality.

关键词： entropy condition high resolution schemes conservation laws

Analysis of φ-divergence for Loglinear Models with Constraints under Product-multinomial Sampling

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Acta Mathematicae Applicatae Sinica 2013年第1期29卷 93-104页

作者： Ying-hua JIN Yao-hua wu Department of Statistics and Finance University of Science and Technology of China Faculty of Applied Mathematics Guangdong University of Technology

The loglinear model under product-multinomial sampling with constraints is considered. The asymptotic expansion and normality of the restricted minimum C-divergence estimator （RMDE） which is a generalization of the maximum likelihood estimator is presented. Then various statistics based on C-divergence and RMCDE are used to test various hypothesis test problems under the model considered. These statistics contain the classical loglikelihood ratio test statistics and Pearson chi-squared test statistics. Ia the last section, a simulation study is implemented.

关键词： loglinear model product-multinomial sampling Restricted minimum C-divergence estimator(RMDE) C-divergence test statistics