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Tau truncation in the pathogenesis of Alzheimer's disease:a narrative review

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Neural Regeneration Research 2024年第6期19卷 1221-1232页

作者： Dandan Chu Xingyue Yang Jing Wang Yan Zhou Jin-hua gu Jin Miao Feng Wu Fei Liu Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsCoinnovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Department of Biochemistry and Molecular Biology School of MedicineNantong UniversityNantongJiangsu ProvinceChina Department of Clinical Pharmacy Affiliated Maternity and Child Health Care Hospital of Nantong UniversityNantong UniversityNantongJiangsu ProvinceChina Laboratory of Animal Center Nantong UniversityNantongJiangsu ProvinceChina Department of Neurochemistry Inge Grundke-Iqbal Research FloorNew York State Institute for Basic Research in Developmental DisabilitiesStaten IslandNYUSA

Alzheimer's disease is characterized by two major neuropathological hallmarks—the extracellularβ-amyloid plaques and intracellular neurofibrillary tangles consisting of aggregated and hyperphosphorylated Tau *** studies suggest that dysregulation of the microtubuleassociated protein Tau,especially specific proteolysis,could be a driving force for Alzheimer's disease *** physiologically promotes the assembly and stabilization of microtubules,whereas specific truncated fragments are sufficient to induce abnormal hyperphosphorylation and aggregate into toxic oligomers,resulting in them gaining prion-like *** addition,Tau truncations cause extensive impairments to neural and glial cell functions and animal cognition and behavior in a fragment-dependent *** review summarizes over 60 proteolytic cleavage sites and their corresponding truncated fragments,investigates the role of specific truncations in physiological and pathological states of Alzheimer's disease,and summarizes the latest applications of strategies targeting Tau fragments in the diagnosis and treatment of Alzheimer's disease.

关键词： Alzheimer's disease cleavage site diagnosis marker neurofibrillary tangles phosphorylation Tau Tau aggregation therapy truncation

Radical involved reactive wetting and retarding mechanism of alumina refractory ceramic by molten slags under weak static magnetic field

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Journal of Iron and Steel Research International 2024年第6期31卷 1355-1366页

作者： Sheng-hao Li Ao huang Fan-bo Zeng Hui Peng Hao-ran Wei Xue-chun huang Sheng-qiang Song hua-zhi gu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

High alumina slag will cause severe corrosion at the interface of alumina refractory,and the wetting behavior of slag is a key factor influencing the corrosion resistance of refractory *** static magnetic field is a promising solution for improvement in the slag resistance of *** wetting of alumina refractory ceramics with different basicities of high alumina slags under a weak static magnetic field was analyzed,given that a weak static magnetic field can affect the corrosion behavior of refractory *** slag S_(3) as an example,when there was an external static magnetic field of 1.0 mT at 1600 ℃,the thickness of calcium aluminate reaction layer at the interface decreased by 36.7%,the denting depth of interface decreased by 35.6%,and the apparent wetting angle increased by 20%.The living radicals and their formation path in oxide melts were verified by first-principles calculation combined with electron paramagnetic resonance spectroscopy *** influence of the flux density of a weak static magnetic field on the wetting behavior of slags was also *** contact angle of the slags increased owing to the inhibitory effect of magnetic field on the radicalinvolved reaction at the interface of the slag and the alumina refractory *** relationships between the magnetic flux density,diffusion coefficient,slag microstructure(hyperfine coupling constant),and contact angle were *** provides a theoretical basis for the field control of radical involved reactive wetting between inorganic oxide slags and solid oxide ceramics.

关键词： Alumina refractory ceramic Molten slag Weak magnetic field effect Reactive wetting Free radical

Chronic sleep deprivation induces alterations in DNA and RNA modifications by liquid chromatography-mass spectrometry analysis

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Chinese Chemical Letters 2024年第8期35卷 413-417页

作者： Tian Feng Yun-Ling Gao Di Hu Ke-Yu Yuan Shu-Yi gu Yao-hua gu Si-Yu Yu Jun Xiong Yu-Qi Feng Jie Wang Bi-Feng Yuan School of Public Health Research Center of Public HealthRenmin Hospital of Wuhan UniversityWuhan UniversityWuhan 430071China Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan 430071China Key Laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhan 430071China University of Chinese Academy of Sciences Beijing 101408China Institute of Neuroscience and Brain Diseases Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441000China Phase I Clinical Trial Laboratory Zhongnan Hospital of Wuhan UniversityWuhan 430071China

Sleep deprivation(SD)is a widespread issue that disrupts the lives of millions of *** effects ini-tiate as changes within neurons,specifically at the DNA and RNA level,leading to disruptions in neuronal plasticity and the dysregulation of various cognitive functions,such as learning and *** acid epigenetic modifications that could regulate gene expression have been reported to play crucial roles in this ***,there is a lack of comprehensive research on the correlation of SD with nucleic acid epigenetic *** the current study,we aimed to systematically investigate the landscape of modifications in DNA as well as in small RNA molecules across multiple tissues,including the heart,liver,kidney,lung,hippocampus,and spleen,in response to chronic sleep deprivation(CSD).Using liquid chromatography-tandem mass spectrometry(LC-MS/MS)analysis,we characterized the dynamic changes in DNA and RNA modification profiles in different tissues of mice under CSD ***,we ob-served a significant decrease in the level of 5-methylcytosine(5mC)and a significant increase in the level of 5-hydroxymethylcytosine(5hmC)in the kidney in CSD *** RNA modifications,we observed an overall increased trend for most of these significantly changed modifications across six tis-sues in CSD *** study sheds light on the significance of DNA and RNA modifications as crucial epigenetic markers in the context of CSD-induced stress.

关键词： Sleep deprivation Epigenetics Mass spectrometry DNA modification RNA modification Small RNA

Integration and development of veterinary Chinese medicine insight into the development of human Chinese medicine

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Natural Therapy Advances 2024年第3期7卷 48-55页

作者： Zhen-Yu Zhao Jin-hua gu China Institute of Veterinary Drug Control Ministry of Agriculture and Rural AffairsBeijing 10081China.2Key Biology of Chinese Veterinary MedcineMinistry of Agriculture and Rural AffairsBeijing 10081China

Chinese veterinarians shine brightly in the long river of *** examine the beginnings and growth of Chinese Medicine(CM)and Chinese Veterinary Medicine(CVM),the evolution of veterinary Chinese medicine and the common use of herbs by humans and animals were *** study summarizes the history of development and the current situation of Chinese veterinary *** that veterinary Chinese medicine refers to drugs and their preparations applied under the guidance of CVM *** on distinguishing the similarities and differences between veterinary Chinese medicine and plant medicine,veterinary Chinese medicine with the complexity and efficacy of integrity,low harmful residue,not easy to produce resistance,and other *** Chinese medicine places great emphasis on clinical *** Chinese medicine has a long history of veterinary clinical experience and data,which reflects the practical characteristics of veterinary Chinese *** application experience of CM in the prevention and control of animal diseases and promoting animal growth was introduced.

关键词： veterinary Chinese medicine development

优化中国(新疆)自由贸易试验区法治保障研究

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新疆社科论坛 2024年第3期191卷 27-35页

作者：顾华详中共新疆维吾尔自治区委员会党史和文献研究院

中国(新疆)自贸试验区法治建设,应坚持人民群众高品质生活、促进人的现代化和人的全面发展,深刻把握高质量发展,坚持以人民为中心的价值导向。着力抓主要矛盾、重点领域、关键环节,聚焦高标准的法治要求建设新疆自贸试验区,要从维护政... 详细信息

中国(新疆)自贸试验区法治建设,应坚持人民群众高品质生活、促进人的现代化和人的全面发展,深刻把握高质量发展,坚持以人民为中心的价值导向。着力抓主要矛盾、重点领域、关键环节,聚焦高标准的法治要求建设新疆自贸试验区,要从维护政治安全和更好统筹发展和安全、开放与稳定和促进新质生产力发展的高度把握新疆自贸试验区法治建设的时代方位及形势任务,统筹加强涉外法治,主动精准对接国际规则,努力以法治建设现代化支撑和服务中国式现代化的自贸试验区建设实践,确保更好发挥法治固根本、稳预期、利长远的重要保障作用,持续拓展自贸试验区安全、稳定、高效的发展空间。

关键词：制度创新 “一带一路” 数据“三权”分置高质量发展新质生产力

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浙江省生物安全实验室智慧化监管实践与展望

实验技术与管理 2024年第1期41卷 232-238页

作者：高颜超胡雪利陈伟顾华中国科学院杭州医学研究所浙江杭州310020 浙江中医药大学公共卫生学院浙江杭州310000 银湖实验室技术与装备研究院浙江杭州310000

为解决实验室监管环节数字化程度低、数据安全保障难度大、监测预警效率低等问题。该文介绍了基于Java EE 11技术规范的生物安全监管矩阵,在MVC架构模式上实现RESTful规范,监管矩阵包括1个平台(生物安全在线监管平台)和4个系统(生物安... 详细信息

为解决实验室监管环节数字化程度低、数据安全保障难度大、监测预警效率低等问题。该文介绍了基于Java EE 11技术规范的生物安全监管矩阵,在MVC架构模式上实现RESTful规范,监管矩阵包括1个平台(生物安全在线监管平台)和4个系统(生物安全眼实验室监管系统、实验室生物安全评价系统、病原微生物样本运输系统、病原微生物实验室备案系统)。该矩阵已在800余家单位完成部署使用,记录异常数据20余万条,帮助相关实验室整改风险点11余万个,帮助实验室管理人员及时发现异常并处置,实现实验室生物安全数字化治理。

关键词：生物安全实验室智慧化监管实践展望

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肥大细胞活性介质对黑色素代谢的影响

中国皮肤性病学杂志 2024年第8期38卷 929-933页

作者：吴盼赵薇张鑫王婷妤姚秋艳华丕砚顾华昆明医科大学第一附属医院皮肤科云南昆明650000

肥大细胞来源于骨髓造血干细胞,参与机体变态反应、损伤修复与重塑、血栓形成以及免疫防御等生理病理过程。近年来研究表明,黄褐斑患者皮损区肥大细胞数量增加,氨甲环酸治疗黄褐斑的机制与肥大细胞活性及数量有关,提示肥大细胞可能参与... 详细信息

肥大细胞来源于骨髓造血干细胞,参与机体变态反应、损伤修复与重塑、血栓形成以及免疫防御等生理病理过程。近年来研究表明,黄褐斑患者皮损区肥大细胞数量增加,氨甲环酸治疗黄褐斑的机制与肥大细胞活性及数量有关,提示肥大细胞可能参与调节皮肤色素沉着。本文就肥大细胞活化后释放的活性介质对黑色素合成、转运的影响进行综述。

关键词：肥大细胞黑素细胞生物胺蛋白酶类花生酸细胞因子

Periodic Solution to BAM-type Cohen-Grossberg Neural Network with Time-varying Delays

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Acta Mathematicae Applicatae Sinica 2011年第3期27卷 427-442页

作者： An-ping Chen Qun-hua gu Department of Mathematics Xiangnan University Chenzhou Hunan 423000 China School of Mathematics and Computational Science Xiangtan University Xiangtan Hunan 411005 China

By using the continuation theorem of Mawhin＇s coincidence degree theory and the Liapunov func tional method, some sufficient conditions are obtained to ensure the existence, uniqueness and the global exponential stab... 详细信息

关键词： periodic solution time-varying delays global exponential stability BAM-type Cohen-Grossberg neural network coincidence degree theory

藤本植物园林景观应用调查分析——以九江市为例

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陕西林业科技 2024年第2期52卷 93-97,100页

作者：吕丹丹聂谷华抚州市林业局江西抚州344000 九江学院江西九江332900

为了解九江市园林景观中藤本植物的应用情况,对九江市濂溪区、浔阳区、柴桑区、八里湖新区四个城区进行抽样实地调查,并详细记录各地点应用的藤本植物名称,应用形式,生长状况,观赏效果等.通过调查发现藤本植物在园林景观应用中存在的问... 详细信息

为了解九江市园林景观中藤本植物的应用情况,对九江市濂溪区、浔阳区、柴桑区、八里湖新区四个城区进行抽样实地调查,并详细记录各地点应用的藤本植物名称,应用形式,生长状况,观赏效果等.通过调查发现藤本植物在园林景观应用中存在的问题,并对九江藤本植物的应用及发展提出合理性建议,以期提高九江市的绿化覆盖率、增加城市绿量.

关键词：藤本植物九江市园林景观调查分析