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Cisplatin-based miRNA delivery strategy inspired by the circCPNE1/miR-330-3p pathway for oral squamous cell carcinoma

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2748-2760页

作者： hua-yang fan Ming-da Zhao Hong-jie Jiang Zhen-wei Yu Yu-jiang fan Xin-hua Liang Ya-ling Tang Yong Sun State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Oral and Maxillofacial Surgery West China Hospital of StomatologySichuan UniversityChengdu 610041China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610065China State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Oral Pathology West China Hospital of StomatologySichuan UniversityChengdu 610041China

Circular RNAs(circRNAs)are ideal biomarkers of oral squamous cell carcinoma(OSCC)because of their highly stable closed-loop structure,and they can act as microRNA(miRNA)sponges to regulate OSCC *** analyzing clinical samples,we identified circCPNE1,a dysregulated circRNA in OSCC,and its expression level was negatively correlated with the clinical stage of OSCC ***-of-function assays revealed the tumor-suppressive effect of circCPNE1,which was then identified as a miR-330-3p ***-330-3p was recognized as a tumor promoter in multiple studies,consistent with our finding that it could promote the proliferation,migration,and invasion of OSCC *** results indicated that selective inhibition of miR-330-3p could be an effective strategy to inhibit OSCC ***,we designed cationic polylysine-cisplatin prodrugs to deliver antagomiR-330-3p(a miRNA inhibitory analog)via electrostatic interactions to form PP@miR nanoparticles(NPs).Paratumoral administration results revealed that PP@miR NPs effectively inhibited subcutaneous tumor progression and achieved partial tumor elimination(2/5),which confirmed the critical role of miR-330-3p in OSCC *** findings provide a new perspective for the development of OSCC treatments.

关键词： Oral squamous cell carcinoma CircRNA MiRNA sponge Antagomir MiRNA delivery Cisplatin-based nanoparticles Drug delivery systems Tumor elimination

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Early changes in corneal densitometry after FS-LASIK combined with accelerated corneal cross-linking for correction of high myopia

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1307-1312页

作者： Qing-Bao Wang Hong-Sheng Bi Xiao-fan Wang hua fan Li Li Peng Ji Shandong University of Traditional Chinese Medicine Jinan 250014Shandong ProvinceChina Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine Shandong Clinical Medicine Research CenterJinan 250002Shandong ProvinceChina Shandong Academy of Eye Disease Prevention and Therapy Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular DiseasesJinan 250002Shandong ProvinceChina

AIM:To observe the effects of femtosecond laserassisted excimer laser in situ keratomileusis combined with accelerated corneal cross-linking(FS-LASIK Xtra)on corneal densitometry after correcting for high ***:In this prospectively study,130 patients underwent FS-LASIK or FS-LASIK Xtra for high *** right eyes were selected for inclusion in the study,of which 65 cases of 65 eyes in the FS-LASIK group,65 patients with 65 eyes in the FS-LASIK Xtra *** were evaluated for corneal densitometry at 1,3,and 6mo postoperatively using Pentacam Scheimpflug ***:Preoperative differences in corneal densitometry between the FS-LASIK and FS-LASIK Xtra groups in different ranges were not statistically significant(P>0.05).Layer-by-layer analysis revealed statistically significant differences in the anterior(120μm),central,and total layer corneal densitometry between the FS-LASIK and FS-LASIK Xtra groups at 1 and 3mo postoperatively(all P0.05).CONCLUSION:There is an increase in internal corneal densitometry during the early postoperative period after FS-LASIK Xtra for correction of high ***,the densitometry values decreased to the level of conventional FS-LASIK at 6mo after surgery,with the most significant changes observed in the superficial central zone.

关键词： femtosecond laser accelerated corneal cross-linking corneal densitometry high myopia femtosecond laser in situ keratomileusis

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Preoperative prediction of hepatocellular carcinoma microvascular invasion based on magnetic resonance imaging feature extraction artificial neural network

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2546-2554页

作者： Jing-Yi Xu Yu-fan Yang Zhong-Yue huang Xin-Ye Qian fan-hua Meng Center of Hepatobiliary Pancreatic Disease Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Department of Surgical Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Department of Anesthesiology Huashan HospitalFudan UniversityShanghai 200040China

BACKGROUND Hepatocellular carcinoma(HCC)recurrence is highly correlated with increased *** invasion(MVI)is indicative of aggressive tumor biology in *** To construct an artificial neural network(ANN)capable of accurately predicting MVI presence in HCC using magnetic resonance *** This study included 255 patients with HCC with tumors<3 *** annotated the tumors on the T1-weighted plain MR ***,a three-layer ANN was constructed using image features as inputs to predict MVI status in patients with *** pathological examination is considered the gold standard for determining *** operating characteristic analysis was used to evaluate the effectiveness of the *** Using the bagging strategy to vote for 50 classifier classification results,a prediction model yielded an area under the curve(AUC)of ***,correlation analysis revealed that alpha-fetoprotein values and tumor volume were not significantly correlated with the occurrence of MVI,whereas tumor sphericity was significantly correlated with MVI(P<0.01).CONCLUSION Analysis of variable correlations regarding MVI in tumors with diameters<3 cm should prioritize tumor *** ANN model demonstrated strong predictive MVI for patients with HCC(AUC=0.79).

关键词： Hepatocellular carcinoma Microvascular invasion Artificial neural network Magnetic resonance imaging Tumor sphericity Area under the curve

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14-bit SAR ADC with On-Chip Digital Bubble Sorting Calibration Technology

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Chinese Journal of Electronics 2024年

作者： hua fan Zhuorui CHEN Tongrui XU Franco Maloberti Qi WEI Quanyuan FENG School of Integrated Circuit Science and Engineering (Exemplary School of Microelectronics) University of Electronic Science and Technology of China (UESTC) Shenzhen Institute for Advanced Study Chongqing Institute of Microelectronics Industry Technology Department of Electrical Computer and Biomedical Engineering University of Pavia Department of Precision Instrument Tsinghua University Institute of Microelectronics Southwest Jiaotong University

This article designs a 14-bit successive approximation register analog-to-digital converter(SAR ADC).A novel digital bubble sorting calibration method is proposed and applied to eliminate the effect of capacitor mismatch on the linearity of the SAR ADC. To reduce the number of capacitors, a hybrid architecture of a high 8-bit binary-weighted capacitor array and a low 6-bit resistor array is adopted by the digital-to-analog(DAC). The common-mode voltage VCM-based switching scheme is chosen to reduce the switching energy and area of the DAC. The time-domain comparator is employed to obtain lower power consumption. Sampling is performed through a gate voltage bootstrapped switch to reduce the nonlinear errors introduced when sampling the input signal. Moreover, the SAR logic and the whole calibration is totally implemented on-chip through digital integrated circuit(IC) tools such as Design Compiler, IC compiler, etc. Finally, a prototype is designed and implemented using 0.18 μm Bipolar-complementary metal oxide semiconductor(CMOS)-double-diffused MOS 1.8 V CMOS technology. The measurement results show that the SAR ADC with on-chip bubble sorting calibration method achieves the signal-to-noise-and-distortion ratio of 69.75 dB and the spurious-free dynamic range of 83.77 dB.

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任务型党组织:地方跨界治理的整合机制——以H省N市全域党建的地方实践为例

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内蒙古社会科学 2024年第1期45卷 92-99页

作者：祁凡骅康媛璐中国人民大学公共管理学院北京100872 内蒙古党校(行政学院)公共管理教研部内蒙古呼和浩特010070

作为治理跨界事务的创新载体,任务型党组织旨在通过党的跨域建设来强化权威整合,前提是跨域吸纳,目标是有效行动。既不同于西方“政治—行政”二分和韦伯的科层制理论,也不同于议事协调小组、领导小组等“高位推动”的运作机制,任务型... 详细信息

作为治理跨界事务的创新载体,任务型党组织旨在通过党的跨域建设来强化权威整合,前提是跨域吸纳,目标是有效行动。既不同于西方“政治—行政”二分和韦伯的科层制理论,也不同于议事协调小组、领导小组等“高位推动”的运作机制,任务型党组织既强调党组织的全域覆盖,又强调党建工作内容的全覆盖,形成组织嵌入机制、合作网络机制、融合党建机制和任务认领机制四种跨界事务治理的整合机制。地方实践对这一组织模式进行了丰富探索,旨在克服体制性壁垒,打破“碎片化”效应;克服物理性壁垒,打破“边际化”效应。结合地方实践,提出“组织吸纳—权威整合—主体行动”的分析框架:通过吸纳性制度构建实现跨界吸纳,提升组织的吸纳力;通过跨域党建实现跨界整合,提升权威的整合力;通过激励赋能实现跨界协同,提升主体的行动力。

关键词：跨界治理全域党建任务型党组织

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长三角城市群生态人居环境与居民幸福水平耦合协调关系（英文）

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Journal of Resources and Ecology 2024年第5期15卷 1251-1262页

作者：樊华赵翠薇贵州师范大学地理与环境科学学院喀斯特山地生态环境保护与资源利用协同创新中心

推进生态人居环境与居民幸福水平协调发展，有助于推动以人民为中心的高质量发展。本研究基于长三角城市群2011–2021年数据，构建生态人居环境与居民幸福水平评价指标体系，运用熵值法、耦合协调度模型、Dagum基尼系数和地理探测器模... 详细信息

推进生态人居环境与居民幸福水平协调发展，有助于推动以人民为中心的高质量发展。本研究基于长三角城市群2011–2021年数据，构建生态人居环境与居民幸福水平评价指标体系，运用熵值法、耦合协调度模型、Dagum基尼系数和地理探测器模型探讨了二者的耦合协调关系及影响因素。研究发现：长三角城市群生态人居环境与居民幸福水平随时间推移呈现上升趋势，到2021年，区域整体水平显著提升。两系统耦合协调水平逐渐增强，呈现东高西低的空间分布格局。Dagum基尼系数显示总体及区域内差异呈波动下降趋势，上海–安徽区域间差异最大，区域间差异是空间差异的主要来源。经济发展水平（Eco）是影响两系统耦合协调的主要因素。研究可为生态人居环境建设、提升居民幸福水平提供借鉴。

关键词：生态人居环境居民幸福水平耦合协调长三角城市群

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A糖基转移酶基因变异所致A_(3)表型1例的遗传学分析

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中华医学遗传学杂志 2024年第7期41卷 862-865页

作者：李敏曦章旭樊华中国医科大学附属第四医院血液科沈阳110032 辽宁省血液中心沈阳中心血站沈阳110044

目的探讨1例A3表型个体的血清学特性和分子机制。方法选取2022年5月12日就诊于中国医科大学附属第四医院的1名27岁汉族女性作为研究对象。使用标准血清学方法检测其ABO血型,通过PCR扩增产物直接测序法鉴定ABO基因及第6~7外显子的单链序... 详细信息

目的探讨1例A3表型个体的血清学特性和分子机制。方法选取2022年5月12日就诊于中国医科大学附属第四医院的1名27岁汉族女性作为研究对象。使用标准血清学方法检测其ABO血型,通过PCR扩增产物直接测序法鉴定ABO基因及第6~7外显子的单链序列,并使用生物信息学软件对变异位点进行分析。结果检测结果提示该个体为A3表型,其第6、7外显子存在c.261delG、c.467C>T和c.745C>T杂合变异。单链测序结果提示样本存在ABO*A3.07和ABO*O.01.01等位基因,其中ABO*A3.07等位基因在ABO*A1.02等位基因的背景下存在c.745C>T(p.R249W)变异。生物信息学分析预测c.745C>T(p.R249W)为可能有害变异,自由能变化(ΔΔG)值预测其可能影响蛋白稳定性。蛋白模拟模型提示p.R249W可造成α-1,3-N-乙酰半乳糖胺转移酶局部氢键网格的改变。结论α-1,3-N-乙酰半乳糖胺转移酶基因的c.745C>T(p.R249W)变异可能造成酶蛋白结构和功能的失稳,进而导致A抗原表达减弱。

关键词： A_(3)亚型 α-1,3-N-乙酰半乳糖胺转移酶分子机制生物信息学分析

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辊压机生料终粉磨系统的优化与调试

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水泥技术 2024年第4期 9-13页

作者：樊华安徽海螺水泥股份有限公司安徽芜湖241000

介绍了某5 000t/d水泥熟料生产线由立磨系统改为辊压机生料终粉磨系统后的系统配置及运行情况。受物料水分大、窑尾废气温度低、稳流仓结皮严重、选粉机分选效率低等不利因素影响,辊压机生料终粉磨系统在投产初期,产量及电耗均与设计目... 详细信息

介绍了某5 000t/d水泥熟料生产线由立磨系统改为辊压机生料终粉磨系统后的系统配置及运行情况。受物料水分大、窑尾废气温度低、稳流仓结皮严重、选粉机分选效率低等不利因素影响,辊压机生料终粉磨系统在投产初期,产量及电耗均与设计目标有所偏离。通过采取加强保温处理、加装收尘管路、改进下料溜子、合理选择辊压机控制方式、增加旁路热风、提高入V型选粉机热风温度、增加喂料装置下料口宽度、提高物料流动性等优化改进措施,生料终粉磨系统平均台时产量较原立磨系统提高了100~120t/h,电耗降低了4~5kW·h/t,实现了节能降耗目标。

关键词：辊压机终粉磨热风温度物料流动性节能降耗

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