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Selenomethionine alleviates chronic heat stress-induced breast muscle injury and poor meat quality in broilers via relieving mitochondrial dysfunction and endoplasmic reticulum stress

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Animal Nutrition 2024年第1期16卷 363-375页

作者： Jinzhong Jing Jiayi Wang Xiaoyu Xiang Shenggang Yin Jiayong Tang Longqiong Wang Gang Jia Guangmang Liu Xiaoling Chen Gang Tian Jingyi cai Bo Kang Lianqiang Che hua Zhao Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education of China Ministry of Agriculture and Rural Affairsof Sichuan ProvinceAnimal Nutrition InstituteSichuan Agricultural University College of Animal Science and Technology Sichuan Agricultural University

In the present study,the chronic heat stress （CHS） broiler model was developed to investigate the potential protection mechanism of organic selenium （selenomethionine,SeMet） on CHS-induced skeletal muscle growth retardation and poor meat quality.Four hundred Arbor Acres male broilers （680±70 g,21 d old） were grouped into 5 treatments with 8 replicates of 10 broilers per replicate.Broilers in the control group were raised in a thermoneutral environment （22±2°C） and fed with a basal diet.The other four treatments were exposed to hyperthermic conditions （33±2°C,24 h in each day） and fed on the basal diet supplied with SeMet at 0.0,0.2,0.4,and 0.6 mg Se/kg,respectively,for 21 d.Results showed that CHS reduced （P<0.05） the growth performance,decreased （P<0.05） the breast muscle weight and impaired the meat quality of breast muscle in broilers.CHS induced protein metabolic disorder in breast muscle,which increased （P<0.05） the expression of caspase 3,caspase 8,caspase 9 and ubiquitin proteasome system related genes,while decreased the protein expression of P-4EBP1.CHS also decreased the antioxidant capacity and induced mitochondrial stress and endoplasmic reticulum （ER） stress in breast muscle,which increased （P<0.05） the ROS levels,decreased the concentration of ATP,increased the protein expression of HSP60 and CLPX,and increased （P<0.05） the expression of ER stress biomarkers.Dietary SeMet supplementation linearly increased （P<0.05） breast muscle Se concentration and exhibited protective effects via up-regulating the expression of the selenotranscriptome and several key selenoproteins,which increased （P<0.05） body weight,improved meat quality,enhanced antioxidant capacity and mitigated mitochondrial stress and ER stress.What's more,SeMet suppressed protein degradation and improved protein biosynthesis though inhibiting the caspase and ubiquitin proteasome system and promoting the mTOR-4EBP1 pathway.In conclusion,dietary SeMet supplementation increases the expression of several key selenoproteins,alleviates mitochondr

关键词： Broiler Chronic heat stress Skeletal muscle Meat quality Mitochondrial dysfunction Endoplasmic reticulum stress

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Comparison of corrosion mechanisms of 510L low alloy steel treated by ACS and EPS techniques under various service environments

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Journal of Iron and Steel Research(International) 2024年第2期31卷 501-518页

作者： Bao-sheng Liu Peng-fei Xu Shao-hua Zhang Yan-rui Li Li-ming Mou Jia-li Li Yue-zhong Zhang Pei-mao Fu Fa-cai Shi College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan030024ShanxiChina College of Chemical and Biological Engineering Taiyuan University of Science and TechnologyTaiyuan030024ShanxiChina Technical Center Taiyuan Iron and Steel(Group)Co.Ltd.Taiyuan030003ShanxiChina

The corrosion mechanism of 510L low alloy steel treated by acid-cleaned surface(ACS)and eco-pickled surface(EPS)techniques in three simulated solutions(S0:atmospheric environment;S1:soil environment;S2:industrial environment)and the influence of interaction between different corrosive anions on corrosion were investigated.The results show that the total corrosion rates of samples in three simulated solutions were in order of S2>S0>S1,which is simultaneously correlated with initial corrosion dissolution processes as well as after the formation of corrosion products.HCO3−will inhibit the initial corrosion owing to the formation of films,whereas HSO3−will accelerate the dissolutions of the matrix based on the synergistic action of HSO3−and Cl−.On the other hand,there is no significant difference in corrosion rates between the samples treated by ACS and EPS techniques.The EPS technique that is safe,reusable and environmentally friendly can be further widely used in future work.

关键词： Corrosion mechanism Low alloy steel Simulated solution Surface technique Immersion time

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Landscape of human organoids:Ideal model in clinics and research

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The Innovation 2024年第3期5卷 146-164页

作者： Xinxin Han Chunhui cai Wei Deng Yanghua Shi Lanyang Li Chen Wang Jian Zhang Mingjie Rong Jiping Liu Bangjiang Fang hua He Xiling Liu Chuxia Deng Xiao He Xin Cao Organ Regeneration X Lab Lisheng East China Institute of BiotechnologyPeking UniversityJiangsu 226200China Shanghai Lisheng Biotech Shanghai 200092China Longhua Hospital Shanghai University of Traditional Chinese Medicine725 Wanping South RoadXuhui DistrictShanghai 200032China Department of Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200125China Department of Neurosurgery Third Affiliated HospitalNaval Medical UniversityShanghai 200438China Shanghai Key Laboratory of Forensic Medicine Shanghai Forensic Service PlatformAcademy of Forensic ScienceMinistry of JusticeShanghai 200063China Cancer Center Faculty of Health SciencesUniversity of MacaoTaipaMacao SARChina Ministry of Education Frontiers Science Center for Precision Oncology University of MacaoTaipaMacao SAR 999078China CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Zhongshan Hospital Institute of Clinical Science Fudan University Shanghai Medical CollegeShanghai 200032China

In the last decade,organoid research has entered a golden era,signifying a pivotal shift in the biomedical landscape.The year 2023 marked a milestone with the publication of thousands of papers in this arena,reflecting exponential growth.However,amid this burgeoning expansion,a comprehensive and accurate overview of the field has been conspicuously absent.Our review is intended to bridge this gap,providing a panoramic view of the rapidly evolving organoid landscape.We meticulously analyze the organoid field from eight distinctive vantage points,harnessing our rich experience in academic research,industrial application,and clinical practice.We present a deep exploration of the advances in organoid technology,underpinned by our long-standing involvement in this arena.Our narrative traverses the historical genesis of organoids and their transformative impact across various biomedical sectors,including oncology,toxicology,and drug development.We delve into the synergy between organoids and avant-garde technologies such as synthetic biology and single-cell omics and discuss their pivotal role in tailoring personalized medicine,enhancing high-throughput drug screening,and constructing physiologically pertinent disease models.Our comprehensive analysis and reflective discourse provide a deep dive into the existing landscape and emerging trends in organoid technology.We spotlight technological innovations,methodological evolution,and the broadening spectrum of applications,emphasizing the revolutionary influence of organoids in personalized medicine,oncology,drug discovery,and other fields.Looking ahead,we cautiously anticipate future developments in the field of organoid research,especially its potential implications for personalized patient care,new avenues of drug discovery,and clinical research.We trust that our comprehensive review will be an asset for researchers,clinicians,and patients with keen interest in personalized medical strategies.We offer a broad view of the present and prospective capabilities of organoi

关键词： landscape intended advances

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Understanding the demand predictability of bike share systems:A station-level analysis

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Frontiers of Engineering Management 2023年第4期10卷 551-565页

作者： Zhuoli YIN Kendrick HARDAWAY Yu FENG Zhaoyu KOU hua cai School of Industrial Engineering Purdue UniversityWest LafayetteIN 47907USA Environmental and Ecological Engineering Purdue UniversityWest LafayetteIN47907USA School for Environment and Sustainability University of MichiganAnn ArborMI 48109USA

Predicting demand for bike share systems(BSSs)is critical for both the management of an existing BSS and the planning for a new BSS.While researchers have mainly focused on improving prediction accuracy and analysing demand-influencing factors,there are few studies examining the inherent randomness of stations'observed demands and to what degree the demands at individual stations are predictable.Using Divvy bike-share one-year data from Chicago,USA,we measured demand entropy and quantified the station-level predictability.Additionally,to verify that these predictability measures could represent the performance of prediction models,we implemented two commonly used demand prediction models to compare the empirical prediction accuracy with the calculated entropy and predictability.Furthermore,we explored how city-and system-specific temporallyconstant features would impact entropy and predictability to inform estimating these measures when historical demand data are unavailable.Our results show that entropy and predictability of demands across stations are polarized as some stations exhibit high uncertainty(a low predictability of 0.65)and others have almost no check-out demand uncertainty(a high predictability of around 1.0).We also validated that the entropy and predictability are a priori model-free indicators for prediction error,given a sequence of bike usage demands.Lastly,we identified that key factors contributing to station-level entropy and predictability include per capita income,spatial eccentricity,and the number of parking lots near the station.Findings from this study provide more fundamental understanding of BSS demand prediction,which can help decision makers and system operators anticipate diverse stationlevel prediction errors from their prediction models both for existing stations and for new ones.

关键词： bike share systems demand prediction prediction errors machine learning entropy

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Beyond 600G fiber-THz wireless seamless integration system employing cascaded MIMO equalizers

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Science China Technological Sciences 2024年第7期67卷 2274-2276页

作者： DING JunJie TONG WeiDong LI XinTong ZHANG Zheng ZHANG Jiao cai YuanCheng LEI MingZheng hua BingChang CHEN XingYu YU JianJun ZHU Min Purple Mountain Laboratories National Mobile Communications Research Laboratory Southeast University Fudan University

Terahertz(THz)-wave communication, with sufficient spectrum resources(0.3 THz～10 THz), can meet the needs of future 6G large-capacity mobile communication services[1-9]. Recently, the seamless integration of existing...

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Probing the Gamma-Ray Emission Region of Five TeV Flat Spectrum Radio Quasars

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Research in Astronomy and Astrophysics 2024年第6期24卷 158-171页

作者： Hu-Bing Xiao Hai-Tao Cao Rui Xue Jin-Ting cai Ge-Ge Wang Marina Manganaro Shao-hua Zhang Zhi-Hao Ouyang Li-Ping Fu Jun-Hui Fan Shanghai Key Lab for Astrophysics Shanghai Normal University School of Information Engineering Department of Physics Zhejiang Normal University College of Mathematics and Physics Guangxi Minzu University Key Laboratory of Cosmology and Astrophysics (Liaoning) College of Sciences Northeastern University Department of Physics University of Rijeka Center for Astrophysics Guangzhou University Key Laboratory for Astronomical Observation and Technology of Guangzhou Astronomy Science and Technology Research Laboratory of Department of Education of Guangdong Province

The location of γ-ray emission of blazars remains a contested topic, inspiring the development of numerous investigative techniques to address this issue. In this work, we analyzed Fermi γ-ray light curves in the GeV and MeV bands, employing the discrete cross-correlation function method to discern time lags between the two bands.For 4C +21.35, Ton 599, B2 1420+32, and PKS 1510-089, we identified a time lag spanning several days, while for PKS 1441+25, the time lag was not statistically found. The results imply that the soft photons necessary for inverse Compton scattering predominantly originate from the dusty torus in the first four sources, whereas for PKS1441+25, they seem to be sourced mainly from the broad-line region. Further analysis of the opacity(τγγ) and the GeV spectra study supports the conclusion that the location of the dissipation region must be beyond the BLR to avoid significant absorption. Notably, for PKS 1441+25, the emission region is also posited to lie outside yet proximate to the BLR. The parameters of describing the emission region were obtained by fitting broadband spectral energy distribution with contemporaneous observation data. Our findings suggest that for the five TeV FSRQs, during Te V flaring events, the jet appears to maintain an equilibrium between the energy density of the magnetic field and that of the particles for all investigated sources, with the exceptions of 4C +21.35 and PKS1441+25. In terms of the overall jet power, particle energy is the dominant contributor, and the observed blazar radiation cannot be solely attributed to the magnetic field, except in the case of 4C +21.35. Consequently,magnetic reconnection is unlikely to be the primary mechanism behind particle acceleration in these systems.

关键词： galaxies: active galaxies: jets gamma-rays: galaxies

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Lithium-induced graphene layer containing Li_(3)P alloy phase to achieve ultra-stable electrode interface for lithium metal anode

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Rare Metals 2024年第2期43卷 562-574页

作者： Jia-Xin Chen Guo-Qiang Zhang Xian-Ying Qin Kui Lin Zi-Jin Yang Ge-Meng Liang Yue Xia Guo-Bin Zhang Hai-Kun Wu Qiu-Chan cai Hai Lin Bao-hua Li Shenzhen Key Laboratory on Power Battery Safety Research and Shenzhen Geim Graphene Center Tsinghua Shenzhen International Graduate SchoolShenzhen518055China Shenzhen Graphene Innovation Center Co. Ltd.Shenzhen518107China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaideSA5005Australia Department of Chemistry City University of Hong KongHong Kong990077China

Uncontrolled growth of lithium dendrite will lead to low Coulombic efficiency and poor cycle stability,which hinders the commercialization of lithium metal batteries.Herein,a novel modified lithium anode with reduced graphene oxide conductive network containing trace lithiophilic phosphorus(P-rGO/Cu)is prepared by electrospraying technique combined with heat treatment process.The rGO layer has a concave and undulating conductive structure,which can significantly improve the effective electrical contact between lithium metal and the current collector,speed up the kinetics of interfacial electron transport and reaction,and improve the resistance of the negative electrode to the internal stress caused by volume change of the lithium,which is advantageous for the stability of the SEI film.The extremely small and uniformly distributed red phosphorus element avoids the volume change caused by lithiation to the maximum extent.Lithiophilic two-phase compound Li_(3)P obtained by alloying P with Li can directionally induce the homogeneous nucleation and dense deposition of lithium metal,address the issue of lithium dendrites and extend the cycle life of the batteries.The obtained P-rGO/Cu exhibits excellent electrochemical performance with an average Coulombic efficiency(CE)of 98%at a current density of 1 mA·cm^(−2) for 400 cycles,and the capacity retention rate of the full cell matched with lithium iron phosphate(LFP)is 83%after 400 cycles at 1C.

关键词： Lithium anode Dendrite-free Lithiophilicity Induced nucleation deposition

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Minocycline in the eradication of Helicobacter pylori infection: A systematic review and meta-analysis

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World Journal of Gastroenterology 2024年第17期30卷 2354-2368页

作者： Kai Zhou cai-Ling Li hua Zhang Bao-Jun Suo Yu-Xin Zhang Xin-Lu Ren Yu-Xin Wang Chang-Min Mi Ling-Ling Ma Li-Ya Zhou Xue-Li Tian Zhi-Qiang Song Department of Gastroenterology Peking University Third HospitalBeijing 100191China

BACKGROUND Difficulty in obtaining tetracycline,increased adverse reactions,and relatively complicated medication methods have limited the clinical application of the classic bismuth quadruple therapy.Therefore,the search for new alternative drugs has become one of the research hotspots.In recent years,minocycline,as a semisynthetic tetracycline,has demonstrated good potential for eradicating Helicobacter pylori(H.pylori)infection,but the systematic evaluation of its role remains lacking.AIM To explore the efficacy,safety,and compliance of minocycline in eradicating H.pylori infection.METHODS We comprehensively retrieved the electronic databases of PubMed,Embase,Web of Science,China National Knowledge Infrastructure,SinoMed,and Wanfang database as of October 30,2023,and finally included 22 research reports on H.pylori eradication with minocycline-containing regimens as per the inclusion and exclusion criteria.The eradication rates of H.pylori were calculated using a fixed or a random effect model,and the heterogeneity and publication bias of the studies were measured.RESULTS The single-arm meta-analysis revealed that the minocycline-containing regimens achieved good overall H.pylori eradication rates,reaching 82.3%[95%confidence interval(CI):79.7%-85.1%]in the intention-to-treat analysis and 90.0%(95%CI:87.7%-92.4%)in the per-protocol analysis.The overall safety and compliance of the minocycline-containing regimens were good,demonstrating an overall incidence of adverse reactions of 36.5%(95%CI:31.5%-42.2%).Further by traditional meta-analysis,the results showed that the minocycline-containing regimens were not statistically different from other commonly used eradication regimens in eradication rate and incidence of adverse effects.Most of the adverse reactions were mild to moderate and well-tolerated,and dizziness was relatively prominent in the minocycline-containing regimens(16%).CONCLUSION The minocycline-containing regimens demonstrated good efficacy,safety,and compliance in H.pylori eradication.Minocycline

关键词： Helicobacter pylori Minocycline Eradication Safety Resistance

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The marriage of immunomodulatory,angiogenic,and osteogenic capabilities in a piezoelectric hydrogel tissue engineering scafold for military medicine

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Military Medical Research 2024年第3期11卷 323-344页

作者： Ping Wu Lin Shen Hui-Fan Liu Xiang-Hui Zou Juan Zhao Yu huang Yu-Fan Zhu Zhao-Yu Li Chao Xu Li-hua Luo Zhi-Qiang Luo Min-Hao Wu Lin cai Xiao-Kun Li Zhou-Guang Wang Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research the Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000ZhejiangChina Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325000ZhejiangChina Department of Spine Surgery and Musculoskeletal Tumor Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Engineering Research Center for Nanomedicine College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Department of Overseas Education College Jimei UniversityXiamen 361021FujianChina School and Hospital of Stomatology Wenzhou Medical UniversityWenzhou 325035ZhejiangChina

Background:Most bone-related injuries to grassroots troops are caused by training or accidental injuries.To establish preventive measures to reduce all kinds of trauma and improve the combat effectiveness of grassroots troops,it is imperative to develop new strategies and scafolds to promote bone regeneration.Methods:In this study,a porous piezoelectric hydrogel bone scafold was fabricated by incorporating polydopamine(PDA)-modified ceramic hydroxyapatite(PDA-hydroxyapatite,PHA)and PDA-modified barium titanate(PDABaTiO3,PBT)nanoparticles into a chitosan/gelatin(Cs/Gel)matrix.The physical and chemical properties of the Cs/Gel/PHA scafold with 0–10 wt%PBT were analyzed.Cell and animal experiments were performed to characterize the immunomodulatory,angiogenic,and osteogenic capabilities of the piezoelectric hydrogel scafold in vitro and in vivo.Results:The incorporation of BaTiO3into the scafold improved its mechanical properties and increased self-generated electricity.Due to their endogenous piezoelectric stimulation and bioactive constituents,the prepared Cs/Gel/PHA/PBT hydrogels exhibited cytocompatibility as well as immunomodulatory,angiogenic,and osteogenic capabilities;they not only effectively induced macrophage polarization to M2 phenotype but also promoted the migration,tube formation,and angiogenic differentiation of human umbilical vein endothelial cells(HUVECs)and facilitated the migration,osteodifferentiation,and extracellular matrix(ECM)mineralization of MC3T3-E1 cells.The in vivo evaluations showed that these piezoelectric hydrogels with versatile capabilities significantly facilitated new bone formation in a rat large-sized cranial injury model.The underlying molecular mechanism can be partly attributed to the immunomodulation of the Cs/Gel/PHA/PBT hydrogels as shown via transcriptome sequencing analysis,and the PI3K/Akt signaling axis plays an important role in regulating macrophage M2 polarization.Conclusion:The piezoelectric Cs/Gel/PHA/PBT hydrogels developed here with favorable immunomodulation,

关键词： Piezoelectric hydrogel Tissue engineering scafold Immunomodulation Angiogenesis Osteogenic differentiation

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Total Coloring of Planar Graphs without Chordal 7-cycles

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Acta Mathematica Sinica,English Series 2015年第12期31卷 1951-1962页

作者： hua cai School of Mathematics Shandong University Department of Mathematics Changji University

A k-total-coloring of a graph G is a coloring of vertices and edges of G using k colors such that no two adjacent or incident elements receive the same color.In this paper,it is proved that if G is a planar graph with... 详细信息

关键词： Planar graph total coloring chordal 7-cycle

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