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Characteristics of Antisense Non-coding RNA in the INK4 Locus and Its Roles in Disease

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Chinese Medical Sciences Journal 2013年第2期28卷 122-123页

作者： Jin-hua He Yu-guang Li Department of Laboratory Panyu Central Hospital

Abstract With the development of genome-wide sequencing technology, 195 types of functional long non-coding RNAs （lncRNAs） have so far been found, and their cellular roles are gradually being revealed. Now lncRNAs have become a hotspot in the life science. These small molecules exist in almost all higher eukaryotes, and have very important regulatory roles in these organisms. This review briefly summarizes recent progress in researches on antisense non-coding RNA in the INK4 locus.

关键词： long non-coding RNAs antisense non-coding RNA in the INK4 locus expression

Multi-party semi-quantum private comparison protocol of size relation based on two-dimensional Bell states

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Chinese Physics B 2024年第11期33卷 184-192页

作者： Bing Wang Li-hua Gong San-Qiu Liu Jiangxi Province Key Laboratory of Fusion and Information Control Department of PhysicsNanchang UniversityNanchang 330031China School of Physics and Materials Nanchang UniversityNanchang 330031China Department of Electronic Information Engineering Nanchang UniversityNanchang 330031China

Currently,all quantum private comparison protocols based on two-dimensional quantum states can only compare equality,via using high-dimensional quantum states that it is possible to compare the size relation in existing *** addition,it is difficult to manipulate high-dimensional quantum states under the existing conditions of quantum information processing,leading to low practicality and engineering feasibility of protocols for comparing size *** this situation,we propose an innovative *** proposed protocol can make size comparison by exploiting more manageable two-dimensional Bell states,which significantly enhances its feasibility with current quantum ***,the proposed protocol enables multiple participants to compare their privacies with the semi-quantum *** communication process of the protocol is simulated on the IBM Quantum Experience platform to verify its *** analysis shows that the proposed protocol can withstand common attacks while preserving the privacies of all ***,the devised protocol may provide an important reference for implementation of quantum private size comparison protocols.

关键词： two-dimensional Bell state size relation multi-party semi-quantum private comparison

Successful splenic artery embolization in a patient with Behçet’s syndrome-associated splenic rupture:A case report

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1184-1188页

作者： Guang-Zhao Zhu Dong-hua Ji Department of Interventional Therapy The First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina

BACKGROUND Splenic rupture associated with Behçet’s syndrome(BS)is extremely rare,and there is no consensus on its *** this case report,a patient with BSassociated splenic rupture was successfully treated with splenic artery embolization(SAE)and had a good prognosis after the *** SUMMARY The patient was admitted for pain in the left upper abdominal *** was diagnosed with splenic *** oral and genital aphthous ulcers were observed,and acne scars were found on his *** had a 2-year history of BS diagnosis,with symptoms of oral and genital *** that time,he was treated with oral corticosteroids for 1 month,but the symptoms did not *** underwent SAE to treat the *** the first day after SAE,the patient reported a complete resolution of abdominal pain and was discharged 5 d *** months after the intervention,a computed tomography examination showed that the splenic hematoma had formed a stable cystic effusion,suggesting a good *** SAE might be a good choice for BS-associated splenic rupture based on good surgical practice and material selection.

关键词： Splenic artery embolization Behçet’s syndrome Splenic rupture Case report

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一种伸缩式防针刺伤注射器的研制

护理研究 2018年第5期32卷 812-813页

作者：张静雷花四川省医学科学院四川省人民医院 610072

研制一种伸缩式防针刺伤注射器,医护人员在配药或者注射工作完成后,针头套能自动将针头包覆在内,避免外部环境污染针头或者针头污染外部环境,减少医护人员针刺伤的风险,且操作简单、方便使用,能提高护士的工作效率。

关键词：伸缩式注射器预防针刺伤注射器

Gastric cancer immunotherapy:A scientometric and clinical trial review

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World Journal of Gastroenterology 2024年第2期30卷 196-198页

作者： Qian-Cheng Du Xin-Yu Wang hua Yu Thoracic Surgery Shanghai Xuhui Central HospitalShanghai 200031China Thyroid Breast and Vascular SurgeryShanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of General Surgery Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China

This letter is intended to arouse your interest in a recent review of comprehensive scientometrics and clinical trials on immunotherapy for gastric cancer(GC).Our study reviews recent advances in immunotherapy in the field of GC and highlights its new prospects as a treatment for *** research reveals China’s leadership in this field,as well as new therapeutic strategies such as immune checkpoint inhibitors,cellular immunotherapy,and *** combined findings highlight the potential of immunotherapy to improve survival and quality of life in patients with stomach *** believe that this study will provide important guidance for the future direction of the GC treatment field.

关键词： Gastric cancer Immunotherapy Bibliometrics Comment Therapeutic strategies

Clinically significant changes in anal sphincter hiatal area in patients with gestational diabetes mellitus and pelvic organ prolapse

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World Journal of Diabetes 2024年第8期15卷 1726-1733页

作者： Qing-Hong Wang Li-hua Liu hua Ying Ming-Xu Chen Chang-Jiang Zhou Hui Li Department of Sonography People's Hospital Affiliated to Shandong First Medical UniversityJinan 271100Shandong ProvinceChina Department of Obstetrics and Gynecology People's Hospital Affiliated to Shandong First Medical UniversityJinan 271100Shandong ProvinceChina

BACKGROUND The prevalence of pelvic organ prolapse(POP)increases with age and ***,the prevalence of POP among women aged 20 to 39 is 9.7%,while it rises to 49%among women over 80 years ***,as the number of deliveries increases,the prevalence of POP also rises accordingly,with a rate of 12.8%for women with one delivery history,18.7%for those with two deliveries,and 24.6%for women with three or more *** causes immense suffering for pregnant *** To evaluate the relationship between the levator ani muscle’s hiatus(LH)area and POP in patients with gestational diabetes mellitus(GDM)using perineal *** The study cohort comprised 104 patients aged 29.8±3.7 years who sought medical care at our institution between January 2021 and June *** were singleton pregnancies consisting of 75 primiparas and 29 multiparas,with an average parity of 1.7±*** to the POP diagnostic criteria,the 104 subjects were divided into two groups with 52 members each:POP group(patients with GDM combined with POP)and non-POP group(patients with GDM without POP).Perineal ultrasound was used to measure differences in the anteroposterior diameter,transverse diameter,and LH *** operating characteristic curves were drawn to determine the optimal cutoff values for the LH anteroposterior diameter,transverse diameter,and area for diagnosing *** Statistically significant increase in the LH area,anteroposterior diameter,and lateral diameter were observed in the POP group compared with the non-POP group(P<0.05).Both groups exhibited markedly elevated incidence rates of macrosomia and stress urinary *** the POP group,the area under the curve(AUC)for the LH area was 0.906 with a 95%confidence interval(CI):*** optimal cutoff was 13.54cm²,demonstrating a sensitivity of 83.2%and a specificity of 64.4%.The AUC for the anteroposterior diameter reached 0.836 with a 95%CI:*** optimal cutoff was 5

关键词： Ultrasound Levator ani muscle hiatus Gestational diabetes mellitus Pelvic organ prolapse

Rock fracture under anti-plane shear (Mode Ⅲ) loading

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Journal of Central South University of Technology 2005年第z1期12卷 125-128页

作者： RAO Qiu-hua LIAO Zhen-feng School of Civil and Architectural Engineering Central South University Changsha 410083 China School of Civil and Architectural Engineering Central South University Changsha 410083 China

Anti-plane punch-through shear test and anti-planefour-point bending test are used to study the crack initiation and propagation under anti-plane shear (Mode Ⅲ) loading. The tensile and shear stresses at the crack tip are calculated by finite element method. The results show that under Mode Ⅲ loading the maximum principal stress σ1 at crack tip is smaller or a little larger than the maximum shear stress τmax. Since the tensile strength of brittle rock is much lower than its shear strength, σ1 is easy to reach its critical value before τmax reaches its critical value and thus results in Mode I fracture. The fracture trajectory is helicoid and the normal direction of tangential plane with the fractured helicoid is along the predicted direction of the maximum principal stress at the notch tip. It is further proved that Mode Ⅰ instead of Mode Ⅲ fracture occurs in brittle rock under Mode Ⅲ loading. The fracture mode depending on the fracture mechanism must be distinguished from the loading form.

关键词： Mode Ⅲ loading Mode Ⅰ fracture fracture mechanism finite element method rock

Effects of combined procedure and devascularization alone on hyperdynamics of the portal venous system in patients with portal hypertension

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Frontiers of Medicine 2008年第3期2卷 244-247页

作者： Rong hua Yongwei SUN Zhiyong WU Department of General Surgery Renji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200127China

Shunts and devascularizations have totally dif-ferent effects on the hemodynamics of the portal venous *** actual results of pericardial devascularization(PCDV)alone and conventional splenorenal shunt com-bined with pericardial devascularization(combined pro-cedure,CP)should be determined by more clinical *** study aimed to evaluate effects on hemodynamics in the portal venous system after CP and PCDV *** 20 patients who received CP and 18 who received PCDV,hemodynamic parameters of the portal venous system were studied by magnetic resonance angio-graphy 1 week before and 2 weeks after *** portal pressure(FPP)was continuously detected by a transducer during the *** to the pre-operative data,a decreased flow in the portal vein(PVF)[(563.12±206.42)mL/min vs(1080.63±352.85)mL/min,P,0.05],a decreased portal vein diameter(PVD)[(1.20±0.11)cm vs(1.30±0.16)cm,P<0.01],a decreased FPP[(21.50±2.67)mmHg vs(29.88±2.30)mmHg,P<0.01]and an increased flow in the superior mesenteric vein(SMVF)[(1105.45±309.03)mL/min vs(569.13±178.46)mL/min,P<0.05]were found in the CP group after operation;a decreased PVD[(1.27±0.16)cm vs(1.40±0.23)cm,P<0.05],a decreased PVF[(684.60±165.73)mL/min vs(1175.64±415.09)mL/min,P<0.05],a decreased FPP[(24.40±3.78)mmHg vs(28.80±3.56)mmHg,P<0.05]and an increased SMVF[(697.91±121.83)mL/min vs(521.30±115.82)mL/min,P<0.05]were observed in the PCDV *** operation,PVF in the CP group[(563.12±206.42)mL/min vs(684.60±165.73)mL/min,P<0.05]had no significant decrease,while FPP[(21.50±2.67)mmHg vs(24.40±3.78)mmHg,P<0.01]had a significant decrease as compared with that in the PCDV *** and FPP could be decreased by both surgical procedures,but the effect of decreasing FPP was much better in the combined procedure than in PCDV ***,there was no significant difference in PVF between the two *** is suggested that the combined surgical procedure could integrate the advan-tages of shunting with tho

关键词： hypertension,portal hemodynamics sple-norenal shunt,surgical

Clinical manifestations and the prenatal diagnosis of trisomy 7 mosaicism:Two case reports

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World Journal of Clinical Cases 2024年第8期12卷 1544-1548页

作者： Fei Hou Yan Li hua Jin Department of Prenatal Diagnosis Jinan Maternal and Child Health HospitalJinan 250001Shandong ProvinceChina

BACKGROUND The clinical manifestations of trisomy 7 mosaicism are diverse and nonspecific,so prenatal diagnosis is very *** SUMMARY Two pregnant women with abnormal prenatal screening results were *** was a 22-year-old woman(G1P0).At 31st week of gestation,ultrasound revealed that the posterior horn of the left lateral ventricle was 10 mm and the right renal pelvis had a separation of 7 *** other pregnant woman was 33 years old(G2P1L1A0),and her fetus was found to have a cardiac malformation at the 24th week of *** number variation sequencing,whole-exome sequencing and karyotype analysis were carried out after amniocentesis,and both fetuses were diagnosed with trisomy 7 *** parental counseling,one woman continued the pregnancy,and the other woman terminated the *** In trisomy 7 mosaicism,the low proportion of trisomy does not lead to abortion,but can result in abnormal fetal development,which can be detected via ***,clinicians need to pay more attention to various aspects of fetal growth and development,combining with imaging,cellular,molecular genetics and other methods to perform comprehensive evaluations of fetuses to provide more reliable genetic counseling for pregnant women.

关键词： Trisomy 7 mosaicism Copy number variation sequencing Whole-exome sequencing Karyotype analysis Prenatal diagnosis Case report