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Simple instruments facilitating achievement of transanal total mesorectal excision in male patients

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World Journal of Gastroenterology 2017年第31期23卷 5798-5808页

作者： Chang Xu hua-Yu Song Shao-Liang Han Shi-Chang Ni hu-xiang zhang Chun-Gen Xing Department of General Surgery the Second Affiliated Hospital of Soochow University Department of Colorectal Surgery the First Affiliated Hospital of Wenzhou Medical University Department of Pathology the First Affiliated Hospital of Wenzhou Medical University

AIM To assess the efficacy of a modified approach with transanal total mesorectal excision(ta TME) using simple customized instruments in male patients with low rectal *** A total of 115 male patients with low rectal cancer from December 2006 to August 2015 were retrospectively studied. All patients had a bulky tumor(tumor diameter ≥ 40 mm). Forty-one patients(group A) underwent a classical approach of transabdominal total mesorectal excision(TME) and transanal intersphincteric resection(ISR), and the other 74 patients(group B) underwent a modified approach with transabdominal TME,transanal ISR, and ta TME. Some simple instruments including modified retractors and an anal dilator with a papilionaceous fixture were used to perform ta TME. The operative time, quality of mesorectal excision, circumferential resection margin, local recurrence, and postoperative survival were *** All 115 patients had successful sphincter preservation. The operative time in group B(240 min, range: 160-330 min) was significantly shorter than that in group A(280 min, range: 200-360 min; P = 0.000). Co m pa r e d w it h g r o up A, m o r e c o m p le t e d is t a l mesorectum and total mesorectum were achieved in group B(100% vs 75.6%, P = 0.000; 90.5% vs 70.7%, P = 0.008, respectively). After 46.1 ± 25.6 mo followup, group B had a lower local recurrence rate and higher disease-free survival rate compared with group A, but these differences were not statistically significant(5.4% vs 14.6%, P = 0.093; 79.5% vs 65.1%, P = 0.130). CONCLUSION Retrograde ta TME with simple customized instruments can achieve high-quality TME, and it might be an effective and economical alternative for male patients with bulky tumors.

关键词： Rectal neoplasm Total mesorectal excision Transanal approach Intersphincteric resection Longterm outcome Local recurrence

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日本和韩国胃癌术后并发症诊断及风险评价

中华胃肠外科杂志 2017年第2期20卷 129-134页

作者：胡祥张驰大连医科大学附属第一医院普通外科 116011

胃癌根治手术（D2淋巴结廓清）作为标准手术已广泛应用于临床并获得良好效果。但手术仍有高频度的并发症发生率和死亡率。日本和韩国大规模循证医学临床研究和大数据库资料显示。胃术后最为常见的并发症有吻合口瘘、胰漏和腹腔脓肿等，... 详细信息

胃癌根治手术（D2淋巴结廓清）作为标准手术已广泛应用于临床并获得良好效果。但手术仍有高频度的并发症发生率和死亡率。日本和韩国大规模循证医学临床研究和大数据库资料显示。胃术后最为常见的并发症有吻合口瘘、胰漏和腹腔脓肿等，并发症总发生率约为20％．死亡率约为1％。高龄、肥胖和共患基础疾病等风险因子的存在，会提升并发症发生率和死亡率，成为预后不良因子。胃术后并发症的诊断评价标准，国际上主要采用Clavien—Dindo标准，韩国也是同样。日本手术后并发症的判定和分级标准主要采用CTCAE4．0版评价标准和日本临床肿瘤学组（JCOG）的手术后并发症标准；日本胃癌大规模循证医学临床研究主要采用上述标准。功能状态评分（PS）、美国麻醉医师协会评分（ASA）、POSSUM、生理能力和评估手术压力（E—PASS）、急性生理学和查尔森健康评估（APACHE Ⅱ）和Charlson加重并存疾患指数虚弱性评价及一些新方法等被用于评价手术后并发症的风险程度和并发症的预测。这些方法将各类风险点数化，评价客观，在此基础上加以手术方式内容的评价，可以帮助选择合理的术式和围手术期管理。

关键词：胃手术并发症风险因子预后围手术期管理

Direct Photolithography of WO_(x)Nanoparticles for High‑Resolution Non‑Emissive Displays

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Nano-Micro Letters 2025年第3期17卷 297-309页

作者： Chang Gu Guojian Yang Wenxuan Wang Aiyan Shi Wenjuan Fang Lei Qian Xiaofei hu Ting zhang Chaoyu xiang Yu‑Mo zhang Laboratory of Optoelectronic Information Technology and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201People’s Republic of China Hangzhou Bay Laboratory of Advanced Nano‑Optoelectronic Materials and Devices Qianwan Institute of CNITECHNingbo 315336People’s Republic of China Smart Materials for Architecture Research Lab Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100People’s Republic of China University of Science and Technology of China Hefei 230026People’s Republic of China State Key Lab of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012People’s Republic of China

High-resolution non-emissive displays based on electrochromic tungsten oxides(WOx)are crucial for future near-eye virtual/augmented reality interactions,given their impressive attributes such as high environmental stability,ideal outdoor readability,and low energy ***,the limited intrinsic structure of inorganic materials has presented a significant challenge in achieving precise patterning/pixelation at the micron ***,we successfully developed the direct photolithography for WOx nanoparticles based on in situ photo-induced ligand *** strategy enabled us to achieve ultra-high resolution efficiently(line width3600 cycles),as well as promising applications in electronic logos,pixelated displays,flexible electronics,*** success and advancements presented here are expected to inspire and accelerate research and development(R&D)in high-resolution non-emissive displays and other ultra-fine micro-electronics.

关键词： Electrochromic Direct photolithography WOx nanoparticles In situ photo-induced ligand exchange High-resolution displays

Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang Liu xiang Li Shen Du Ming Gao Yanbin Yin Jiongming zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

Unraveling brain aging through the lens of oral microbiota

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Neural Regeneration Research 2025年第7期20卷 1930-1943页

作者： Qinchao hu Si Wang Weiqi zhang Jing Qu Guang-hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

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含裂纹多材料反平面分析的解析奇异单元

中国科学：技术科学 2016年第12期46卷 1225-1231页

作者：姚伟岸李翔胡小飞张兆军大连理工大学工业装备结构分析国家重点实验室大连116024

含裂纹多材料反平面问题是一个典型的III型断裂问题,已有的文献给出了其极坐标辛体系下的辛本征解,并讨论了其裂纹尖端的应力奇异性阶次.本文在此基础上,首先补充给出界面有外力作用时其非齐次边界条件所对应的特解,然后利用辛本征解和... 详细信息

含裂纹多材料反平面问题是一个典型的III型断裂问题,已有的文献给出了其极坐标辛体系下的辛本征解,并讨论了其裂纹尖端的应力奇异性阶次.本文在此基础上,首先补充给出界面有外力作用时其非齐次边界条件所对应的特解,然后利用辛本征解和特解构造出相关问题分析的一类解析奇异单元.将所提出的奇异单元与外部的常规单元相结合,就可用于多材料III型断裂问题的分析,并直接给出应力强度因子的数值结果.数值算例表明,本方法具有很好的求解精度,是相关问题分析的一个非常有效的数值方法.

关键词：辛弹性力学奇异单元反平面问题多材料裂纹应力强度因子

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan zhang Xin Liu Jian zhang Ya Gao Shuyue Li Cui Chang xiang Liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders:drug stability,targeting efficiency,and safety

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Neural Regeneration Research 2025年第7期20卷 1883-1899页

作者： Mingyu zhang Chunyu xiang Renrui Niu Xiaodong He Wenqi Luo Wanguo Liu Rui Gu Department of Orthopedic Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely ***,their inability to cross the blood–brain barrier hampers the clinical translation of these therapeutic *** are nanoparticles composed of lipid bilayers,which can effectively encapsulate drugs and improve drug delivery across the blood–brain barrier and into brain tissue through their targeting and ***,they can potentially treat traumatic and nontraumatic central nervous system *** this review,we outlined the common properties and preparation methods of liposomes,including thin-film hydration,reverse-phase evaporation,solvent injection techniques,detergent removal methods,and microfluidics ***,we comprehensively discussed the current applications of liposomes in central nervous system diseases,such as Alzheimer's disease,Parkinson's disease,huntington's disease,amyotrophic lateral sclerosis,traumatic brain injury,spinal cord injury,and brain *** studies related to liposomes are still in the laboratory stage and have not yet entered clinical ***,their application as drug delivery systems in clinical practice faces challenges such as drug stability,targeting efficiency,and ***,we proposed development strategies related to liposomes to further promote their development in neurological disease research.

关键词： Alzheimer's disease amyotrophic lateral sclerosis brain tumors central nervous system huntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury

氢气气氛中热处理对Ni-W合金镀层组织和性能的影响

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材料导报 2017年第16期31卷 94-97页

作者：谢蔚张亚东周琼宇成祥胡安伟张路江西理工大学材料科学与工程学院赣州341000 上海大学材料科学与工程学院上海200072 江西省科学院应用物理研究所南昌330029

研究了在氢气气氛中,不同的热处理温度对Ni-W合金镀层表面状态、相结构及显微硬度和耐蚀性的影响。结果表明,镀态的Ni-W合金镀层存在一种未知相(2θ≈41.4°),热处理过程中这一未知相消失,同时镀层中析出NiW、Ni_4W等沉淀相。随着热处... 详细信息

研究了在氢气气氛中,不同的热处理温度对Ni-W合金镀层表面状态、相结构及显微硬度和耐蚀性的影响。结果表明,镀态的Ni-W合金镀层存在一种未知相(2θ≈41.4°),热处理过程中这一未知相消失,同时镀层中析出NiW、Ni_4W等沉淀相。随着热处理温度的升高,镀层的晶粒度逐渐增大,镀层在热处理过程中形成的孔隙逐渐增多。当热处理温度达到1 000℃后,镀层表面出现明显的裂纹,同时镀层中可还原形成单质W。Ni-W合金镀层的显微硬度经热处理后显著增大,热处理温度为500℃时镀层的显微硬度最大,同时镀层具有与镀态Ni-W合金相近的耐蚀性,热处理温度进一步升高后镀层的耐蚀性降低。

关键词： Ni-W合金镀层氢气气氛热处理显微硬度耐蚀性