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Clinical features of neoplastic pathological fracture in long bones

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Chinese Medical Journal 2012年第17期125卷 3127-3132页

作者： hu yong-cheng LUN Deng-xing WANG Han Department of Bone Oncology Tianjin Hospital Tianjin 300211 China Department of Spine Surgery Weifang People's Hospital Weifang Shandong 261041 China

Background Pathological fractures signify a potentially more aggressive subset of the original disease with higher misdiagnosis rates and inferior oncologic results. The purpose of the present study was to explore the clinical features of neoplastic pathological fracture in extremities. Methods From August 2002 to December 2010, a consecutive series of 139 patients suffering neoplastic pathological fracture were recruited, including 79 males and 60 females with a mean age of 31.3 years. Fractures were classified into five groups： tumor-like lesions （55）, benign bone tumors （13）, giant cell tumors （7）, primary malignant bone tumors （28）, and metastatic bone tumors （36）. Based on their inducing forces, pathologic fractures were classified into four grades： spontaneous fracture, functional fracture, minor injury, and traumatic injury. Patients＇ age, fracture site, histological diagnoses, fracture forces, prodromes, and misdiagnosis were well reviewed. Kruskal-Wallis and X2 tests were used to compare forces and prodromes within different types of bone tumors. Results The highest pathologic fracture morbidity was 32.3% （45/139）, which lay in the 11-20 year group, and 86.1% of metastatic tumors occurred in the 50-80 year group. The common sites of fractures were femur, humerus, and tibia. The fracture forces in benign bone tumors and tumor-like lesions are the strongest, followed by metastatic tumors and primary malignant bone tumors （Hc=80.980, P=0.000）. Sixty-seven patients （48.2%） had local prodromes before pathologic fracture. The incidence rates of prodromes between primary malignant tumors and metastatic bone tumors had no significant difference （P=0.146）, but they were all obviously higher than that of benign bone tumors and tumor-like lesions. Twenty patients experienced misdiagnosis. Conclusion Minor injury forces and local prodromes are clinical features of neoplastic pathologic fractures and they are also the critical factor avoiding misdiagnoses.

关键词： long bone neoplastic pathological fracture

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同种异体肌腱处理技术的进展

中国矫形外科杂志 2024年第15期32卷 1398-1402页

作者：张净宇马荣星王丽敏胡永成天津市天津医院天津300211 北京威达峰医学生物材料有限责任公司北京101102

本综述全面总结了同种异体肌腱处理工艺的研究现状和前沿技术。同种异体肌腱处理流程为核心,系统总结了该领域的研究现状和前沿技术。肌腱移植成为肌腱损伤重建的主要手段之一。首先介绍了同种异体肌腱的应用背景和发展趋势,深入探讨了... 详细信息

本综述全面总结了同种异体肌腱处理工艺的研究现状和前沿技术。同种异体肌腱处理流程为核心,系统总结了该领域的研究现状和前沿技术。肌腱移植成为肌腱损伤重建的主要手段之一。首先介绍了同种异体肌腱的应用背景和发展趋势,深入探讨了免疫原性与排斥反应相关的物理冷冻法和化学法,以及脱脂技术、脱细胞技术等处理方法。强调了同种异体肌腱处理工艺优化对于提高临床手术效果的重要性,为其运用于临床提供了科学依据和技术支持。

关键词：同种异体肌腱免疫原性处理技术

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同种异体肌腱羟脯氨酸测定的正交试验

中国矫形外科杂志 2024年第4期32卷 356-361页

作者：万彦林高冰王丽敏胡永成夏群天津市第一中心医院骨科天津300192 北京威达峰医学生物材料有限责任公司北京101102 天津市天津医院骨与软组织肿瘤科天津300211

[目的]探讨不同因素对检测同种异体肌腱中羟脯氨酸(hydroxyproline,HYP)含量的影响。[方法]使用分光光度计,基于正交试验的方法,对同种异体肌腱进行HYP含量检测,以样品的酶解时间(4、12、24 h)、酶解的水浴温度(37℃、60℃、100℃),根... 详细信息

[目的]探讨不同因素对检测同种异体肌腱中羟脯氨酸(hydroxyproline,HYP)含量的影响。[方法]使用分光光度计,基于正交试验的方法,对同种异体肌腱进行HYP含量检测,以样品的酶解时间(4、12、24 h)、酶解的水浴温度(37℃、60℃、100℃),根据样品在酶解过程中需要盐酸优化酶解,设定酸酶比(1∶2,1∶1,2∶1),样品酶解时的水浴震荡频率(180 r/min、200 r/min、250 r/min)4个单因素变量交替试验,得到最优化检测因素。[结果]单因素分析结果表明,在其他变量不变的情况下,酶解时间12 h,水浴温度为60℃,酸酶比为2∶1,保证pH值为7.4左右,200 r/min震荡频率,能保证HYP酶解效果最佳,正交试验及极差分析表明酸酶比影响作用最大,其他影响因素依次为水浴温度、震荡频率和时间。[结论]同种异体肌腱HYP含量检测,需调整pH值、温度、震荡频率及酶解时间保证酶的活性做高,使样本检测率达到最高,以期合理使用资源,同时达到最佳的检测效果。

关键词：同种异体肌腱羟脯氨酸分光光度法检测正交试验

Rare variants of Bosworth fracture-dislocation: Bosworth fracture-dislocation with medial malleolus adduction type fracture

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Chinese Journal of Traumatology 2019年第2期22卷 120-124页

作者： Wei Ren yong-cheng hu Ji-Ke Lu Department of Orthopedic Surgery United Family Hospital Beijing 100015 China Department of Orthopedic Tianjin Hospital Tianjin 300211 China Tianjin Medical University Tianjin 300070 China

Bosworth ankle fracture-dislocation is rare, known to be an irreducible type of ankle injury, with a high incidence of complication. We present two cases of even rarer variants of Bosworth ankle fracturedislocation. The first case is a type of supination external rotation adduction, and the second case is a type of supination external rotati on adduction. These types have not bee n described before .In both of the cases we failed to achieve close reduction, and therefore proceeded with emergency surgeries, with open reduction and internal fixation. Both of the cases were performed with a postero-lateral approach to reduce the dislocations, and fix the fractures successfully. Unfortunately in one of the cases, acute compartment syndrome developed post-surgically. However, both cases showed good functional outcomes.

关键词： Fracture dislocation Supination Rotation Ankle injuries Complications

Un displaced subtle ligamentous Lisfranc injuries, con servative or surgical treatment with percutaneous position screws?

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Chinese Journal of Traumatology 2019年第4期22卷 196-201页

作者： Wei Ren Hai-Bo Li Ji-Ke Lu yong-cheng hu Tianjin Medical University Tianjin 300070 China Department of Orthopedic Surgery United Family Hospital Beijing 100015 China Department of Orthopedic Tianjin Hospital Tianjin 300211 China

Purpose: Un displaced subtle ligamentous Lisfranc injuries are easy to miss or underestimate, and many cases are treated without surgical fixation. It has not yet widely known whether conservative treatment for undisplaced subtle ligamentous Lisfranc injuries may lead to a poor outcome. The purpose of this study is to compare the outcomes of conservative versus surgical management (percutaneous position screw) of undisplaced subtle ligamentous Lisfranc injury. Methods: We analysed 61 cases in this retrospective study, including 38 males and 23 females. Forty-one patients were managed conservatively, while 20 patients received surgical treatment involving minimal invasive percutaneous pos让ion screw. American orthopaedic foot &ankle society (AOFAS), foot function index (FFI, including FFI disability, FFl pain score and activity limitation scale) scores, Maryland foot score and short form-36 (SF-36) were recorded and compared after a follow-up of 10-16 months (average 12.3). Results: Patients in the surgical management group had higher scores in all evaluation methods (p < 0.05). The complications in the conservative management group had higher incidenee, mainly including secondary diastasis (34.1% vs. 5.0%), joint stiffness after 3 months (82.9% vs. 0%), and secondary arthrodesis (12.2% vs. 0%). The highest rate of complication in surgical management group was temporary forefoot pain (55.0%). Conclusion: The results of this study suggest that the outcomes of the surgical management with percutaneous position screw fixation are better than the conservative management to treat undisplaced subtle ligamentous Lisfranc injuries. This study can serve as a resource for orthopaedic surgeons in recog nizing and man aging such injuries.

关键词： Undisplaced subtle ligamentous Lisfranc injuries Conservative management Surgical management Percutaneous position screw Complications

Long-term results and radiographic findings of percutanous vertebroplasties with polymethylmethacrylate for vertebral osteoporotic fractures

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Chinese Medical Journal 2012年第16期125卷 2832-2836页

作者： XU Bao-shan hu yong-cheng YANG Qiang XIA Qun MA Xin-long JI Ning Department of Spinal Surgery Tianjin HospitalTianjin 300211China

Background Percutaneous vertebroplasty （PVP） has become a popular procedure for painful vertebral osteoporotic fracture （VOF）, with immediate pain relief and improved mobility; however, polymethylmethacrylate （PMMA） injected into the vertebral body is not absorbable and little information is available concerning the long-term results. In this retrospective study, we evaluated the long-term clinical results and radiological changes after PVPs for VOFs. Methods Fifty-one patients with VOFs were treated by PVPs with PMMA between 2000 and 2004. After 〉7 years of follow-up, eight patients had died from causes unrelated to the intervention and 12 patients were lost to follow-up, thus leaving 31 patients available for evaluation with an average length of follow-up of 9.2 years （follow-up rate, 72.1%）. Among these 31 patients, the PMMA was injected at 43 levels with a mean volume of 4.3 ml per level （range, 2-6 ml）. The pain was assessed with a visual analog scale （VAS）, and the mobility was graded as walking without difficulty （grade 1）, walking with assistance （grade 2）, and bedridden （grade 3）. Plain radiographs and computed tomography （CT） were obtained and assessed pre-operatively, immediately post-operatively, and after 7 years of follow-up. The PMMA, vertebral height, and Cobb angle were assessed and compared. Results All of the patients experienced pain relief and improved mobility after intervention and during the follow-up period. Cement leakage was detected in post-operative CT scans in 9 of 51 patients, but without neurological compromise. For the 31 patients followed up over 7 years, the VAS decreased from 8.3±2.6 pre-operatively, to 2.1±1.6 immediately post-operatively, and 1.0±0.9 at the final follow-up evaluation, with significantly improved mobility. Additional compression fractures occurred at adjacent levels in three patients, and there were no new fractures at the augmented vertebrae. Based on a review of the radiographs, neither loose nor displaced ceme

关键词： osteoporotic fractures vertebroplasty polymethylmethacrylate treatment outcome

Assessing validation of dual fluoroscopic image matching method for measurement of in vivo spine kinematics

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Chinese Medical Journal 2011年第11期124卷 1689-1694页

作者： BAI Jian-qiang hu yong-cheng DULi-qing HE Jing-liang LIU Kai LIU Zhongjun XIA Qun Department of Orthopaedics Peking University Third HospitalBeijing 100191 China Department of Spinal Surgery Tianjin Hospital Tianjin 300211China Institute of Radiation Medicine Chinese Academy of MedicalSciences & Peking Union Medical College Tianjin KeyLaboratory of Molecular Nuclear Medicine Tianjin 300192 China

Background Accurate knowledge of the spinal structural functions is critical to understand the biomechanical factors that affect spinal pathology. Many studies have investigated the human vertebral motion both in vitro and in vivo. However, determination of in vivo motion of the vertebrae under physiologic loading conditions remains a challenge in biomedical engineering because of the limitations of current technology and the complicated anatomy of the spine. Methods For in vitro validation, a human lumbar specimen was imbedded with steel beads and moved to a known distance by an universal testing machine （UTM）.

关键词： lumbar spine validation dual fluoroscopes matching method

How to Fill the Cavity after Curettage of Giant Cell Tumors around the Knee？ A Multicenter Analysis

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Chinese Medical Journal 2017年第21期130卷 2541-2546页

作者： Kai Zheng Xiu-Chun Yu yong-cheng hu Zhen Wang Su-Jia Wu Zhao-Ming Ye Giant Cell Tumor Group of China (GTOC) Department of Orthopaedics The General Hospital of Jinan Military Commanding Region Jinan Shandong 250031 China Department of Bone Oncology Tianjin Hospital Tianjin 300211 China Department of Orthopaedics Xijing Hospital The Fourth Military Medical University Xi&#39 an Shaanxi 710032 China Department of Orthopaedics Jinling Hospital Clinical School of Medical College Nanjing University Nanjing Jiangsu 210000 China Department of Orthopaedics The Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310009 China

Background： Intralesional excision with curettage is the standard method of giant cell tumor （GCT） treatment, but the ideal filling material after curettage remains controversial. The purpose of this study was to compare the oncological and functional outcomes which underwent cementation or bone grafting after GCT curettage around the knee. Methods： We reported 136 cases with GCTs in distal femur or proximal tibia who accepted curettage from five clinical centers during the last 15 years. All patients were divided into two groups according to filling materials. Recurrence-free survival proportions were used to evaluate oncological outcomes while the Musculoskeletal Tumor Society （MSTS） 93 functional score was used to evaluate functional outcomes. Other parameters including surgical complication, general condition, and radiological classification had been analyzed. The valid statisitical data was analyzed using SPSS 13.0 software. Results： After GCT curettage, 86 patients （63.2%） accepted bone grafting while 50 patients （36.8%） accepted cementation. There was no statistical difference in age, gender, tumor location, radiological classification, fixation, follow-up time, and MSTS 93 functional score between cementation group and bone grafting group. The recurrence-free survival proportions showed that the recurrence rate in bone grafting group was higher than it in cementation group （P = 0.034）. Surgical complication was lower in cementation group than that in bone grafting group but without statistically significant difference （P = 0.141）. Conclusions： Parameters including patients＆#39;age, gender, tumor location, and radiological classification did not affect surgeons＆#39;treatments in cavity filling after GCT curettage. Cementation should be recommended because of easy usage, the similar postoperative knee function with bone grafting, and the better local tumor control than bone grafting.

关键词： Bone Grafting Cementation Giant Cell Tumor Knee

Triboelectric‘electrostatic tweezers'for manipulating droplets on lubricated slippery surfaces prepared by femtosecond laser processing

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International Journal of Extreme Manufacturing 2024年第3期6卷 411-426页

作者： Jiale yong Xinlei Li Youdi hu Yubin Peng Zilong cheng Tianyu Xu Chaowei Wang Dong Wu CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Precision Machinery and Precision InstrumentationUniversity of Science and Technology of ChinaHefei 230027People’s Republic of China

The use of‘Electrostatic tweezers'is a promising tool for droplet manipulation,but it faces many limitations in manipulating droplets on superhydrophobic ***,we achieve noncontact and multifunctional droplet manipulation on Nepenthes-inspired lubricated slippery surfaces via triboelectric electrostatic tweezers(TETs).The TET manipulation of droplets on a slippery surface has many advantages over electrostatic droplet manipulation on a superhydrophobic *** electrostatic field induces the redistribution of the charges inside the neutral droplet,which causes the triboelectric charged rod to drive the droplet to move forward under the electrostatic *** or negatively charged droplets can also be driven by TET based on electrostatic attraction and *** enables us to manipulate droplets under diverse conditions,including anti-gravity climb,suspended droplets,corrosive liquids,low-surface-tension liquids(*** with a surface tension of 22.3 mN·m^(-1)),different droplet volumes(from 100 nl to 0.5 ml),passing through narrow slits,sliding over damaged areas,on various solid substrates,and even droplets in an enclosed *** droplet-related applications,such as motion guidance,motion switching,droplet-based microreactions,surface cleaning,surface defogging,liquid sorting,and cell labeling,can be easily achieved with TETs.

关键词： triboelectric electrostatic tweezer droplet manipulation slippery surface superhydrophobic surface femtosecond laser