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Paracrine function amplifies pro-tumor electrochemical signal within neuron-glioma synapses

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Science China(Life Sciences) 2024年第6期67卷 1318-1320页

作者： yan hu Peishan hu Xiaozhong Peng Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE State Key Laboratory of BiotherapyWest China Second University HospitalSichuan UniversityChengdu 610041China Guangdong Institute of Gastroenterology Department of General SurgeryGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China Department of Molecular Biology and Biochemistry Institute of Basic Medical SciencesMedical Primate Research CenterNeuroscience CenterChinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100730China State Key Laboratory of Respiratory Health and Multimorbidity Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100730China Institute of Laboratory Animal Science Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Neuronal activity plays a pivotal role in various physiological processes,including tissue development,homeostasis,and *** in recent years have improved our understanding of neuronal activity in brain cancers,such as glioblastoma(GBM)and diffuse midline gliomas(DMG),which are among the most prevalent and lethal cancers affecting children and ***,the neurons regulate brain cancers via two routes.

关键词： glioma homeostasis function

Large deviations viewpoints for a heavy-tailed β-mixing sequence

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Science China Mathematics 2005年第11期48卷 1554-1566页

作者： LIU yan hu Yijun School of Mathematics and Statistics Wuhan University Wuhan 430072 China School of Mathematics and Statistics Wuhan University Wuhan 430072 China

Let (Xn;n≥1) be a stationary sequence of non-negative random variables with heavy tails. Under mixing conditions, we study logarithmic asymptotics for the distributions of the partial sums sn=X1+X2+…+Xn. We obtain the crude estimates P(Sn>nx)≈n-αx+1 for appropriate values of x, where a is a specific parameter. The related conjecture proposed by Gantert is investigated. As a by-product, the so-called supremum large deviations principle is also studied.

关键词： logarithmic asymptotics,large deviations,heavy tails,mixing

Summarizing Software Artifacts： A Literature Review

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Journal of Computer Science & Technology 2016年第5期31卷 883-909页

作者： Najam Nazar yan hu He Jiang Key Laboratory for Ubiquitous Network and Service Software of Liaoning Province School of Software Dalian University of Technology Dalian 116621 China State Key Laboratory of Software Engineering Wuhan University Wuhan 430072 China

This paper presents a literature review in the field of summarizing software artifacts, focusing on bug reports, source code, mailing lists and developer discussions artifacts. From Jan. 2010 to Apr. 2016, numerous summarization techniques, approaches, and tools have been proposed to satisfy the ongoing demand of improving software performance and quality and facilitating developers in understanding the problems at hand. Since aforementioned artifacts contain both structured and unstructured data at the same time, researchers have applied different machine learning and data mining techniques to generate summaries. Therefore, this paper first intends to provide a general perspective on the state of the art, describing the type of artifacts, approaches for summarization, as well as the common portions of experimental procedures shared among these artifacts. Moreover, we discuss the applications of summarization, i.e., what tasks at hand have been achieved through summarization. Next, this paper presents tools that are generated for summarization tasks or employed during summarization tasks. In addition, we present different summarization evaluation methods employed in selected studies as well as other important factors that are used for the evaluation of generated summaries such as adequacy and quality. Moreover, we briefly present modern communication channels and complementarities with commonalities among different software artifacts. Finally, some thoughts about the challenges applicable to the existing studies in general as well as future research directions are also discussed. The survey of existing studies will allow future researchers to have a wide and useful background knowledge on the main and important aspects of this research field.

关键词： mining software repositories mining software engineering data machine learning summarizing softwar eartifacts summarizing source code

An Experimental Study for Intelligent Logistics:A Middleware Approach

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Chinese Journal of Electronics 2016年第3期25卷 561-569页

作者： yanG Rong LI Bing hu yan College of Computer Science and Technology Hubei University of Science and Technology International School of Software Wuhan University Science and Technology on Integrated Information System Laboratory Institute of SoftwareUniversity of Chinese Academy of Sciences

Recent years have witnessed a rapid growth in using Internet of things(Io T), which facilitates and simultaneously raises challenges for the intelligent logistics. The real-world devices can provide their functionality as Web services. Because of the dynamicity and heterogeneity of the target networking environment, the services offered by Io T resources cannot be composed by simply extending existing Service oriented architecture(SOA) approaches. Logistics, which consists of a complex network of organizations and business processes, must be monitored in real time. Based on the proper understanding of the possible exceptions, we propose a middleware approach to solve the logistics service composition in Io T, where a decentralized coordination mechanism is used to monitor the component services with few resources efficiently. Through a set of experiments, the effectiveness and robustness of our approach are evaluated.

关键词： Internet of things(IoT) Intelligent logistics Exceptions Monitoring

Microstructure Characterization of a Complex Branched Low-density Polyethylene

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Chinese Journal of Polymer Science 2015年第3期33卷 508-522页

作者： yan-hu Xue yan-di Fan Shu-qin Bo 姬相玲 State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of Sciences University of Chinese Academy of Sciences

A low-density polyethylene （LDPE） resin with excellent processing and film-forming properties is fractionated through temperature rising elution fractionation （TREF） technique. The chain structures of both the original resin and its fractions are further analyzed using high-temperature gel permeation chromatography （GPC） coupled with triple detectors （refractive index （RI）-light scattering （LS）-viscometer （VIS））, ^13C-nuclear magnetic resonance spectroscopy （^13C-NMR）, Fourier transform infrared spectroscopy （FTIR）, differential scanning calorimetry （DSC） and successive self- nucleation/annealing （SSA） thermal fractionation. The ^13C-NMR results show that the original resin has both short chain branch （SCB）（2.82 mol%） and long chain branch （LCB）（0.52 mol%） structures. The FTIR results indicate that the methyl numbers （per 1000 C） of the fractions gradually decrease from 81 to 46 with increasing elution temperature from 25 ℃ to 75 ℃. The TREF-GPC cross-fractionation results show that the main component is collected at around 68 ℃. The molecular weight of the components in the high elution temperatures of 60 ℃ to 75 ℃ is from 2.0× 10^3 g/mol to 2.0 × 10^6 g/mol, and the relative amount is more than 80%. In the low elution temperature region below 50 ℃, the molecular weights of the components range from 1.0 × 10^3 g/mol to 1.6 × 10^4 g/mol, and the relative amount is less than 10%. In the DSC results, the melting peaks of the fractions gradually increase from 80.1℃ to 108.8 ℃ with elution temperature. In the SSA thermal fractionation, each resin fraction shows a broad range of endotherm with multiple melting peaks （more than eight peaks）. The melting peaks shift toward high temperatures with the elution temperature. The characteristic chain microstructure for the resin is also discussed in detail.

关键词： Polyethylene Cross-fractionation Microstructure Characterization TREF.

Comparison of Chain Structures between High-speed Extrusion Coating Polyethylene Resins by Preparative Temperature Rising Elution Fractionation and Cross-fractionation

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Chinese Journal of Polymer Science 2015年第11期33卷 1586-1597页

作者： yan-hu Xue Shu-qin Bo 姬相玲 State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of Sciences

Two polyethylene（PE） resins（samples A and B） are synthesized as high-speed extrusion coatings with similar minimum coating thickness and neck-in performance but different maximum coating speeds. Both samples are separated into seven fractions using preparative temperature rising elution fractionation. The microstructures of the original samples and their fractions are studied by high-temperature gel permeation chromatography, Fourier transform infrared spectroscopy, 13 C nuclear magnetic resonance spectroscopy, differential scanning calorimetry, and successive self-nucleation/annealing thermal fractionation. Compared with sample B, sample A has a broader MWD, more LCB contents, and less SCB contents. Moreover, sample A contains slightly more 30 ℃ and 50 ℃ fractions with lower molecular weights, and more fractions at 75 ℃ and 85 ℃ with higher molecular weight. The chain structure and its distribution in the two PE resins are studied in detail, and the relationship between the chain structure and resin properties is also discussed.

关键词： Polyethylene High-speed extrusion coating Chain structure TREF Cross-fractionation

Deployment dynamics of a simplified spinning IKAROS solar sail via absolute coordinate based method

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Acta Mechanica Sinica 2013年第1期29卷 132-142页

作者： Jing Zhao Hai-yan hu Qiang Tian State Key Lab of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and Astronautics School of Aerospace Engineering Beijing Institute of Technology

The spinning solar sail of large scale has been well developed in recent years. Such a solar sail can be considered as a rigid-flexible multibody system mainly composed of a spinning central rigid hub, a number of flexible thin tethers, sail membranes, and tip masses. A simplified interplanetary kite-craft accelerated by radiation of the Sun （IKAROS） model is established in this study by using the absolute-coordinate-based （ACB） method that combines the natural coordinate formulation （NCF） describing the central rigid hub and the absolute nodal coordinate formulation （ANCF） describing flexible parts. The initial configuration of the system in the second-stage deployment is determined through both dynamic and static analyses. The huge set of stiff equations of system dynamics is solved by using the generalized-alpha method, and thus the deployment dynamics of the system can be well understood.

关键词： Solar sail · Spinning deployment - Natural coordinate formulation Absolute nodal coordinate formulation

Calibration Curve Establishment and Fractionation Temperature Selection of Polyethylene for Preparative Temperature Rising Elution Fractionation

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Chinese Journal of Polymer Science 2015年第7期33卷 1000-1008页

作者： yan-hu Xue Shu-qin Bo 姬相玲 State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of Sciences University of Chinese Academy of Sciences

A series of copolymers of ethylene with 1-hexene synthesized using a metallocene catalyst are selected and mixed. The blend is fractionated via preparative temperature rising elution fractionation（P-TREF）. All fractions are characterized via high-temperature gel permeation chromatography（GPC）, 13 C nuclear magnetic resonance spectroscopy（13C-NMR）, and differential scanning calorimetry（DSC）. The changes in the DSC melting peak temperatures of the fractions from P-TREF as a function of elution temperature are almost linear, thereby providing a reference through which the elution temperature of TREF experiments could be selected. Moreover, the standard calibration curve（ethylene/1-hexene） of P-TREF is established, which relates to the degree of short-chain branching of the fractions. The standard calibration curve of P-TREF is beneficial to study on the complicated branching structure of polyethylene. A convenient method for selecting the fractionation temperature for TREF experiments is elaborated. The polyethylene sample is fractionated via successive self-nucleation and annealing（SSA） thermal fractionation. A multiple-melting endotherm is obtained through the final DSC heating scan for the sample after SSA thermal fractionation. A series of fractionation temperatures are then selected through the relationship between the DSC melting peak temperature and TREF elution temperature.

关键词： TREF Calibration curve Fractionation temperature SSA Polyethylene

Design,preparation,and characterization of a novel ZnO/CuO/Al energetic diode with dual functionality:Logic and destruction

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Defence Technology（防务技术） 2024年第4期34卷 57-68页

作者： Jialu yang Jiaheng hu Yinghua Ye Jianbing Xu yan hu Ruiqi Shen School of Chemistry and Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094China Micro-Nano Energetic Devices Key Laboratory of MIIT Nanjing 210094China Institute of Space Propulsion Nanjing University of Science and TechnologyNanjing 210094China

Self-destructing chips have promising applications for securing *** paper proposes a new concept of energetic diodes for the first time,which can be used for self-destructive chips.A simple two-step electrochemical deposition method is used to prepare ZnO/CuO/Al energetic diode,in which N-type ZnO and P-type CuO are constricted to a PN *** paper comprehensively discusses the material properties,morphology,semiconductor characteristics,and exploding performances of the energetic *** results show that the energetic diode has typical rectification with a turn-on voltage of about 1.78 V and a reverse leakage current of about 3×10^(-4)*** a constant voltage of 70 V loads to the energetic diode in the forward direction for about 0.14 s or 55 V loads in the reverse direction for about 0.17 s,the loaded power can excite the energetic diode exploding and the current rises to about100 *** to the unique performance of the energetic diode,it has a double function of rectification and *** energetic diode can be used as a logic element in the normal chip to complete the regular operation,and it can release energy to destroy the chip accurately.

关键词： Energetic diode ZnO—CuO—Al thermite ZnO/CuO PN junction Electrical explosion performance Self-destructing chips