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Eye-movement Patterns of Chinese Children with Developmental Dyslexia during the Stroop Test

Biomedical and Environmental Sciences 2018年第9期31卷 677-685页

作者： WU Yu Jia YANG Wen Han WANG Qing Xiong YANG De Sheng hu xiao yun JING Jin LI Xiu Hong Department of Maternal and Child Health School of Public Health Sun Yat-sen University

Objective To compare the eye-movement patterns of Chinese children with developmental dyslexia（DD children） with those of non-dyslexic children as they perform the Stroop Color and Word Test（SCWT）, and to explore the relationship between their eye-movement patterns and interference effect. Methods An EyeLink II was used to record the eye-movement parameters of 32 DD children and 37 non-dyslexic children as they performed the SCWT. The independent samples t-test and repeated measures were used to analyze behavioral and eye-movement parameters. Results Compared to the control group, Chinese DD children presented lower accuracy（F = 8.488）, slower response time（F = 25.306）, and larger interference effect（t = 2.29）; Chinese DD children also exhibited lower frequency of fixations（F = 6.069）, greater numbers of saccades（F = 7.914） and fixations（F = 5.272）, and shorter mean saccade distance（F = 4.03）. All behavioral and eye-movement parameters differed significantly among the three tasks in the SCWT. There was significant interaction between groups and tasks in accuracy（F = 5.844）, and marginally significant interaction in response time（F = 3.040）. Chinese DD children tended to have lower accuracy and longer response time than the control group in the ＇color-word naming＇ task. Conclusion Compared to non-dyslexic children, Chinese DD children are subject to a stronger interference effect. When performing the SCWT, Chinese DD children exhibit abnormal eye-movement patterns, namely shorter mean saccade distance, lower frequency of fixations, and more fixations and saccades. These abnormal eye movements may be relatively stable oculomotor patterns of DD children performing visual processing, and not influenced by impaired interference effect.

关键词： Developmental dyslexia Chinese children Eye movement Stroop Color and Word Test

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Design and synthesis of novel triazole antifungal derivatives based on the active site of fungal lanosterol 14a-demethylase(CYP51)

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Chinese Chemical Letters 2009年第8期20卷 935-938页

作者： Zhi Gang Dan Jun Zhang Shi Chong Yu Hong Gang hu xiao yun Chai Qing Yan Sun Qiu Ye Wu Department of Organic Chemistry School of Pharmacy Second Military Medical University Shanghai 200433 China

A series of 1-（1H-1,2,4-triazole-1-yl）-2-（2,4-difluoropheny1）-3-（N-isoproy1-N-substituted-amino）-2-propanols have been designed and synthesized on the basis of the active site of lanosterol 14a-demethylase （CYP51）. Their structures were confirmed by MS and ^1H NMR. In vitro antifungal activities of these synthesized compounds were evaluated against eight human pathogenic fungi. The results showed that all title compounds exhibited activity against fungi tested to some extent. Compounds 3c, 3d, 7a, 7b and 7e exhibited more potent antifungal activities against nearly all fungi tested except AspergiUus fumigatus than fluconazole. ？2009 Qiu Ye Wu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All fights reserved.

关键词： Triazole Synthesis Antifungal activity

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Glomus tumor of the gastric body:helical CT findings

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Chinese Medical Journal 2007年第14期120卷 1289-1291页

作者： hu xiao-yun hu Chun-hong FANG Xiang-ming ZHANG Tong-hua Medical Imaging Center First Affiliated Hospital Soochow University Suzhou 215006 China

Glomus tumors, also known as glomangiomas, are rare and originate in the neuromyoarterial glomus, a normal arteriovenous shunt which is abundantly supplied with nerve fibers and fulfills a temperature-regulating function. The classic location of glomus tumor is the subungual region, but the tumor can occur elsewhere in the skin, soft tissues, nerves, stomach, nasal cavity, and *** the gastrointestinal （GI） tract the tumor occurs more often in the stomach than other parts, and typically occurs as a solitary submucosal nodule in the antrum. We reported a case of glomus tumor originating from the greater curvature of stomach which was studied with contrast-enhanced helical computed tomography （CT） and described the characteristic helical CT findings of the rare lesion.

关键词： glomus tumor computed tomography diagnostic imaging

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Expression and significance of myeloid differentiation factor 88 in marrow dendritic cells in asthmatic rats with cigarette smoke exposure

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Chinese Medical Journal 2012年第14期125卷 2556-2561页

作者： LI Yi DU Yong-cheng XU Jian-ying hu xiao-yun Department of Respiration Medicine People's Hospital of ShanxiProvince Taiyuan Shanxi 030001 China

Background Smoking causes frequent asthma attacks, leading to a rapid decline in lung function in patients with asthma, and it can also reduce the therapeutic effect of glucocorticoids in patients with asthma. Therefore, the present study aimed to investigate the effect of cigarette smoke on the expression of myeloid differentiation factor 88 （MyD88） in marrow dendritic cells （DCs） in asthmatic rats, and to explore the molecular mechanism of cigarette smoke exposure on asthma by DCs. Methods Forty Wistar rats were randomly divided into the following groups： control, smoke exposure, asthma, and asthma combined with smoke exposure. The animal model was established, and then rat bone marrow-derived DCs were collected. Additionally, rat spleen lymphocytes and bone marrow-derived DCs were cultured together for mixed lymphocyte responses. Interferon （IFN）-gamma and interleukin （IL）-4, IL-10, and IL-12 expressions were determined by enzyme-linked immunosorbent assay （ELISA）. MyD88 expression was determined by Western blotting. The proliferation of lymphocytes was examined with methyl thiazolyl tetrazolium （MTT） colorimetric assay. Results MyD88 expression was decreased in the asthma combined with smoke exposure group compared to the asthma group （P 〈0.01）, and IL-10 and IL-12 expressions were decreased in the asthma combined with smoke exposure group compared to control group （P 〈0.01）. In addition, DCs stimulating activity on allogeneic lymphocytes were significantly decreased in the smoke exposure combined with asthma group compared to the control and asthma groups （P 〈0.01）. After allogeneic mixed lymphocyte responses, IL-4 expression was increased and IFN-gamma was decreased in the asthma group and the asthma combined with smoke exposure group compared to control group （P 〈0.01）. IL-4 expression was increased and IFN-gamma was decreased in the asthma combined with smoke exposure group compared to the asthma group （P 〈0.01）. The study also showed that MyD88 expression w

关键词： smoking, myeloid differentiation factor 88 dendritic cells asthma, lymphocyte activation

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Effects of simvastatin on cigarette smoke extract induced tissue-type plasminogen activator and plasminogen activator inhibitor-1 expression in human umbilical vein endothelial cells

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Chinese Medical Journal 2009年第19期122卷 2380-2385页

作者： hu xiao-yun MA Yu-hui WANG Chen YANG Yuan-hua Department of Respiration Medicine First Hospital Shanxi Medical University Taiyuan Shanxi 030001 China Department of Respiratory Medicine Beijing Chaoyang Hospital Beijing Institute of Respiratory Medicine Capital Medical University Beijing 100020 China

Background Cigarette smoking has an influence on both arterial-type and venous-type thrombosis. However, little is known about the direct effect of cigarette smoke extract （CSE） on fibrinolytic activity of human umbilical vein endothelial cells （huVECs）. Most recently, simvastatin has been marked in its effect on endothelial cells protection and anticoagulation. In this study, the effect of CSE on the expression of tissue-type plasminogen activator （t-PA） and plasminogen activator inhibitor-l（PAl-1） in huVECs was addressed. The role of simvastatin in CSE-induced fibrinolytic activity changes was investigated as well. Methods The fourth to fifth generation of huVECs were incubated respectively with 0, 5%, 10% and 20% CSE for 6 hours or exposed to 5% CSE for 0, 4, 6, 8, 12, 24 hours to determine the expression changes of t-PA and PAl-1 protein. Meanwhile, cells were also accordingly exposed either to 5% CSE alone or simvastatin pre-treated and 5% CSE for 24 hours to assess the role of simvastatin in CSE-induced t-PA and PAl-1 protein and mRNA expression in huVECs. RT-PCR and ELISA techniques were used for detecting the t-PA or PAl-1 mRNA and protein. Results After 6-hour exposure to CSE, the expression levels of t-PA protein in 10% and 20% CSE-treated groups reduced significantly （（0.0365±0.0083） ng/ml, （0.0255±0.0087） ng/ml） when compared with that of control group （（0.0660±0.0120） ng/ml）（P 〈0.05）. In contrast, the levels of PAl-1 protein in 5%, 10% and 20% CSE-treated groups increased remarkably （（13.3225±0.5680） ng/ml, （14.2675±1.5380） ng/ml, （14.4292±1.6230） ng/ml） when compared with that of control group （（8.5193_±0.7537）ng/ml）（P〈0.05）. After stimulation with 5% CSE for 0, 4, 6, 8, 12, 24 hours, the levels of PAl-1 protein increased over time and reached the peak at 24 hours （（14.6400±1.0651） ng/ml）, which was significantly higher than that of control group （（12.0656±0.6148） ng/ml）（P 〈0.05）. Additionally, CSE could up-regulate PAl-1 expression at both the mRNA

关键词： cigarette smoke extract simvastatin tissue-type plasminogen activator plasminogen activator inhibitor-1 human umbilical vascular endothelial cells

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与全身性感染相关急性肾损伤的诊断与治疗

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中国危重病急救医学 2010年第12期22卷 709-710页

作者：杜斌胡小芸北京协和医院 100750

全身性感染是重症监护病房（ICU）的常见临床综合征,常导致多器官功能衰竭.急性肾损伤（AKI）是全身性感染最常见的并发症之一.研究表明,严重全身性感染和感染性休克患者AKI的罹患率分别为19%和51%[1].肾脏支持治疗的开始与结束研究（BE... 详细信息

全身性感染是重症监护病房（ICU）的常见临床综合征,常导致多器官功能衰竭.急性肾损伤（AKI）是全身性感染最常见的并发症之一.研究表明,严重全身性感染和感染性休克患者AKI的罹患率分别为19%和51%[1].肾脏支持治疗的开始与结束研究（BEST-kidney研究）报道,全身性感染是ICU患者发生AKI的最常见原因（约占47.5%）[2].近期研究表明,与其他病因相比,感染相关AKI的发病机制有所不同,病情进展更迅速,肾脏损害更严重,ICU病死率更高[2].

关键词：严重全身性感染急性肾损伤支持治疗多器官功能衰竭 ICU患者诊断重症监护病房肾脏损害

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A male with chronic thromboembolic pulmonary hypertension caused by isolated noncompaction of ventricular myocardium

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Chinese Medical Journal 2012年第15期125卷 2797-2799页

作者： XING Ai-ping hu xiao-yun DU Yong-cheng LIU Zhi-hong ZHANG Li-qin Department of Respiration Medicine First Hospital ShanxiMedical University Taiyuan Shanxi 030001 China Department of Respiration Medicine the Provincial People'sHospital of Shanxi Province Taiyuan Shanxi 030012 China

Noncompaction of the ventricular myocardium （NVM） is a rare disease of endomyocardialmorphogenesis characterized by numerous, prominent trabeculations and deep intertrabecular recesses. It is commonly associated with congenital heart disease. Isolated noncompaction of the ventricular myocardium （INVM） is thought to be caused by arrest of normal embryogenesis of the endocardium and myocardimn. A significant amount of data on INVM are available for the left ventricle but right ventricular involvement is rare.

关键词： noncompaction, chronic thromboembolic pulmonary hypertension right ventricle

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Practical value of intravenous urography combined with add-on CT in diagnosina ureteral abnormalities

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Chinese Medical Journal 2012年第7期125卷 1287-1291页

作者： hu xiao-yun hu Chun-hong FANG Xiang-ming YAO Xuan-jun Alexander Lemer CHEN Hong-wei Zhu Zhong-ming Imaging Center First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215006China Imaging Center Wuxi People’s Hospital Affiliated to Nanjing Medical UniversityWuxiJiangsu 214023China

Background Intravenous urography （IVU） combined with add-on CT （IVU-CT） can help to provide more diagnostic information for determining the localization and nature of ureteral abnormalities with less irradiation dose. This study aimed to determine the value of IVU-CT for diagnosis of ureteral diseases, where IVU is insufficient to determine the diagnosis. Methods Two hundred and eighty patients underwent IVU for suspected ureteral disorders, which identified a definite diagnosis in 184 cases and was insufficient for definite diagnosis in 96 cases designated as indeterminate diagnosis. Subsequently 90 patients （six patients declined CT） with indeterminate diagnosis consented to undergo immediate or delayed helical CT scan. The CT data were transferred to the workstation for post-processing, and the cost and mean effective dose for each imaging method were calculated and compared indirectly. Results Of the 90 indeterminate diagnosis cases, diagnosis was determined in 86 cases by IVU-CT with a diagnostic accordance rate of 95.6%, while 184/280 （65.7%） had diagnosis determined by IVU alone. There was a significant difference between IVU and IVU-CT in the determination of the diagnosis of ureteral diseases （X2=36.4, P 〈0.05）. The cost of IVU equals to 1/8-1/9 of that for CT urography （CTU）, and the cost of IVU-CT is as much as 1/3 of CTU. CTU results in the highest mean effective dose, approximately nine times that for IVU and three times that for IVU-CT. Conclusion IVU-CT provides valuable information for the localization and diagnosis of ureteral abnormalities and may be considered as an efficient, cost-effective and low-dose diagnostic technique in this setting.

关键词： tomography ureteral disease urography diagnosis

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Receiver operating characteristic curve analysis for image quality in the detection of solitary pulmonary nodules on high resolution paper prints versus dry laser film

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Chinese Medical Journal 2013年第7期126卷 1378-1380页

作者： hu xiao-yun FANG Xiang-ming CAO Yang hu Chun-hong YAO Xuan-jun CHEN Hong-wei hu Su SHAO Ling hu Gang-feng Jiangsu Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection Medical College of Soochow University Suzhou Jiangsu 215123 China Imaging Center Wuxi People's Hospital Affiliated to Nanjing Medical University Wuxi Jiangsu 214023 China Department of Radiology Wuxi Huishan People's Hospital WuxiJiangsu 214187 China

Along with the development of digital X-ray imaging technology, a new, economical and practicalpaper-based output system gradually emerged. To reduce cost, more and more radiologic institutions began to change from film copies to lower-priced paper prints for documenting radiologic ***, laser paper printers are frequently used as an alternative to duplicating film though the use of printed images is not yet widespread. The aim of this study was to compare the practical value of high-resolution paper printer with dry film copies for detecting small solitary pulmonary nodules （SPNs）.

关键词： receiver operating characteristic paper printer solitary pulmonary nodule dry laser printer

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武器系统生存能力的稳定性分析

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火炮发射与控制学报 2009年第3期30卷 1-4页

作者：胡小云南昌陆军学院江西南昌330103

武器系统生存能力的稳定性直接影响到作战效能。在设定外部打击环境为调制外场的基础上,将武器系统的生存能力看成是时间的函数,建立了在一定初始条件下随着调制外场变化而改变的武器系统生存能力稳定性的数学模型,分析了如何相对初始... 详细信息

武器系统生存能力的稳定性直接影响到作战效能。在设定外部打击环境为调制外场的基础上,将武器系统的生存能力看成是时间的函数,建立了在一定初始条件下随着调制外场变化而改变的武器系统生存能力稳定性的数学模型,分析了如何相对初始生存能力保持其稳定的相应条件,即通过调节调制外场反作用特征量n和a来获得稳定的生存能力。因此,可以通过降低环境因素对武器系统的影响和改善武器系统自身的环境适应能力以提高武器系统生存能力,从而为武器系统研制以及提高武器系统作战能力提供理论指导。

关键词：信息科学与系统科学基础学科武器系统生存能力稳定性调制外场数学模型

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