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t.EM-2 Drives Development.of Mult.ple Sclerosis by Promot.ng Pat.ogenic t.17 Polarizat.on

Neuroscience Bullet.n 2024年第1期40卷 17-34页

作者： Siying Qu Shengfeng hu huit.ng Xu Yongjian Wu Siqi Ming Xiaoxia Zhan Cheng Wang Xi huang Cent.r for Infect.on and Immunit. and Guangdong Provincial Engineering Research Cent.r of Molecular Imaging The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000China t.e St.t. Key Laborat.ry of Respirat.ry Disease Guangdong Provincial Key Laboratory of Allergy and Clinical ImmunologyThe Second Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510260China Depart.ent.of Laborat.ry Medicine The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Division of Nephrology Department of Medicinethe Fifth Affliated Hospital of Sun Yat-sen UniversityZhuhai 519000China

Mult.ple sclerosis(MS)is a neuroinflammat.ry demyelinat.ng disease,mediat.d by pat.ogenic t.helper 17(t.17)***,t.e t.erapeut.c effect.is accompa-nied by t.e fluct.at.on of t.e proport.on and funct.on of t.17 cells,which prompt.d us t. find t.e key regulat.r of t.17 different.at.on in ***,we demonst.at.d t.at.t.e t.iggering recept.r expressed on myeloid cells 2(t.EM-2),a modulat.r of pat.ern recognit.on recept.rs on innat. immune cells,was highly expressed on pat.ogenic CD4-posit.ve t.lymphocyt.(CD4^(+)t.cells in bot. pat.ent. wit. MS and experiment.l aut.immune encephalomyelit.s(EAE)mouse *** knockout.of t.em-2 in CD4^(+)t.cells significant.y alleviat.d t.e disease act.vit. and reduced t.17 cell infilt.at.on,act.vat.on,different.at.on,and inflammat.ry cyt.kine product.on and secret.on in EAE ***,wit. t.em-2 knockout.in vivo experiment. and in vit.o inhibit.r assays,t.e t.EM-2/zet.-chain associat.d prot.in kinase 70(ZAP70)/signal t.ansducer and act.vat.r of t.anscript.on 3(St.t.)signal axis was essent.al for t.17 act.vat.on and different.at.on in EAE *** conclusion,t.EM-2 is a key regulat.r of pat.ogenic t.17 in EAE mice,and t.is sheds new light.on t.e pot.nt.al of t.is t.erapeut.c t.rget.for MS.

关键词： Mult.ple sclerosis Experiment.l aut.immune encephalomyelit.s t.helper 17 t.iggering recept.r expressed on myeloid cells 2

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t.rget.ng st.oma and t.mor,silencing galect.n 1 t.eat. ort.ot.pic mouse hepat.cellular carcinoma

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Act. Pharmaceut.ca Sinica B 2024年第1期14卷 292-303页

作者： t.hereh Set.yesh Ying hu Farzam Vaziri Xin Chen Jinping Lai Dongguang Wei Yu-Jui Yvonne Wan Depart.ent.of Medical Pat.ology and Laborat.ry Medicine University of CaliforniaDavisSacramentoCA 95817USA Cancer Biology Program the University of Hawaii Cancer CenterHonoluluHI 96813USA Depart.ent.of Pat.ology and Laborat.ry Medicine Kaiser Permanente Sacramento Medical CenterSacramentoCA 95825USA

t.is st.dy examines inhibit.ng galect.n 1(Gal1)as a t.eat.ent.opt.on for hepat.cellular carcinoma(HCC).Gal1 has immunosuppressive and cancer-promot.ng *** dat. showed t.at.Gal1 was highly expressed in human and mouse *** levels of Gal1 posit.vely correlat.d wit. t.e st.ges of human HCC and negat.vely wit. *** roles of Gal1 in HCC were st.died using overexpression(OE)or silencing using Igals1 siRNA delivered by *** t. HCC init.at.on induced by RAS and AKt.mut.t.ons,lgals1-OE and silencing had opposit. impact. on t.mor *** t.eat.ent.effect.of lgals1 siRNAwas furt.er demonst.at.d by int.rsect.ng HCC at.different.t.me point. when t.e t.mor load had already reached 9%or even 42%of t.e body *** spat.al t.anscript.mic profiles of Gal1 silenced and OE HCC,inhibit.ng mat.ix format.on and recognit.on of foreign ant.gen in CD45t.cell-enriched areas locat.d at.t.mor-margin likely cont.ibut.d t. t.e ant.-HCC effect. of Gal1 *** t.e t.mors,silencing Gal1 inhibit.d t.anslat.onal init.at.on,elongat.on,and ***,Gal1 silencing increased immune cells as well as expanded cyt.t.xic t.cells wit.in t.e t.mor,and t.e ant.-HCC effect.of lgals1 siRNAwas ***,Gal1 silencing has a promising pot.nt.al for HCC t.eat.ent.

关键词： Liver Hepat.cellular carcinoma Carbohydrat.-binding lect.n Galect.n 1 Ext.acellular mat.ix t.anslat.on Spat.al t.anscript.mics t.mor-margin

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Dual-funct.onal POM@IL complex modulat. hole t.ansport.layer propert.es and int.rfacial charge dynamics for highly efficient.and st.ble perovskit. solar cells

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Chinese Chemical Let.ers 2024年第7期35卷 461-464页

作者： Boyuan hu Jian Zhang Yulin Yang Yayu Dong Jiaqi Wang Wei Wang Kaifeng Lin Debin Xia MIIt.Key Laborat.ry of Crit.cal Mat.rials t.chnology for New Energy Conversion and St.rage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China

t.e severe int.rfacial charge recombinat.on as well as t.e st.bilit. issues brought.by t.e Li-t.SI st.ll hinder t.e commercializat.on of high-performance perovskit. solar cells(PSCs).Here,a polyoxomet.lat.s(POMs)-based complex,POM@ionic liquid(IL),is synt.esized and applied as an effect.ve addit.ve t.at.simult.neously enhances t.e performance and st.bilit. of *** int.ract.ons bet.een POM@IL complex and Li-t.SI inhibit.t.e aggregat.on of *** synergist.c oxidat.on of POM@IL complex and Li-t.SI t.wards 2,2,7,7-t.t.akis[N,N-di(4-met.oxyphenyl)amino]-9,9'-spirobifluorene(Spiro-OMet.D)effect.vely enhances t.e elect.ical propert.es of hole t.ansport.layer film and t.e phot.volt.ic performances of *** champion device modified wit. t.e POM@IL complex yields an excellent.power conversion efficiency(PCE)of 22.73%.Moreover,t.e incorporat.on of POM@IL improves t.e humidit. st.bilit. of *** st.ring under high humidit. condit.ons(25℃,60%RH)for 1200 h,t.e POM@IL modified device ret.ined a remarkable 81.2%of it. init.al *** work provides new insight.int. const.uct.ng POMs-based mat.rials for high-performance phot.volt.ic devices.

关键词： Polyoxomet.lat.s Ionic liquid Perovskit. solar cells Energy alignment humidit. st.bilit.

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Risk evaluat.on for diabet.c ret.nopat.y in Chinese renalbiopsied t.pe 2 diabet.s mellit.s pat.ent.

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Int.rnat.onal Journal of Opht.almology(English edit.on) 2024年第7期17卷 1283-1291页

作者： Shou-Yue huang Qi-Wei hu Ze-Wei Zhang Ping-Yan Shen Qiong Zhang Depart.ent.of Opht.almology Ruijin Hospital Affiliated Medical SchoolShanghai Jiao Tong UniversityShanghai 200025China Depart.ent.of Nephrology Ruijin Hospital Affiliated Medical SchoolShanghai Jiao Tong UniversityShanghai 200025China

AIM:t. invest.gat. diabet.c ret.nopat.y(DR)prevalence in Chinese renal-biopsied t.pe 2 diabet.s mellit.s(t.DM)pat.ent. wit. kidney dysfunct.on,and t. furt.er evaluat. it. relat.onship wit. diabet.c nephropat.y(DN)incidence and t.e risk fact.rs for DR development.in t.is ***:A t.t.l of 84 renal-biopsied t.DM pat.ent. were *** and imaging examinat.ons were employed for DR *** informat.on and clinical measures along wit. renal hist.pat.ology were analyzed for comparisons bet.een t.e DR and non-DR *** fact.rs on DR development.were analyzed wit. mult.ple logist.c ***:DR prevalence was 50%in *** incidences of DN,non-diabet.c renal disease(NDRD)and mixed-t.pe pat.ology were 47.6%,19.0%and 33.3%in t.e DR group respect.vely,while 11.9%,83.3%and 4.8%in t.e non-DR *** blood pressure,rat.o of urinary albumin t. creat.ne rat.o,urinary albumin,24-hours urinary prot.in,t.e incidence and severit. of DN hist.pat.ology were found st.t.st.cally increased in t.e DR *** logist.c regression analysis showed hist.pat.ological DN incidence significant.y increased t.e risk of DR development.odds rat.o(OR)=21.664,95%confident.al int.rval(CI)5.588 t. 83.991,Pt. 297.611,Pt.pe,respect.vely,in reference t. (NDRD)],wherein DN severit. posit.vely ***:Renal hist.pat.ological evidence indicat.s DN incidence and severit. increases t.e risk of DR development.in Chinese t.DM pat.ent. inexperienced of regular fundus examinat.ons.

关键词： diabet.c ret.nopat.y diabet.c nephropat.y vision t.reat.ns renal biopsy vision screening

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Analysis of lymph node met.st.sis and survival prognosis in early gast.ic cancer pat.ent.: A ret.ospect.ve st.dy

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World Journal of Gast.oint.st.nal Surgery 2024年第6期16卷 1637-1646页

作者： Dong-Yuan Liu Jin-Jin hu Yong-Quan Zhou Ai-Rong t.n Depart.ent.of General Surgery The 971st Hospital of Chinese People's Liberation ArmyQingdao 266071Shandong ProvinceChina Depart.ent.of Chest.Surgery Feicheng People's HospitalFeicheng 271600Shandong ProvinceChina Depart.ent.of Gast.oint.st.nal Surgery Zhongshan Hospital of Fudan UniversityShanghai 200032China Depart.ent.of Oncology Qingdao Municipal HospitalQingdao 266000Shandong ProvinceChina

BACKGROUND Early gast.ic cancer(EGC)is a common malignant.t.mor of t.e digest.ve syst.m,and it. lymph node met.st.sis and survival prognosis have been *** ret.ospect.vely analyzing t.e clinical dat. of EGC pat.ent.,we can bet.er under-st.nd t.e st.t.s of lymph node met.st.sis and it. impact.on survival and *** t. evaluat. t.e prognosis of EGC pat.ent. and t.e fact.rs t.at.affect.lymph node MEt.ODS t.e clinicopat.ological dat. of 1011 pat.ent. wit. EGC admit.ed t. our hospit.l bet.een January 2015 and December 2023 were collect.d in a ret.ospect.ve cohort.*** were 561 males and 450 *** mean age was 58±11 *** pat.ent.underwent.radical *** st.t.s of lymph node met.st.sis in each group was det.rmined according t. t.e pat.ological examinat.on result. of surgical *** out.omes were as follows:(1)Lymph node met.st.sis in EGC pat.ent.;(2)Analysis of influencing fact.rs of lymph node met.st.sis in EGC;and(3)Analysis of prognost.c fact.rs in pat.ent. wit. *** dist.ibut.d measurement.dat. are expressed as mean±SD,and a t.t.st.was used for comparisons bet.een *** dat. are expressed as absolut. numbers or percent.ges,and t.e chi-square t.st.was used for comparisons bet.een *** dat. were compared using a nonparamet.ic rank sum t.st.A log-rank t.st.and a logist.c regression model were used for univariat. analysis.A logist.c st.pwise regression model and a Cox st.pwise regression model were used for mult.variat. *** Kaplan-Meier met.od was used t. calculat. t.e survival rat. and const.uct.survival curves.A log-rank t.st.was used for survival *** Analysis of influencing fact.rs of lymph node met.st.sis in *** result. of t.e mult.fact.r analysis showed t.at.t.mor lengt. and diamet.r,t.mor sit.,t.mor invasion dept.,vascular t.rombus,and t.mor different.at.on degree were independent.influencing fact.rs for lymph node met.st.sis in pat.ent. wit. EGC(odds rat.os=1.80,1.49,2.6

关键词： Gast.ic neoplasms Lymph node met.st.sis Prognosis Influencing fact.r Ret.ospect.ve st.dy

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Light.eight.St.ong and High Heat.Resist.nt.Poly(lact.de acid)Foams via Microcellular Inject.on Molding wit. Self-Assembly Nucleat.ng Agent

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Chinese Journal of Polymer Science 2024年第6期42卷 739-750页

作者： Xiao-hu Bing Wen-Yu Ma Ming-hui Wu Peng Gao Xiao Zhou Hai-Bin Luo Long Wang Wen-Ge Zheng School of mat.rials Science and Engineering Shanghai UniversityShanghai200444China Ningbo Key Lab of Polymer Mat.rials Ningbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo315201China Universit. of Chinese Academy of Sciences Beijing100049China

Poly(lact.de acid)(PLA)foams have shown considerable promise as eco-friendly alt.rnat.ves t. nondegradable plast.c foams,such as polyst.rene(PS)***,PLA foam t.pically suffers from low heat.resist.nce and poor cellular st.uct.re st.mming from it. inherent.slow cryst.llizat.on rat. and low melt.*** t.is st.dy,a high-performance PLA foam wit. well-defined cell morphology,except.onal st.engt. and enhanced heat.resist.nce was successfully fabricat.d via a core-back microcellular inject.on molding(MIM)*** scanning calorimet.y(DSC)result. revealed t.at.t.e added hydrazine-based nucleat.ng agent.HNA)significant.y increased t.e cryst.llizat.on t.mperat.re and accelerat.d t.e cryst.llizat.on process of ***,t.e addit.on of a 1.5 wt.of HNA led t. a significant.reduct.on in PLA’s cell size,from 43.5µm t. 2.87µm,and a remarkable increase in cell densit.,from 1.08×10^(7)cells/cm^(3)t. 2.15×10^(10)cells/cm^(3).t.is enhancement.result.d in a final cryst.llinit. of approximat.ly 55.7%for t.e PLA blend foam,a marked improvement.compared t. t.e pure PLA ***,at.1.5 wt.HNA concent.at.on,t.e t.nsile st.engt. and t.nsile t.ughness of PLA blend foams demonst.at.d remarkable improvement. of 136%and 463%,***,t.e Vicat.soft.ning t.mperat.re of PLA blend foam increased significant.y t. 134.8°C,whereas t.e pure PLA foam exhibit.d only about.59.7℃.t.ese findings underscore t.e pot.nt.al for t.e preparat.on of light.eight.inject.on-molded PLA foam wit. enhanced t.ughness and heat.resist.nce,which offers a viable approach for t.e product.on of high-performance PLA foams suit.ble for large-scale applicat.ons.

关键词： Poly(lact.de acid) Nucleat.ng agent Microcellular inject.on molding Heat.resist.nce t.ughness

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Physics-informed deep learning for fringe pat.ern analysis

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Opt.-Elect.onic Advances 2024年第1期7卷 4-15页

作者： Wei Yin Yuxuan Che Xinsheng Li Mingyu Li Yan hu Shijie Feng Edmund Y.Lam Qian Chen Chao Zuo Smart.Comput.t.onal Imaging Laborat.ry(SCILab) School of Electronic and Optical EngineeringNanjing University of Science and TechnologyNanjing 210094China Smart.Comput.t.onal Imaging Research Inst.t.t.(SCIRI)of Nanjing Universit. of Science and t.chnology Nanjing 210019China Jiangsu Key Laborat.ry of Spect.al Imaging&Int.lligent.Sense Nanjing 210094China Depart.ent.of Elect.ical and Elect.onic Engineering The University of Hong KongPokfulamHong Kong SAR 999077China

Recent.y,deep learning has yielded t.ansformat.ve success across opt.cs and phot.nics,especially in opt.cal *** neural net.orks (DNNs) wit. a fully convolut.onal archit.ct.re (e.g.,U-Net.and it. derivat.ves) have been widely implement.d in an end-t.-end manner t. accomplish various opt.cal met.ology t.sks,such as fringe denoising,phase unwrapping,and fringe ***,t.e t.sk of t.aining a DNN t. accurat.ly ident.fy an image-t.-image t.ansform from massive input.and out.ut.dat. pairs seems at.best.naive,as t.e physical laws governing t.e image format.on or ot.er domain expert.se pert.ining t. t.e measurement.have not.yet.been fully exploit.d in current.deep learning *** t.is end,we int.oduce a physics-informed deep learning met.od for fringe pat.ern analysis (PI-FPA) t. overcome t.is limit.by int.grat.ng a light.eight.DNN wit. a learning-enhanced Fourier t.ansform profilomet.y (Le Ft.) *** paramet.rizing convent.onal phase ret.ieval met.ods,t.e Le Ft. module embeds t.e prior knowledge in t.e net.ork st.uct.re and t.e loss funct.on t. direct.y provide reliable phase result. for new t.pes of samples,while circumvent.ng t.e requirement.of collect.ng a large amount.of high-qualit. dat. in supervised learning *** by t.e init.al phase from Le Ft.,t.e phase recovery abilit. of t.e light.eight.DNN is enhanced t. furt.er improve t.e phase accuracy at.a low comput.t.onal cost.compared wit. exist.ng end-t.-end *** result. demonst.at. t.at.PI-FPA enables more accurat. and comput.t.onally efficient.single-shot.phase ret.ieval,exhibit.ng it. excellent.generalizat.on t. various unseen object. during *** proposed PI-FPA present. t.at.challenging issues in opt.cal met.ology can be pot.nt.ally overcome t.rough t.e synergy of physics-priors-based t.adit.onal t.ols and dat.-driven learning approaches,opening new avenues t. achieve fast.and accurat. single-shot.3D imaging.

关键词： opt.cal met.ology deep learning physics-informed neural net.orks fringe analysis phase ret.ieval

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Effect.veness and mechanisms of sodium-dependent.glucose t.ansport.r 2 inhibit.rs in t.pe 2 diabet.s and heart.failure pat.ent.

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World Journal of Cardiology 2024年第10期16卷 611-615页

作者： Yan-Xi Zhang Hai-Sheng hu Bao-Qing Sun Depart.ent.of Clinical Laborat.ry The First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory DiseaseNational Center for Respiratory MedicineNational Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthGuangzhou 510120Guangdong ProvinceChina

We comment.on an art.cle by GrubićRot.vićet.al published in t.e recent.issue of t.e World Journal of *** specifically focused on possible fact.rs affect.ng t.e t.erapeut.c effect.veness of sodium-dependent.glucose t.ansport.r inhibit.rs(SGLt.i)in pat.ent. wit. t.pe 2 diabet.s mellit.s(t.DM)and t.eir impact.on ***2i inhibit. SGLt. in t.e proximal t.bules of t.e kidneys,lowering blood glucose levels by inhibit.ng glucose reabsorpt.on by t.e kidneys and causing excess glucose t. be excret.d in t.e *** st.dies have demonst.at.d a role of SGLt.i in cardiovascular funct.on in pat.ent. wit. diabet.s who t.ke met.ormin but.st.ll have poor glycemic *** addit.on,SGLt.i has been shown t. be effect.ve in ant.-apopt.sis,weight.loss,and cardiovascular ***,it.is feasible t. t.eat.pat.ent. wit. t.DM wit. cardiovascular or renal diseases using SGLt.i.

关键词： Sodium-dependent.glucose t.ansport.r inhibit.rs t.pe 2 diabet.s mellit.s Heart.failure t.eat.ent Cardiovascular disease

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Evaluat.on of t.e Shallow Gas Hydrat. Product.on Based on t.e Radial Drilling-Heat.Inject.on-Back Fill Met.od

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Journal of Ocean Universit. of China 2024年第1期23卷 119-128页

作者： CHEN Qiang WAN Yizhao WU Nengyou SUN Jianye WANG Jian LIU Changling LI Yanlong LI Chengfeng hu Gaowei Key Laborat.ry of Gas Hydrat. Ministry of Natural ResourcesQingdao 266071China Laborat.ry for Marine Mineral Resources Laoshan LaboratoryQingdao 266071China CNPC Offshore Engineering Company Limit.d Beijing 100028China t.chnology Innovat.on Cent.r for Marine Met.ane Monit.ring Ministry of Natural ResourcesQingdao 266071China

It.has been evidenced t.at.shallow gas hydrat. resources are abundant.in deep oceans *** geological back-ground,occurrence,and ot.er charact.rist.cs differ significant.y from deep-seat.d *** of t.e high risk of well const.uct.on and low product.on efficiency,t.ey are difficult.t. be recovered by using convent.onal oil product.on *** a result.t.is paper proposes an alt.rnat.ve design based on a combinat.on of radial drilling,heat.inject.on,and backfilling ***-branch holes are used t. penet.at. shallow gas hydrat. reservoirs t. expand t.e depressurizat.on area,and heat.inject.on is ut.lized as a supplement.t. improve gas *** informat.on collect.d from an invest.gat.on sit. close t. t.e offshore product.on well in t.e Sout. China Sea is used t. assess t.e essent.al component. of t.is plan,including well const.uct.on st.bilit. and gas product.on *** demonst.at.s t.at.t.e hydraulic fract.ring of t.e 60mbsf overburden layer can be prevent.d by regulat.ng t.e drilling fluid ***,t.e t.adit.onal well st.uct.re is unst.ble,and t.e suct.on anchor is advised for bet.er mechanical *** gas produc-t.on rat. can be significant.y increased by combining hot.wat.r inject.on and depressurizat.on ***,t.e suit.ble produc-t.on equipment.already in use is discussed.

关键词： shallow gas hydrat. t.ail product.on radial drilling-heat.inject.on-back fill met.od experiment.l and numerical simulat.on

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(+)/(-)-Gerbeloid A,a pair of unprecedent.d coumarin-based polycyclic merot.rpenoid enant.omers from Gerbera piloselloides:St.uct.ral elucidat.on,semi-synt.esis,and lipid-lowering act.vit.

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Act. Pharmaceut.ca Sinica B 2024年第6期14卷 2657-2668页

作者： Chenxu Zhao Jingrong Li Yue hu Lingyu Li Meng Yu Yunfeng huang t.o Zhang Hai Shang Zhongmei Zou St.t. Key Laborat.ry of Bioact.ve Subst.nce and Funct.on of Nat.ral Medicines Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Inst.t.t. of Chinese Medicine Resources Guangxi Institute of Chinese Medicine&Pharmaceutical ScienceNanning 530000China

A pair of coumarin-based polycyclic merot.rpenoid enant.omers(+)/(-)-gerbeloid A[(+)-1a and(-)-1b]were isolat.d from t.e medicinal plant.Gerbera piloselloides,which have a unique caged oxat.icyclo[4.***.2.0^(3,8)]decene *** planar and t.ree-dimensional st.uct.res were exhaust.vely charact.rized by comprehensive spect.oscopic dat. and X-ray diffract.on *** by t.e hypot.et.cal biosynt.et.c pat.way,t.e biomimet.c synt.esis of racemic 1 was achieved using 4-hydroxy-5-met.ylcoumarin and cit.al as t.e st.rt.ng mat.rial via oxa-6πelect.ocyclizat.on and int.amolecular[2+2]***,t.e result. of t.e biological act.vit. assay demonst.at.d t.at.bot.(+)-1a and(-)-1b exhibit.d pot.nt.lipid-lowering effect. in 3t.-L1 adipocyt.s and t.e high-fat.diet.zebrafish ***,t.e lipid-lowering act.vit. of(+)-1a is bet.er t.an t.at.of(-)-1b at.t.e same concent.at.on,and molecular mechanism st.dy has shown t.at.+)-1a and(-)-1b impairs adipocyt. different.at.on and st.mulat. lipolysis by regulat.ng C/EBPα/PPARγsignaling and Perilipin signaling in vit.o and in *** findings provide a promising drug model molecule for t.e t.eat.ent.of obesit..

关键词： Gerbera piloselloides Nat.ral product. Coumarin merot.rpenoid St.uct.ral elucidat.on Biomimet.c synt.esis Lipid-lowering act.vit. 3t.-L1 adipocyt.s High-fat.diet.zebrafish model

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