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Diurnal Variability of Precipitation Depth Over the Tibetan Plateau and Its Surrounding Regions

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Advances in Atmospheric Sciences 2010年第1期27卷 115-122页

作者：胡亮 Song YANG 李耀东高守亭 Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 Graduate University of Chinese Academy of Sciences Beijing 100049 I. M. Systems Group at NOAA/NESDIS Camp Springs MD Beijing Aviation Meteorological Institute Beijing 100085

The diurnal variability of precipitation depth over the Tibetan Plateau and its surrounding regions is investigated using nine years of Tropical Rainfall Measuring Mission （TRMM） precipitation radar （PR） measurements. The Tibetan Plateau, the plains area, and the East China Sea are selected as the focus regions in this study. The average precipitation depths （PD） are about 4.6 km, 5.8 km, and 5.6 km, while convective （stratiform） PDs are about 6.6 （4.5） km, 7.5 （5.7） km, and 6.0 （5.6） km over the plateau, the plains, and the ocean region, respectively. Results demonstrate a prominent PD diurnal cycle, and its diurnal phase is generally a few hours behind the surface precipitation. The spatial variation of the PD diurnal magnitude is weaker near the coastal areas than that of surface precipitation. The height of the PD diurnal peak is around 6 7 km for convective systems and 5-6 km for stratifrom systems. The dominant afternoon diurnal peak for convective PD and the flat diurnal peak for stratiform PD over the Tibetan Plateau indicate that solar diurnal forcing is the key mechanism of the PD diurnal cycle over land. In addition, the diurnal variation is obvious for shallow and deep convective systems, but not for shallow and deep stratiform systems.

关键词： precipitation depth diurnal variability total rain convective rain stratiform rain

Altered gut microbiota composition in children and their caregivers infected with the SARS‑CoV‑2 Omicron variant

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World Journal of Pediatrics 2023年第5期19卷 478-488页

作者： Yi‑Zhong Wang Jian‑Guo Zhou Yan‑Ming Lu hui hu Fang‑Fei Xiao Ting Ge Xing Wang Lu Zheng lian‑hu Yu Jun Le hui Yu Guang‑Jun Yu Qiang Xia Ting Zhang Wen‑Hao Zhou Department of Gastroenterology Hepatologyand NutritionShanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong University355 Luding RoadShanghai 200062China Gut Microbiota and Metabolic Research Center Institute of Pediatric InfectionImmunity and Critical Care MedicineSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neonatology Children’s Hospital of Fudan UniversityShanghaiChina Department of Pediatrics Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityShanghaiChina Department of Liver Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Birth Defects Department of NeonatologyMolecular Medical CenterChildren’s Hospital of Fudan University399 Wanyuan RoadShanghai 201101China

Background Gut microbiota alterations have been implicated in the pathogenesis of coronavirus disease 2019(COVID-19).This study aimed to explore gut microbiota changes in a prospective cohort of COVID-19 children and their asymptomatic caregivers infected with the severe acute respiratory syndrome coronavirus type 2(SARS-CoV-2)Omicron *** A total of 186 participants,including 59 COVID-19 children,50 asymptomatic adult caregivers,52 healthy children(HC),and 25 healthy adults(HA),were recruited between 15 April and 31 May *** gut microbiota composition was determined by 16S rRNA gene sequencing in fecal samples collected from the *** microbiota functional profling was performed by using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States(PICRUSt)*** The gut microbiota analysis of beta diversity revealed that the fecal microbial community of COVID-19 children remained far distantly related to *** relative abundances of the phyla Actinobacteria and Firmicutes were decreased,whereas Bacteroidetes,Proteobacteria,and Verrucomicrobiota were increased in COVID-19 *** from COVID-19 children exhibited notably lower abundances of the genera Blautia,Bifdobacterium,Fusicatenibacter,Streptococcus,and Romboutsia and higher abundances of the genera Prevotella,Lachnoclostridium,Escherichia-Shigella,and Bacteroides than those from *** enterotype distributions of COVID-19 children were characterized by a high prevalence of enterotype *** changes in gut microbiota compositions were observed in asymptomatic ***,the microbial metabolic activities of KEGG(Kyoto Encyclopedia of Genes and Genomes)and COG(cluster of orthologous groups of proteins)pathways were perturbed in feces from subjects infected with the SARS-CoV-2 Omicron *** Our data reveal altered gut microbiota compositions in both COVID-19 children and their asymptomatic caregivers infected with

关键词： Caregivers Children Coronavirus disease 2019(COVID-19) Gut microbiota Severe acute respiratory syndrome coronavirus type 2(SARS-CoV-2)

贫困地区农民专业合作社与农户收入增长——基于双重差分法的实证分析

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财经科学 2014年第12期 117-126页

作者：胡联安徽财经大学经济学院

合作社一直被人们视为一个由贫困群体通过自助和互助而实现脱贫的理想载体。本文通过DID模型对贫困地区农民专业合作社对农户收入增长的影响进行实证分析。研究发现:(1)贫困地区农民专业合作社促进了农户收入增长;(2)通过分位数回归,结... 详细信息

合作社一直被人们视为一个由贫困群体通过自助和互助而实现脱贫的理想载体。本文通过DID模型对贫困地区农民专业合作社对农户收入增长的影响进行实证分析。研究发现:(1)贫困地区农民专业合作社促进了农户收入增长;(2)通过分位数回归,结果表明贫困地区农民专业合作社对不同分位数农户收入增长的影响存在差异性,高收入农户的收入增幅更大;(3)贫困农户人均资产影响了农民专业合作社对农户收入增长的促进作用。

关键词：贫困地区专业合作社 DID方法分位数回归

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农民工子女教育的社会援助效果

统计与信息论坛 2016年第1期31卷 69-74页

作者：胡联安徽财经大学经济学院安徽蚌埠233030

农民工子女教育问题本质上是"三农"问题在教育领域的延伸。农民工子女是教育弱势群体,而社会援助能有效解决农民工子女教育面临社会支持不足的问题。运用双重差分模型和三重差分模型评估获得社会援助对农民工子女学业成绩产生的影响,研... 详细信息

农民工子女教育问题本质上是"三农"问题在教育领域的延伸。农民工子女是教育弱势群体,而社会援助能有效解决农民工子女教育面临社会支持不足的问题。运用双重差分模型和三重差分模型评估获得社会援助对农民工子女学业成绩产生的影响,研究结果表明:获得社会援助有助于农民工子女的学业成绩提高;成绩差的农民工子女的社会援助效果更好;心理援助和物质援助相结合对农民工子女学业成绩的促进作用更大,尤其是对成绩差的农民工子女。

关键词：农民工子女教育社会援助双重差分三重差分

Method for measuring the steering wheel angle of paddy field agricultural machinery by integrating RTK-GNSS and dual-MEMS gyroscope

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International Journal of Agricultural and Biological Engineering 2022年第6期15卷 197-205页

作者： Pei Wang lian hu Jie He Siqi Ke Zhongxian Man Tuanpeng Tu Luning Yang Yuanyuan Li Yanling Yi Weicong Li Xiwen Luo College of Engineering South China Agricultural UniversityGuangzhou 510642China Key Laboratory of Key Technology on Agricultural Machine and Equipment Ministry of EducationSouth China Agricultural UniversityGuangzhou 510642China Guangdong Provincial Key Laboratory for Agricultural Artificial Intelligence(GDKL-AAI) Guangzhou 510642China Maoming Branch Guangdong Laboratory for Lingnan Modern AgricultureMaoming 525000GuangdongChina

Aiming at the application environment of paddy agricultural machinery with bumpy and undulating changes,the problems affecting the method for steering wheel angle measurement by MEMS gyroscope were analyzed,and a wheel angle measurement method combining Dual-MEMS gyroscope(dual MEMS gyroscope)and RTK-GNSS was *** adaptive weighting method was used to fuse the heading angle differentiation of RTK-GNSS,the MEMS gyroscope angle rate,and velocity data,and the rod-arm compensation was performed to accurately obtain the angle rates of the body and steering wheels of agricultural machinery;the difference between the combined angular rate of the steering wheel of the agricultural machinery and the angular rate of the agricultural machinery body was obtained,and the integrator is used to integrate the difference to get the wheel steering angle value,and the Kalman filter was designed to make feedback correction for the integration process of angle calculation to eliminate the errors caused by the gyroscope zero bias,random drift,and gyroscope rod arm effect,and to obtain the accurate value of wheel steering angle.A comparative test with the connecting rod wheel angle sensor was designed,and the results show that the maximum deviation is 4.99°,the average absolute average value is 1.61°,and the average standard deviation is 0.98°.The method in this study and the connecting rod wheel angle sensor were used on paddy farm *** wheel angle measurement deviation of the proposed method and the connecting rod wheel angle sensor was not more than 1°,which is relatively *** has good stability,speed adaptability,and dynamic responsiveness that meets the accuracy requirements of steering wheel angle measurement for paddy field agricultural machinery unmanned driving and can be used instead of connecting rod angle sensors for unmanned agricultural machinery.

关键词： steering wheel angle MEMS gyroscope Kalman filter agricultural machinery navigation agricultural machinery

Jrokinase-type plasminogen activator： a new target for male contraception？

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Asian Journal of Andrology 2015年第2期17卷 269-273,I0009页

作者： Ying Qin Yan Han Cheng-liang Xiong Hong-Gang Li lian hu Ling Zhang Family Planning Research Institute Tongji Medical College Huazhong University of Science and Technology Wuhan China.

Urokinase-type plasminogen activator （uPA） is closely related to male reproduction. With the aim of investigating the possibility for uPA as a potential contraceptive target, in the present work, Kunming male mice were immunized by human uPA subcutaneous injection at three separate doses for 3 times. Then the potency of the anti-human uPA antibody in serum was analyzed, and mouse fertility was evaluated. Serum antibody titers for human uPA in immunized groups all reached 1：10,240 or higher levels by enzyme linked immunosorbent assay, and mating experiments revealed that pregnancy rates and the mean number of embryos implanted after mating declined obviously （P 〈 0.05） when compared with control groups. However, the mating capacity and reproductive organ weights had no obvious change, and histological analysis of the testes and epididymides also showed normal morphology for immunized male mice. Sperm function tests suggested that the sperm concentration, sperm viability, sperm motility, and in vitro fertilization rate for the cauda epididymis sperm in uPA-immunized groups were lower than those in the controls （P 〈 0.05）. Together, these observations indicated that subcutaneous injection human uPA to the male mice could effectively reduce their fertility, and uPA could become a new target for immunocontraception in male contraceptive development.

关键词： contraception male mouse urokinase-type plasminogen activator

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罕见病药物政策和药物经济学研究的特征

国际药学研究杂志 2019年第9期46卷 652-658页

作者：胡善联复旦大学公共卫生学院

当前,在罕见病药物发展中,有诸多问题面临着挑战。本文通过介绍罕见病治疗的伦理基础、孤儿药经济学研究的特殊性、孤儿药报销对医保基金的风险、平衡孤儿药的可及性和费用控制的国际经验,以及中国香港特区颁布的罕见病药物目录和中国... 详细信息

当前,在罕见病药物发展中,有诸多问题面临着挑战。本文通过介绍罕见病治疗的伦理基础、孤儿药经济学研究的特殊性、孤儿药报销对医保基金的风险、平衡孤儿药的可及性和费用控制的国际经验,以及中国香港特区颁布的罕见病药物目录和中国罕见病药物医保现状,基于中国已公布罕见病目录和临床急需进口的抗肿瘤和孤儿药物现状,以及国际对于罕见病高价药物控费的经验,探讨了其对未来医疗保险可能带来的影响。从不同角度分析美国孤儿药法案、英国国家卫生和临床技术优化研究所高特技术新概念、爱尔兰国家药物经济学中心对不含抗肿瘤孤儿药药物经济学回顾性评阅、瑞典药物评估中心对孤儿药评价原则、土耳其对进口罕见病药物的专题研究、韩国对高价药费用控制的4种措施等实践经验,以期为中国罕见病药物政策的制定以及相关药物经济学发展提供借鉴。

关键词：罕见病孤儿药药物政策药物经济学研究

Static and modal analyzing for the working table components of a machining center in ANSYS

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Computer Aided Drafting,Design and Manufacturing 2012年第2期22卷 59-62页

作者： XIA lian hu Chunyang HAN Jiang School of Mechanical and Automotive Engineering Hefei University of Technology Hefei 230009 China

In this paper, modal analysis theory, equivalent dynamic model of the joint surface of assembly and identification methods of joint surface parameters are the main theories. Static and modal analysis of the working table components of the FM6324 machining center is done. The three-dimensional model of the working table components is established using Pro E at first, then static characteristics is obtained through ANSYS contact analysis; finally, the dynamic model is established in ANSYS, and its dynamic characteristics is obtained through ANSYS modal analysis.

关键词： assembly ANSYS static analysis modal analysis

Hepatitis C virus cure with direct acting antivirals: Clinical,economic, societal and patient value for China

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World Journal of Hepatology 2019年第5期11卷 421-441页

作者： Qing Xie Jian-Wei Xuan Hong Tang Xiao-Guang Ye Peng Xu I-Heng Lee Shan-lian hu Department of Infectious Diseases Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China Health Economic Research Institute School of PharmacySun Yat-Sen UniversityGuangzhou 510006Guangdong ProvinceChina Center of Infectious Diseases West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Second Affiliated Hospital of Guangzhou Medical University Guangzhou 510260Guangdong ProvinceChina Gilead Sciences Inc Shanghai 200122China Gilead Sciences Inc Foster CityCA 94404United States School of Public Health Fudan UniversityShanghai 200032China Shanghai Health Development Research Center Shanghai 200032China

About 10 million people in China are infected with hepatitis C virus(HCV),with the seroprevalence of anti-HCV in the general population estimated at 0.6%.Delaying effective treatment of chronic hepatitis C(CHC)is associated with liver disease progression,cirrhosis,hepatocellular carcinoma,and liver-related *** extrahepatic manifestations of CHC further add to the disease burden of *** CHC-related advanced liver diseases and systemic manifestations are costly for both the healthcare system and *** of work productivity due to reduced well-being and quality of life in CHC patients further compounds the economic burden of the ***,pegylatedinterferon plus ribavirin(PR)was the standard of ***,a substantial number of patients are ineligible for PR treatment,and only 40%–75%achieved sustained virologic ***,PR is associated with impairment of patient-reported outcomes(PROs),high rates of adverse events,and poor *** the advent of direct acting antivirals(DAAs),the treatment of CHC patients has been *** have broader eligible patient populations,higher efficacy,better PRO profiles,fewer adverse events,and better adherence rates,thereby making it possible to cure a large proportion of all CHC *** article aims to provide a comprehensive evaluation on the value of effective,curative hepatitis C treatment from the clinical,economic,societal,and patient experience perspectives,with a focus on recent data from China,supplemented with other Asian and international experiences where China data are not available.

关键词： Hepatitis C Value of cure Sustained virologic response End stage liver disease Prevention of transmission Cost-effectiveness Productivity Societal value Patient-reported outcomes