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World Journal of Clinical Cases 2019年第20期7卷 3310-3315页

作者： fang hu Liao Sun Department of Endocrinology and Metabolism Fifth Affiliated Hospital Sun Yat-Sen University Sun Yat-Sen University

BACKGROUND The SEMA3A gene,which is located at 7q21.11,is involved in hypothalamic neuron migration,heart development,kidney development,and skeleton *** of the SEMA3A gene is associated with Kallmann syndrome 16 with or without a normal sense of *** addition,two case reports showed that mutation of the SEMA3A gene could cause short stature,low gonadotropin,hypogonadism,thoracic deformity,a high scapula,rib and lower limb deformity,facial deformity(long face,epicanthic folds,backwards ears),and arterial *** SUMMARY We reported the case of a 26-year-old Chinese man who was admitted because of short *** examination showed that he had many abnormal symptoms,including a short neck,facial moles,knee valgus,transverse palm,continuous grade 5/6 murmurs in the pulmonary auscultation area,no whiskers,or pubic hair,no Adam’s apple,short penis and *** examination showed pituitary,gonad,heart,kidney and skeletal *** laboratory tests revealed low growth hormone,luteinizing hormone,folliclestimulating hormone,testosterone and *** whole-exome detection showed that our patient,unlike previously reported patients,has a new SEMA3A gene mutation(c.950A>G).Now,his height has increased by 3 *** addition,he has a good appetite and reduced subcutaneous fat over 3 mo of recombinant human growth hormone injections ***,he refuses further treatment about *** Patients who come to a hospital because of their short stature must undergo gene detection if they have other simultaneous abnormal phenotypes.

关键词： Pituitary dysplasia Heart dysplasia Kidney dysplasia Short stature Cryptorchidism SEMA3A Case report

Recent advances in antimony removal using carbon-based nanomaterials:A review

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Frontiers of Environmental Science & Engineering 2022年第4期16卷 95-110页

作者： Xuemei hu Shijie You fang Li Yanbiao Liu Textile Pollution Controlling Engineering Center of Ministry of Environmental Protection College of Environmental Science and EngineeringDonghua UniversityShanghai 201620China State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150090China

Recently,special attention has been deserved to environmental risks of antimony(Sb)element that is of highly physiologic toxicity to *** coagulation and ion exchange methods for Sb removal are faced with challenges of low efficiency,high cost and secondary *** based on carbon nanomaterials(CNMs;e.g.,carbon nanotubes,graphene,graphene oxide,reduced graphene oxide and their derivatives)may provide effective alternative because the CNMs have high surface area,rich surface chemistry and high *** particular,good conductivity makes it possible to create linkage between adsorption and electrochemistry,thereby the synergistic interaction will be expected for enhanced Sb *** review article summarizes the state of art on Sb removal using CNMs with the form of nano-adsorbents and/or filtration *** details,procedures of synthesis and functionalization of different forms of CNMs were ***,adsorption behavior and the underlying mechanisms toward Sb removal using various CNMs were presented as resulting from a retrospective analysis of ***,we prospect the needs for mass production and regeneration of CNMs adsorbents using more affordable precursors and objective assessment of environmental impacts in future studies.

关键词： Antimony Carbon nanomaterials Adsorption Membrane separation

Modeling of gas porosity and microstructure formation during dendritic and eutectic solidification of ternary Al-Si-Mg alloys

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Journal of Materials Science & Technology 2021年第17期76卷 76-85页

作者： Mengdan hu Taotao Wang hui fang Mingfang Zhu Jiangsu Key Laboratory of Advanced Metallic Materials School of Materials Science and EngineeringSoutheast UniversityNanjing211189China

A two-dimensional(2-D)multi-component and multi-phase cellular automaton(CA)model coupled with the Calphad method and finite difference method(FDM)is proposed to simulate the gas pore formation and microstructures in solidification process of hypoeutectic Al-Si-Mg *** this model,the pore growth,and dendritic and eutectic solidification are simulated using a CA *** achieve the equilibrium among multiple phases during ternary Al-based alloy solidification,the phase transition thermodynamics and kinetics are evaluated by adopting the Calphad *** diffusion equations of hydrogen and two solutes are solved by *** developed CA-FDM coupled model can be used for simulating the evolution of gas microporosity and microstructures,involving dendrites and irregular binary and ternary eutectics,of ternary hypoeutectic Al-Si-Mg *** has the capability of reproducing the interactions between the hydrogen microporosity formation and the growth of dendrites and eutectics,the competitive growth among the growing gas pores of different sizes,together with the time-evolving concentration fields of hydrogen and *** simulated morphology of gas pore and microstructure has a good agreement with the experimental *** influences of the initial hydrogen concentration and cooling rate on the microporosity formation are *** is found that the main portion of porosity formation occurs in the eutectic solidification stage through analyzing the profiles of porosity percentage and solid fraction varying with solidification *** varying features of simulated porosity percentage,the maximum and average pores radii indicate that increasing initial hydrogen concentration promotes the formation of higher final porosity percentage and larger pores,while the size of gas pores will significantly reduce with increasing cooling rate,leading to a lower final porosity percentage.

关键词： Porosity Solidification microstructures Ternary Al-Si based alloys diffusion Cellular automaton

Impacts of reducing air pollutants and CO_(2) emissions in urban road transport through 2035 in Chongqing, China

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Environmental Science and Ecotechnology 2021年第4期8卷 55-66页

作者： Linfeng Duan Wei hu di Deng Weikai fang Min Xiong Peili Lu Zhenliang Li Chongzhi Zhai Key Laboratory of the Three Gorges Reservoir Region's Eco-Environment Ministry of EducationChongqing UniversityChongqing400045PR China Department of Environmental Science College of Environment and EcologyChongqing UniversityChongqing400045PR China Chongqing Academy of Ecological and Environmental Science Chongqing401147PR China

The road transport sector in megacities is confronted with pressing local air pollution and carbon dioxide(CO_(2))control *** determine effective policy instruments for saving energy and the co-control of air pollutants and CO_(2),several mainstream measures were examined and compared in Chongqing's road transport sector from 2017 to *** integration assessment framework was developed by combining the Long-range Energy Alternatives Planning(LEAP)system and a set of quantitative methods for evaluating the co-benefits of emission reductions(including the air pollutant equivalent(APeq),cocontrol coordinate system,and pollutant reduction cross-elasticity(Elsa/b)).Results showed that the shifting transportation modes scenario presented the most significant potential for energy-saving and emission reductions,reducing energy use by 30.9%and air pollutants and CO_(2) emissions by approximately 27e32%compared with the business as usual(BAU)scenario in *** improving energy efficiency scenario also provided significant co-benefits for reducing air pollutants and CO_(2) ***,the promoting alternative fuel scenario may increase fine particulate matter(PM2.5)emissions by 2.2%compared to BAU in 2035 under the cleanness of regional electricity in *** findings suggest that the shifting transportation modes were effective measures to reduce air pollutants and CO_(2) in the short term synergistically,and highlighted the importance of cleaner electricity generation to develop electric vehicles in the medium and long term.

关键词： Co-benefits Air pollutants Carbon dioxide Energy consumption Road transport

Asymmetric transportation induced by thermal noise at the nanoscale

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Science China(Physics,Mechanics & Astronomy) 2012年第5期55卷 751-756页

作者： WAN RongZheng hu Jun fang HaiPing division of lnterfacial Water and Laboratory of Physical Biology Shanghai Institute of Applied PhysicsChinese Academy of SciencesP.O.Box 800-204Shanghai 201800China

Based on a simple model, we theoretically show that asymmetric transportation is possible in nanoscale systems experiencing thermal noise without the presence of extemal fluctuations. The key to this theoretical advance is that the correlation lengths of the thermal fluctuations become significantly long for nanoscale systems. This differs from macroscopic systems in which the thermal noises are usually treated as white noise. Our observation does not violate the second law of thermodynamics, since at the nanoscale, extra energy is required to keep the asymmetric structure against thermal fluctuations.

关键词： ratchet nanoscale thermal fluctuations

Pedestrian Attributes Recognition in Surveillance Scenarios with Hierarchical Multi-Task CNN Models

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China Communications 2018年第12期15卷 208-219页

作者： Wenhua fang Jun Chen Ruimin hu National Engineering Research Center for Multimedia Software Computer School of Wuhan UniversityWuhan 430072China hubei Key Laboratory of Multimedia and Network Communication Engineering Wuhan UniversityWuhan 430072China Collaborative Innovation Center of Geospatial Technology Wuhan 430079China

Pedestrian attributes recognition is a very important problem in video surveillance and video forensics. Traditional methods assume the pedestrian attributes are independent and design handcraft features for each one. In this paper, we propose a joint hierarchical multi-task learning algorithm to learn the relationships among attributes for better recognizing the pedestrian attributes in still images using convolutional neural networks(CNN). We divide the attributes into local and global ones according to spatial and semantic relations, and then consider learning semantic attributes through a hierarchical multi-task CNN model where each CNN in the first layer will predict each group of such local attributes and CNN in the second layer will predict the global attributes. Our multi-task learning framework allows each CNN model to simultaneously share visual knowledge among different groups of attribute categories. Extensive experiments are conducted on two popular and challenging benchmarks in surveillance scenarios, namely, the PETA and RAP pedestrian attributes datasets. On both benchmarks, our framework achieves superior results over the state-of-theart methods by 88.2% on PETA and 83.25% on RAP, respectively.

关键词： attributes recognition CNN multi-task learning

Local Walsh-average-based estimation and variable selection for single-index models

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Science China Mathematics 2019年第10期62卷 1977-1996页

作者： Jing Yang fang Lu hu Yang Key Laboratory of High Performance Computing and StochasticInformation Processing(Ministry of Education of China) College of Mathematics and Computer ScienceHunan Normal UniversityChangsha410081China College of Mathematics and Statistics Chongqing UniversityChongqing401331China

We propose a robust estimation procedure based on local Walsh-average regression(LWR) for single-index models. Our novel method provides a root-n consistent estimate of the single-index parameter under some mild regularity conditions;the estimate of the unknown link function converges at the usual rate for the nonparametric estimation of a univariate covariate. We theoretically demonstrate that the new estimators show significant efficiency gain across a wide spectrum of non-normal error distributions and have almost no loss of efficiency for the normal error. Even in the worst case, the asymptotic relative efficiency(ARE) has a lower bound compared with the least squares(LS) estimates;the lower bounds of the AREs are 0.864 and 0.8896 for the single-index parameter and nonparametric function, respectively. Moreover, the ARE of the proposed LWR-based approach versus the ARE of the LS-based method has an expression that is closely related to the ARE of the signed-rank Wilcoxon test as compared with the t-test. In addition, to obtain a sparse estimate of the single-index parameter, we develop a variable selection procedure by combining the estimation method with smoothly clipped absolute deviation penalty;this procedure is shown to possess the oracle property. We also propose a Bayes information criterion(BIC)-type criterion for selecting the tuning parameter and further prove its ability to consistently identify the true model. We conduct some Monte Carlo simulations and a real data analysis to illustrate the finite sample performance of the proposed methods.

关键词： single-index models local Walsh-average regression asymptotic relative efficiency variable selection oracle property

A new family of covariate-adjusted response adaptive designs and their properties

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Applied Mathematics(A Journal of Chinese Universities) 2009年第1期24卷 1-13页

作者： ZHANG Li-Xin hu Fei-fang Institute of Statist. and Dept. of Math. Zhejiang Univ. Hongzhou 310027 China Dept. of Statist. Univ. of Virginia Charlottesville VA 22904-4135 USA

It is often important to incorporate covariate information in the design of clinical trials. In literature there are many designs of using stratification and covariate-adaptive randomization to balance certain known covariate. Recently, some covariate-adjusted response-adaptive （CARA） designs have been proposed and their asymptotic properties have been studied （Ann. Statist. 2007）. However, these CARA designs usually have high variabilities. In this paper, a new family of covariate-adjusted response-adaptive （CARA） designs is presented. It is shown that the new designs have less variables and therefore are more efficient.

关键词： adaptive design covariate efficiency asymptotic variability

Effect of Seasonality on distribution of Macroalgae in a Stream System(Xin'an Spring) in Shanxi Province,North China

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Journal of Integrative Plant Biology 2006年第8期48卷 889-896页

作者： Bian-fang hu Shu-Lian Xie School of Life Science and Technology Shanxi University Taiyuan 030006 China

A survey of the seasonal distribution of macroalgae in a stream system in Shanxi Province, north China, was undertaken from July 2004 to April 2005. The relative abundance and percentage cover of macroalgae, and several environmental factors were monitored along a 20-m stretch at each of four sites, at intervals of approximately three months （one sampling per season）. Several stream conditions were relatively constant over the sampling period （pH, maximum width and maximum depth）, whereas others exhibited a distinct seasonal pattern （water temperature and specific conductance）, and some fluctuated with no discernable seasonal pattern （current velocity and dissolved oxygen）. Forty-two species of macroalgae were found, with a predominance of Chlorophyta （26 species, 61.9%）. Rhodophyts and Charophyta represented the smallest proportion （1 species each, 2.38%）. Six macroalgae species were the most widespread, occurring in all four sampling sites. Twelve species were found at only one site each. In terms of seasonality, eight species occurred throughout the year, whereas 16 species were found in only one season each. The macroalgal community at Xin＇an Spring was species rich relative to other streams. Species richness per sampling site was negatively correlated with pH. Principal component analysis revealed that no single variable had much influence on the macroalgal seasonal dynamics. We calculated Sorensen similarity indices to compare our study with other continent-wide surveys of stream macroalgae, but the similarity indices were all very low. This study also shows that macroalgae in different locations have significant reproductive isolation.

关键词： China distribution environmental factors seasonality stream macroalgae.

Dynamic hybrid multimedia distribution scheme based on network reconfiguration

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Science China(Information Sciences) 2014年第10期57卷 107-116页

作者： DONG fang hu YuXiang LAN JuLong National digital Switching System Engineering and Technological Research Center

This paper addresses a key challenge in the design and implementation of multimedia distribution systems so that users can experience good performance with minimal operational costs. In current structures,the conflict between network architectures and service provision causes a decline in users’ expectations of quality. Network reconfiguration provides a feasible solution for dynamic distribution as a primitive for both quality and efficiency. In this paper, we first present a scheme for a layer-based hybrid multimedia distribution system LHMDS, and then introduce a dynamic sliding push-delivery mechanism based on reconfiguration of the distribution of hotspot files. The LHMDS adopts a unique structure with hybrid channels, including broadcast and unicast ones, and adjusts its distribution topology according to the congestion status, thereby pushing hotspot files dynamically. The mechanism dynamically pushes files to upper or lower network layers depending on the network status while distributing hotspot files by broadcast channels and other files by unicast *** guarantees service quality as well as improving resource utilization. Finally, we validate the feasibility and performance of the scheme through a simulation.

关键词： network reconfiguration hybrid distribution dynamic sliding push-delivery