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拔风管对CANON型人工湿地脱氮性能的影响

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中国环境科学 2022年第3期42卷 1191-1201页

作者：赵子健程瑞何凯雯胡晶晶胡莹莹王振安徽农业大学资源与环境学院安徽合肥230036

以猪场沼液为处理对象,探究了拔风管对基于亚硝化的全程自养脱氮(CANON)型潮汐流人工湿地(TFCW)氮素转化性能及微生物种群结构的影响.结果表明,拔风管数量可显著影响CANON型TFCW中脱氮功能微生物的数量与活性,进而影响其氮素转化速率.... 详细信息

以猪场沼液为处理对象,探究了拔风管对基于亚硝化的全程自养脱氮(CANON)型潮汐流人工湿地(TFCW)氮素转化性能及微生物种群结构的影响.结果表明,拔风管数量可显著影响CANON型TFCW中脱氮功能微生物的数量与活性,进而影响其氮素转化速率.在水力负荷(HLR)≤0.18m^(3)/(m^(2)·d)的前提下,随着拔风管数量由0增至6,TFCW填料层中的氧环境逐渐优化,促进了其中短程硝化性能的提高与厌氧氨氧化菌的富集,进而使系统中形成了同步亚硝化、厌氧氨氧化与反硝化耦合反应体系,其脱氮效能不断提高;而当拔风管数量>6后,填料层中亚硝酸盐氧化菌的过量增殖破坏了短程硝化作用的稳定性,厌氧氨氧化作用与反硝化作用随之受阻,系统脱氮性能复又有所下降.当HLR=0.18m^(3)/(m^(2)·d)且拔风管数量为6时,TFCW中Nitrosomomas和Candidutus Brocadia2种菌属的相对丰度分别可达20.05%和18.38%,而Nitrospira的相对丰度仅为1.92%,此时CANON作用可得到较大限度的强化,且可与Denitratisoma等菌属主导的反硝化作用耦合,使系统的TN和NH;-N去除率分别达(90.29±3.70)%和(93.30±2.97)%.

关键词：潮汐流人工湿地(TFCW) 拔风管基于亚硝化的全程自养脱氮(CANON) 短程硝化氮素转化

Mass spectrometry analysis of intact protein N-glycosylation signatures of cells and sera in pancreatic adenocarcinomas

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第1期25卷 51-64页

作者： Mingming XU Zhaoliang LIU Wenhua hu ying HAN Zhen WU Sufeng CHEN Peng XIA Jing DU Xumin ZHANG Piliang HAO Jun XIA Shuang YANG Center for Clinical Mass Spectrometry College of Pharmaceutical SciencesSoochow UniversitySuzhou215123China School of Life Science and Technology ShanghaiTech UniversityShanghai201210China State Key Laboratory of Genetic Engineering Department of BiochemistrySchool of Life SciencesFudan UniversityShanghai200438China Department of Clinical Laboratory Center Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou310014China

Pancreatic cancer is among the most malignant cancers,and thus early intervention is the key to better survival ***,no methods have been derived that can reliably identify early precursors of development into ***,it is urgent to discover early molecular changes during pancreatic *** aberrant glycosylation is closely associated with cancer progression,numerous efforts have been made to mine glycosylation changes as biomarkers for diagnosis;however,detailed glycoproteomic information,especially site-specific N-glycosylation changes in pancreatic cancer with and without drug treatment,needs to be further ***,we used comprehensive solid-phase chemoenzymatic glycoproteomics to analyze glycans,glycosites,and intact glycopeptides in pancreatic cancer cells and patient *** profiling of N-glycans in cancer cells revealed an increase in the secreted glycoproteins from the primary tumor of MIA PaCa-2 cells,whereas human sera,which contain many secreted glycoproteins,had significant changes of glycans at their specific *** results indicated the potential role for tumor-specific glycosylation as disease *** also found that AMG-510,a small molecule inhibitor against Kirsten rat sarcoma viral oncogene homolog(KRAS)G12C mutation,profoundly reduced the glycosylation level in MIA PaCa-2 cells,suggesting that KRAS plays a role in the cellular glycosylation process,and thus glycosylation inhibition contributes to the anti-tumor effect of AMG-510.

关键词： Pancreatic cancer Glycosylation Biomarker Glycoproteomics Mass spectrometry

Efficacy and safety of dacomitinib as first-line treatment for advanced non-small cell lung cancer patients with epidermal growth factor receptor 21L858R mutation:A multicenter, case-series study in China

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Chinese Journal of Cancer Research 2024年第4期36卷 398-409页

作者： Shouzheng Wang Jiayu Liu Yan Wang ying hu Ziling Liu Yu Yao Li Liang Yutao Liu Lin Wang Junling Li Puyuan Xing Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Medical Oncology Beijing Chest Hospital Capital Medical University Beijing Tuberculosis and Thoracic Tumor Research Institute Cancer Center the First Hospital of Jilin University Department of Medical Oncology the First Affiliated Hospital of Xi'an Jiaotong University Department of Medical Oncology and Radiation Sickness Peking University Third Hospital

Objective: To provide real-world evidence for the application of first-line dacomitinib treatment for epidermal growth factor receptor(EGFR) 21L858R mutant non-small cell lung cancer(NSCLC) patients in China and to explore the factors influencing the efficacy and ***: A longitudinal, consecutive case-series, multicenter study with mixed prospective and retrospective data was conducted. The primary endpoint was progression-free survival(PFS), and the secondary endpoints included duration of treatment(DOT), overall survival(OS), objective response rate(ORR), disease control rate(DCR) and ***: A total of 155 EGFR 21L858R mutant patients treated with first-line dacomitinib were included. The median follow-up time for these patients was 20.4 months. Among 134 patients with evaluable lesions, the ORR was 70.9% and the DCR was 96.3%. The median PFS was 16.3 [95% confidence interval(95% CI), 13.7-18.9]months. Multivariate Cox regression analysis suggested that the baseline brain metastasis(BM) status [with *** BM: hazard ratio(HR), 1.331; 95% CI, 0.720-2.458; P=0.361] and initial doses(45 mg vs. 30 mg: HR,0.837; 95% CI, 0.427-1.641; P=0.604) did not significantly affect the median PFS. The median DOT was 21.0(95% CI, 17.5-24.6) months and the median OS was not reached. Genetic tests were performed in 64 patients after progression, among whom 29(45.3%) patients developed the EGFR 20T790M mutation. In addition, among the 46patients who discontinued dacomitinib treatment after progression, 31(67.4%) patients received subsequent thirdgeneration EGFR-tyrosine kinase inhibitors. The most common grade 3-4 adverse events were rash(10.4%),diarrhea(9.1%), stomatitis(7.1%) and paronychia(4.5%). The incidence of grade 3-4 rash was significantly higher in the 45 mg group than that in the 30 mg group(21.9% vs. 7.5%, P=0.042).Conclusions: First-line dacomitinib treatment demonstrated promising efficacy and tolerable adverse events among EGFR 21L858R mutant NSC

关键词： Epidermal growth factor receptor molecular targeted therapy non-small cell lung cancer safety treatment efficacy

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心率对iCT冠状动脉成像质量的影响

中国医学影像技术 2011年第5期27卷 1086-1087页

作者：王玉丽胡莹莹王武中日友好医院放射诊断科北京100029

心率是影响冠状动脉CT成像的重要因素。Phil-ips iCT大大提高了扫描的时间、空间分辨力。本研究通过对不同心率的冠状动脉影像进行质量分析,评价心率对Philips iCT冠状动脉成像质量的影响。

关键词：体层摄影术,X线计算机冠状血管成像心率

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正交试验法优选三叶青中总黄酮的提取工艺

中国现代应用药学 2008年第1期25卷 34-36页

作者：黄真胡瑛瑛浙江中医药大学药学院杭州310053

目的优选三叶青中总黄酮的提取工艺。方法以三叶青总黄酮为指标,采用单因素考察和正交试验相结合的方法,对乙醇浓度、乙醇用量、提取时间、提取次数4个影响因素进行研究,优选提取工艺。结果乙醇浓度对三叶青总黄酮的提取影响较大,其他3... 详细信息

目的优选三叶青中总黄酮的提取工艺。方法以三叶青总黄酮为指标,采用单因素考察和正交试验相结合的方法,对乙醇浓度、乙醇用量、提取时间、提取次数4个影响因素进行研究,优选提取工艺。结果乙醇浓度对三叶青总黄酮的提取影响较大,其他3个因素影响程度排序为:提取次数(提取时间(乙醇用量。结论最佳提取工艺参数为:50%乙醇、15倍量、回流提取3次、以及每次2 h。

关键词：三叶青总黄酮正交试验提取工艺

辽河口近岸海域水体营养物推荐基准值的制定方法

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中国环境科学 2011年第6期31卷 996-1000页

作者：胡莹莹王菊英张志锋宗虎民陈淑梅国家海洋环境监测中心国家海洋局近岸海域生态环境重点实验室辽宁大连116023

确定水质参照状态是近岸海域营养物及其响应指标基准制定的关键,基于现场观测数据分析确定参照状态并提出推荐基准值是一种重要的方法.以辽河口近岸海域为例,根据1995年～1999年和2003年～2009年的数据分析,主要应用频数分析法确定了参... 详细信息

确定水质参照状态是近岸海域营养物及其响应指标基准制定的关键,基于现场观测数据分析确定参照状态并提出推荐基准值是一种重要的方法.以辽河口近岸海域为例,根据1995年～1999年和2003年～2009年的数据分析,主要应用频数分析法确定了参照状态,并结合1976年的数据分析,提出了该海域营养物(溶解无机氮、总氮、活性磷酸盐、总磷)及响应指标(叶绿素、溶解氧)的推荐基准值.分析显示,辽河口近岸海域营养物溶解无机氮、总氮、活性磷酸盐和总磷的推荐基准值分别为0.11,0.19,0.006,0.032mg/L;响应指标叶绿素、溶解氧的推荐基准值分别为0.0009,6.14mg/L.

关键词：营养物基准参照状态推荐基准值辽河口近岸海域

Graphene binding on black phosphorus enables high on/off ratios and mobility

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National Science Review 2024年第2期11卷 188-195页

作者： Fanrong Lin Zhonghan Cao Feiping Xiao Jiawei Liu Jiabin Qiao Minmin Xue Zhili hu ying Liu huan Lu Zhuhua Zhang Jens Martin Qingjun Tong Wanlin Guo Yanpeng Liu Key Laboratory for Intelligent Nano Materials and Devices of Ministry of Education State Key Laboratory of Mechanics and Control of Mechanical Structures and Institute for Frontier Science Nanjing University of Aeronautics and Astronautics Centre for Advanced 2D Materials National University of Singapore School of Physics and Electronics Hunan University Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and MeasurementSchool of PhysicsBeijing Institute of Technology Leibniz Institute für Kristallzüchtung

Graphene is one of the most promising candidates for integrated circuits due to its robustness against short-channel effects, inherent high carrier mobility and desired gapless nature for Ohmic contact, but it is difficult to achieve satisfactory on/off ratios even at the expense of its carrier mobility, limiting its device applications. Here, we present a strategy to realize high back-gate switching ratios in a graphene monolayer with well-maintained high mobility by forming a vertical heterostructure with a black phosphorus multi-layer. By local current annealing, strain is introduced within an established area of the graphene, which forms a reflective interface with the rest of the strain-free area and thus generates a robust off-state via local current depletion. Applying a positive back-gate voltage to the heterostructure can keep the black phosphorus insulating, while a negative back-gate voltage changes the black phosphorus to be conductive because of hole accumulation. Then, a parallel channel is activated within the strain-free graphene area by edge-contacted electrodes, thereby largely inheriting the intrinsic carrier mobility of graphene in the on-state. As a result, the device can provide an on/off voltage ratio of >10～3 as well as a mobility of ～8000 cm2V-1s-1at room temperature, meeting the low-power criterion suggested by the International Roadmap for Devices and Systems.

关键词： graphene on/off ratio mobility black phosphorus reflective interface

Enhancing the Interaction of Carbon Nanotubes by Metal-Organic Decomposition with Improved Mechanical Strength and Ultra-Broadband EMI Shielding Performance

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Nano-Micro Letters 2024年第7期16卷 281-294页

作者： Yu-ying Shi Si-Yuan Liao Qiao-Feng Wang Xin-Yun Xu Xiao-Yun Wang Xin-Yin Gu You-Gen hu Peng-Li Zhu Rong Sun Yan-Jun Wan Shenzhen Institute of Advanced Electronic Materials Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China Southern University of Science and Technology Shenzhen 518055People’s Republic of China National Key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050People’s Republic of China

The remarkable properties of carbon nanotubes(CNTs)have led to promising applications in the field of electromagnetic inter-ference(EMI)***,for macroscopic CNT assemblies,such as CNT film,achieving high electrical and mechanical properties remains challenging,which heavily depends on the tube-tube interac-tions of ***,we develop a novel strategy based on metal-organic decomposition(MOD)to fabricate a flexible silver-carbon nanotube(Ag-CNT)*** Ag particles are introduced in situ into the CNT film through annealing of MOD,leading to enhanced tube-tube *** a result,the electrical conductivity of Ag-CNT film is up to 6.82×10^(5) S m^(-1),and the EMI shielding effectiveness of Ag-CNT film with a thickness of~7.8μm exceeds 66 dB in the ultra-broad frequency range(3-40 GHz).The tensile strength and Young’s modulus of Ag-CNT film increase from 30.09±3.14 to 76.06±6.20 MPa(~253%)and from 1.12±0.33 to 8.90±0.97 GPa(~795%),***,the Ag-CNT film exhibits excellent near-field shield-ing performance,which can effectively block wireless *** innovative approach provides an effective route to further apply macroscopic CNT assemblies to future portable and wearable electronic devices.

关键词： EMI shielding Mechanical strength Carbon nanotubes Metal-organic decomposition Flexibility

新型可吸收生物玻璃注射体在骨质疏松椎体内支撑及诱导成骨的机制

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中国组织工程研究 2016年第12期20卷 1690-1696页

作者：隆海滨胡营营孙桂森东营市胜利油田中心医院脊柱外科山东省东营市257034 东营市胜利油田中心医院病理科山东省东营市257034

背景:生物玻璃具有良好的生物活性和生物相容性,将其与磷酸钙骨水泥复合形成新型可吸收生物玻璃注射体,可兼具二者优点,预计有更佳的应用空间。目的:探讨新型可吸收生物玻璃注射体在骨质疏松椎体内支撑及诱导成骨的机制。方法:切除27只... 详细信息

背景:生物玻璃具有良好的生物活性和生物相容性,将其与磷酸钙骨水泥复合形成新型可吸收生物玻璃注射体,可兼具二者优点,预计有更佳的应用空间。目的:探讨新型可吸收生物玻璃注射体在骨质疏松椎体内支撑及诱导成骨的机制。方法:切除27只雌性SD大鼠双侧卵巢,制作骨质疏松模型,造模后1个月将大鼠随机分为3组,均在L_4椎体制作骨缺损,实验组置入新型可吸收生物玻璃注射体,对照1组置入聚甲基丙烯酸甲酯骨水泥,对照2组置入注射性磷酸钙骨水泥。置入后12周,检测植入体抗压强度、降解性能、组织学成骨情况,以及血清骨形态发生蛋白2和转化生长因子β水平。结果与结论:实验组抗压强度、羟基磷灰石沉积量、失重率显著高于两对照组(P<0.05),骨小梁相对体积、厚度和数量显著大于两对照组(P<0.05),骨形态发生蛋白2和转化生长因子β水平显著高于两对照组(P<0.05)。表明新型可吸收生物玻璃注射体可能通过提高骨形态发生蛋白2和转化生长因子β水平,增强骨质疏松椎体的支撑力,提高诱导成骨效果。

关键词：玻璃聚甲基丙烯酸类骨质疏松组织工程生物材料骨生物材料新型可吸收生物玻璃注射体聚甲基丙烯酸甲酯注射性磷酸钙骨水泥力学性能骨形态发生蛋白转化生长因子