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Comparing Arsenic-Containing Qinghuang Powder and Low-Intensity Chemotherapy in Elderly Patients with Acute Myeloid Leukemia

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Chinese Journal of Integrative Medicine 2023年第9期29卷 832-837页

作者： WU Yu-he xiao Hai-yan QUAN Ri-cheng TANG Xu-dong LIU Wei-yi LYU Yan CHEN Zhuo LIU Chi hu xiao-mei Department of Hematology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China Graduate School China Academy of Chinese Medical SciencesBeijing100700China

Objective To compare the clinical effect of arsenic-containing Qinghuang Powder(QHP)and low-intensity chemotherapy(LIC)in treatment of elderly acute myeloid leukemia(eAML)*** Clinical data of 80 eAML patients treated at Xiyuan Hospital of China Academy of Chinese Medical Sciences from January 2015 to December 2020 were retrospectively *** treatment scheme was designed by real world study according to patients’preference,and patients were divided into a QHP group(35 cases)and a LIC group(45 cases).The median overall survival(mOS),1-,2-,and 3-year OS rates,and incidence of adverse events were compared between the two *** The mOS of 80 patients was 11 months,and the 1-,2-,and 3-year OS rates were 45.51%,17.96%,and 11.05%,*** QHP and LIC groups demonstrated no significant difference in mOS(12 months vs.10 months),1-(48.57%vs.39.65%),2-(11.43%vs.20.04%),and 3-year OS rates(5.71%vs.13.27%,all P>0.05).Moreover,the related factors of mOS demonstrated no significant difference in patients with age>75 years(11 months vs.8 months),secondary AML(11 months vs.8 months),poor genetic prognosis(9 months vs.7 months),Eastern Cooperative Oncology Group performance status score≥(10 months vs.7 months)and hematopoietic stem cell transplant comorbidity index≥4(11 months vs.7 months)between the QHP and LIC groups(all P>0.05).However,the incidence of myelosuppression was significantly lower in the QHP group than that in the LIC group(28.57%vs.73.33%,P<0.01).Conclusions QHP and LIC had similar survival rates in eAML patients,but QHP had a lower myelosuppression ***,QHP can be an alternative for eAML patients who do not tolerate LIC.

关键词： acute myeloid leukemia elderly Qinghuang Powder low-intensity chemotherapy Chinese medicine

Application of the combination of 1,3-dichloropropene and dimethyl disulfide by soil injection or chemigation: effects against soilborne pests in cucumber in China

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Journal of Integrative Agriculture 2016年第1期15卷 145-152页

作者： MAO Lian-gang WANG Qiu-xia YAN Dong-dong LIU Peng-fei SHEN Jin FANG Wen-sheng hu xiao-mei LI Yuan OUYANG Can-bin GUO mei-xia CAO Ao-cheng Department of Pesticides Institute of Plant Protection Chinese Academy of Agricultural Sciences State Key Laboratory for Biology of Plant Diseases and Insect Pests Ministry of Agriculture

The combination of 1,3-dichloropropene＋dimethyl disulfide （1,3-D＋DMDS）, which forms a pre-plant soil fumigant, can provide a substitute for the environmentally unfriendly methyl bromide （MB）. Three greenhouse trials were performed to evaluate the root-knot nematode and soilborne fungi control efficacy in the suburbs of Beijing in China in 2010-2014. Randomized blocks with three replicates were designed in each trial. The combination of 1,3-D＋DMDS （10＋30 g m-2） significantly controlled Meloidogyne incognita, effectively suppressed the infestation of Fusarium oxysporum and Phytophthora spp., and successfully provided high commercial fruit yields （equal to MB but higher than 1,3-D or DMDS）. The fumigant soil treatments were significantly better than the untreated controls. These results indicate that 1,3-D＋DMDS soil treatments can be applied by soil injection or chemigation as a promising MB alternative against soilborne pests in cucumber in China.

关键词： soil fumigation 1,3-dichloropropene dimethyl disulfide soilborne pest cucumber

Effect of Qinghuang Powder(青黄散) Combined with Bupi Yishen Decoction(补脾益肾方) in Treating Patients with Refractory Cytopenia with Multilineage Dysplasia through Regulating DNA Methylation

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Chinese Journal of Integrative Medicine 2019年第5期25卷 354-359页

作者： ZHOU Qing-bing YANG xiao-hong WANG Hong-zhi WANG De-xiu XU Yong-gang hu xiao-mei XU Feng-qin MA Rou National Hematological Medical Center of Traditional Chinese Medicine Department of HematologyXiyuan HospitalChina Academy of Chinese Medical SciencesBeijing(100091)China

Objective: To explore the effect of Qinghuang Powder(QHP, 青黄散) combined with Bupi Yishen Decoction(BPYS, 补脾益肾方)on myelodysplastic syndromes(MDS) patients with refractory cytopenia with multilineage dysplasia(RCMD) and determine the change of DNA methylation in MDS-RCMD patients after the treatment of Chinese medicine formula. Methods: All 308 MDS-RCMD patients were treated with QHP combined with BPYS for 2 months at least, absolute neutrophil count(ANC), hemoglobin(Hb), platelets(PLT), primitive bone marrow cells and chromosome karyotype were chosen as the main evaluation indexes to analyze the treatment effect according to criteria from the MDS International Working Group. Then 43 bone marrow samples from 15 MDS-RCMD patients and 28 healthy donors were obtained for the examination of DNA *** Ontology(GO) and Pathway analysis were applied to analyze the methylation data. Results: The overall MDS response rate to QHP was 61.68%(190/360) including hematologic improvement-neutrophil(HI-N) or hematologic improvement-erythroid(HI-E) or hematologic improvement-platelet(HI-P). Patients with anemia had a better response rate than patients with neutropenia or thrombocypenia(55.88% vs 31.54% or 55.88%vs. 36.9%). The DNA methylation microarray analysis disclosed that 4,257 hypermethylated genes were demethylated upon the treatment with QHP and BPYS. GO analysis and Pathway analysis showed that these demethylated genes were involved in a lot of tumor-related pathways and functions. Conclusions: QHP combined with BPYS could effectively treat MDS-RCMD patients through hematologic improvement(HI-N, HI-P or HI-E)and PLT and RBC transfusion independence due to the demethylation, thereby providing another choice for the treatment of patients with MDS-RCMD.

关键词： Qinghuang Powder Bupi Yishen Decoction myelodysplastic syndromes demethylation Chinese medicine

Association of Gene Mutations with Response to Arsenic-Containing Compound Qinghuang Powder(复方青黄散)in Patients with Myelodysplastic Syndromes

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Chinese Journal of Integrative Medicine 2019年第6期25卷 409-415页

作者： ZHAO Pan LIANG Jun-bin DENG Zhong-yang WANG Ming-jing QIN Jia-yue CHEN Chong-jian hu xiao-mei Department of Hematology Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing (100091) China Annoroad Gene Technology Co. Ltd. Beijing (100176) China

Objective: To in vestigate the relati on ship betwee n gene mutations and resp onse to Compo und Qinghuang Powder (复方青黄散,CQHP) in patients with myelodysplastic syndrome (MDS). Methods: Forty-three MDS patients after treatment with CQHP for 6 months were genotyped by ultra-deep targeted sequencing and the clinical data of patients were collected and the relationship between them was analyzed. Results: Up to 41.86% of patie nts harbored genet mutations, in most cases with more than one mutation. The most comm on mutations were in SF3B1, U2AF1, ASXL1, and DNMT3A. After treatment with CQHP, about 88.00% of patients no longer required blood transfusion, or needed half of prior transfusions. Conlusion: CQHP is an effective treatment for patients with MDS, especially those with gene mutations in SF3B1, DNMT3A, U2AF1, and/or ASXL1.

关键词： myelodysplastic syndromes arsenic next-generation sequencing realgar

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虚假医疗信息的道德缺失与伦理重建

医学与哲学（A） 2008年第5期29卷 33-34,37页

作者：胡笑梅安徽财经大学信息工程学院信息管理系安徽蚌埠233041

伴随着经济和信息技术的发展,医疗信息环境的污染和失衡已严重影响到了医疗卫生事业的健康发展。从虚假医疗信息的表现入手,剖析了虚假医疗信息产生的根源,着重分析了虚假医疗信息的道德缺失,从实际出发提出了具有可操作性的伦理道德重建。

关键词：虚假医疗信息道德缺失伦理重建

Arsenic-Containing Qinghuang Powder(青黄散)Is An Alternative Treatment for Elderly Acute Myeloid Leukemia Patients Refusing Low-Intensity Chemotherapy

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Chinese Journal of Integrative Medicine 2020年第5期26卷 339-344页

作者： FAN Teng QUAN Ri-cheng LIU Wei-yi xiao Hai-yan TANG Xu-dong LIU Chi LI Liu LV Yan WANG Hong-zhi XU Yong-gang GUO xiao-qing hu xiao-mei Department of Hematology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijin g(100091)China Graduate School China Academy of Chinese Medical SciencesBeijing(100700)China

Objective:To analyze the overall survival(OS)of elderly acute myeloid leukemia(AML)patients treated with oral arsenic-containing Qinghuang Powder(青黄散,QHP)or low-intensity chemotherapy(LIC).Methods:Forty-two elderly AML patients treated with intravenous or subcutaneous LIC(1 month for each course,at least 3 courses)or oral QHP(3 months for each course,at least 2 courses)were retrospectively analyzed from January 2015 to December *** main endpoints of analysis were OS and 1-,2-,3-year OS rates of patients,*** the adverse reactions induding bone marrow suppression,digestive tract discomfort and myocardia injury were ***:Out of 42 elderly AML patients,22 received LIC treatment and 20 received QHP treatment,according to patients'*** was no significant difference on OS between LIC and QHP patients(13.0 months vs.13.5 months,P>0.05).There was no significant difference on OS rates between LIC and QHP groups at 1 year(59.1%vs.70.0%),2 years(13.6%vs.15%),and 3 years(4.6%vs.5.0%,all P>0.05).Furthermore,there was no significant difference of OS on prognosis stratification of performance status>2(12 months vs.12 months),age>75 year-old(12.0 months vs.12.5 months),hematopoietic stem cell transplant comorbidity index>2(12 months vs.13 months),poor cytogenetics(12 months vs.8 months),and diagnosis of secondary AML(10 months vs.14 months)between LIC and QHP patients(P>0.05).Conclusion:QHP may be an alternative treatment for elderly AML patients refusing LIC therapy.

关键词： acute myeloid leukemia Qinghuang Powder Realgar arsenic elderly patient Chinese medicine

关于2n+1分Cantor集构造的一个基本性质及其应用

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郑州大学学报（理学版） 2011年第2期43卷 16-19页

作者：胡晓梅咸宁学院数学与统计学院湖北咸宁437100

将三分Cantor集构造的一个基本性质推广到2n+1(n∈N)分Cantor集,并用它简便计算出2n+1分Cantor集的Hausdorff测度,给出了计算此类广义Cantor集Hausdorff测度的一种新方法.最后介绍了此方法在其他方面的应用.

关键词： 2n+1分Cantor集 Hausdorff测度 k-级基本区间应用

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英汉对比视阈下的汉语二语写作研究综述

汉语学习 2023年第1期 94-103页

作者：莫丹胡笑梅北京语言大学汉语速成学院北京100083

本文以2011年1月—2021年12月发表的94篇写作研究论文为对象,从研究主题与研究方法两个角度与同时期5份英语外语教学与研究期刊刊载的194篇论文进行对比分析。研究结果显示:11年间,研究主题的理论视角得到拓展,研究数量稳步提升,主题不... 详细信息

本文以2011年1月—2021年12月发表的94篇写作研究论文为对象,从研究主题与研究方法两个角度与同时期5份英语外语教学与研究期刊刊载的194篇论文进行对比分析。研究结果显示:11年间,研究主题的理论视角得到拓展,研究数量稳步提升,主题不断深化,其中,关于学习者写作文本特征的研究最为细致和充分;注重教学法的研究与实践,尝试借鉴前沿的二语写作教学方法;研究方法表现出立体化、综合化的趋势,实证研究成为主流。同时,汉语二语写作研究在研究主题的深度、广度和创新性等方面还可继续深入,需进一步加强实证研究,更紧密地与现代化技术手段结合,以拓展新的研究局面。

关键词：汉语二语写作研究英汉对比综述

维普期刊数据库博看期刊

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国内产业竞争情报研究进展

情报科学 2016年第12期34卷 161-167页

作者：胡笑梅刘帅安徽财经大学管理科学与工程学院安徽蚌埠233000

总结国内产业竞争情报的研究现状,提出当前研究中值得关注的问题,利用知网、万方、维普检索到的文献,从统计分析的角度揭示文献的外部特征,通过内容分析梳理现有成果,探讨产业竞争情报研究的特点和局限。结果表明从文献数量发现现有研... 详细信息

总结国内产业竞争情报的研究现状,提出当前研究中值得关注的问题,利用知网、万方、维普检索到的文献,从统计分析的角度揭示文献的外部特征,通过内容分析梳理现有成果,探讨产业竞争情报研究的特点和局限。结果表明从文献数量发现现有研究力量较为集中和薄弱,研究成果虽然质量较高但数量比较有限,同时尚未形成良好的学科交叉。通过内容分析,了解到目前研究存在视角相对局限,对象范围偏窄,内容缺乏广度和深度,类型较为单一,方法较少等问题。最后基于两个方面的分析,根据以上分析结果提出相应的建议。

关键词：产业竞争情报综述文献计量内容分析