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催化裂化油浆柔性脱固技术(RSFF)侧线试验和工业应用

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石油炼制与化工 2024年第5期55卷 8-13页

作者：牛传峰龙有武文斌胡志海韩勇吴岳林邵志才方强中石化石油化工科学研究院有限公司北京100083 中国石化茂名分公司中国石化上海石油化工股份有限公司上海上阳流体科技有限公司安徽实华工程技术股份有限公司

采用催化裂化油浆柔性脱固(RSFF)技术在中国石化上海石油化工股份有限公司5 kt/a油浆脱固侧线试验装置上进行了油浆过滤试验。结果表明:侧线试验中脱固油浆产品收率为90%左右,脱固油浆中(Al+Si)质量分数为10μg/g左右,RSFF技术可有效脱... 详细信息

采用催化裂化油浆柔性脱固(RSFF)技术在中国石化上海石油化工股份有限公司5 kt/a油浆脱固侧线试验装置上进行了油浆过滤试验。结果表明:侧线试验中脱固油浆产品收率为90%左右,脱固油浆中(Al+Si)质量分数为10μg/g左右,RSFF技术可有效脱除粒径小于1μm的颗粒;在过滤开始阶段,过滤压差快速上升,然后缓慢上升,压差拐点与进料量呈正相关关系;提高再生触发压差可有效延长过滤周期。基于上述试验结果,在茂名外联石化有限公司300 kt/a装置上进行了工业应用试验,结果表明,脱固油浆产品平均收率达到92%以上,脱固油浆中灰分为100μg/g以下,灰分脱除率达到98%以上。RSFF油浆脱固技术不需要大量物流循环,对设备磨损低,既适用于加工直接来自催化裂化装置的油浆,也适用于加工来自罐区的油浆甚至外购油浆。

关键词：催化裂化油浆柔性脱固过滤侧线试验

Discrete element simulation of effects of multicontact loading on single particle crushing

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Particuology 2022年第10期20卷 49-60页

作者： chuanfeng Fang Zhihong Nie Jian Gong Bo Li Wei hu Ashiru Mohammed School of Civil Engineering Central South UniversityChangsha 410075China College of Civil of Engineering and Architecture Guangxi UniversityNanning530004China College of Architecture and Civil Engineering Wenzhou UniversityWenzhou 325035China hunan Province Key Laboratory of Geotechnical Engineering Stability Control and Health Monitoring Hunan University of Science and TechnologyXiangtan411201China

Particle crushing commonly occurs in granular materials and affects their structures and mechanical properties.Unlike idealized particles in experimental single particle crushing tests with two loading points,natural particles are crushed under multicontact loading.To date,the criteria and patterns of par-ticle crushing under multicontact conditions are not fully understood.By using the three-dimensional discrete element method,this report explores the effect of multicontact loading on the crushing criterion of a single particle,the crushing pattern,and the relationship between the particle crushing strength and loading distribution.The particles are modelled as aggregates of glued Voronoi polyhedra.The numer-ical results indicate that the logarithm of the mean principal stress has a good linear correlation with the coordination number.For a specific coordination number,the number of child particles presents a significant normal distribution.For a specific number of child particles,the volumes of child particles can be statistically described as normal or gamma distribution.Three typical models are proposed to qual-itatively analyse the relationship between the loading distribution and crushing strength.The relevant conclusions can be helpful in engineering practice and in further studies on crushable granular materials via the discrete element method.

关键词： DEM Multiple contacts Particle crushing Crushing criterion Crushing pattern Loading distribution

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宁夏固原市一顺层滑坡勘察及稳定性分析

能源与节能 2024年第6期 112-114页

作者：李凤洋杨川枫王楠虎亭宁夏回族自治区水文环境地质调查院宁夏银川750021

滑坡是公路工程施工安全的重要隐患之一,消除其对工程造成的影响是一项重要而有意义的工作。结合宁夏固原市一顺层滑坡的工程实例,根据滑坡形态特征和不同工况下的稳定性状态,分析了滑坡的发生机理,最终提出有效的治理措施和方案,可为... 详细信息

滑坡是公路工程施工安全的重要隐患之一,消除其对工程造成的影响是一项重要而有意义的工作。结合宁夏固原市一顺层滑坡的工程实例,根据滑坡形态特征和不同工况下的稳定性状态,分析了滑坡的发生机理,最终提出有效的治理措施和方案,可为将来类似的边坡治理提供一定的参考。

关键词：顺层滑坡成因分析稳定性评价治理措施

Emerging drug design strategies in anti-influenza drug discovery

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Acta Pharmaceutica Sinica B 2023年第12期13卷 4715-4732页

作者： chuanfeng Liu Lide hu Guanyu Dong Ying Zhang Edeildo Ferreira da Silva-Jinior Xinyong Liu Luis Menendez-Arias Peng Zhan Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesShandong UniversityJinan 250012China Laboratory of Medicinal Chemistry Institute of Pharmaceutical SciencesFederal University of AlagoasMaceio 57072-970AlagoasBrazil Centro de Biologia Molecular“Severo Ochoa”(Consejo Superior de Investigaciones Cientificas&Universidad Autonoma de Madrid) Madrid 28049Spain

Influenza is an acute respiratory infection caused by influenza viruses(IFV),According to the World Health Organization(WHO),seasonal IFV epidemics result in approximately 3-5 million cases of severe illness,leading to about half a million deaths worldwide,along with severe economic losses and social burdens.Unfortunately,frequent mutations in IFV lead to a certain lag in vaccine development as well as resistance to existing antiviral drugs.Therefore,it is of great importance to develop anti-IFV drugs with high efficiency against wild-type and resistant strains,needed in the fight against current and future outbreaks caused by different IFV strains.In this review,we summarize general strategies used for the discovery and development of antiviral agents targeting multiple IFV strains(including those resistant to available drugs).Structure-based drug design,mechanism-based drug design,multivalent interaction-based drug design and drug repurposing are amongst the most relevant strategies that provide a framework for the development of antiviral drugs targeting IFV.

关键词： Influenza virus Drug design strategies Anti-drugresistance High efficiency Broad spectrum

Understanding Third Pole Atmospheric Dynamics and Land Surface Processes and Their Associations with the Cryosphere,Air Quality,and Climate Change--Preface to the Special Issue on Third Pole Atmospheric Physics,Chemistry,and Hydrology

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Advances in Atmospheric Sciences 2022年第7期39卷 1017-1020页

作者： Yun Qian Hailong Wang chuanfeng Zhao Chun Zhao Siyu Chen Xiao-Ming hu Shichang Kang Pacific Northwest National Laboratory RichlandWA 99354USA College of Global Change and Earth System Science Beijing Normal UniversityBeijing 100875China School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China Center for Analysis and Prediction of Storms University of OklahomaNorman 73019OKUSA State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of Sciences(CAS)Lanzhou 730000China

The Tibetan Plateau(TP),widely known as the Third Pole,is the highest and largest plateau on Earth.The TP not only plays an important role in influencing the atmospheric circulation,surface energy budget,ecology,weather,and climate but also acts as the Asian Water Tower by holding the largest ice mass outside the polar regions to supply fresh water to over 1.4 billion people downstream in Asia(Qin et al.,2006).The observed historical warming and projected future warming over the TP are much stronger than the corresponding global average(Wang et al.,2008).Glaciers on the TP have been retreating extensively in recent decades,driven by atmospheric warming and circulation changes associated with increasing concentrations of greenhouse gases and aerosols in the atmosphere,light-absorbing particles(e.g.,black carbon,dust)on snow,and other factors(Duan et al.,2012;Qian et al.,2011;Zhao et al.,2020).In addition,due to the thermal and dynam-ical effects of the TP,as well as its proximity to the stratosphere,unique atmospheric boundary layer structures often develop over the TP and in the surrounding areas,which have important impacts on local weather,climate,and mixing and transport of atmospheric constituents(Zhao et al.,2020).The TP is considered a natural laboratory to study multi-sphere inter-actions.A systematic mechanistic understanding of the atmospheric chemical and microphysical processes,climate change,cryospheric variability,and the subsequent environmental impacts is particularly important in the context of the unpreceden-ted warming over the TP(Yao et al.,2019).

关键词： warming weather plateau

宁夏地区咸水层CO_(2)封存选区及潜力预测

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水文地质工程地质 2024年第4期51卷 21-32页

作者：杨川枫刘廷程国强刁玉杰马鑫王楠李凤洋杨凌雪马晶虎亭孙建任建国宁夏回族自治区水文环境地质调查院宁夏银川750021 中国地质调查局水文地质环境地质调查中心天津300304

宁夏局部地区高碳排放源集中且碳排量巨大,亟需开展碳封存潜力评价等工作,以支撑未来碳捕集、利用与封存规划与重大示范。文章在宁夏地区碳封存基本地质条件的基础上,采用美国能源部(US-DOE)体积法,评估宁夏地区深部咸水层CO_(2)封存预... 详细信息

宁夏局部地区高碳排放源集中且碳排量巨大,亟需开展碳封存潜力评价等工作,以支撑未来碳捕集、利用与封存规划与重大示范。文章在宁夏地区碳封存基本地质条件的基础上,采用美国能源部(US-DOE)体积法,评估宁夏地区深部咸水层CO_(2)封存预测地质潜力约867.421×10~8 t,预测技术容量约423.34×10^(8) t,主力储层主要集中分布在宁夏东部盐池地区和六盘山盆地。综合封存潜力、盖层封闭性、地质体稳定性、社会环境风险等因素,开展了宁夏地区咸水层封存适宜性初步评价,结果表明:宁夏东部盐池地区储盖层条件良好、构造较稳定、人口密度低,是宁夏地区开展咸水层CO_(2)封存的有利远景区。

关键词：宁夏深部咸水层 CO_(2)地质封存预测潜力远景区

Trivariate B-spline solid construction by pillow operation and geometric iterative fitting

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Science China(Information Sciences) 2018年第11期61卷 232-234页

作者： Hongwei LIN Hao huANG chuanfeng hu School of Mathematical Science State Key Laboratory of CAD&CG Zhejiang University

While the traditional geometric design community focuses on the design of curves and surfaces, the advent of isogeometric analysis (IGA)[1] has made the development of methods for designing trivariate B-spline solids (TBSs) imperative. In IGA, a valid TBS should have a positive Jacobian value at every point in its domain. A negative Jacobian value at any point in the domain of the TBS can render the IGA invalid.

关键词： TBS Trivariate B-spline solid construction by pillow operation and geometric iterative fitting GFD Figure

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通道压裂支撑剂缝内分布规律研究

河南科学 2024年第1期42卷 8-15页

作者：刘承婷胡传峰王智刚董佩鑫彭占刚管恩东东北石油大学石油工程学院黑龙江大庆163318 提高油气采收率教育部重点实验室(东北石油大学) 黑龙江大庆163318 中国石油大庆油田有限责任公司第一采油厂黑龙江大庆163001 辽河油田公司高升采油厂辽宁盘锦124099

通道压裂是低渗透致密油气藏高效、低成本开发的关键技术,通过采用非连续簇团铺砂的方式,使裂缝中形成具有高导流能力的通道,但目前关于通道压裂的理论研究仍然处于起步阶段.因此,基于计算流体力学建立欧拉-欧拉固液两相流模型,对通道... 详细信息

通道压裂是低渗透致密油气藏高效、低成本开发的关键技术,通过采用非连续簇团铺砂的方式,使裂缝中形成具有高导流能力的通道,但目前关于通道压裂的理论研究仍然处于起步阶段.因此,基于计算流体力学建立欧拉-欧拉固液两相流模型,对通道压裂过程中支撑剂的分布状态进行模拟,通过与实验结果进行对比,证明了所建立模型的有效性,并系统研究了不同中顶压裂液(纯压裂液脉冲段)黏度、支撑剂密度、泵注排量对通道压裂通道率的影响.结果表明,中顶压裂液的黏度从1 mPa·s增加到20 mPa·s,通道内平均通道率增加5%;支撑剂密度从1400 kg/m^(3)增加到2000 kg/m^(3)时,缝内通道率减小了7%;排量由3 m^(3)/min增加到7 m^(3)/min时,通道率由28%增加到33.5%后减小到31%.现场应用过程中应使用较高黏度中顶压裂液、较低密度支撑剂和合理的泵注排量以保证裂缝中形成有效支撑通道.

关键词：通道压裂支撑剂固液两相流携砂规律参数优化

南京市新生儿听力筛查联合耳聋基因筛查结果分析

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华南预防医学 2024年第4期50卷 319-322,328页

作者：孔木飞李舒胡传凤张林林夏丽黄晓丽欧阳娟南京市江宁医院江苏南京211100 南京鼓楼医院南京市中医院

目的探讨分析南京市新生儿听力筛查联合耳聋基因筛查结果。方法选取南京市江宁医院、南京鼓楼医院、南京市中医院妇产科2020年1月至2022年12月期间出生的新生儿为研究对象,进行听力联合耳聋基因筛查,其中听力筛查使用耳声发射、自动听... 详细信息

目的探讨分析南京市新生儿听力筛查联合耳聋基因筛查结果。方法选取南京市江宁医院、南京鼓楼医院、南京市中医院妇产科2020年1月至2022年12月期间出生的新生儿为研究对象,进行听力联合耳聋基因筛查,其中听力筛查使用耳声发射、自动听性脑干反应;耳聋基因筛查检测GJB2基因、GJB3基因、SLC26A4基因、线粒体12SrRNA。结果本研究共纳入13256名新生儿,男婴6870名,女婴6386名;筛查出存在耳聋基因突变者658例,检出率为4.96%;其中有656例患儿存在4种基因单个位点突变,检出率为4.90%;GJB2基因突变患儿382例,突变率为2.88%;GJB3基因突变患儿34例,突变率为0.26%;SLC264A基因突变患儿212例,突变率为1.60%;线粒体DNA突变患儿22例,突变率为0.17%。双重/双基因杂合突变患儿10例,突变率为0.08%,其中GJB2-235/GJB2-299双重杂合子突变6例,突变率为0.05%;GJB3/SLC26A4双基因杂合突变4例,突变率0.03%。在658例耳聋基因突变者患儿中,确诊听力损失者12例,听力损失检出率为1.82%。在12598名无耳聋基因突变的新生儿中经听力初筛及复筛最终确诊听力损失者12例,听力损失检出率为0.10%;耳聋基因突变患儿的听力损失检出率明显高于无耳聋基因突变新生儿(P<0.01)。早产、外耳畸形新生儿的听力损失检出率明显更高(均P<0.01)。结论南京市新生儿的耳聋基因主要突变类型为GJB2基因、SLC264A基因,听力联合耳聋基因筛查可明显提高新生儿遗传性耳聋的检出率,有利于及早防治。

关键词：新生儿听力耳聋基因筛查