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Advanced strategies for 3D-printed neural scaffolds: materials, structure, and nerve remodeling

BIO-DESIGN AND MANUFACTURING 2024年第5期7卷 747-770页

作者： He, Jian Qiao, Liang Li, Jiuhong Lu, Junlin Fu, Zhouping Chen, Jiafang Zhang, Xiangchun hu, xulin Henan Univ Sci & Technol Coll Basic Med & Forens Med Luoyang 471023 Peoples R China Henan Univ Sci & Technol Affiliated Hosp 1 Coll Clin Med Luoyang 471003 Peoples R China Chinese Acad Agr Sci Tea Res Inst Hangzhou 310008 Peoples R China Chengdu Univ Affiliated Hosp Clin Med Coll Chengdu 610081 Peoples R China Sichuan Univ West China Hosp Dept Cardiovasc Surg Dept BiotherapyCanc Ctr Chengdu 610041 Peoples R China Sichuan Univ West China Hosp State Key Lab Biotherapy Chengdu 610041 Peoples R China Sichuan Univ West China Hosp Dept Neurosurg Chengdu 610041 Peoples R China

Nerve regeneration holds significant potential in the treatment of various skeletal and neurological disorders to restore lost sensory and motor functions. The potential of nerve regeneration in ameliorating neurological diseases and injuries is critical to human health. Three-dimensional (3D) printing offers versatility and precision in the fabrication of neural scaffolds. Complex neural structures such as neural tubes and scaffolds can be fabricated via 3D printing. This review comprehensively analyzes the current state of 3D-printed neural scaffolds and explores strategies to enhance their design. It highlights therapeutic strategies and structural design involving neural materials and stem cells. First, nerve regeneration materials and their fabrication techniques are outlined. The applications of conductive materials in neural scaffolds are reviewed, and their potential to facilitate neural signal transmission and regeneration is highlighted. Second, the progress in 3D-printed neural scaffolds applied to the peripheral and central nerves is comprehensively evaluated, and their potential to restore neural function and promote the recovery of different nervous systems is emphasized. In addition, various applications of 3D-printed neural scaffolds in peripheral and neurological diseases, as well as the design strategies of multifunctional biomimetic scaffolds, are discussed.

关键词： Nerve regeneration 3D printing based neural scaffolds Biomaterials Nervous system Design strategies SPINAL-CORD-INJURY PERIPHERAL-NERVE STEM-CELLS 3D FABRICATION DIFFERENTIATION INKS

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Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections

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Bone Research 2024年第2期12卷 270-288页

作者： Leilei Qin Shuhao Yang Chen Zhao Jianye Yang Feilong Li Zhenghao Xu Yaji Yang Haotian Zhou Kainan Li Chengdong Xiong Wei huang Ning hu xulin hu Department of Orthopaedics The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Orthopedic Laboratory of Chongqing Medical University Chongqing 400016China Clinical Medical College and Affiliated Hospital of Chengdu University Chengdu UniversityChengduSichuan 610081China University of Chinese Academy of Sciences Bei Jing 101408China Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan 610041China

Osteomyelitis is a devastating disease caused by microbial infection in deep bone *** high recurrence rate and impaired restoration of bone deficiencies are major challenges in *** have evolved numerous mechanisms to effectively evade host intrinsic and adaptive immune attacks to persistently localize in the host,such as drug-resistant bacteria,biofilms,persister cells,intracellular bacteria,and small colony variants(SCVs).Moreover,microbial-mediated dysregulation of the bone immune microenvironment impedes the bone regeneration process,leading to impaired bone defect *** advances in surgical strategies and drug applications for the treatment of bone infections within the last decade,challenges remain in clinical *** development and application of tissue engineering materials have provided new strategies for the treatment of bone infections,but a comprehensive review of their research progress is *** review discusses the critical pathogenic mechanisms of microbes in the skeletal system and their immunomodulatory effects on bone regeneration,and highlights the prospects and challenges for the application of tissue engineering technologies in the treatment of bone *** will inform the development and translation of antimicrobial and bone repair tissue engineering materials for the management of bone infections.

关键词： impaired infections treatment

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Advanced strategies for 3D-printed neural scaffolds:materials,structure, and nerve remodeling

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Bio-Design and Manufacturing 2024年第05期 747-770页

作者： Jian He Liang Qiao Jiuhong Li Junlin Lu Zhouping Fu Jiafang Chen Xiangchun Zhang xulin hu College of Basic Medicine and Forensic Medicine Henan University of Science and Technology The First Affiliated Hospital College of Clinical Medicine of Henan University of Science and Technology Department of Cardiovascular Surgery Department of Biotherapy Cancer Center and State Key Laboratory of Biotherapy West China Hospital Sichuan University Department of Neurosurgery West China Hospital Sichuan University Tea Research Institute Chinese Academy of Agricultural Sciences Clinical Medical College Affiliated Hospital of Chengdu University Chengdu University

Nerve regeneration holds significant potential in the treatment of various skeletal and neurological disorders to restore lost sensory and motor functions. The potential of nerve regeneration in ameliorating neurological diseases and injuries is critical to human health. Three-dimensional(3D) printing offers versatility and precision in the fabrication of neural scaffolds. Complex neural structures such as neural tubes and scaffolds can be fabricated via 3D printing. This review comprehensively analyzes the current state of 3D-printed neural scaffolds and explores strategies to enhance their design. It highlights therapeutic strategies and structural design involving neural materials and stem cells. First, nerve regeneration materials and their fabrication techniques are outlined. The applications of conductive materials in neural scaffolds are reviewed, and their potential to facilitate neural signal transmission and regeneration is highlighted. Second, the progress in 3D-printed neural scaffolds applied to the peripheral and central nerves is comprehensively evaluated, and their potential to restore neural function and promote the recovery of different nervous systems is emphasized. In addition, various applications of 3D-printed neural scaffolds in peripheral and neurological diseases, as well as the design strategies of multifunctional biomimetic scaffolds, are discussed.

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宫腔粘连中水凝胶促内膜修复的研究与进展

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中国组织工程研究 2024年第17期28卷 2774-2781页

作者：邬浩明王瑶陈圆梦朱慧莉李开南熊成东胡旭麟成都大学临床医学院/附属医院四川省成都市610081 四川大学华西第二医院生殖医学科-出生缺陷与相关妇儿疾病教育部重点实验室四川省成都市610041 中国科学院大学北京市100049 四川大学生物治疗国家重点实验室四川省成都市610041

背景:防止宫腔粘连复发的关键是重建具有正常功能的子宫内膜,国内外对于宫腔粘连复发治疗的最新突破在于利用可降解材料制备水凝胶类物质防止粘连复发。目的:综述宫腔粘连中水凝胶促内膜修复的研究进展。方法:系统检索PubMed数据库、Web... 详细信息

背景:防止宫腔粘连复发的关键是重建具有正常功能的子宫内膜,国内外对于宫腔粘连复发治疗的最新突破在于利用可降解材料制备水凝胶类物质防止粘连复发。目的:综述宫腔粘连中水凝胶促内膜修复的研究进展。方法:系统检索PubMed数据库、Web of Science、中国知网、万方数据库,以“宫腔粘连,子宫内膜损伤,子宫内膜再生,水凝胶,Intrauterine adhesions,Endometrial injury,Endometrium regeneration,hydrogel”为关键词,收集各数据库1990年1月至2023年3月发表的相关文献。结果与结论:近年来国内外关于宫腔粘连中水凝胶促内膜修复的研究取得了一定进展,对于宫腔粘连的防治和促进内膜修复具有重要作用:①水凝胶作为组织工程中一大重要载体,它本身具有优秀的生物相容性、生物降解性和三维网状结构,可以更好地应用在宫腔粘连治疗中;②以水凝胶为基础的搭载体系,可以通过运输药物/生物制剂/干细胞来促进子宫内膜上皮细胞的增殖分化,并恢复正常子宫形态,防止粘连复发;③透明质酸类水凝胶在满足良好生物相容性的同时还可以促进内膜上皮细胞的增殖分化,且在子宫内会被相应的酶类物质水解,不会影响机体正常代谢,是目前临床常用的子宫防粘连剂,也是组织工程研究中最常用的一种水凝胶载体;④以温敏特性出众的泊洛沙姆水凝胶可以在进入体内迅速凝胶化,快速形成物理屏障,并可对搭载物质起到缓释作用和提供细胞生长/黏附平台;⑤利用不同特性材料制备治疗性水凝胶的前景广阔,比如温敏特性水凝胶、pH响应性水凝胶以及光敏水凝胶等,但还存在诸多问题需要解决,例如水凝胶体系的安全性以及降解产物是否引起免疫反应、对正常机体经期是否具有影响等问题,还需要大量动物实验及临床试验来验证其安全性和有效性,不断完善治疗策略。

关键词：宫腔粘连水凝胶修复子宫内膜再生生长因子干细胞

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“医工交叉”时代背景下的教学改革与实践——以临床医学专业生物医用高分子材料课程为例

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创新创业理论研究与实践 2024年第7期7卷 41-43页

作者：胡旭麟王瑶彭超李开南时政成都大学临床医学院四川成都610008

生物医用高分子材料是近年来快速发展的一门交叉学科,它隶属于材料科学的一个分支领域,在临床医学中有着十分重要的作用和地位。为了满足临床医学的教学与科研需求,成都大学临床医学院面向医学检验技术和临床医学两个本科专业开设了生... 详细信息

生物医用高分子材料是近年来快速发展的一门交叉学科,它隶属于材料科学的一个分支领域,在临床医学中有着十分重要的作用和地位。为了满足临床医学的教学与科研需求,成都大学临床医学院面向医学检验技术和临床医学两个本科专业开设了生物医用高分子材料通识课程。该文从课程的教学现状出发并结合目前“医工交叉”的时代背景,从教学背景、课程建设和教学方法与评价体系3个方面初步探讨了该课程在教学实践中面临的问题,并提出了相应的改革措施。

关键词： “医工交叉” 生物医用高分子材料临床医学教学改革课程建设教学评价

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Quantitative angiographic haemodynamic evaluation of bypasses for complex aneurysms: a preliminary study

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Stroke & Vascular Neurology 2022年第1期7卷 54-61页

作者： Junlin Lu Chao Xue xulin hu Yuanli Zhao Dong Zhang Xiaolin Chen Ji Zong Zhao Neurosurgery Beijing Tiantan HospitalBeijingPeople's Republic of China Department of Industrial Engineering Tsinghua UniversityBeijingPeople's Republic of China Chengdu Institute of Organic Chemistry Chinese Academy of SciencesChengduPeople's Republic of China University of the Chinese Academy of Sciences BeijingPeople's Republic of China China National Clinical Research Center for Neurological Diseases BeijingPeople's Republic of China Stroke Center Beijing Institute for Brain DisordersBeijingPeople's Republic of China Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease BeijingPeople's Republic of China Beijing Translational Engineering Enter for 3D Printer in Clinical Neuroscience BeijingPeople's Republic of China

Objective Open microsurgery,often with bypass techniques,is indispensable for complex *** date,it remains unknown whether arterial anatomy or quantitative blood flow measurements can predict insufficient flow-related stroke(IRS).The present study aimed to evaluate the risk factors for IRS in patients treated with open microsurgery with bypass procedures for complex internal carotid artery *** Patients with complex aneurysms undergoing bypass surgery were retrospectively *** recipient/donor flow index(RDFI)was preoperatively evaluated using colour-coding *** was defined as the ratio of the cerebral blood volume of the recipient and donor *** sizes of the recipient and donor arteries were *** recipient/donor diameter index(RDDI)was then *** was defined as the presence of new postoperative neurological deficits and infarction on postoperative CT *** assessed the association between RDFI and other variables and the *** Twenty patients(38±12 years)were *** was observed in 12 patients(60%).Patients with postoperative IRS had a higher RDFI than those without postoperative IRS(p2.3 were more likely to develop IRS(p2.3,rather than RDDI,was significantly associated with postoperative *** preoperative evaluation allows appropriate decisions regarding the treatment strategy for preventing postoperative IRS.

关键词： bypass anatomy aneurysm

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Novel 3D printed shape-memory PLLA-TMC/GA-TMC scaffolds for bone tissue engineering with the improved mechanical properties and degradability

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Chinese Chemical Letters 2023年第1期34卷 221-224页

作者： xulin hu Weiming Zhao Zhen Zhang Jianping Xie Jian He Jianfei Cao Qing Li Yajing Yan Chengdong Xiong Kainan Li Clinical Medical College&Affiliated Hospital of Chengdu University Chengdu UniversityChengdu 610081China Chengdu Institute of Organic Chemistry Chinese Academy of SciencesChengdu 610041China University of Chinese Academy of Sciences Beijing 100049China College of Medical Henan University of Science and TechnologyLuoyang 471023China School of Materials and Environmental Engineering Chengdu Technological UniversityChengdu 610031China

The biodegradable substitution materials for bone tissue engineering have been a research *** is known to all,the biodegradability,biocompatibility,mechanical properties and plasticity of the substitution materials are the important indicators for the application of implantation *** this article,we reported a novel binary substitution material by blending the poly(lactic-acid)-co-(trimethylenecarbonate)and poly(glycolic-acid)-co-(trimethylene-carbonate),which are both biodegradable polymers with the same segment of flexible trimethylene-carbonate in order to accelerate the degradation rate of poly(lactic-acid)-co-(trimethylene carbonate)substrate and improve its mechanical ***,we further fabricate the porous poly(lactic-acid)-co-(trimethylene-carbonate)/poly(glycolic-acid)-co-(trimethylene-carbonate)scaffolds with uniform microstructure by the 3D extrusion printing technology in a mild printing *** physicochemical properties of the poly(lactic-acid)-co-(trimethylenecarbonate)/poly(glycolic-acid)-co-(trimethylene-carbonate)and the 3D printing scaffolds were investigated by universal tensile dynamometer,fourier transform infrared reflection(FTIR),scanning electron microscope(SEM)and differential scanning calorimeter(DSC).Meanwhile,the degradability of the PLLATMC/GA-TMC was performed in vitro degradation *** with PLLA-TMC group,PLLA-TMC/GATMC groups maintained the decreasing Tg,higher degradation rate and initial mechanical ***,the PLLA-TMC/GA-TMC 3D printing scaffolds provided shape-memory ability at 37℃.In summary,the PLLA-TMC/GA-TMC can be regarded as an alternative substitution material for bone tissue engineering.

关键词： Bone scaffolds Biodegradable polymers 3D printed Shape memory Tissue engineering

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三维无单元法模拟裂纹扩展

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宁夏大学学报（自然科学版） 2011年第1期32卷 35-38页

作者：马泽玲虎旭林北方民族大学信息与计算科学学院宁夏银川750021

介绍了三维无单元法的基本思想和程序设计思路,计算了梁和薄板的裂纹扩展.计算结果表明,无单元法的计算精度是比较高的,可以很好地描述裂纹的扩展.

关键词：无单元法梁板壳裂纹扩展

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10 Gb/s classical secure key distribution based on temporal steganography and private chaotic phase scrambling

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Photonics Research 2024年第2期12卷 321-330页

作者： ZHENSEN GAO ZHITAO DENG LIHONG ZHANG xulin GAO YUEhuA AN ANBANG WANG SONGNIAN FU ZHAOhuI LI YUNCAI WANG YUWEN QIN School of Information Engineering Guangdong University of TechnologyGuangzhou 510006China Pengcheng Laboratory Shenzhen 518062China Key Laboratory of Photonic Technology for Integrated Communication and Sensing Ministry of EducationGuangzhou 510006China School of Optoelectronic Engineering Guangdong Polytechnic Normal UniversityGuangzhou 510665China School of Electrical and Information Technology Sun Yat-sen UniversityGuangzhou 510006China

Secure distribution of high-speed digital encryption/decryption keys over a classical fiber channel is strongly pursued for realizing perfect secrecy communication ***,it is still challenging to achieve a secret key rate in the order of tens of gigabits per second to be comparable with the bit rate of commercial fiber-optic *** this paper,we propose and experimentally demonstrate a novel solution for high-speed secure key distribution based on temporal steganography and private chaotic phase scrambling in the classical physical *** encryption key is temporally concealed into the background noise in the time domain and randomly phase scrambled bit-by-bit by a private chaotic signal,which provides two layers of enhanced security to guarantee the privacy of key distribution while providing a high secret key *** experimentally achieved a record classical secret key rate of 10 Gb/s with a bit error rate lower than the hard-decision forward error correction(HD-FEC)over a 40 km standard single mode *** proposed solution holds great promise for achieving high-speed key distribution in the classical fiber channel by combining steganographic transmission and chaotic scrambling.

关键词： chaotic distribution phase

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VPD modifies CO_(2)fertilization effect on tomato plants via abscisic acid and jasmonic acid signaling pathways

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Horticultural Plant Journal 2024年第5期10卷 1165-1176页

作者： Dalong Zhang huihua Yang Xiaolu Chen Yan Li Yunzhou Li Hongye Liu xulin Wu Min Wei College of Horticultural Science and Engineering Shandong Agricultural UniversityTai'anShandong 271018China College of Agriculture Guizhou UniversityGuiyangGuizhou 550025China

Atmospheric CO_(2)concentration is elevated globally,which has“CO_(2)fertilization effects”and potentially improves plant photosynthesis,yield,and *** the beneficial effect of CO_(2)fertilization being modulated by vapor pressure deficit(VPD),the underlying mechanism is highly *** the present study,the potential roles of hormones in determining CO_(2)fertilization effects under contrasting high and low VPD conditions were investigated by integrated physiological and transcriptomic *** CO_(2)fertilization effects were offset under high VPD conditions and were constrained by plant water stress and photosynthetic CO_(2)*** VPD induced a large passive water driving force,which disrupted the water balance and consequently caused plant water *** water potential,turgor pressure,and hydraulic conductance declined under high VPD *** physiological evidence combined with transcriptomic analyses demonstrated that abscisic acid(ABA)and jasmonic acid(JA)potentially acted as drought-signaling molecules in response to high VPD *** foliar ABA and JA content triggered stomatal closure to prevent excessive water loss under high VPD stress,which simultaneously increased the diffusion resistance for CO_(2)uptake from atmosphere to leaf intercellular *** VPD also significantly increased mesophyll resistance for CO_(2)transport from stomatal cavity to fixation site inside *** chloroplast“sink”CO_(2)availability was constrained by stomatal and mesophyll resistance under high VPD stress,despite the atmospheric“source”CO_(2)concentration being ***,ABA-and JA-mediated drought-resistant mechanisms potentially modified the beneficial effect of CO_(2)fertilization on photosynthesis,plant growth,and yield *** study provides valuable information for improving the utilization efficiency of CO_(2)fertilization and a better understanding of the physiological processes.

关键词： Abscisic acid CO_(2)fertilization Jasmonic acid Mesophyll conductance Stomatal conductance Vapor pressure deficit

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