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Quantitative Trait Loci for Resistance Against Fusarium Wilt Based on Three Cotton F_2 Populations

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Agricultural Sciences in China 2010年第12期9卷 1799-1806页

作者： WANG Pei-zheng SHI li-fang SU li hu Bao-min Xinjiang Condy Seed Science ＆ Technology Development Co. Ltd Urumqi 830011 P.R.China

Fusarium wilt （FW） is one of the most common cotton diseases in the world. Identification of QTLs conferring resistance to FW is key for the incorporation of resistance genes into elite cultivars. Two intraspecific （cross between Gossypium hirsuturn L.） and one interspecific （cross between Gossypium hirsutum L. and Gossypium bardence L.） F2 populations were constructed by using a highly resistant cultivar and crossing it to a susceptible cultivar with 154, 79, and 148 offsprings, respectively. Simple sequence repeats （SSR） were used to screen genomic regions closely linked to FW resistance. The results showed that five QTLs associated with FW resistance were detected in two intraspecific populations using a composite interval mapping method under four different conditions. Four of these loci located on Chr. 2/Chr. 17 neighboring markers JESPR304 or CIR305 which explained 13.1 to 45.9% of the phenotypic effect. Furthermore, JESPR304 and CIR305 were previously testified and found to be tightly linked. It is possible that these four QTLs detected under different conditions were the same resistance QTL/gene. We consider that there is the possibility of a major FW resistant gene in intraspecific populations. In the interspecific mapping populations two QTLs were detected on Chr. 9 and Chr. 12/26 which explained great phenotypic variance of 49.4 and 45.7%. As the location of QTLs for FW resistance among the intraspecific and the interspecfic populations were totally different, it is suggested that there may be different resistance mechanisms between G. bardence L. and G. hursutum L. Thus, the present research provides an opportunity to understand the genetic control of resistance to FW in Gossypium hirsutum and Gossypium bardence and to conduct MAS in breeding programs to develop FW resistant cultivars.

关键词： cotton Fusarium wilt resistance QTL molecular mapping

Synthesis,Structure and Luminescence of a Novel 2D Cadmium Coordination Polymer with a ligand Generated in situ

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Chinese Journal of Structural Chemistry 2007年第3期26卷 333-337页

作者： huANG Xi-He SHENG Tian-Lu XIANG Sheng-Chang FU Rui-Biao hu Sheng-min li Ya-min WU Xin-Tao State Key Laboratory of Structural Chemistry Fujian Institute of Research on theStructure of Matter The Chinese Academy of Sciences Fuzhou Fujian 350002 China

The hydrothermal reaction of 1,2-dicyanobenzene with NaN3 in the presence of Cd（NO3）2 affords a novel 2D cadmium tetrazolyl-benzoate, {Cd（tzbz）（H2O）}n （H2tzbz is 2-（5-tetrazolyl）-benzoate）. The tzbz ligand is generated in situ through the [2＋3] Sharpless cycloaddition reaction and hydrolyzation. Its crystal structure was determined by single-crystal X-ray diffraction method. The crystal crystallizes in the orthorhombic system, space group Pbca with a = 9.6659（19）, b = 7.6366（15）, c = 25.964（5）A, V= 1916.5（7）A^3, Z= 8, Mr = 318.57, Dc = 2.208 g/cm^3, F（000） = 1232 and p = 2.276 mm^-1. The Cd（Ⅱ） atom is coordinated by four tzbz ligands and one water molecule to form a severely distorted pentangle bipyramid. While each tzbz ligand connects to four Cd（Ⅱ） atoms in a μ4-η1, η, η1, η1, η1 coordination mode to construct a 2D architecture of the title complex. Additionally, the title complex exhibits strong fluorescence at room temperature in the solid state.

关键词： hydrothermal synthesis in situ crystal structure cadmium

Synthesis and Structure of a Dinuclear Copper(Ⅱ)-ditetrazolate Involving in situ ligand Synthesis

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Chinese Journal of Structural Chemistry 2007年第2期26卷 161-164页

作者： huANG Xi-He SHENG Tian-Lu XIANG Sheng-Chang FU Rui-Biao hu Sheng-min li Ya-min WU Xin-Tao State Key Laboratory of Structural Chemistry Fufian Institute of Research on theStructure of Matter The Chinese Academy of Sciences Fuzhou Fufian 350002 China

The hydrothermal reaction of 1,2-dicyanobenzene with NaN3 in the presence of CuC12, 2,2＇-bipyridine and H2O affords a novel dinuclear copper（Ⅱ）-ditetrazolate, [Cu（bpy）- （pdtz）]2 （Hpdtz = 5,5＂-1,2-phenylene-ditetrazole, bpy = 2,2＇-bipyridine）. The pdtz ligand is generated in situ through Sharpless 2＋3 cycloaddition reaction. Its crystal structure was determined by single-crystal X-ray diffraction method. The crystal crystallizes in the monoclinic system, space group P211n with a = 8.2096（16）, b = 18.580（4）, c = 11.838（2） A, β = 103.12（3）°, V = 1758.5（6） A^3, Z = 2, Mr = 863.83, Dc = 1.631 g/cm^3, F（000） = 876 and μ = 1.272 mm^-1. In this novel dinuclear structure, the pdtz ligand adopts a peculiar μ2-η1,η2 coordination mode.

关键词： hydrothermal synthesis in situ crystal structure copper ditetrazolate

Local excision of ciliary body tumors： a long-term prospective cohort study in China

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Chinese Medical Journal 2008年第21期121卷 2152-2156页

作者： WEI Wen-bin YANG Wen-li hu Shi-min li Bin Ophthalmology and Visual Science Key Laboratory Beijing Tongren Eye Center Beijing Tongren HospitaL Capital Medical University Beijing 100730 China

Background Ciliary body tumors are usually difficult to diagnose and treat in early stages. However, treatment of such tumors has trended toward ocular conservation instead of enucleation. Local excision of ciliary body tumors has become effective with the development of the modern vitrectomy, but long-term outcomes are still not clear. Therefore, we reported the outcome of locally excised ciliary body tumors after long-term follow-up. Methods Twenty-two patients （22 eyes）, who had been diagnosed with ciliary body tumors in Beijing Tongren Hospital from January 1996 to June 2001, were enrolled in this prospective cohort study. Localized lamellar sclera-ciliary excisions were performed. In some cases, vitrectomies, scleral graft transplantations, and further excisions of the anterior choroid were performed. Diagnoses were confirmed by histopathologic examination. Patients were followed from five to eleven years after surgery. Their visual acuity, intraocular pressure and local recurrence were recorded with descriptive percentages. Results After surgery, all patients maintained normal eyeball appearances. Six patients maintained circular pupils. The final best corrected visual acuities （BCVA） varied from 0.02-1.00, including 18 patients （81.82%） who had BCVA equal to or better than that before surgery. Fifteen patients （68.18%） had BCVA better than 0.3. Only two patients had intraocular pressure （lOP） of less than 10 mmHg and the other patients maintained normal lOP. Nine cases （40.91%） were given confirmed diagnosis of malignant melanoma, four （18.18%） of melanocytoma, six （27.27%） of nonpigmented ciliary epithelial adenoma, two （9.09%） of neurofibroma, and one （4.55%） of neurinoma. Twenty patients （90.91%） had no recurrence during the follow-up period. In one case melanocytoma recurred seven years after surgery and enucleation was performed. One patient, whose operation removed a malignant melanoma with a diameter of 16 mm, died of hepatic metastasis five years

关键词： ciliary body tumor local excision prospective cohort study

Non-Synchronous Deformation Effect of Particle in Sheet Metal Forming Process

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Computer Aided Drafting,Design and Manufacturing 2005年第2期15卷 14-18页

作者： DAI hu-min li Zan XIA Ju-chen hu Guo-an State Key Laboratory of Plastic Forming Simulation and Die ＆ Mould Technology Huazhong University of Science and Technology Wuhan 430074 China

A new concept referred to the non-synchronous deformation effect of particle in sheet metal forming is proposed. The results of finite element analysis show that the flow resistance of sheet metal can be effectively reduced and thus the forming property can be greatly improved if the moving and deformation state of the neighboring elements with equal perpendicular distance to the entrance contour of die is non-synchronous. Experiment tests are presented and the results agree well with FEA simulation. In addition, the mechanism of the non-synchronous effect is analyzed in detail.

关键词： forming process flow resistance particle non-synchronous effect

GPS和类GPS测距技术联合用于双星编队星座的状态确定

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国防科技大学学报 2006年第5期28卷 11-16页

作者：王威胡利民国防科技大学机电工程与自动化学院湖南长沙410073

编队卫星状态的高精度确定是编队星座功能实现的重要基础。针对对地观测的双星编队星座的状态确定问题,为了提高状态确定的精度,在GPS技术的基础上,引入了类GPS测距技术,建立了联合GPS和类GPS测距技术进行状态整体确定的两种数学模型,... 详细信息

编队卫星状态的高精度确定是编队星座功能实现的重要基础。针对对地观测的双星编队星座的状态确定问题,为了提高状态确定的精度,在GPS技术的基础上,引入了类GPS测距技术,建立了联合GPS和类GPS测距技术进行状态整体确定的两种数学模型,并讨论了GPS星间单差模糊度和类GPS星内单差模糊度的同时初始化方法,最后进行了数值仿真。仿真结果显示,类GPS观测值尤其是类GPS星内载波单差观测值的引入,明显提高了双星编队星座的状态确定精度,其中绝对姿态角的精度达到rad,相对位置的精度达到m,相对钟差的精度达到s。仿真证明方法正确有效,模型二更优于模型一。

关键词： GPS 类GPS测距技术双星编队星座状态确定整周模糊度

Effect of phacoemulsification with conjunctival Angle scleral margin tunnel incision on postoperative ocular surface in patients with diabetic cataract

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Journal of Hainan Medical University 2019年第16期25卷 60-63页

作者： Zhao Nan-nan ling-hu min-li Chen li-ping Institute of Ophthalmology First Affiliated Hospital of Hainan Medical UniversityHaikou 570100China

Objective:To study the effect of the conjunctival flap with limbus tunnel incision on change in tear function after phacoemulsification cataract surgery in diabetic ***:One hundred and twenty patients with type 2diabetes(120 eyes)were enrolled,The patients were randomly divided into two groups,A:3.0mm clear corneal incision phacoemulsification cataract extraction and intraocular lens(IOL)implantation;sixty patients(60 eyes)in group,B:3.0mm conjunctival flap with limbus tunnel incision phacoemulsification cataract extraction and intraocular lens(IOL)implantation;sixty patients(60 eyes)in *** difference of demographic characteristics between two groups were *** surface disease index(OSDI),corneal sensation,break up time(BUT)and corneal fluorescein staining(FL)were examined preoperatively and 1wk,1 and 3mo ***:the OSDI score of group A was significantly higher than those of group B and the differences were statistically significant(Plimbal tunnel incision,and the tunnel incision into the anterior chamber,closed more general limbal incision closed better,not easy infection and without the stitches,affecting small ocular tear film,This is especially suitable for patients with type 2 diabetes and *** is worthy of clinical applicatio

关键词： Phacoemulsification limbal tunnel incision ocular surface Diabetic cataract

Xueshuantong for Injection(Lyophilized,注射用血栓通)Alleviates Streptozotocin-Induced Diabetic Retinopathy in Rats

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Chinese Journal of Integrative Medicine 2020年第11期26卷 825-832页

作者： li Rui-lin WANG Jin-xin CHAI li-juan GUO Hong WANG Hong CHEN Lu hu li-min WANG Shao-xia Tianjin State Key Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin(300193)China Key Laboratory of Pharmacology of Traditional Chinese Medical Formula Ministry of EducationTianjin University of Traditional Chinese MedicineTianjin(300193)China School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin(300193)China

Objective To investigate the ameliorate effect and underlying mechanism of Xueshuantong for Injection(Lyophilized,注射用血栓通,XST)in streptozocin(STZ)-induced diabetic retinopathy(DR)*** Diabetes mellitus(DM)model was induced by intraperitoneal(i.p.)injection of STZ(60 mg/kg)in Sprague-Dawley *** rats were randomized into 3 groups(n=10)according to a random number table,including DM,XST50 and XST100 *** treatment groups were daily *** with 50 or 100 mg/kg XST for 60 days,*** control and DM groups were given *** with *** glucose level and body weight were recorded every *** changes in the retina tissues were observed with hematoxylin-eosin *** and inflammation related factors,including cleaved caspase-3,glial fifibrillary acidic protein(GFAP),tumor necrosis factor-α(TNF-α)and intercellular cell adhesion molecule-1(ICAM-1)were detected by Western blot or real-time polymerase chain ***,the levels of advanced glycation end product(AGE)and its receptor(RAGE)were *** junctions proteins(Zonula occludens-1(ZO-1),Occludin and Claudin-5)of blood-retinal barrier were detected by Western *** levels of retinal fifibrosis,transforming growth factor-β1(TGF-β1)-Smad2/3 signaling pathway were evaluated at *** There was no signifificant difference in the body weight and blood glucose level between XST and DM groups(P>0.05).Compared with the DM group,XST treatment signifificantly increased the retinal thickness of rats(P<0.05 or P<0.01),and suppressed cleaved caspase-3 expression(P<0.01).XST increased the protein expressions of ZO-1,Occludin and Claudin-5 and decreased the mRNA expressions of matrix metalloproteinase 2(MMP-2)and MMP-9(P<0.05 or P<0.01).Moreover,XST signifificantly reduced the productions of AGE and RAGE proteins in the retina of rats(P<0.05 or P<0.01),suppressed the over-expression of TNF-α,and decreased the elevated level of ICAM-1 in reti

关键词： Xueshuantong for Injection(Lyophilized) diabetic retinopathy Panax notoginseng saponin transforming growth factor-βp/Smad2/3 signaling pathway Chinese medicine

Higher concentration of CO2 and 37℃ stabilize the less virulent opaque cell of Candida albicans

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Chinese Medical Journal 2010年第17期123卷 2446-2450页

作者： liU Ze-hu li min LU Xue-lian SHE Xiao-dong hu Su-quan CHEN Wei liU Wei-da Department of Medical Mycology Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing Jiangsu 210042 China

Background Candida albicans （C. albicans） strains can spontaneously switch at a very low frequency from white to opaque phase. The ability to switch reversibly between white and opaque phenotype and contributes to the pathogenicity of C. albicans. White and opaque switching can be induced by various environmental signals. Previous study showed that opaque cells switch en masse to white when transferred in vitro to 37℃, the temperature of their animal host. The objective of the present study was to determine the effect of different concentration of carbon dioxide and temperature on white-opaque switching, and to determine the different anti-candida killing activity of white and opaque form by human monocyte-macrophage cell line *** White-opaque switching and opaque-white switching were assayed. Modified Lee＇s medium supplemented with phloxine B was used to detect white and opaque forms of C. albicans under 0.03% CO2 at 25℃, 0.03% CO2 at 37℃ and 5% CO2 at 37℃. Growth curve of C. albicans was monitored using OD value at 630 nm simultaneously. White and opaque forms of C. albicans and THP-1 cells were cocultured at ratio of 1：10. Colony serial dilutions were used to assay for intracellular candidacidal activity. MTT assay was used to measure the extracellular candidacidal *** Phenotype switching was successfully induced in vitro in all three strains of C. albicans. When evaluating white to opaque switching, opaque colony proportion of all colonies was 0.572±0.087, 0.920±0.030 and 0.985±0.026 exposure of white cells to 0.03% CO2 at 25℃, 0.03% CO2 at 37℃ and 5% CO2 at 37℃. When evaluating opaque to white switching, opaque colony proportion of all colonies was 0.600±0.114, 0.983±0.003 and 0.998±0.003 exposure of white cells to 0.03% CO2 at 25℃, 0.03% CO2 at 37℃ and 5% CO2 at 37℃. No significant difference of white or opaque form growth rate was found among three conditions （P〉0.05）. THP-1 mediated extracellular anti-candida activity in white form was

关键词： Candida albicans white, opaque carbon dioxide THP-1