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Morbidity and Mortality of Acute Renal Failure in COVID-19 Patients in Intensive Care According to Waves/Variant: Case of the Grand Hôpital de l’Est Francilien Site de Meaux

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Open Journal of Internal Medicine 2024年第1期14卷 16-29页

作者： Khazy Anga ariel Makembi Éric Amisi Éric Delpierre Vivien Hong Tuan Ha Wilfrid Mbombo Jean Claude Mubenga Dan Kankonde Chris Nsituavibidila Lionel Diyamona Noelly Mukuna Gracia Likinda Tharcisse Mabiala Martin Mukenga Médard Bula-Bula Berthe Barhayiga Département d’Anesthésie Réanimation Université de Kinshasa Kinshasa République démocratique du Congo Service de Réanimation Grand H&ocircpital de l’Est Francilien Meaux France Département de Médecine Interne Université de Kinshasa Kinshasa République démocratique du Congo Service d’Anesthésie Réanimation Centre Hospitalier Monkole Kinshasa République démocratique du Congo Department of Anaesthesia and Intensive Care H&ocircpital Général de Référence de Kinshasa Kinshasa République démocratique du Congo Department of Anaesthesia and Intensive Care Université Protestante du Congo Kinshasa République démocratique du Congo

Introduction: The incidence of acute renal failure (ARF) varies between 20% and 40% of cases for COVID-19 patients admitted to the intensive care unit, with very high mortality, but heterogeneous according to the different epidemic waves, probably due to the genetic variant phenomenon of the virus. The aim of this study is to determine the morbidity and mortality of COVID-19 patients admitted with ARF to the intensive care unit of the Grand H?pital Est Francilien (GHEF) according to the waves and variants. Methods: Cross-sectional observational study of COVID-19 patients with ARF admitted to the intensive care unit of the GHEF site in Meaux covering the period from March 1st 2020 to December, 31st 2021. Per-hospitalisation and outcome data were collected and analysed with SPSS version 25.0 software using the Chi-square or Fischer’s exact test or Student’s t-test and logistic regression for p Results: A total of 86 patients were included. The mean age was higher (70 ± 8.5) in patients in the fourth wave than in the other waves (p = 0.015), with male predominance in all waves without significant difference. Co-morbidities: hypertension, diabetes, heart disease, dyslipidaemia and arrhythmia complete with fibrillation were present in all waves. The majority of patients were classified as KDIGO 1 for the different waves (1st: 61.9%, 2nd: 86.5%, 3rd: 80%, and 4th: 75%), with the same trend according to variant (alpha: 80%, beta: 75%, delta: 81.3%, omicron: 75%). Mortality by the wave was: 1st: 28.5%, 2nd: 37.5%, 3rd: 23% and 4th: 11%) and by variant: alpha: 24.2%, beta: 44.8%, delta: 20.7%, omicron: 10.3%). Overall mortality was 33.7%. Case fatality was higher in the fourth wave. Hypertension, shock, failure to recover renal function, acute lung oedema, ventilator-associated lung disease and hyperkalaemia were factors associated with mortality (p Conclusion: Acute renal failure is common in COVID-19 patients admitted to the intensive care unit, and m

关键词： Mortality COVID-19 Morbidity Renal Failure Intensive Care Unit

Image resizing by reconstruction from deep features

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Computational Visual Media 2021年第4期7卷 453-466页

作者： Dov Danon Moab Arar Daniel Cohen-Or ariel Shamir Tel Aviv University Tel Aviv69978Israel The Interdisciplinary Center Herzliya Herzliya4610101

Traditional image resizing methods usually work in pixel space and use various saliency *** challenge is to adjust the image shape while trying to preserve important *** this paper we perform image resizing in feature space using the deep layers of a neural network containing rich important semantic *** directly adjust the image feature maps,extracted from a pre-trained classification network,and reconstruct the resized image using neuralnetwork based *** novel approach leverages the hierarchical encoding of the network,and in particular,the high-level discriminative power of its deeper layers,that can recognize semantic regions and objects,thereby allowing maintenance of their aspect *** use of reconstruction from deep features results in less noticeable artifacts than use of imagespace resizing *** evaluate our method on benchmarks,compare it to alternative approaches,and demonstrate its strengths on challenging images.

关键词： image retargeting reconstruction deep seam carving image resizing

Evaluation of Pressure Boundary Conditions for Permeability Calculations Using the Lattice-Boltzmann Method

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Advances in Applied Mathematics and Mechanics 2010年第5期2卷 685-700页

作者： ariel Narvaez Jens Harting Department of Applied Physics Eindhoven University of TechnologyP.O.Box 5135600MB EindhovenThe Netherlands Institute for Computational Physics University of StuttgartPfaffenwaldring 2770569 StuttgartGermany

Lattice-Boltzmann(LB)simulations are a common tool to numerically estimate the permeability of porous *** valuable results,the porous structure has to be well resolved resulting in a large computational effort as well as high memory *** order to estimate the permeability of realistic samples,it is of importance to not only implement very efficient codes,but also to choose the most appropriate simulation setup to achieve accurate *** the focus on accuracy and computational effort,we present a comparison between different methods to apply an effective pressure gradient,efficient boundary conditions,as well as two LB implementations based on pore-matrix and pore-list data structures.

关键词： Fluid dynamics fluid flow through porous media

The National Interest and Global Justice:Contradictory Terms,Incomparable and Non-commensurable Goods,Yet Compatible?

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Fudan Journal of the Humanities and Social Sciences 2019年第2期12卷 233-253页

作者： ariel Colonomos CNRS-CER1 Sciences PoParisFrance

Prima facie,the pursuit of national interest stands in contradiction with the rules of global ***,the former relies upon selfishness and the maximization of national utility,while the latter presupposes distributive measures at the global level that exercise some constrain on state ***,these two notions are open to interpretation and,sometimes,even lack *** paper will look for clarification and will ask whether it is possible to go beyond the radical difference between those two logics.I will start by underlining the reasons why the national interest and global justice are in contradiction with each *** they are not commensurable,the paper will then argue the two can be compatible in specific equilibriums of international politics,I will refer to as the“rationalist”and the“revolutionist”***,the paper will discuss whether,in the best of all possible worlds,we should strive for this compatibility.

关键词： International politics International relations theory Global justice National interest Commensurability Realism

Landform type mediates compositional change in a hurricane-disturbed subtropical forest

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Ecological Processes 2020年第1期9卷 292-304页

作者： Robert L.Spicer ariel ELugo Nathan Ruhl Department of Biological Science Rowan UniversityGlassboroNJ 08028USA International Institute of Tropical Forestry United States Department of Agriculture Forest ServiceJardín Botánico SurRío PiedrasPRUSA

Background:Categorization of topographical features into landform type is a long-standing method for understanding physiographic patterns in the *** in forest composition between landform types are driven primarily by concurrent differences in soil composition and moisture,but also disturbance *** studies have focused on the interaction between fire disturbance,succession,and landforms,but the effects of hurricane disturbance on compositional differences between landforms are poorly *** the study presented here,we assess compositional and structural differences between landform types in the tree community of a young sub-tropical forest that is frequently subjected to ***,we ask whether the tree community(1)changed structurally over the study period,(2)experienced compositional change over the study period,(3)is compositionally different between landform types,and(4)exhibits compositional change mediated by landform ***:The tree community experienced significant structural change over the course of our study,but compositional change was only significant for some ***:Despite large-scale,intense,and frequent hurricane disturbance to our study system,compositional change in the tree community was localized and only significant for some landform types.

关键词： Hurricane Forest Community Composition Change Succession Landform

Biomass and dominance of conservative species drive above-ground biomass productivity in a mediterranean-type forest of Chile

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Forest Ecosystems 2019年第4期6卷 339-351页

作者： ariel Isaías Ayma-Romay Horacio E.Bown Facultad de Ciencias Forestales y Conservación de la Naturaleza Universidad de Chile

Background: Forest productivity has a pivotal role in human well-being. Vegetation quantity, niche complementarity, mass-ratio, and soil resources are alternative/complementary ecological mechanisms driving productivity. One challenge in current forest management depends on identifying and manipulating these mechanisms to enhance productivity. This study assessed the extent to which these mechanisms control aboveground biomass productivity(AGBP) of a Chilean mediterranean-type matorral. AGBP measured as tree aboveground biomass changes over a 7-years period, was estimated for twelve 25 m × 25 m plots across a wide range of matorral compositions and structures. Variables related to canopy structure, species and functional diversity, species and functional dominance, soil texture, soil water and soil nitrogen content were measured as surrogates of the four mechanisms proposed. Linear regression models were used to test the hypotheses. A multimodel inference based on the Akaike’s information criterion was used to select the best models explaining AGBP and for identifying the relative importance of each ***: Vegetation quantity(tree density) and mass-ratio(relative biomass of Cryptocarya alba, a conservative species) were the strongest drivers increasing AGBP, while niche complementarity(richness species) and soil resources(sand, %) had a smaller effect either decreasing or increasing AGBP, respectively. This study provides the first assessment of alternative mechanisms driving AGBP in mediterranean forests of Chile. There is strong evidence suggesting that the vegetation quantity and mass-ratio mechanisms are key drivers of AGBP, such as in other tropical and temperate forests. However, in contrast with other studies from mediterranean-type forests, our results show a negative effect of species diversity and a small effect of soil resources on ***: AGBP in the Chilean matorral depends mainly on the vegetation quantity and mass-ratio mechanisms

关键词： Above-ground biomass productivity Diversity Niche complementarity Mass-ratio Mediterranean Soil resources

Little effect of climate change on body size of herbivorous beetles

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Insect Science 2018年第2期25卷 309-316页

作者： Yuval Baar ariel Leib Leonid Friedman Shai Meiri Inon Scharf Department of Zoology Faculty of Life Sciences ＆ Steinhardt Museum of Natural History and National Research Center Tel Aviv University Tel Aviv Israe

Ongoing climate change affects various aspects of an animal＇s life, with impor- tant effects on distribution range and phenology. The relationship between global warming and body size changes in mammals and birds has been widely studied, with most find- ings indicating a decline in body size over time. Nevertheless, little data exist on similar size change patterns of invertebrates in general and insects in particular, and it is unclear whether insects should decrease in size or not with climate warming. We measured over 4000 beetle specimens, belonging to 29 beetle species in 8 families, collected in Israel during the last 100 years. The sampled species are all herbivorous. We examined whether beetle body size had changed over the years, while also investigating the relationships between body size and annual temperature, precipitation, net primary productivity （NPP） at the collection site and collection month. None of the environmental variables, including the collection year, was correlated with the size of most of the studied beetle species, while there were strong interactions of all variables with species. Our results, though mostly neg- ative, suggest that the effect of climate change on insect body size is species-specific and by no means a general macro-ecological rule. They also suggest that the intrapopulation variance in body size of insects collected as adults in the field is large enough to conceal intersite environmental effects on body size, such as the effect of temperature and NPE

关键词： Coleoptera museum collections rain temperature-size rule thermal ecol-ogy

Choroid plexus trophic factors in the developing and adult brain

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Frontiers in Biology 2016年第3期11卷 214-221页

作者： Karen Amaud ariel A. Di Nardo Center for Interdisciplinary Research in Biology (CIRB) CNRS UMR 7241/INSERM U1050 Labex Memolife CollOge de France 75231 Paris France Universite Pierre et Marie Curie Paris VI Paris France

The choroid plexus （CP）, localized in brain ventricles, is the major source of cerebrospinal fluid （CSF） and participates in the blood-CSF barrier. It is essential for brain immunosurveillance and the clearance of toxics, and for brain development and activity. Indeed, the CP secretes a large variety of trophic factors in the CSF that impact the entire brain. These factors are mainly implicated in neurogenesis, but also in the maintenance of brain functions and the vasculature. In this mini-review, we provide an overview of the various trophic factors secreted by the CP in the CSF, and describe their roles in the developing, adult and diseased brain.

关键词： choroid plexus trophic factors CSF neurogenesis development adult brain

Current and Future Treatment of Hepatocellular Carcinoma:An Updated Comprehensive Review

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Journal of Clinical and Translational Hepatology 2018年第1期6卷 69-78页

作者： Saleh Daher Muhammad Massarwa ariel A. Benson Tawfik Khoury Gastroenterology and Liver Units Department of MedicineHadassah-Hebrew University Medical CenterJerusalemIsrael

Hepatocellular carcinoma(HCC)is among the leading causes of cancer-related *** principal treatment is surgical resection or liver transplantation,depending on whether the patient is a suitable transplant ***,in most patients with HCC the diagnosis is often late,thereby excluding the patients from definitive surgical *** treatment includes sorafenib,which is the most commonly used systemic therapy;although,it has been shown to only minimally impact patient survival by several *** and radiotherapy are generally *** to the poor prognosis of patients with HCC,newer treatments are needed with several being in development,either in preclinical or clinical *** this review article,we provide an update on the current and future medical and surgical management of HCC.

关键词： HCC Treatments Sorafenib Mortality